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Volumn 9, Issue 12, 2010, Pages 2286-2291

Migratory potential of rheumatoid arthritis synovial fibroblasts: Additional perspectives

Author keywords

Fibroblast; Inflammation; Migration; Rheumatoid arthritis; Synovium

Indexed keywords

ARTICULAR CARTILAGE; CELL MIGRATION; FIBROBLAST; HOMEOSTASIS; IMMUNE SYSTEM; IMMUNITY; JOINT DESTRUCTION; REVIEW; RHEUMATOID ARTHRITIS; TISSUE REPAIR; TUMOR CELL; WOUND HEALING;

EID: 77954156032     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.12.11907     Document Type: Review
Times cited : (23)

References (68)
  • 1
    • 10444242596 scopus 로고    scopus 로고
    • CC and CXC chemokine receptors mediate migration, proliferation and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients
    • Garcia-Vicuna R, Gomez-Gaviro MV, Dominguez-Luis MJ, Pec MK, Gonzalez-Alvaro I, Alvaro-Gracia JM, et al. CC and CXC chemokine receptors mediate migration, proliferation and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheum 2004; 50:34-6.
    • (2004) Arthritis Rheum , vol.50 , pp. 34-36
    • Garcia-Vicuna, R.1    Gomez-Gaviro, M.V.2    Dominguez-Luis, M.J.3    Pec, M.K.4    Gonzalez-Alvaro, I.5    Alvaro-Gracia, J.M.6
  • 2
    • 1242274550 scopus 로고    scopus 로고
    • Autocrine/Paracrine Role of the Angiopoietin-1 and -2/Tie2 System in Cell Proliferation and Chemotaxis of Cultured Fibroblastic Synoviocytes in Rheumatoid Arthritis
    • DOI 10.1016/j.humpath.2003.11.010
    • Takahara K, Iioka T, Furukawa K, Uchida T, Nakashima M, Tsukazaki T, et al. Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis. Hum Pathol 2004; 35:150-8. (Pubitemid 38240896)
    • (2004) Human Pathology , vol.35 , Issue.2 , pp. 150-158
    • Takahara, K.1    Iioka, T.2    Furukawa, K.3    Uchida, T.4    Nakashima, M.5    Tsukazaki, T.6    Shindo, H.7
  • 4
  • 5
  • 6
    • 0029855587 scopus 로고    scopus 로고
    • Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
    • Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996; 149:1607-15.
    • (1996) Am J Pathol , vol.149 , pp. 1607-1615
    • Muller-Ladner, U.1    Kriegsmann, J.2    Franklin, B.N.3    Matsumoto, S.4    Geiler, T.5    Gay, R.E.6
  • 7
    • 33749023888 scopus 로고    scopus 로고
    • Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis
    • Muller-Ladner U, Pap T, Gay RE, Neidhart M, Gay S. Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 2005; 1:102-10.
    • (2005) Nat Clin Pract Rheumatol , vol.1 , pp. 102-110
    • Muller-Ladner, U.1    Pap, T.2    Gay, R.E.3    Neidhart, M.4    Gay, S.5
  • 8
    • 0034469496 scopus 로고    scopus 로고
    • Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
    • Pap T, Muller-Ladner U, Gay RE, Gay S. Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2000; 2:361-7.
    • (2000) Arthritis Res , vol.2 , pp. 361-367
    • Pap, T.1    Muller-Ladner, U.2    Gay, R.E.3    Gay, S.4
  • 9
    • 34548136162 scopus 로고    scopus 로고
    • Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar
    • Ghahary A, Ghaffari A. Role of keratinocyte-fibroblast cross-talk in development of hypertrophic scar. Wound Repair Regen 2007; 15:46-53.
    • (2007) Wound Repair Regen , vol.15 , pp. 46-53
    • Ghahary, A.1    Ghaffari, A.2
  • 10
    • 63849275879 scopus 로고    scopus 로고
    • Macrophages and fibroblasts during inflammation, tissue damage and organ injury
    • Glaros T, Larsen M, Li L. Macrophages and fibroblasts during inflammation, tissue damage and organ injury. Front Biosci 2009; 14:3988-93.
