Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter

Behavioural Brain Research

Volumn 213, Issue 2, 2010, Pages 195-200

  Miguel, Tatiana Longo Borges ^a   Pobbe, Roger Luis Henschel ^a   Spiacci, Ailton ^a   Zangrossi, Hélio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

5 HT1A receptors; Dorsal periaqueductal gray; Dorsal raphe nucleus; Escape; Panic; Serotonin

Indexed keywords

HOMOCYSTEIC ACID; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; HOMOCYSTEINE; KAINIC ACID; LINSIDOMINE; MOLSIDOMINE; N-(2-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDINYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 AGONIST; SEROTONIN 1 ANTAGONIST;

AMYGDALOID NUCLEUS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DORSAL RAPHE NUCLEUS; ESCAPE BEHAVIOR; EVOKED RESPONSE; FRONTAL CORTEX; LOCOMOTION; MALE; NEUROTRANSMISSION; NONHUMAN; PANIC; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; SENSORY STIMULATION; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY; RAPHE NUCLEUS; WISTAR RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DISEASE MODELS, ANIMAL; ESCAPE REACTION; HOMOCYSTEINE; KAINIC ACID; MALE; MOLSIDOMINE; PANIC DISORDER; PERIAQUEDUCTAL GRAY; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS;

EID: 77953915330     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.04.055     Document Type: Article

References (53)

