Biological activities of hydrazide derivatives in the new millennium

Acta Pharmaceutica Sciencia

Volumn 52, Issue 2, 2010, Pages 169-180

  Narasimhan, Balasubramanian ^a   Kumar, Pradeep ^a   Sharma, Deepika ^b  

^a MAHARSHI DAYANAND UNIVERSITY   (India)

^b MAHARISHI MARKANDESHWAR DEEMED TO BE UNIVERSITY   (India)

Author keywords

Biological activity; Hydrazides; Hydrazones

Indexed keywords

(4 PHENYL 5 PYRIDIN 4 YL 4H [1,2,4]TRIAZOL 3 YLSULFANYL)ACETIC ACID (2 HYDROXYBENZYLIDENE)HYDRAZIDE; (7 HYDROXY 2 OXO 2H CHROMEN 4 YL)ACETIC ACID (3 NITRO BENZYLIDENE)HYDRAZIDE; 1 (4 FLUOROPHENYL) 3 [4 [1 [(PYRIDINE 4 CARBONYL)HYDRAZONO]ETHYL]PHENYL]THIOUREA; 1 CYCLOPROPYL 6 FLUORO 8 METHOXY 7 [[N4 [2 [2 (2,6 DICHLOROPHENYLAMINO)PHENYL]ACETYL] 3 METHYL] N PIPERAZINYL] 4 OXO 1,4 DIHYDRO 3 QUINOLINE CARBOXYLIC ACID; 2 AMINO 5 METHYL BENZO[D]ISOTHIAZOL 3 ONE; 2 AMINO BENZO[D]ISOTHIAZOL 3 ONE; 2 [2 (5 METHYL 2 BENZOXAZOLINONE 3 YL)ACETYL] 4 CHLOROBENZYLIDENEHYDRAZINE; 2',4' DIFLUORO 4 HYDROXY BIPHENYL 3 CARBOXYLIC ACID BENZYLIDENE HYDRAZIDE; 2,6 DIMETHYLIMIDAZO[2,1 B][1,3,4]THIADIAZOLE 5 CARBOXYCLIC ACID (2 HYDROXYBENZYLIDENE)HYDRAZIDE; 3 (4 BROMOPHENYLIMINO) 1 [(DIPHENYLAMINO)METHYL] 5 NITRO 1,3 DIHYDRO INDOL 2 ONE; 3 (4 BROMOPHENYLIMINO) 5 NITRO 1,3 DIHYDRO INDOL 2 ONE; 4 ACETYLBENZOIC ACID [(5 NITROTHIOPHEN 2 YL)METHYLENE]HYDRAZIDE; 4 ADAMANTAN 1 YL QUINOLINE 2 CARBOXYLIC ACID (2 CHLOROBENZYLIDENE)HYDRAZIDE; 4 FLUOROBENZOIC ACID [(5 NITROTHIOPHEN 2 YL)METHYLENE]HYDRAZIDE; 4 NITROBENZOIC ACID [4 (4 NITROPHENYL)CYCLOPENTA 1,3 DIENYLMETHYLENE]HYDRAZIDE; 5 BUTYLAMINO 1 PROPYL 2,3,9,9B TETRAAZACYCLOPENTA[A]NAPHTHALENE 4 CARBOXYLIC ACID DIETHYLAMIDE; 5 ETHYLAMINO 1 PROPYL 2,3,9,9B TETRAAZACYCLOPENTA[A]NAPHTHALENE 4 CARBOXYLIC ACID DIETHYLAMIDE; 6 CHLORO 2 (4 METHOXYPHENYL)QUINOLINE 4 CARBOXYLIC ACID 4 (NITROBENZYLIDENE) HYDRAZIDE; 6 [[2 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)HYDRAZONO]METHYL] 9 OXO 9H XANTHENE 1,3 DIYLDIACETIC ACID; 7 HYDROXY 4 [(5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL)METHYL] 2H CHROMEN 2 ONE; 7 HYDROXY 4 [(5 MERCAPTO 4H 1,3,4 OXADIAZOL 2 YL)METHYL] 2H CHROMEN 2 ONE; 8 (3 CHLOROPHENYL) 4 OXO 4,6,7,8 TETRAHYDRO IMIDAZO[2,1,C][1,2,4]TRIAZINE 3 CARBOXYLIC ACID HYDRAZIDE; ACYLHYDRAZINE BENZENEDIASULFONAMIDE DERIVATIVE; BENZO[D]ISOTHIAZOLE 3 CARBOXYLIC ACID (4 METHOXYBENZYLIDENE)HYDRAZIDE; HYDRAZIDE DERIVATIVE; N (7 CHLORO QUINOLIN 4 YL) N' (4 PYRROLIDIN 1 YLMETHYL BENZYLIDENE)HYDRAZINE; N' (4 CHLOROBENZYLIDENE) N (PYRIDINE 4 CARBONYL)HYDRAZIDE PYRAZINOIC ACID; N' [(1H INDOL 3 YL)METHYLENE] 4 METHYL BENZENESULFONOHYDRAZIDE; N' [(1H INDOL 3 YL)METHYLENE]BENZENESULFONOHYDRAZIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTHELMINTIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; CANDIDA ALBICANS; DIABETES MELLITUS; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; LEISHMANIA MEXICANA; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM; STAPHYLOCOCCUS AUREUS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 77954189491     PISSN: 13072080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Al-Macrosaur, L.Q., Dayam, R., Taheri, L., Witvrouw, M., Debyser, Z. and Neamati, N. (2007). Discovery of novel non-cytotoxic salicylhydrazine containing HIV-1 integrase Inhibitors. Bioorg. Med. Chem. Lett. 17: 6472-6475.
