Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection

Immunologic Research

Volumn 47, Issue 1-3, 2010, Pages 56-64

  Sadegh Nasseri, Scheherazade ^a   Natarajan, Sateesh ^a,b   Chou, Chih Ling ^a,c   Hartman, Isamu Z ^a,d   Narayan, Kedar ^a,e   Kim, Aeryon ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dendreon   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Conformational heterogeneity; H bonds; Immunodominance; Kinetics; MHC class II; Peptide receptive conformation

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CHAPERONE; EPITOPE; HETERODIMER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TAPASIN; HLA ANTIGEN CLASS 2; HLA D ANTIGEN; HLA-DM ANTIGENS; PEPTIDE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; BIOCHEMISTRY; CELL SURFACE; CELL TRANSPORT; CONFORMATION; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DISSOCIATION; DRUG TRANSPORT; EFFECTOR CELL; HELPER CELL; HLA SYSTEM; HUMAN; KINETICS; LABORATORY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; REVIEW; T LYMPHOCYTE; CHEMISTRY; IMMUNOLOGY; METABOLISM; PROTEIN CONFORMATION;

ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; MOLECULAR CHAPERONES; PEPTIDES; PROTEIN CONFORMATION;

EID: 77953960092     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-009-8138-1     Document Type: Review

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