Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2

Cellular Immunology

Volumn 250, Issue 1-2, 2007, Pages 31-39

  Van De Wiele, C Justin ^a   Marino, Julie H ^a   Tan, Chibing ^a   Kneale, Hilary A ^a   Weber, John ^a   Morelli, John N ^a   Davis, Brenda K ^a   Taylor, Ashlee A ^a   Teague, T Kent ^a,b,c  

^a University of Oklahoma Tulsa College of Medicine   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF PHARMACY   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Cellular differentiation; Cytokine receptors; Rodent; Thymus; Transgenic mice

Indexed keywords

INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; PROTEIN BCL 2; STAT5 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DNA, COMPLEMENTARY; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOPOIESIS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-BCL-2; THYMUS GLAND;

MURINAE; MUS; MUS MUSCULUS; RODENTIA;

EID: 40949148983     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2008.01.002     Document Type: Article

References (21)

1. Maki K., Sunaga S., Komagata Y., Kodaira Y., Mabuchi A., Karasuyama H., Yokomuro K., Miyazaki J.I., and Ikuta K. Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc. Natl. Acad Sci. USA 93 (1996) 7172-7177
2. Moore T.A., von Freeden-Jeffry U., Murray R., and Zlotnik A. Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice. J. Immunol 157 (1996) 2366-2373
3. Peschon J.J., Morrissey P.J., Grabstein K.H., Ramsdell F.J., Maraskovsky E., Gliniak B.C., Park L.S., Ziegler S.F., Williams D.E., and Ware C.B. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180 (1994) 1955-1960
4. DeLuca .D., and Clark D.R. Interleukin-7 negatively regulates the development of mature T cells in fetal thymus organ cultures. Dev. Comp. Immunol 26 (2002) 365-384
5. Plum J., De Smedt M., Leclercq G., Verhasselt B., and Vandekerckhove B. Interleukin-7 is a critical growth factor in early human T-cell development. Blood 88 (1996) 4239-4245
6. Yasuda Y., Kaneko A., Nishijima I., Miyatake S., and Arai K. Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice. Immunology 106 (2002) 212-221
7. Hozumi K., Kondo M., Nozaki H., Kobori A., Nishimura T., Nishikawa S., Sugamura K., and Habu S. Implication of the common gamma chain of the IL-7 receptor in intrathymic development of pro-T cells. Int. Immunol 6 (1994) 1451-1454
8. Akashi K., Kondo M., von Freeden-Jeffry U., Murray R., and Weissman I.L. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89 (1997) 1033-1041
9. Maraskovsky E., O'Reilly L.A., Teepe M., Corcoran L.M., Peschon J.J., and Strasser A. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell 89 (1997) 1011-1019
10. El Kassar N., Lucas P.J., Klug D.B., Zamisch M., Merchant M., Bare C.V., Choudhury B., Sharrow S.O., Richie E., Mackall C.L., and Gress R.E. A dose effect of IL-7 on thymocyte development. Blood 104 (2004) 1419-1427
11. Van De Wiele C.J., Marino J.H., Murray B.W., Vo S.S., Whetsell M.E., and Teague T.K. Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J. Immunol 172 (2004) 4235-4244
12. Yu Q., Erman B., Park J.H., Feigenbaum L., and Singer A. IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development. J. Exp. Med. 200 (2004) 797-803
13. Munitic I., Williams J.A., Yang Y., Dong B., Lucas P.J., El Kassar N., Gress R.E., and Ashwell J.D. Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis. Blood 104 (2004) 4165-4172
14. Porter B.O., Scibelli P., and Malek T.R. Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail. J. Immunol 166 (2001) 262-269
15. Thompson L.F., Van de Wiele C.J., Laurent A.B., Hooker S.W., Vaughn J.G., Jiang H., Khare K., Kellems R.E., Blackburn M.R., Hershfield M.S., and Resta R. Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. J. Clin Invest. 106 (2000) 1149-1157
16. Van De Wiele C.J., Joachims M.L., Fesler A.M., Vaughn J.G., Blackburn M.R., McGee S.T., and Thompson L.F. Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. J. Immunol 176 (2006) 5925-5933
17. Van De Wiele C.J., Vaughn J.G., Blackburn M.R., Ledent C.A., Jacobson M., Jiang H., and Thompson L.F. Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. J. Clin Invest. 110 (2002) 395-402
18. Marino J.H., Van De Wiele C.J., Everhart J.M., Masengale R., Naukam R.J., Schniederjan M.J., Vo S., and Teague T.K. Attenuation of cytokine responsiveness during T cell development and differentiation. J. Interferon Cytokine Res. 26 (2006) 748-759
19. Teague T.K., Schaefer B.C., Hildeman D., Bender J., Mitchell T., Kappler J.W., and Marrack P. Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling. J. Exp. Med. 191 (2000) 915-926
20. Van De Wiele C.J., Marino J.H., Whetsell M.E., Vo S.S., Masengale R.M., and Teague T.K. Loss of interferon-induced Stat1 phosphorylation in activated T cells. J. Interferon Cytokine Res. 24 (2004) 169-178
21. Ortman C.L., Dittmar K.A., Witte P.L., and Le P.T. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol 14 (2002) 813-822