2. Bedia, K., Elcin, O., Seda, U., Fatma, K., Nathalay, S., Sevim, R. and Dimoglo, A. (2006). Synthesis and characterization of novel hydrazide-hydrazones and the study of their structure-antituberculosis activity. Eu. J. Med. Chem. 41: 1253-1261.
3. Cacic, M., Trkovnik, M., Cacic, F. and Has-Schon, E. (2006). Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide. Molecules. 11: 134-147.
4. Caffrey, C.R., Schanz, M., Nkemgu-Njinkeng, J., Brush, M., Hausell, E., Cohen, F.E., Flaherty, T.M., Mckerrow, J.H. and Steverding, D. (2002). Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int. J. Antimicrob. Agents. 19: 227-251.
5. Gemma, S., Kukreja, G., Fattorusso, C., Persico, M., Romano, M.P., Altarelli, M., Savini, L., Campiani, G., Fattorusso, E., Basilico, N., Taramelli, D., Yardley, V. and Butini, S. (2006). Synthesis of N1- amylidene-N2- quinolyl- and N2- acryldinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorg. Med. Chem. Lett. 16: 5384-5388.
6. Hanna, M.L., Tarasow, T.M. and Perkins, J. (2007). Mechanistic differences between in vitro assays for hydrazone based small molecule Inhibitors of antrax lethal factor. Bioorg. Med. Chem. 35: 50-58.
7. Kucukguzel, S.G., Mazi, A., Sahin, F., Ozturk, S. and Stables, J. (2003). Synthesis and biological activities of difulunisal hydrazide-hydrazones. Eur. J. Med. Chem. 38: 1005-1013.
8. Leite, A.C.L., de Lima, R.S., Moreira, D.R., Cardoso, M.V., de Brito, A.C.G., dos Santos, L.M.F., Hernandes, M.Z., Kipustok, A.C., de Lima, R.S. and Soares, M.B.P. (2006). Synthesis, docking, and in vitro activity of thiosemiconbazone, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi. Bioorg. Med. Chem. 14: 3749-3757.
9. Manvar, A., Malde, A., Verma, J., Virsodia, V., Mishra, A., Upadhyay, K., Acharya, H., Countinhe, E. and Shah, A. (2008). Synthesis, anti-tubercular activity and 3D-QSAR study of coumarin-4-acetic acid benzylidene hydrazides. Eur. J. Med. Chem. [In Press].
10. Masunari, A. and Tavares, L.C. (2007). A new class of nifuroxazide analogues: synthesis of 5-nitrothiophine derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus. Bioorg. Med. Chem. 15: 4229-4236.
11. Metwally, K.A., Abdel-Aziz, L.M., Lashine, E.M., Husseiny, M.I. and Badawy R.H. (2006). Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents. Bioorg. Med. Chem. 14: 8675-8682.
12. Nayyar, A., Monga, V., Malde, A., Coutinho, E. and Jain, R. (2007). Synthesis, anti-tuberculosis activity and 3D-QSAR study of 4-(adamantan-1-yl)-2-substituted quinolines. Bioorg. Med. Chem. 15: 626-640.
13. Radhwan, M.A.A., Ragab, E.A., Sabry, N.M. and El-Shenawy, S.M. (2007). Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents. Bioorg. Med. Chem. 15: 3832-3841.
14. Roma, G., Braccio, M.D., Grossi, G., Mattioli, F. and Ghia, M. (2000). 1,8-naphthyridines IV. 9-substituted. N,N-dialkyl-5-(alkylamino or cycloalkyl amino) [1,2,4] triazolo [4,3-a] [1,8] naphthyridine -6-carboxamides, new compounds with antiaggressive and potent anti-inflammatory activities. Eur. J. Med. Chem. 35: 1021-1035.
