P75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: Insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology

British Journal of Dermatology

Volumn 163, Issue 1, 2010, Pages 138-145

  Krahl, D ^a   Sellheyer, K ^b,c  

^a Institut fur Dermatohistologie   (Germany)

^b LERNER RESEARCH INSTITUTE   (United States)

^c Nelson Dermatopathology Associates   (United States)

Author keywords

basal cell carcinoma; embryology; hair follicle; p75 neurotrophin receptor; trichoepithelioma

Indexed keywords

CYTOKERATIN 20; NEUROTROPHIN RECEPTOR P75;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOPLASTIC TRICHOEPITHELIOMA; EMBRYOLOGY; FEMALE; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; HISTOGENESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MERKEL CELL; MORPHOEIC BASAL CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CANCER; SKIN TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, BASAL CELL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HAIR FOLLICLE; HUMANS; MALE; MERKEL CELLS; MIDDLE AGED; NEOPLASMS, ADNEXAL AND SKIN APPENDAGE; RECEPTOR, NERVE GROWTH FACTOR; SKIN; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77953972580     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2010.09711.x     Document Type: Article

References (54)

1. Levi-Montalcini R, Meyer H, Hamburger V. In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo. Cancer Res 1954 14 : 49 57.
2. Roux PP, Barker PA. Neurotrophin signaling through the p75 neuro-trophin receptor. Prog Neurobiol 2002 67 : 203 233.
3. Botchkarev VA, Botchkareva NV, Peters EM, Paus R. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle. Prog Brain Res 2004 146 : 493 513.
4. Di Marco E, Mathor M, Bondanza S et al. Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem 1993 268 : 22838 22846.
5. Yaar M, Grossman K, Eller M, Gilchrest BA. Evidence for nerve growth factor-mediated paracrine effects in human epidermis. J Cell Biol 1991 115 : 821 828.
6. Friedman WJ, Greene LA. Neurotrophin signaling via Trks and p75. Exp Cell Res 1999 253 : 131 142.
7. Lindner G, Botchkarev VA, Botchkareva NV et al. Analysis of apoptosis during hair follicle regression (catagen). Am J Pathol 1997 151 : 1601 1617.
8. Botchkarev VA, Botchkareva NV, Albers KM et al. A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. FASEB J 2000 14 : 1931 1942.
9. Peters EM, Hendrix S, Gölz G et al. Nerve growth factor and its precursor differentially regulate hair cycle progression in mice. J Histochem Cytochem 2006 54 : 275 288.
10. Peters EM, Stieglitz MG, Liezman C et al. p75 Neurotrophin receptor-mediated signaling promotes human hair follicle regression (catagen). Am J Pathol 2006 168 : 221 234.
11. Adly MA, Assaf HA, Hussein MR. Expression pattern of p75 neurotrophin receptor protein in human scalp skin and hair follicles: hair cycle-dependent expression. J Am Acad Dermatol 2009 60 : 99 109.
12. Sellheyer K, Krahl D. Basal cell (trichoblastic) carcinoma. Common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: a clue to the adnexal nature of basal cell carcinoma? J Am Acad Dermatol 2008 58 : 158 167.
13. Sellheyer K, Krahl D. Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol 2009 Oct 26 [Epub ahead of print].
14. Krahl D, Sellheyer K. Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and β-catenin. Br J Dermatol 2010 Jan 22 [Epub ahead of print].
15. Yang SH, Andl T, Grachtchouk V et al. Pathological responses to oncogenic hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet 2008 40 : 1130 1135.
16. Smoller BR, van de Rijn M, Lebrun D, Warnke RA. bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. Br J Dermatol 1994 131 : 28 31.
17. Verhaegh ME, Arends JW, Majoie IM et al. Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. Dermatol Surg 1997 23 : 695 700.
18. Basarab T, Orchard G, Russell-Jones R. The use of immunostaining for bcl-2 and CD34 and the lectin peanut agglutinin in differentiating between basal cell carcinomas and trichoepitheliomas. Am J Dermatopathol 1998 20 : 448 452.
19. Swanson PE, Fitzpatrick MM, Ritter JH et al. Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens. J Cutan Pathol 1998 25 : 153 159.
20. Poniecka AW, Alexis JB. An immunohistochemical study of basal cell carcinoma and trichoepithelioma. Am J Dermatopathol 1999 21 : 332 336.
21. Abdelsayed RA, Guijarro-Rojas M, Ibrahim NA, Sangueza OP. Immunohistochemical evaluation of basal cell carcinoma and trichepithelioma using Bcl-2, Ki67, PCNA and P53. J Cutan Pathol 2000 27 : 169 175.
22. Lum CA, Binder SW. Proliferative characterization of basal-cell carcinoma and trichoepithelioma in small biopsy specimens. J Cutan Pathol 2004 31 : 550 554.
23. Vigneswaran N, Haneke E, Peters KP. Peanut agglutinin immunohistochemistry of basal cell carcinoma. J Cutan Pathol 1987 14 : 147 153.