1. Adell A., Celada P., Abellan M.T., Artigas F. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res Rev 2002, 39(2-3):154-180.
2. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe. J Comp Neurol 1978, 179:641-668.
3. Beckett S., Marsden C.A. Computer analysis and quantification of periaqueductal grey-induced defence behaviour. J Neurosci Methods 1995, 58(1-2):157-161.
4. 1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour. J Psychopharmacol 1997, 11(1):35-40.
5. 1A receptor agonists administered into the periaqueductal gray. Psychopharmacology (Berl) 1992, 108(1-2):110-114.
6. Canto-de-Souza A., Nunes-de-Souza R., Rodgers R.J. Anxiolytic-like effect of Way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience. Brain Res 2002, 928(1-2):50-59.
7. Cheeta S., Irvine E.E., Kenny P.J., File S.E. The dorsal raphe nucleus is a crucial structure mediating nicotine's anxiolytic effects and the development of tolerance and withdrawal responses. Psychopharmacology (Berl) 2001, 155(1):78-85.
8. 2A receptors in the rat dorsal periaqueductal gray. Psychopharmacology (Berl) 2006, 183(4):422-428.
9. (2A) receptors in the rat dorsal periaqueductal gray. Psychopharmacology (Berl) 2008, 198(3):341-349.
10. de Oliveira R.M., Del Bel E.A., Guimarães F.S. Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray. Neurosci Biobehav Rev 2001, 25(7-8):679-685.
11. 2 receptors of the dorsal periaqueductal gray in the regulation of the defensive behaviors generated by the elevated T-maze. Brain Res Bull 2004, 64(2):181-188.
12. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defense. J Psychopharmacol 1991, 5:305-315.
13. 1A-receptor ligands in dorsal raphe and ventral hippocampus. Pharmacol Biochem Behav 1996, 54(1):123-128.
14. File S.E., Gonzalez L.E., Andrews N. Comparative study of pre- and postsynaptic 5-HT1A receptor modulation of anxiety in two ethological animal tests. J Neurosci 1996, 16(15):4810-4815.
15. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci 1994, 55(3):163-167.
16. Graeff F.G. On serotonin and experimental anxiety. Psychopharmacology 2002, 163(3-4):467-476.
17. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci Biobehav Rev 2004, 28(3):239-259.
18. Graeff F.G., Viana M.B., Mora P.O. Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated T-maze. Pharmacol Biochem Behav 1996, 53:171-177.
19. Graeff F.G., Zangrossi H. Animal models of anxiety disorders. Biological psychiatry 2002, 879-893. Wiley, Chichester. H. D'Haenen, J.A. den Boer, P. Willner (Eds.).
20. Gray J.A., McNaughton N. The neuropsychology of anxiety: an enquiry into the functions of the septo-hippocampal system 2000, Oxford University Press, Oxford.
21. Haddjeri N., Lavoie N., Blier P. Electrophysiological evidence for the tonic activation of 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus. Neuropsychopharmacology 2004, 29(10):1800-1806.
22. Hajos M., Hoffmann W.E., Tetko I.V., Hyland B., Sharp T., Villa A.E. Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. Neurosci Lett 2001, 304(3):129-132.
23. Higgins G.A., Bradbury A.J., Jones B.J., Oakley N.R. Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphe nucleus of the rat. Neuropharmacology 1988, 27(10):993-1001.
24. Hjorth S., Sharp T. Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe innervated rat brain regions as measured by in vivo microdialysis. Life Sci 1991, 48:1779-1786.
25. Hogg S., Andrews N., File S.E. Contrasting behavioural effects of 8-OH DPAT in the dorsal raphe nucleus and ventral hippocampus. Neuropharmacology 1994, 33(3-4):343-348.
26. Jenck F., Moreau J.L., Martin J.R. Dorsal periaqueductal gray-induced aversion as a simulation of panic anxiety: elements of face and predictive validity. Psychiatric Res 1995, 57:181-191.
27. Liu R.J., Lambe E.K., Aghajanian G.K. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l-tryptophan and tryptophan hydroxylase-activating kinases. Eur J Neurosci 2005, 21(4):945-958.
28. Lovick T.A. Panic disorder - a malfunction of multiple transmitter control systems within the midbrain periaqueductal gray matter?. Neuroscientist 2000, 6:48-59.
29. 1A-receptor-mediated inhibition of panic-like behaviours in rats. Psychopharmacology 1997, 131:321-328.
30. Mongeau R., Marsden C.A. Effect of central and peripheral administrations of cholecystokinin-tetrapeptide on panic-like reactions induced by stimulation of the dorsal periaqueductal grey area in the rat. Biol Psychiatry 1997, 42(5):335-344.
31. Moreira F.A., Guimaraes F.S. Benzodiazepine receptor and serotonin 2A receptor modulate the aversive-like effects of nitric oxide in the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl) 2004, 176(3-4):362-368.
32. Moreira F.A., Guimaraes F.S. Role of serotonin receptors in panic-like behavior induced by nitric oxide in the rat dorsolateral periaqueductal gray: effects of chronic clomipramine treatment. Life Sci 2005, 77:1972-1982.
33. 1A antagonists WAY-100135 and WAY-100635, on guinea-pig behavior and dorsal raphe 5-HT neuron firing. Br J Pharmacol 1996, 117:750-756.
34. Nogueira R.L., Graeff F.G. Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion. Pharmacol Biochem Behav 1995, 52:1-6.
35. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2007, Academic Press, New York, p. 462.
36. 1A compounds 8-hydroxy-2-(di-n-propylamino) tetralin and ipsapirone in the social interaction paradigm: evidence of a presynaptic action. Brain Res Bull 1995, 37(2):169-175.
37. 2A receptors in the rat dorsal periaqueductal gray mediate the antipanic-like effect induced by the stimulation of serotonergic neurons in the dorsal raphe nucleus. Psychopharmacology 2005, 183:314-321.
38. Schenberg L.C., Bittencourt A.S., Sudré E.C.M., Vargas L.C. Modeling panic attacks. Neurosci Biobehav Rev 2001, 25:647-659.
39. Schütz M.T.B., Aguiar J.C., Graeff F.G. Anti-aversive role of serotonin in the dorsal periaqueductal grey matter. Psychopharmacology 1985, 85:340-345.
40. Sena L.M., Bueno C., Pobbe R.H., Andrade T.G.C.S., Zangrossi H., Viana M.B. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav Brain Res 2003, 142(1-2):125-133.
41. Sharp T., Bramwell S.R., Grahame-Smith D.G. Release of endogenous 5-hydroxytryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonists. Neuroscience 1990, 39(3):629-637.
42. Sharp T., Bramwell S.R., Hjorth S., Grahame-Smith D.G. Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. Br J Pharmacol 1989, 98:989-997.
43. 1B agonists. Synapse 1987, 1(1):3-9.
44. Tao R., Auerbach S.B. Regulation of serotonin release by GABA and excitatory amino acids. J Psychopharmacol 2000, 14(2):100-113.
45. Treit D., Robinson A., Rotzinger S., Pesold C. Anxiolytic effects of serotonergic interventions in the shock-probe burying test and the elevated plus-maze test. Behav Brain Res 1993, 54(1):23-34.
46. Vertes R.P. A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J Comp Neurol 1991, 313(4):643-668.
47. Vertes R.P., Kocsis B. Projections of the dorsal raphe nucleus to the brainstem: PHA-L analysis in the rat. J Comp Neurol 1994, 340(1):11-26.
48. Viana M.B., Graeff F.G., Loschmann P.A. Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray. Pharmacol Biochem Behav 1997, 58:167-172.
49. Viana M.B., Tomaz C., Graeff F.G. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 1994, 49(3):549-554.
50. Zangrossi H., Viana M.B., Zanoveli J., Bueno C., Nogueira R.L., Graeff F.G. Serotonergic regulation of inhibitory avoidance and one-way escape in the rat elevated T-maze. Neurosci Biobehav Ver 2001, 25(7-8):637-645.
51. Zanoveli J.M., Nogueira R.L., Zangrossi H. Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze. Eur J Pharmacol 2003, 473(2-3):153-161.
52. 2A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety. Behav Pharmacol 2005, 16(7):543-552.
53. Zanoveli J.M., Nogueira R.L., Zangrossi H. Enhanced reactivity of 5-HT1A receptors in the rat dorsal periaqueductal gray matter after chronic treatment with fluoxetine and sertraline: evidence from the elevated T-maze. Neuropharmacology 2007, 52(4):1188-1195.