Toward clinical X-ray phase-contrast CT: Demonstration of enhanced soft-tissue contrast in human specimen

Investigative Radiology

Volumn 45, Issue 7, 2010, Pages 445-452

  Donath, Tilman ^a   Pfeiffer, Franz ^b   Bunk, Oliver ^a   Grünzweig, Christian ^a   Hempel, Eckhard ^c   Popescu, Stefan ^c   Vock, Peter ^d   David, Christian ^a  

^a PAUL SCHERRER INSTITUTE   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c SIEMENS AG   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

computed tomography; Talbot grating interferometer; X ray phase contrast; X ray tube

Indexed keywords

ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; HUMAN; IMAGE ANALYSIS; INFANT; MALE; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SOFT TISSUE; CADAVER; CONNECTIVE TISSUE; HAND; NEWBORN; PILOT STUDY; PROCEDURES; RADIOGRAPHY; X RAY DIFFRACTION;

CADAVER; CONNECTIVE TISSUE; HAND; HUMANS; INFANT, NEWBORN; PILOT PROJECTS; TOMOGRAPHY, X-RAY COMPUTED; X-RAY DIFFRACTION;

EID: 77954088018     PISSN: 00209996     EISSN: 15360210     Source Type: Journal    
DOI: 10.1097/RLI.0b013e3181e21866     Document Type: Article

References (43)

