Analogs of vitamin e epitomized by α-tocopheryl succinate for pancreatic cancer treatment: In vitro results induce caution for in vivo applications

Pancreas

Volumn 39, Issue 5, 2010, Pages 662-668

  Greco, Eliana ^a   Basso, Daniela ^a   Fadi, Elisa ^a   Padoan, Andrea ^a   Fogar, Paola ^b   Zambon, Carlo Federico ^b   Navaglia, Filippo ^a   Bozzato, Dania ^a   Moz, Stefania ^a   Pedrazzoli, Sergio ^b   Plebani, Mario ^a,b  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

tocopherylsuccinate; 5 fluorouracil; ancreatic cancer; Bax Bak; BxPC3; CAPAN1; MIA PaCa2; PANC1; pancreatic cancer cell lines; PSN1; SMAD DPC4

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOPHEROL SUCCINATE; FLUOROURACIL; PROTEIN BAK; PROTEIN BAX; SMAD4 PROTEIN; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CULTURE; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG SENSITIVITY; GENE DELETION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MONOCYTE; MYOBLAST; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; DRUG EFFECTS; FIBROBLAST; HUMAN; MOUSE; PANCREATIC NEOPLASMS; TUMOR CELL LINE;

ALPHA-TOCOPHEROL; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; FIBROBLASTS; FLUOROURACIL; HUMANS; MICE; MONOCYTES; MYOBLASTS; PANCREATIC NEOPLASMS; SMAD4 PROTEIN; VITAMIN E;

EID: 77954103615     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181c8b48c     Document Type: Article

References (39)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics 2009. CA Cancer J Clin. 2009;59:225-249.
2. Loos M, Kleeff J, Friess H, et al. Approaches to localized pancreatic cancer. Curr Oncol Rep. 2008;10:212-219.
3. Verslype C, Van Cutsem E, Dicato M, et al. The management of pancreatic cancer. Current expert opinion and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol. 2007;18:vii1-vii10.
4. Pedrazzoli S, Pasquali C, Sperti C. Role of surgery in the treatment of bilio-pancreatic cancer: the European experience. Semin Oncol. 2002;29:23-30.
5. Han SS, Jang JY, Kim SW, et al. Analysis of long-term survivors after surgical resection for pancreatic cancer. Pancreas. 2006;32:271-275.
6. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007;297:267-277.
7. Neuhaus P, Riess H, Post S, et al. CONKO-001: final results of the randomized, prospective, multicenter phase III trial of adjuvant chemotherapy with gemcitabine versus observation in patients with resected pancreatic cancer (PC). J Clin Oncol. 2008 (ASCO annual meeting proceedings [postmeeting edition]);26(15S; May 20 supplement). Abstract LBA4504).
8. Cartwright T, Richards D, Boehm K. Cancer of the pancreas: are we making progress? A review of studies in the US oncology research network. Cancer Control. 2008;15:308-313.
9. Neoptolemos JP, Stocken DD, Tudur Smith C, et al. Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3 (v1) trial. Br J Cancer. 2009;100:246-250.
10. Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nat Rev Cancer. 2002;2:897-909.
11. Ranganathan P, Harsha HC, Pandey A. Molecular alterations in exocrine neoplasms of the pancreas. Arch Pathol Lab Med. 2009;133:405-412.
12. Scotto KW. Transcriptional regulation of ABC drug transporters. Oncogene. 2003;22:7496-7511.
13. Ke Z, Zhang X, Ma L, et al. Deleted in pancreatic carcinoma locus 4/Smad4 participates in the regulation of apoptosis by affecting the Bcl-2/Bax balance in no-small cell lung cancer. Human Pathol. 2008;39:1438-1445.
14. Adorno M, Cordenonsi M, Montagner M, et al. A mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009;137:87-98.
15. Neuzil J, Wang X-F, Dong L, et al. Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett. 2006;580:5125-5129.
16. Neuzil J, Tomasetti M, Zhao Y, et al. Vitamin E analogs, a novel group of "mitocans", as anticancer agents: the importance of being redox-silent. Molecular Pharm. 2007;71:1185-1199.
17. Tomasetti M, Neuzil J. Vitamin E analogues and immune response in cancer treatment. Vitam Horm. 2007;76:463-491.
18. Wang X, Dong L, Zhao Y, et al. Vitamin E analogues as anticancer agents: lessons from studies with α-tocopheryl succinate. Mol Nutrition and Food Res. 2006;50:675-685.
19. Shiau C, Huang J, Wang D, et al. α-Tocopheryl succinate induces apoptosis in prostate cancer cells in part trough inhibition of Bcl-xl/Bcl-2 function. J Biol Chem. 2006;281:11819-11825.
20. Pussinen P, Lindner H, Glatter O, et al. Lipoprotein-associated α-tocopheryl-succinate inhibits cell growth and induces apoptosis in human MCF-7 and HBL-100 breast cancer cells. Biochim Biophys Acta. 2000;1485:129-144.
21. Rose A, McFadden D. Alpha-tocopheryl succinate inhibits growth of gastric cancer cells in vitro. J Surg Res. 2001;95:19-22.
22. Swettenham E, Witting P, Salvatore B, et al. α-Tocopheryl succinate induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? J Neurochem. 2005;94:1448-1456.
23. Alleva R, Benassi M, Pazzaglia L, et al. α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. Biochem Biophys Res Commun. 2005;331:1515-1521.
24. Wu XX, Kakehi Y, Jin XH, et al. Induction of apoptosis in human renal cell carcinoma cells by vitamin E succinate in caspase-independent manner. Urology. 2009;73:193-199.
25. Newmeyer D, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 2003;112:481-490.
26. Green D, Kroemer G. The pathophysiology of mitochondrial cell death. Science. 2004;305:626-629.
27. Heisler T, Towfigh S, Simon N, et al. Peptide YY augments gross inhibition by vitamin E succinate of human pancreatic cancer cell growth. J Surg Res. 2000;88:23-25.
28. Ohlsson B, Albrechtsson E, Axelson J. Vitamin A and D but not E and K decreased the cell number in human pancreatic cancer cell lines. Scand J Gastroenterol. 2004;9:882-885.
29. Fogar P, Navaglia F, Basso D, et al. Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer. Pancreas. 2007;35:224-231.
30. Moore PS, Sipos B, Orlandini S, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virch Arch. 2001;439:798-802.
31. Sipos B, Moser S, Kalthoff H, et al. A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virch Arch. 2003;442:444-452.
32. Neuzil J, Weber T, Gellert N, et al. Selective cancer cell killing by α-tocopheryl succinate. Br J Cancer. 2008;84:87-89.
33. Schniewind B, Christgen M, Kurdow R, et al. Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. Int J Cancer. 2004;109:182-188.
34. Trauzold A, Schmiedel S, Röder C, et al. Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells. Br J Cancer. 2003;89:1714-1721. (Pubitemid 37464145)
35. Shi X, Liu S, Keeff J, et al. Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes. Oncology. 2002;62:354-362.
36. Xu Z, Friess H, Solioz M, et al. Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine. Int J Cancer. 2001;94:268-274.
37. Trapasso F, Yendamuri S, Dumon KR, et al. Restoration of receptor-type protein tyrosine phosphatase G function inhibits human pancreatic carcinoma cell growth in vitro and in vivo. Carcinogenesis. 2004; 25:2107-2114.
38. Trapasso F, Sarti M, Cesari R, et al. Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models. Cancer Gene Ther. 2004;11:633-641.
39. Derynck R, Akhurst RJ, Balmain A. TGF-beta signalling in tumor suppression and cancer progression. Nat Genet. 2001;29:117-129.