    • (2009) Front Biosci , vol.14 , pp. 3988-3993
    • Glaros, T.1    Larsen, M.2    Li, L.3
  • 11
    • 77954167763 scopus 로고    scopus 로고
    • Fibroblasts and myofibroblasts in wound healing: Force generation and measurement
    • Li B, Wang JH. Fibroblasts and myofibroblasts in wound healing: Force generation and measurement. J Tissue Viability 2009.
    • (2009) J Tissue Viability
    • Li, B.1    Wang, J.H.2
  • 12
    • 65549138993 scopus 로고    scopus 로고
    • Suppressive influences in the immune response to cancer
    • Bronte V, Mocellin S. Suppressive influences in the immune response to cancer. J Immunother 2009; 32:1-11.
    • (2009) J Immunother , vol.32 , pp. 1-11
    • Bronte, V.1    Mocellin, S.2
  • 13
    • 56749160117 scopus 로고    scopus 로고
    • Tumor-host interactions: The role of inflammation
    • Le Bitoux MA, Stamenkovic I. Tumor-host interactions: the role of inflammation. Histochem Cell Biol 2008; 130:1079-90.
    • (2008) Histochem Cell Biol , vol.130 , pp. 1079-1090
    • Le Bitoux, M.A.1    Stamenkovic, I.2
  • 14
    • 52049107370 scopus 로고    scopus 로고
    • Tumor dormancy and immunoescape
    • Quesnel B. Tumor dormancy and immunoescape. Apmis 2008; 116:685-94.
    • (2008) Apmis , vol.116 , pp. 685-694
    • Quesnel, B.1
  • 17
    • 0034118827 scopus 로고    scopus 로고
    • High-resistance MDCK-C7 monolayers used for measuring invasive potency of tumour cells
    • Zak J, Schneider SW, Eue I, Ludwig T, Oberleithner H. High-resistance MDCK-C7 monolayers used for measuring invasive potency of tumour cells. Pflugers Arch 2000; 440:179-83.
    • (2000) Pflugers Arch , vol.440 , pp. 179-183
    • Zak, J.1    Schneider, S.W.2    Eue, I.3    Ludwig, T.4    Oberleithner, H.5
  • 18
    • 72849130461 scopus 로고    scopus 로고
    • Integrins in bone metastasis formation and potential therapeutic implications
    • Clezardin P. Integrins in bone metastasis formation and potential therapeutic implications. Curr Cancer Drug Targets 2009; 9:801-6.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 801-806
    • Clezardin, P.1
  • 19
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10:9-22.
    • Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 21
    • 70450218151 scopus 로고    scopus 로고
    • Cell adhesion molecules: Role and clinical significance in cancer
    • Makrilia N, Kollias A, Manolopoulos L, Syrigos K. Cell adhesion molecules: role and clinical significance in cancer. Cancer Invest 2009; 27:1023-37.
    • (2009) Cancer Invest , vol.27 , pp. 1023-1037
    • Makrilia, N.1    Kollias, A.2    Manolopoulos, L.3    Syrigos, K.4
  • 23
    • 70350238658 scopus 로고    scopus 로고
    • Inflammation: A driving force speeds cancer metastasis
    • Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle 2009; 8:3267-73.
    • (2009) Cell Cycle , vol.8 , pp. 3267-3273
    • Wu, Y.1    Zhou, B.P.2
  • 24
    • 71549117557 scopus 로고    scopus 로고
    • Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
    • Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009; 15:1414-20.
    • (2009) Nat Med , vol.15 , pp. 1414-1420
    • Lefevre, S.1    Knedla, A.2    Tennie, C.3    Kampmann, A.4    Wunrau, C.5    Dinser, R.6
  • 26
    • 0000154714 scopus 로고    scopus 로고
    • "Inverse wrap" - An improved implantation technique for virus-transduced synovial fibroblasts in the SCID-mouse model for RA
    • Judex M, Neumann E, Fleck M, Pap T, Mountz JD, Gay RE, et al. "Inverse wrap" - an improved implantation technique for virus-transduced synovial fibroblasts in the SCID-mouse model for RA. Mod Rheumatol 2001; 11:145-50.