15. Salgin-Goksen, U., Gokhan-Kelekci, N., Goktas, O., Koysal, Y., Kilic, E., Trik, S., Aktay, G. and Ozalp, M. (2007). 1-Acyl thiosemicarbazides, 1,2,4-triazole -5(4H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: synthesis, analgesic anti-inflammatory and antimicrobial activities. Bioorg. Med. Chem. 15: 5738-5751.
16. Sinha, N., Jain, S., Thilekar, A., Upadhayaya, R.S., Kishore, N., Sinha, R.K. and Arora, S.K. (2005). Synthesis and antimycobacterial activity of some N, N'-disubstituted isonicotinohydrazide derivatives. ARKIVOC ii: 4-19.
17. Smalley, T.L., Jr., Peat, A.J., Boucheron, J.A., Dickerson, S., Garrido, D., Preugschat, F., Schweiker, S.L., Thomson, S.A. and Wang, T.Y. (2006). Synthesis and evaluation of novel heterocylclic Inhibitors of GSK-3. Bioorg. Med. Chem. Lett. 16: 2091-2094.
18. Sridhar, S.K., Saravanan, M. and Ramesh, A. (2001). Synthesis and antibacterial screening of hydrazones, schiff and mannich bases of isatin Derivatives. Eur. J. Med. Chem. 36: 615-625.
19. Sriram, D., Yogeeswari, P. and Devakaram, R.V. (2006). Synthesis, in vitro and in vivo antimycobacterial activities of diclofenac acid hydrazones and amides. Bioorg. Med. Chem. 14: 3113-3118.
20. Sriram, D., Yogeswari, P. and Madhu, K. (2006). Synthesis and in vitro antitubercular activity of some 1-[(4-sub) phenyl]-3-(4-{1-[(pyridine-4-carboxyl) hydrazono] ethyl} phenyl) thiourea. Bioorg. Med. Chem. 16: 876-878.
21. Sunidhi, S.M., Dinodia, M. and Kumar, A. (2006) Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives. Bioorg. Med. Chem. 14: 4657-4663.
22. Sztanke, K., Pasterhak, K., Rzymowska, J., Sztanke, M. and Kandefer-Szerszen, M. (2007). Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives. Eur. J. Med. Chem. 43: 404-419.
23. Terzioglu, N. and Gursoy, A. (2003). Synthesis and anticancer evaluation of some new hydrazone derivatives of 2,6-dimethylimidazo[2,1-b] [1,3,4] thiadiazole-5-carbohydrazine. Eur. J. Med. Chem. 38: 781-786.
24. Varache-Lembege, M., Moreau, S., Larrouture, S., Montaudon, D., Robert, J. and Nuhrich, A. (2007). Synthesis and antiproliferative activity of aryl and heteroaryl-hydrazones derived from xanthene carbaldehyde. Eur. J. Med. Chem. (In Press).
25. Vicini, P., Incerti, M., Doytchinova, I.A., Colla, P.L., Busonera, B. and Loddo, R. (2006). Synthesis and antiproliperative activity of benzo[d]isothiazole hydrazones. 41: 624-632.
26. Vicini, P., Zani, F., Cozzini, P. and Doytchinova, I. (2002). Hydrazone of 1,2-Benzisothiazole Hydrazides: Synthesis, antimicrobial activity and QSAR investigations. Eur. J. Med. Chem. 37: 553-564.
27. Visbal, G., Marchan, E., Maldonado, A., Simoni, Z. and Navarro, M. (2008). Synthesis and characterization of platinum-sterol hydrazone complexes with biological activity against Leishmania (L.) mexicana. J. Inorg. Biochem. 102: 547-554.
28. Zareef, M., Iqbal, R., Mirza, B., Khan, K.M., Manan, A., Asim, F. and Khan, W. (2008). Synthesis and antimicrobial activity of some derivatives of acylhydrazine including novel benzenidiazasulfonamides. ARKIVOC ii: 141-152.