Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes

Pharmaceutical Biology

Volumn 48, Issue 7, 2010, Pages 724-731

  Nayak, Smita ^a   Mengi, Sushma ^a  

^a SNDT WOMEN S UNIVERSITY   (India)

Author keywords

BCG vaccine; Cell mediated immune response; Humoral immune response; Morinda citrifolia; MTT assay; Sheep red blood cells; Splenocytes

Indexed keywords

ALCOHOL; IMMUNOSTIMULATING AGENT; MORINDA CITRIFOLIA EXTRACT; PREDNISOLONE; WITHANIA SOMNIFERA EXTRACT;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; FRUIT; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SOLVENT EXTRACTION; SPLEEN CELL; T LYMPHOCYTE; TRADITIONAL MEDICINE; WITHANIA SOMNIFERA;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; B-LYMPHOCYTES; CATTLE; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; FEMALE; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOCOMPROMISED HOST; LYMPHOCYTE ACTIVATION; MALE; MORINDA; PLANT EXTRACTS; RATS; RATS, WISTAR; SHEEP; SPLEEN; T-LYMPHOCYTES; WITHANIA;

MORINDA CITRIFOLIA; OVIS ARIES; RUBIACEAE;

EID: 77954097953     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880200903264434     Document Type: Article

References (56)