    • (2001) Mod Rheumatol , vol.11 , pp. 145-150
    • Judex, M.1    Neumann, E.2    Fleck, M.3    Pap, T.4    Mountz, J.D.5    Gay, R.E.6
  • 27
    • 14044271507 scopus 로고    scopus 로고
    • The role of macrophages in rheumatoid arthritis
    • Ma Y, Pope RM. The role of macrophages in rheumatoid arthritis. Curr Pharm Des 2005; 11:569-80.
    • (2005) Curr Pharm des , vol.11 , pp. 569-580
    • Ma, Y.1    Pope, R.M.2
  • 28
    • 0036164195 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction
    • DOI 10.1002/1529-0131(200201)46:1<52::AID-ART10048>3.0.CO;2-1
    • Neumann E, Kullmann F, Judex M, Justen HP, Wessinghage D, Gay S, et al. Identification of differentially expressed genes in rheumatoid arthritis by a combination of complementary DNA array and RNA arbitrarily primed-polymerase chain reaction. Arthritis Rheum 2002; 46:52-63. (Pubitemid 34121650)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.1 , pp. 52-63
    • Neumann, E.1    Kullmann, F.2    Judex, M.3    Justen, H.P.4    Wessinghage, D.5    Gay, S.6    Scholmerich, J.7    Muller-Ladner, U.8
  • 30
    • 18744405989 scopus 로고    scopus 로고
    • Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway
    • Neumann E, Judex M, Kullmann F, Grifka J, Robbins PD, Pap T, et al. Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway. Gene Ther 2002; 9:1508-19.
    • (2002) Gene Ther , vol.9 , pp. 1508-1519
    • Neumann, E.1    Judex, M.2    Kullmann, F.3    Grifka, J.4    Robbins, P.D.5    Pap, T.6
  • 32
    • 33747203514 scopus 로고    scopus 로고
    • Cartilage destruction by matrix degradation products
    • DOI 10.1007/s10165-006-0490-6
    • Yasuda T. Cartilage destruction by matrix degradation products. Mod Rheumatol 2006; 16:197-205. (Pubitemid 44227338)
    • (2006) Modern Rheumatology , vol.16 , Issue.4 , pp. 197-205
    • Yasuda, T.1
  • 33
    • 37149053758 scopus 로고    scopus 로고
    • Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: Limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation
    • Blaney Davidson EN, Vitters EL, van Beuningen HM, van de Loo FA, van den Berg WB, van der Kraan PM. Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation. Arthritis Rheum 2007; 56:4065-73.
    • (2007) Arthritis Rheum , vol.56 , pp. 4065-4073
    • Blaney Davidson, E.N.1    Vitters, E.L.2    Van Beuningen, H.M.3    Van De Loo, F.A.4    Van Den Berg, W.B.5    Van Der Kraan, P.M.6
  • 34
    • 0042704757 scopus 로고    scopus 로고
    • Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation
    • Hutchings H, Ortega N, Plouet J. Extracellular matrix-bound vascular endothelial growth factor promotes endothelial cell adhesion, migration, and survival through integrin ligation. Faseb J 2003; 17:1520-2.
    • (2003) Faseb J , vol.17 , pp. 1520-1522
    • Hutchings, H.1    Ortega, N.2    Plouet, J.3
  • 35
    • 0036839553 scopus 로고    scopus 로고
    • Bone destruction in arthritis
    • Gravallese EM. Bone destruction in arthritis. Ann Rheum Dis 2002; 61:84-6.
    • (2002) Ann Rheum Dis , vol.61 , pp. 84-86
    • Gravallese, E.M.1
  • 36
    • 33646342760 scopus 로고    scopus 로고
    • B cell-targeted therapy for rheumatoid arthritis: An update on the evidence
    • Looney RJ. B cell-targeted therapy for rheumatoid arthritis: an update on the evidence. Drugs 2006; 66:625-39.
    • (2006) Drugs , vol.66 , pp. 625-639
    • Looney, R.J.1
  • 37
    • 34249286630 scopus 로고    scopus 로고
    • Matrix-bound growth factors in tissue repair
    • Hubbell JA. Matrix-bound growth factors in tissue repair. Swiss Med Wkly 2007; 137:72-6.
