A multiparametric assessment of oxygen efflux from the brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 26, Issue 1, 2006, Pages 79-91

  Hermán, Peter ^a,b   Trübel, Hubert K F ^a,c,d   Hyder, Fahmeed ^a,e  

^a YALE UNIVERSITY   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

^e Yale University   (United States)

Author keywords

Extravascular pO2; Intravascular pO2; Metabolism; Mitochondrial pO2; Neuroimaging; Oxygen back flux; Perfusion

Indexed keywords

CHLORALOSE; OXYGEN 15; OXYGEN 17; OXYHEMOGLOBIN;

ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; BRAIN OXYGEN TENSION; COMPARTMENT MODEL; FLUORESCENCE ANALYSIS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; MALE; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXYGEN BLOOD LEVEL; OXYGEN DISSOCIATION CURVE; OXYGEN TRANSPORT; PARAMETRIC TEST; PHOTOCHEMICAL QUENCHING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; CHLORALOSE; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, ANIMAL; OXYGEN; OXYGEN CONSUMPTION; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY;

EID: 29144465717     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600165     Document Type: Article

References (80)

1. Adair G (1925) The hemoglobin system. VI. The oxygen dissociation curve of hemoglobin. J Biol Chem 63:529-535
2. Ances BM, Buerk DG, Greenberg JH, Detre JA (2001a) Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats. Neurosci Lett 306:106-10
3. 2 during functional activation using oxygen phosphorescence quenching. J Cereb Blood Flow Metab 21:511-6
4. Beard DA, Bassingthwaighte JB (2000) Advection and diffusion of substances in biological tissues with complex vascular networks. Ann Biomed Eng 28:253-268
5. Beard DA, Bassingthwaighte JB (2001) Modeling advection and diffusion of oxygen in complex vascular networks. Ann Biomed Eng 29:298-310
6. Bereczki D, Wei L, Otsuka T, Acuff V, Pettigrew K, Patlak C, Fenstermacher J (1993) Hypoxia increases velocity of blood flow through parenchymal microvascular systems in rat brain. J Cereb Blood Flow Metab 13:475-86
7. Braun RD, Lanzen JL, Snyder SA, Dewhirst MW (2001) Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am J Physiol Heart Circ Physiol 280:H2533-44
8. Buxton R (2002) Introduction to functional magnetic resonance imaging: principles and techniques. Cambridge, UK: Cambridge University Press, 41-61
9. Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17:64-72
10. Chinard FP (2000) Water and solute exchanges. How far have we come in 100 years? What's next? Ann Biomed Eng 28:849-59
11. Clark A, Jr, Clark PA (1985) Local oxygen gradients near isolated mitochondria. Biophys J 48:931-8
12. 2 between cytosol and mitochondrion? Am J Physiol 252:C583-7
13. Clark A, Jr, Federspiel WJ, Clark PA, Cokelet GR (1985) Oxygen delivery from red cells. Biophys J 47:171-81
14. Cobb S, Talbott J (1927) Studies in cerebral circulation II. A quantitative study of cerebral capillaries. Transaction Association American Physicians 42:255-62
15. Craigie E (1945) The architecture of the cerebral capillary bed. Biol Rev 20:133-46
16. Crone C (1963) The permeability of capillaries in various organs as determined by use of the 'Indicator Diffusion' method. Acta Physiol Scand 58:292-305
17. Crone C (1984) Oxygen supply to the brain. In: Advances in the biosciences: oxygen transport in red blood cells (Nicolau C, ed) New York, USA: Pergamon Press, 105-17
18. Crumrine RC, LaManna JC (1991) Regional cerebral metabolites, blood flow, plasma volume, and mean transit time in total cerebral ischemia in the rat. J Cereb Blood Flow Metab 11:272-82
19. Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37-45
20. 15O] oxygen tracer data for estimating oxygen consumption. Am J Physiol 270:H1115-30
21. Eke A, Hermán P (1999) Fractal analysis of spontaneous fluctuations in human cerebral hemoglobin content and its oxygenation level recorded by NIRS. Adv Exp Med Biol 471:49-55