1. Bhandari C (1985): Vanaushadhi Chandroday, An Encyclopedia of Indian Botanies and Herbs (Part I). Varanasi, Chaukhambha Sanskrit Samsthan, pp. 123.
2. Boyd W (1947): Fundamentals of Immunology. New York, Interscience Publishers, pp. 227.
3. Brain K, Turner T (1975): The Practical Evaluation of Phytopharmaceuticals. Bristol, Wright Scientechnica Publication, pp. 106.
4. Burger R, Torres A, Warren R, Caldwell V, Hughes B (1997): Echinaceainduced cytokine production by human macrophages. Int J Immunopharmacol 19: 371-379.
5. Chambers M, Marshall G, Wangoo A, Bune A, Cook H, Shaw R, Young D (1997): Differential responses to challenge with live and dead Mycobacterium bovis Bacillus Calmette-Guerin. J Immunol 158: 1742-1748.
6. Chan-Blanco Y, Vaillant F, Perez A, Reynes M, Brillouet J, Brat P (2006): The noni fruit (Morinda citrifolia L.): a review of agricultural research, nutritional and therapeutic properties. J Food Comp Anal 19: 645-654.
7. Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwala P, Ramakrishnan R, Sainis K (1999): An immunologically active arabinogalactan from Tinospora cordifolia. Phytochemistry 52: 1089-1093.
8. Cho J, Nam K, Kim A, Park J, Yoo E, Baik, K, Yu Y, Park M (2001): In vitro and in vivo immunomodulatory effects of syringin. J Pharm Pharmacol 53: 1287-1294.
9. Davis L, Kuttan G (2000): Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 71: 193-200.
10. Davis L, Kuttan G (2002): Effect of Withania somnifera on cell mediated immune responses in mice. J Exp Clin Cancer Res 21: 585-590.
11. DerMarderasian A (1999): Morinda. In: Guide to Popular Natural Products. St. Louis, MO, Facts and Comparisons Publishing Group, pp. 160.
12. Dikshit V, Damre A, Kulkarni K, Gokhale A, Saraf M (2000): Preliminary screening of immunocin for immunomodulatory activity. Indian J Pharm Sci 62: 257-260.
13. Djilani A, Legseir B, Soulmani R, Dicko A, Younos C (2006): New extraction technique for alkaloids. J Braz Chem Soc 17: 518-520.
14. Eiichi F (2003): Anti-cancer activity of noni fruit juice against tumors in mice. In: Proceedings of the 2002 Hawaii Noni Conference, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, pp. 23-24.
15. Fulzele S, Bhurchandi P, Kanoje V, Joshi S, Dorle A (2002): Immunostimulant activity of Ashtamangal ghrita in rats. Indian J Pharmacol 34: 194-197. (Pubitemid 34601014)
16. Geeta S, Ram M, Singh V, Ilavazhagan G, Sawhney R (2002): Antioxidant and immunomodulatory properties of seabuckthorn (Hippophae rhamnoides) - an in vitro study. J Ethnopharmacol 79: 373-378.
17. Hiramatsu T, Imoto M, Koyano K, Umezawa K (1993): Induction of normal phenotypes in RAS-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett 73: 161-166.
18. Hirazumi A, Furusawa E, Chou S, Hokama Y (1994): Anticancer activity of Morinda citrifolia on intraperitoneally implanted Lewis lung carcinoma in syngenic mice. Proc West Pharmacol Soc 37: 145-146.
19. Hirazumi A, Furusawa E, Chou S, Hokama Y (1996): Immunomodulation contributes to the anticancer activity of Morinda citrifolia (noni) fruit juice. Proc West Pharmacol Soc 39: 7-9.
20. Hirazumi A, Furusawa E (1999): An immunomodulatory polysaccharide- rich substance from the fruit juice of Morinda citrifolia (noni) with antitumor activity. Phytother Res 13: 380-387.
21. Honda S, Miyamoto A, Shibuya A (2005). Fcd¢/?R, a novel Fc receptor for innate antibodies IgM and IgA. Int Cong Series 1285: 78-83.
22. Joharapurkar A, Zambad S, Wanjari M, Umathe S (2003): In-vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia Linn. and its influence on ethanol-induced immunosuppression. Indian J Pharmacol 35: 232-236.
23. Johnson A, Hemscheidt S, Csiszar W (2002): Cytotoxicity of water and ethanol extracts of Morinda citrifolia (L.) against normal epithelial and breast cancer cell lines. In: Proceedings of the 2002 Hawaii Noni Conference, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, p. 22.
24. Kirtikar K, Basu B (1933): Indian Medicinal Plants, Vol.II. Delhi, Periodical Expert Book Agency, pp. 1295.
25. Kralovec J, Metera K, Kumar J, Watson L, Girouard G, Guan Y, Carr R, Barrow C, Ewart H (2007): Immunostimulatory principles from Chlorella pyrenoidosa - Part 1: Isolation and biological assessment in vitro. Phytomedicine 14: 57-64.
26. Krishnamoorthy N, Reddy S (1970): Preliminary phytochemical and pharmacological study of Morinda citrifolia Linn. Antiseptic 67: 167-171.
27. Lagranderie M, Balazuc A, Deriaud E, Leclerc C, Gheorghiu M (1996): Comparison of immune responses of mice immunized with five different Mycobacterium bovis BCG vaccine strains. Infect Immun 64: 1-10.
28. Lin K (2005): Ethnobotanical study of medicinal plants used by the Jah hut people in Malaysia. Indian J Med Sci 59: 156-161.
29. Liu G, Bode A, Ma W, Sang S, Ho C, Dong Z (2001): Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res 61: 5749-5756.
30. Malik F, Singh J, Khajuria A, Suri A, Satti N, Singh S, Kaul K, Kumar A, Bhatia A, Qazi G (2007): A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice. Life Sci 80: 1525-1538.
31. McClatchey W (2002): From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 1: 110-120.
32. McKoy M, Thomas E, Simon O (2002): Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (noni). Proc West Pharmacol Soc 45: 76-78.
33. Mediratta P, Sharma R, Singh S (2002): Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action. J Ethnopharmacol 80: 15-20.
34. Mosmann T (1983): Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
35. Nair R, Rodriguez S, Ramachandran R, Alamo A, Melnick S, Escalon E (2004): Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Int Immunopharmacol 4: 1645-1659.
36. Nayak S, Sandiford S, Maxwell A (2009): Evaluation of the wound healing activity of ethanol extract of Morinda citrifolia L. leaf. Evid Based Complement Alternat Med 6: 351-356.
37. Ooi V, Liu F. (2000): Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem 7: 715-729.
38. Oveido-Chavez I, Ramirez-Apan T, Soto-Hernandez M, Martinez-Vazquea M (2004): Principles of the bark of Amphipterygium adstringens (Julianaceae) with anti-inflammatory activity. Phytomedicine 11: 436-445.
39. Palu A, Hirazumi A, West B, Deng S, Jensen J, White L (2008): The effects of Morinda citrifolia L. (noni) on the immune system: Its molecular mechanisms of action. J Ethnopharmacol 115: 502-506.
40. Potterat O, Hamburger M (2007): Morinda citrifolia (noni) fruit - phytochemistry, pharmacology, safety. Planta Med 73: 191-199.
41. Prasad V, Jain V, Dorle A (2006): Evaluation of Momordica charantia ghrita for immunomodulatory activity. J Plant Sci 1: 80-85.
42. Saludes J, Garson M, Franzblau S, Aguinaldo A (2002): Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytother Res 16: 683-685.
43. Schepetkin I, Faulkner C, Nelson-Overton L, Wiley J, Quinn M (2005): Macrophage modulatory activity of polysaccharides isolated from Juniperus scopolorum. Int Immunopharmacol 5: 1783-1799.
44. Sharma M, Rao C, Duda P (1994): Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 41: 185-192.
45. Sharma S, Ray S (1997): Effect of herbal preparation on immune response of immunosuppressed mice. Indian J Physiol Pharmacol 41: 293-296.
46. Su S, Ferguson N (2006): Extraction and separation of anthraquinone glycosides. J Pharm Sci 62: 899-901.
47. Tanaka T, Suguira H, Inaba R, Nishikawa A, Murukami A, Koshimizu K, Ohigashi H (1999): Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BaLB/c mice. Carcinogenesis 20: 1471-1476.
48. Takashima J, Ikeda Y, Komiyama K, Hayashi M, Kishida A, Ohsaki A (2007): New constituents from the leaves of Morinda citrifolia. Chem Pharm Bull 55: 343-345.
49. Tiwari U, Rastogi B, Thakur S, Jain S, Jain N, Saraf D (2004): Studies on the immunomodulatory effects of Cleome viscosa. Indian J Pharm Sci 66: 171-176.
50. Tziabanos A (2000): Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clin Microbiol Rev 13: 523-533.
51. Van Crevel R, Ottenhoff T, Van der Meer J (2002): Innate immunity to Mycobacterium tuberculosis. Clin Microbiol Rev 15: 294-309.
52. Vishin ML, Gupta D (1967): Estimation of alkaloids of Kurchi by nonaqueous titration. Indian J Pharm Sci 29: 3.
53. Wang M, Su C (2001): Cancer preventive effect of Morinda citrifolia (noni). Ann NY Acad Sci 952: 161-168.
54. Wang M, West B, Jensen C, Nowicki D, Su C, Palu A, Anderson G (2002): Morinda citrifolia (noni): A literature review and recent advances in noni research. Acta Pharmacol Sin 23: 1127-1141.
55. Younos C, Rolland J, Fluerentin M, Lanhers R, Misslin R, Mortier F (1990): Analgesic and behavioural effects of Morinda citrifolia. Planta Med 56: 430-434.
56. Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B (1996): Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 50: 69-76.