    • (2007) Swiss Med Wkly , vol.137 , pp. 72-76
    • Hubbell, J.A.1
  • 40
    • 77649192868 scopus 로고    scopus 로고
    • Fibrocytes: Bringing new insights into mechanisms of inflammation and fibrosis
    • Keeley EC, Mehrad B, Strieter RM. Fibrocytes: Bringing new insights into mechanisms of inflammation and fibrosis. Int J Biochem Cell Biol 2009.
    • (2009) Int J Biochem Cell Biol
    • Keeley, E.C.1    Mehrad, B.2    Strieter, R.M.3
  • 41
    • 64749117099 scopus 로고    scopus 로고
    • The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders
    • Keeley EC, Mehrad B, Strieter RM. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders. Thromb Haemost 2009; 101:613-8.
    • (2009) Thromb Haemost , vol.101 , pp. 613-618
    • Keeley, E.C.1    Mehrad, B.2    Strieter, R.M.3
  • 43
    • 34250648476 scopus 로고    scopus 로고
    • Laser-mediated microdissection for analysis of gene expression in synovial tissue
    • Hashimoto A, Matsui T, Tanaka S, Ishikawa A, Endo H, Hirohata S, et al. Laser-mediated microdissection for analysis of gene expression in synovial tissue. Mod Rheumatol 2007; 17:185-90.
    • (2007) Mod Rheumatol , vol.17 , pp. 185-190
    • Hashimoto, A.1    Matsui, T.2    Tanaka, S.3    Ishikawa, A.4    Endo, H.5    Hirohata, S.6
  • 47
    • 70349774436 scopus 로고    scopus 로고
    • Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha/vascular endothelial growth factor-mediated pathway in immunodeficient mice
    • del Rey MJ, Izquierdo E, Caja S, Usategui A, Santiago B, Galindo M, et al. Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1alpha/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum 2009; 60:2926-34.
    • (2009) Arthritis Rheum , vol.60 , pp. 2926-2934
    • Del Rey, M.J.1    Izquierdo, E.2    Caja, S.3    Usategui, A.4    Santiago, B.5    Galindo, M.6
  • 48
    • 33751341522 scopus 로고    scopus 로고
    • Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton
    • Cazes A, Galaup A, Chomel C, Bignon M, Brechot N, Le Jan S, et al. Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res 2006; 99:1207-15.
    • (2006) Circ Res , vol.99 , pp. 1207-1215
    • Cazes, A.1    Galaup, A.2    Chomel, C.3    Bignon, M.4    Brechot, N.5    Le Jan, S.6
  • 50
    • 14244262503 scopus 로고    scopus 로고
    • Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2
    • Hall H, Hubbell JA. Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Microvasc Res 2004; 68:169-78.
    • (2004) Microvasc Res , vol.68 , pp. 169-178
    • Hall, H.1    Hubbell, J.A.2
  • 51
    • 0028157338 scopus 로고
    • Matrix-bound thrombospondin promotes angiogenesis in vitro
    • Nicosia RF, Tuszynski GP. Matrix-bound thrombospondin promotes angiogenesis in vitro. J Cell Biol 1994; 124:183-93.
    • (1994) J Cell Biol , vol.124 , pp. 183-193
    • Nicosia, R.F.1    Tuszynski, G.P.2
  • 52
    • 77954153829 scopus 로고    scopus 로고
    • Absence of cell and matrix-bound VEGF isoforms is associated with abnormal lens development
    • Saint-Geniez M, Kurihara T, D'Amore PA. Absence of cell and matrix-bound VEGF isoforms is associated with abnormal lens development. Invest Ophthalmol Vis Sci 2008.
    • (2008) Invest Ophthalmol Vis Sci
    • Saint-Geniez, M.1    Kurihara, T.2    D'Amore, P.A.3
  • 53
    • 8444234996 scopus 로고    scopus 로고
    • Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis
    • Schedel J, Wenglen C, Distler O, Muller-Ladner U, Scholmerich J, Heinegard D, et al. Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis. Scand J Immunol 2004; 60:514-23.
    • (2004) Scand J Immunol , vol.60 , pp. 514-523
    • Schedel, J.1    Wenglen, C.2    Distler, O.3    Muller-Ladner, U.4    Scholmerich, J.5    Heinegard, D.6
  • 54
    • 33646695439 scopus 로고    scopus 로고
    • Role of adhesion molecules in synovial inflammation
    • Agarwal SK, Brenner MB. Role of adhesion molecules in synovial inflammation. Curr Opin Rheumatol 2006; 18:268-76.