22. Eke A, Hutiray G, Kovach AG (1979) Induced hemodilution detected by reflectometry for measuring microregional blood flow and blood volume in cat brain cortex. Am J Physiol 236:H759-68
23. Eke A, Strong E, Halsey JH, Jr (1981) Stability of oxygen transmissibility during ischemia. Neurol Res 3:211-28
24. Federspiel WJ, Popel AS (1986) A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries. Microvasc Res 32:164-89
25. Federspiel WJ, Sarelius IH (1984) An examination of the contribution of red cell spacing to the uniformity of oxygen flux at the capillary wall. Microvasc Res 27:273-85
26. 2 for maximum cytochrome turnover in red muscle in situ. Am J Physiol 252:H906-15
27. Gjedde A (2001) Brain energy metabolism and the physiological basis of the hemodynamic response. In: Functional magnetic resonance imaging: Methods for neuroscience (Jezzard P, Matthews P, Smith S, eds), Oxford, UK: Oxford University Press, 37-66
28. Gobel U, Theilen H, Kuschinsky W (1990) Congruence of total and perfused capillary network in rat brains. Circ Res 66:271-81
29. 13C]-NMR spectroscopy. Magn Reson Med 49:37-46
30. 2 indicator-dilution technique. J Appl Physiol 58:1929-41
31. Gruetter R, Seaquist ER, Ugurbil K (2001) A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol 281:E100-12
32. Henry PG, Roussel R, Vaufrey F, Dautry C, Bloch G (2000) Semiselective POCE NMR spectroscopy. Magn Reson Med 44:395-400
33. Holm JE, Botha EC (1999) Leap-frog is a robust algorithm for training neural networks. Network 10:1-13
34. Homer LD, Shelton JB, Williams TJ (1983) Diffusion of oxygen in slices of rat brain. Am J Physiol 244:R15-22
35. Homer LD, Weathersby PK, Kiesow LA (1981) Oxygen gradients between red blood cells in the microcirculation. Microvasc Res 22:308-23
36. Hudetz AG (1999) Mathematical model of oxygen transport in the cerebral cortex. Brain Res 817:75-83
37. Hyder F (2004) Neuroimaging with calibrated fMRI. Stroke 35(Suppl 1):2635-41
38. 13C turnover and oxygen consumption by in vivo NMR. Adv Exp Med Biol 530:29-39
39. Hyder F, Kennan RP, Kida I, Mason GF, Behar KL, Rothman D (2000a) Dependence of oxygen delivery on blood flow in rat brain: a 7 tesla nuclear magnetic resonance study. J Cereb Blood Flow Metab 20:485-98
40. Hyder F, Kida I, Behar KL, Kennan RP, Maciejewski PK, Rothman DL (2001) Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR Biomed 14:413-31
41. Hyder F, Renken R, Kennan RP, Rothman DL (2000b) Quantitative multi-modal functional MRI with blood oxygenation level dependent exponential decays adjusted for flow attenuated inversion recovery (BOLDED AFFAIR). Magn Reson Imaging 18:227-35
42. 2]glutamate/glutamine tomography in rat brain. Magn Reson Med 42:997-1003
43. Hyder F, Rothman DL, Blamire AM (1995) Image reconstruction of sequentially sampled echo-planar data. Magn Reson Imaging 13:97-103
44. Hyder F, Shulman RG, Rothman DL (1998) A model for the regulation of cerebral oxygen delivery. J Appl Physiol 85:554-64
45. Ivanov KP, Derry AN, Vovenko EP, Samoilov MO, Semionov DG (1982) Direct measurements of oxygen tension at the surface of arterioles, capillaries and venules of the cerebral cortex. Pflugers Arch 393:118-120
46. Jesmin S, Hattori Y, Sakuma I, Liu MY, Mowa CN, Kitabatake A (2003) Estrogen deprivation and replacement modulate cerebral capillary density with vascular expression of angiogenic molecules in middle-aged female rats. J Cereb Blood Flow Metab 23:181-9
47. Kagawa T, Mochizuki M (1982) Numerical solution of partial differential equation describing oxygenation rate of the red blood cell. Jpn J Physiol 32:197-218
48. Kassissia IG, Goresky CA, Rose CP, Schwab AJ, Simard A, Huet PM, Bach GG (1995) Tracer oxygen distribution is barrier-limited in the cerebral microcirculation. Circ Res 77:1201-11
49. O2 mapping in rat cortex: a multi-parametr. J Cereb Blood Flow Metab 20:847-60
50. Krogh A (1919) The number and the distribution of capillaries in muscles with the calculation of the oxygen pressure head necessary for supplying the tissue. J Physiol (London) 52:409-41