1. Fitzgerald R. Phase-sensitive X-ray imaging. Phys Today. 2000;53:82.
2. Lewis RA. Medical phase contrast X-ray imaging: current status and future prospects. Phys Med Biol. 2004;49:3573-3583.
3. Momose A. Recent advances in X-ray phase imaging. Jpn J Appl Phys. 2005;44:6355-6367.
4. Zhou SA, Brahme A. Development of phase-contrast X-ray imaging techniques and potential medical applications. Phys Med. 2008;24:129-148.
5. Wang G, Yu HY, De Man B. An outlook on X-ray CT research and development. Med Phys. 2008;35:1051-1064.
6. Pfeiffer F, Kottler C, Bunk O, et al. Hard X-Ray phase tomography with low-brilliance sources. Phys Rev Lett. 2007;98:108105.
7. Bonse U, Hart M. An X-ray interferometer with long separated interfering beam paths. Appl Phys Lett. 1965;6:155-156.
8. Momose A, Takeda T, Itai Y, et al. Phase-contrast X-ray computed tomography for observing biological soft tissues. Nat Med. 1996;2:473-475.
9. Beckmann F, Bonse U, Busch F, et al. X-ray microtomography using phase contrast for the investigation of organic matter. J Comp Assist Tomogr. 1997;21:539-553.
10. Beckmann F, Heise K, Kölsch B, et al. Three-dimensional imaging of nerve tissue by X-ray phase-contrast microtomography. Biophys J. 1999;76:98-102.
11. Chapman D, Thomlinson W, Johnston RE, et al. Diffraction enhanced X-ray imaging. Phys Med Biol. 1997;42:2015-2025.
12. Dilmanian FA, Zhong Z, Ren B, et al. Computed tomography of X-ray index of refraction using the diffraction enhanced imaging method. Phys Med Biol. 2000;45:933-946.
13. David C, Nöhammer B, Solak HH, et al. Differential X-ray phase contrast imaging using a shearing interferometer. Appl Phys Lett. 2002;81:3287-3289.
14. Weitkamp T, Diaz A, David C, et al. Quantitative X-ray phase imaging with a grating interferometer. Opt Express. 2005;13:6296-6304.
15. Momose A, Yashiro W, Takeda Y, et al. Phase tomography by X-ray Talbot interferometry for biological imaging. Jpn J Appl Phys. 2006;45:5254-5262. (Pubitemid 43925072)
16. Davis TJ, Gao D, Gureyev TE, et al. Phase-contrast imaging of weakly absorbing materials using hard X-rays. Nature. 1995;373:595-598.
17. Wilkins SW, Gureyev TE, Gao D, et al. Phase-contrast imaging using polychromatic hard X-rays. Nature. 1996;384:335-337.
18. Zabler S, Cloetens P, Guigay JP, et al. Optimization of phase contrast imaging using hard x rays. Rev Sci Instrum. 2005;76:1-7.
19. Cloetens P, Mache R, Schlenker M, et al. Quantitative phase tomography of Arabidopsis seeds reveals intercellular void network. Proc Natl Acad Sci USA. 2006;103:14626-14630.
20. Pfeiffer F, Bunk O, David C, et al. High-resolution brain tumor visualization using three-dimensional X-ray phase contrast tomography. Phys Med Biol. 2007;52:6923-6930.
21. Weitkamp T, David C, Bunk O, et al. X-ray phase radiography and tomography of soft tissue using grating interferometry. Eur J Radiol. 2008;68:S13-S17.
22. Pfeiffer F, Weitkamp T, Bunk O, et al. Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources. Nat Phys. 2006;2: 258-261.
23. Weitkamp T, David C, Kottler C, et al. Tomography with grating interferometers at low-brilliance sources. Proc SPIE. 2006;6318:63180S.
24. Bech M, Jensen TH, Feidenhans'l R, et al. Soft-tissue phase-contrast tomography with an X-ray tube source. Phys Med Biol. 2009;54:2747-2753.
25. Engelhardt M, Baumann J, Schuster M, et al. High-resolution differential phase contrast imaging using a magnifying projection geometry with a microfocus X-ray source. Appl Phys Lett. 2007;90:224101.
26. Herzen J, Donath T, Pfeiffer F, et al. Quantitative phase-contrast tomography of a liquid phantom using a conventional X-ray tube source. Opt Express. 2009;17:10010-10018.
27. Donath T, Chabior M, Pfeiffer F, et al. Inverse geometry for grating-based X-ray phase-contrast imaging. J Appl Phys. 2009;106:054703.
28. Hounsfield GN. Computerized transverse axial scanning (tomography). Part 1: description of system. Brit J Radiol. 1973;46:1016-1022.
29. Brooks RA. A Quantitative theory of the Hounsfield unit and its application to dual energy scanning. J Comput Assist Tomogr. 1977;1:487-493.
30. Kalender WA. Computed Tomography. 2nd ed. Erlangen, Germany: Publicis Corporate Publishing; 2005.
31. David C, Bruder J, Rohbeck T, et al. Fabrication of diffraction gratings for hard X-ray phase contrast imaging. Microelectron Eng. 2007;84:1172-1177. (Pubitemid 46678358)
32. Patorski K. The Self-imaging phenomenon and its applications. Progr Opt. 1989;27:3-108.
33. Clauser JF, Li S. Talbot-vonLau atom interferometry with cold slow potassium. Phys Rev A. 1994;49:R2213-R2216.
34. Kak AC, Slaney M. Principles of Computerized Tomographic Imaging. New York, NY: IEEE Press; 1988.
35. Faris GW, Byer RL. Three-dimensional beam-deflection optical tomography of a supersonic jet. Appl Opt. 1988;27:5202-5212.
36. Chen GH, Qi ZH. Image reconstruction for fan-beam differential phase contrast computed tomography. Phys Med Biol. 2008;53:1015-1025.
37. Wang D, Strugnell W, Cowin G, et al. Geometric distortion in clinical MRI systems part I: evaluation using a 3D phantom. Magn Reson Imaging. 2004;22:1211-1221. (Pubitemid 39647719)
38. Krumm M, Kasperl S, Franz M. Reducing non-linear artifacts of multi-material objects in industrial 3D computed tomography. NDT E Int. 2008; 41:242-251.
39. Holdsworth DW, Thornton MM. Micro-CT in small animal and specimen imaging. Trends Biotechnol. 2002;20:S34-S39.
40. Badea CT, Drangova M, Holdsworth DW, et al. In vivo small-animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol. 2008; 53:R319-R350.
41. Donath T, Pfeiffer F, Bunk O, et al. Phase-contrast imaging and tomography at 60 keV using a conventional X-ray tube source. Rev Sci Instrum. 2009;80: 053701.
42. Schneider U, Pedroni E, Lomax A. The calibration of CT Hounsfield units for radiotherapy treatment planning. Phys Med Biol. 1996;41:111-124.
43. Pfeiffer F, Bech M, Bunk O, et al. Hard-X-ray dark-field imaging using a grating interferometer. Nat Mater. 2008;7:134-137.