24. Tsubura A, Fujita Y, Sasaki M, Morii S. Lectin-binding profiles for normal skin appendages and their tumors. J Cutan Pathol 1992 19 : 483 489.
25. Thewes M, Worret WI, Engst R, Ring J. Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma. Am J Dermatopathol 1998 20 : 140 142.
26. Pham TT, Selim MA, Burchette JL Jr. et al. CD10 expression in trichoepithelioma and basal cell carcinoma. J Cutan Pathol 2006 33 : 123 128.
27. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol 1994 130 : 589 592.
28. Kirchmann TT, Prieto VG, Smoller BR. Use of CD34 in assessing the relationship between stroma and tumor in desmoplastic keratinocytic neoplasms. J Cutan Pathol 1995 22 : 422 426.
29. Krahl D, Sellheyer K. Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma. J Cutan Pathol 2007 34 : 782 787.
30. Fernandez-Flores A. Advanced differentiation in trichoepithelioma and basal cell carcinoma investigated by immunohistochemistry against neurofilaments. Folia Histochem Cytobiol 2009 47 : 61 4.
31. Hartschuh W, Schulz T. Merkel cells are integral constituents of desmoplastic trichoepithelioma: an immunohistochemical and electron microscopic study. J Cutan Pathol 1995 22 : 413 421.
32. Abesamis-Cubillan E, El-Shabrawi-Caelen L, LeBoit PE. Merkel cells and sclerosing epithelial neoplasms. Am J Dermatopathol 2000 22 : 311 315.
33. Costache M, Bresch M, Böer A. Desmoplastic trichoepithelioma versus morphoeic basal cell carcinoma: a critical reappraisal of histomorphological and immunohistochemical criteria for differentiation. Histopathology 2008 52 : 865 876.
34. Fernandez EM, Helm T, Ioffreda M, Helm KF. The vanishing biopsy: the trend toward smaller specimens. Cutis 2005 76 : 335 339.
35. McCalmont TH. A call for logic in the classification of adnexal neoplasms. Am J Dermatopathol 1996 18 : 103 109.
36. Mercer BM, Sklar S, Shariatmadar A et al. Fetal foot length as a predictor of gestational age. Am J Obstet Gynecol 1987 156 : 350 355.
37. Drey EA, Kang MS, McFarland W, Darney PD. Improving the accuracy of fetal foot length to confirm gestational duration. Obstet Gynecol 2005 105 : 773 778.
38. Takei Y, Fukushiro S, Ackerman AB. Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Am J Dermatopathol 1985 7 : 207 221.
39. Cotton D. Troublesome tumours. 1. Adnexal tumours of the skin. J Clin Pathol 1991 44 : 543 548.
40. Botchkareva NV, Botchkarev VA, Chen LH et al. A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol 1999 216 : 135 153.
41. Holbrook KA, Minami SI. Hair follicle embryogenesis in the human. Characterization of events in vivo and in vitro. Ann NY Acad Sci 1991 642 : 167 196.
42. Holbrook KA, Smith LT, Kaplan ED et al. Expression of morphogens during human follicle development in vivo and a model for studying follicle morphogenesis in vitro. J Invest Dermatol 1993 101 (Suppl. 1 S39 49.
43. Akiyama M, Smith LT, Holbrook KA. Growth factor and growth factor receptor localization in the hair follicle bulge and associated tissue in human fetus. J Invest Dermatol 1996 106 : 391 396.
44. Lever WF. Pathogenesis of benign tumors of cutaneous appendages and of basal cell epithelioma. Arch Derm Syphilol 1948 57 : 709 724.
45. Kumakiri M, Hashimoto K. Ultrastructural resemblance of basal cell epithelioma to primary epithelial germ. J Cutan Pathol 1978 5 : 53 67.
46. Ackerman AB, Reddy VB, Soyer HP. Neoplasms with Follicular Differentiation.
47. Asada M, Schaart FM, de Almeida HL Jr. et al. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. Acta Derm Venereol (Stockh) 1993 73 : 286 292.
48. Fanburg-Smith JC, Miettinen M. Low-affinity nerve growth factor receptor (p75) in dermatofibrosarcoma protuberans and other nonneural tumors: a study of 1,150 tumors and fetal and adult normal tissues. Hum Pathol 2001 32 : 976 983.
49. Chen-Tsai CP, Colome-Grimmer M, Wagner RF Jr. Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas. Dermatol Surg 2004 30 : 1009 1016.
50. Chan MM, Tahan SR. Low-affinity nerve growth factor receptor (P75 NGFR) as a marker of perineural invasion in malignant melanomas. J Cutan Pathol 2009 Jul 13 [Epub ahead of print].
51. Kinkelin I, Stucky CL, Koltzenburg M. Postnatal loss of Merkel cells, but not of slowly adapting mechanoreceptors in mice lacking the neurotrophin receptor p75. Eur J Neurosci 1999 11 : 3963 3969.
52. Izikson L, Bhan A, Zembowicz A. Androgen receptor expression helps to differentiate basal cell carcinoma from benign trichoblastic tumors. Am J Dermatopathol 2005 27 : 91 5.
53. Vollmer RT. Panel vs. single marker for discriminating desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma. J Cutan Pathol 2009 36 : 283 (Letter).
54. Katona TM, Perkins SM, Billings SD. Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? J Cutan Pathol 2008 35 : 174 179.