51. Lawson WH, Jr, Forster RE (1967) Oxygen tension gradients in peripheral capillary blood. J Appl Physiol 22:970-3
52. 2 distribution in the living tissue. Kidney Int 51:372-80
53. Makhijani VB, Cokelet GR, Clark A, Jr (1990) Dynamics of oxygen unloading from sickle erythrocytes. Biophys J 58:1025-52
54. Mason GF, Rothman DL, Behar KL, Shulman RG (1992) NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain. J Cereb Blood Flow Metab 12:434-47
55. Mayhew JE (2003) Neuroscience. A measured look at neuronal oxygen consumption. Science 299:1023-4
56. Meier P, Zierler KL (1954) On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 6:731-44
57. Mintun MA, Lundstrom BN, Snyder AZ, Vlassenko AG, Shulman GL, Raichle ME (2001) Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data. Proc Natl Acad Sci USA 98:6859-64
58. Mitnick MH, Jobsis FF (1976) Pyrenebutyric acid as an optical oxygen probe in the intact cerebral cortex. J Appl Physiol 41:593-7
59. Mochizuki M (1966) On the velocity of oxygen dissociation of human hemoglobin and red cell. Jpn J Physiol 16:649-57
60. Nicholson C, Sykova E (1998) Extracellular space structure revealed by diffusion analysis. Trends Neurosci 21:207-15
61. 2 in rats. Brain Res 868:150-156
62. Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL (2004) Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab 24:972-85
63. 13C] D-glucose. Magn Reson Med 41:1077-83
64. Pinard E, Seylaz J (1978) Intracerebral gas partial pressure changes under vasoactive drugs. A mass spectrometry study. Pflugers Arch 375:25-30
65. Popel AS (1989) Theory of oxygen transport to tissue. Crit Rev Biomed Eng 17:257-321
66. Raichle ME, Welch MJ, Grubb RL, Jr, Larson KB, Laux BE, Ter-Pogossian MM (1979) Regional cerebral oxygen utilization with positron emission tomography. Trans Am Neurol Assoc 104:154-6
67. Rothman DL, Sibson NR, Hyder F, Shen J, Behar KL, Shulman RG (1999) In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci 354:1165-77
68. Roughton F (1932) Diffusion and chemical reaction velocity as joint factors in determining the rate of uptake of oxygen and carbon monoxide by the red blood cell corpuscle. Proc R Soc Lond B 111:1-11
69. Schwarzbauer C, Morrissey SP, Haase A (1996) Quantitative magnetic resonance imaging of perfusion using magnetic labeling of water proton spins within the detection slice. Magn Reson Med 35:540-6
70. Shulman RG, Rothman DL, Behar KL, Hyder F (2004) Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 27:489-95
71. Snyman J (1982) A new and dynamic method for unconstrained minimization. Appl Mathematical Modelling 6:449-62
72. Ursino M, Di Giammarco P, Belardinelli E (1989a) A mathematical model of cerebral blood flow chemical regulation - Part I: diffusion processes. IEEE Trans Biomed Eng 36:183-91
73. Ursino M, Di Giammarco P, Belardinelli E (1989b) A mathematical model of cerebral blood flow chemical regulation - Part II: reactivity of cerebral vascular bed. IEEE Trans Biomed Eng 36:192-201
74. Valabregue R, Aubert A, Burger J, Bittoun J, Costalat R (2003) Relation between cerebral blood flow and metabolism explained by a model of oxygen exchange. J Cereb Blood Flow Metab 23:536-45
75. Vanderkooi JM, Wilson DF (1986) A new method for measuring oxygen concentration in biological systems. Adv Exp Med Biol 200:189-93
76. Vovenko E (1999) Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats. Pflugers Arch 437:617-23
77. Walley KR (1996) Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol 81:885-94
78. Young WK, Vojnovic B, Wardman P (1996) Measurement of oxygen tension in tumours by time-resolved fluorescence. Br J Cancer Suppl 27:S256-9
79. Zheng Y, Martindale J, Johnston D, Jones M, Berwick J, Mayhew J (2002) A model of the hemodynamic response and oxygen delivery to brain. Neuroimage 16:617-37
80. 17O relaxation time and NMR sensitivity of cerebral water and their field dependence. Magn Reson Med 45:543-9