CD28 expression redefines thymocyte development during the pre-T to DP transition

International Immunology

Volumn 22, Issue 5, 2010, Pages 387-397

  Teague, T Kent ^a,b,c   Tan, Chibing ^a   Marino, Julie H ^a   Davis, Brenda K ^a   Taylor, Ashlee A ^a   Huey, Ryan W ^a   Van De Wiele, C Justin ^a,b  

^a University of Oklahoma Tulsa College of Medicine   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF PHARMACY   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

selection; IL 7; IL 7R

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD69 ANTIGEN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; MESSENGER RNA; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL COMPARTMENTALIZATION; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CELL TRANSFORMATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-7; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; THYMUS GLAND;

EID: 77954024488     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq020     Document Type: Article

References (31)

1. Bhandoola, A., von Boehmer, H., Petrie, H. T. and Zuniga-Pflucker, J. C. 2007. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26:678.
2. Rodewald, H. R. 1995. Pathways from hematopoietic stem cells to thymocytes. Curr. Opin. Immunol. 7:176.
3. Bhandoola, A., Sambandam, A., Allman, D., Meraz, A. and Schwarz, B. 2003. Early T lineage progenitors: new insights, but old questions remain. J. Immunol. 171:5653.
4. Rothenberg, E. V., Moore, J. E. and Yui, M. A. 2008. Launching the T-cell-lineage developmental programme. Nat. Rev. Immunol. 8:9.
5. Godfrey, D. I. and Zlotnik, A. 1993. Control points in early T-cell development. Immunol. Today 14:547.
6. Ceredig, R. and Rolink, T. 2002. A positive look at double-negative thymocytes. Nat. Rev. Immunol. 2:888.
7. Dudley, E. C., Petrie, H. T., Shah, L. M., Owen, M. J. and Hayday, A. C. 1994. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1:83.
8. Zuniga-Pflucker, J. C. and Lenardo, M. J. 1996. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8:215.
9. Shortman, K. 1992. Cellular aspects of early T-cell development. Curr. Opin. Immunol. 4:140.
10. Porritt, H. E., Rumfelt, L. L., Tabrizifard, S., Schmitt, T. M., Zuniga-Pflucker, J. C. and Petrie, H. T. 2004. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20:735.
11. Sambandam, A., Maillard, I., Zediak, V. P. et al. 2005. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat. Immunol. 6:663.
12. Masuda, K., Kakugawa, K., Nakayama, T., Minato, N., Katsura, Y. and Kawamoto, H. 2007. Tcell lineage determination precedes the initiation of TCR beta gene rearrangement. J. Immunol. 179:3699.
13. Taghon, T., Yui, M. A., Pant, R., Diamond, R. A. and Rothenberg, E. V. 2006. Developmental and molecular characterization of emerging beta-and gammadelta-selected pre-T cells in the adult mouse thymus. Immunity 24:53.
14. Williams, J. A., Hathcock, K. S., Klug, D. et al. 2005. Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J. Immunol. 175:4199.
15. Munitic, I., Williams, J. A., Yang, Y. et al. 2004. Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood 104:4165.
16. Trigueros, C., Hozumi, K., Silva-Santos, B. et al. 2003. Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur. J. Immunol. 33:1968.
17. Van De Wiele, C. J., Marino, J. H., Murray, B. W., Vo, S. S., Whetsell, M. E. and Teague, T. K. 2004. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J. Immunol. 172:4235.
18. Van de Wiele, C. J., Marino, J. H., Tan, C. et al. 2007. Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell. Immunol. 250:31.
19. Yu, Q., Erman, B., Park, J. H., Feigenbaum, L. and Singer, A. 2004. IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J. Exp. Med. 200:797.
20. Marino, J. H., Tan, C., Davis, B. et al. 2008. Disruption of thymopoiesis in ST6Gal I-deficient mice. Glycobiology 18:719.
21. Schmitt, T. M. and Zuniga-Pflucker, J. C. 2002. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749.
22. Marino, J. H., Van De Wiele, C. J., Everhart, J. M. et al. 2006. Attenuation of cytokine responsiveness during T cell development and differentiation. J. Interferon Cytokine Res. 26:748.
23. Yamashita, I., Nagata, T., Tada, T. and Nakayama, T. 1993. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 5:1139.
24. Falk, I. and Eichmann, K. 2002. Heterogeneity of the DN4 (CD44-CD25-) subset of CD4-CD8- double negative thymocytes; dependence on CD3 signaling. Immunol. Lett. 82:123.
25. Falk, I., Nerz, G., Haidl, I., Krotkova, A. and Eichmann, K. 2001. Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset. Eur. J. Immunol. 31:3308.
26. Budd, R. C. and Mixter, P. F. 1995. The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity. Immunol. Today 16:428.
27. Jiang, Q., Li, W. Q., Hofmeister, R. R. et al. 2004. Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Mol. Cell. Biol. 24:6501.
28. Taghon, T., Van de Walle, I., De Smet, G. et al. 2009. Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development. Blood 113:3254.
29. Akashi, K., Kondo, M. and Weissman, I. L. 1998. Role of interleukin-7 in T-cell development from hematopoietic stem cells. Immunol. Rev. 165:13.
30. von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E. and Murray, R. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519.
31. DiSanto, J. P., Muller, W., Guy-Grand, D., Fischer, A. and Rajewsky, K. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl Acad. Sci. USA 92:377.