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 268-276
    • Agarwal, S.K.1    Brenner, M.B.2
  • 56
    • 0032981308 scopus 로고    scopus 로고
    • Pathogenesis of joint damage in rheumatoid arthritis
    • Bresnihan B. Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol 1999; 26:717-9. (Pubitemid 29125598)
    • (1999) Journal of Rheumatology , vol.26 , Issue.3 , pp. 717-719
    • Bresnihan, B.1
  • 58
    • 0021350154 scopus 로고
    • An electron microscopic study of the synovial-bone junction in rheumatoid arthritis
    • Ishikawa H, Ohno O, Hirohata K. An electron microscopic study of the synovial-bone junction in rheumatoid arthritis. Rheumatol Int 1984; 4:1-8.
    • (1984) Rheumatol Int , vol.4 , pp. 1-8
    • Ishikawa, H.1    Ohno, O.2    Hirohata, K.3
  • 59
    • 60249098721 scopus 로고    scopus 로고
    • Differential transcriptome analysis of intraarticular lesional vs. intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    • Geyer M, Grassel S, Straub RH, Schett G, Dinser R, Grifka J, et al. Differential transcriptome analysis of intraarticular lesional vs. intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 2009; 17:328-35.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 328-335
    • Geyer, M.1    Grassel, S.2    Straub, R.H.3    Schett, G.4    Dinser, R.5    Grifka, J.6
  • 62
    • 14144253706 scopus 로고    scopus 로고
    • Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein
    • Neidhart M, Zaucke F, von Knoch R, Jungel A, Michel BA, Gay RE, et al. Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Ann Rheum Dis 2005; 64:419-24.
    • (2005) Ann Rheum Dis , vol.64 , pp. 419-424
    • Neidhart, M.1    Zaucke, F.2    Von Knoch, R.3    Jungel, A.4    Michel, B.A.5    Gay, R.E.6
  • 65
    • 62449202978 scopus 로고    scopus 로고
    • Cell death in rheumatoid arthritis
    • Korb A, Pavenstadt H, Pap T. Cell death in rheumatoid arthritis. Apoptosis 2009; 14:447-54.
    • (2009) Apoptosis , vol.14 , pp. 447-454
    • Korb, A.1    Pavenstadt, H.2    Pap, T.3
  • 66
    • 67650065025 scopus 로고    scopus 로고
    • The small ubiquitin-like modifier mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against fas-induced apoptosis
    • Meinecke I, Pap G, Mendoza H, Drange S, Ender S, Strietholt S, et al. The small ubiquitin-like modifier mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against fas-induced apoptosis. Arthritis Rheum 2009; 60:2065-70.
    • (2009) Arthritis Rheum , vol.60 , pp. 2065-2070
    • Meinecke, I.1    Pap, G.2    Mendoza, H.3    Drange, S.4    Ender, S.5    Strietholt, S.6
  • 67
    • 0031982940 scopus 로고    scopus 로고
    • Apoptosis in rheumatoid arthritis: A novel pathway in the regulation of synovial tissue
    • DOI 10.1002/1529-0131(199801)41:1<1::AID-ART1>3.0.CO;2-V
    • Nishioka K, Hasunuma T, Kato T, Sumida T, Kobata T. Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue. Arthritis Rheum 1998; 41:1-9. (Pubitemid 28041916)
    • (1998) Arthritis and Rheumatism , vol.41 , Issue.1 , pp. 1-9
    • Nishioka, K.1    Hasunuma, T.2    Kato, T.3    Sumida, T.4    Kobata, T.5
  • 68
    • 0034467058 scopus 로고    scopus 로고
    • Activation of synovial fibroblasts in rheumatoid arthritis: Lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction
    • Pap T, Franz JK, Hummel KM, Jeisy E, Gay R, Gay S. Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction. Arthritis Res 2000; 2:59-64.
    • (2000) Arthritis Res , vol.2 , pp. 59-64
    • Pap, T.1    Franz, J.K.2    Hummel, K.M.3    Jeisy, E.4    Gay, R.5    Gay, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.