Tumour-infiltrating lymphocytes and survival in patients with adenocarcinoma of the oesophagus

European Journal of Surgical Oncology

Volumn 36, Issue 7, 2010, Pages 670-677

  Zingg, U ^a   Montani, M ^b   Frey, D M ^a   Dirnhofer, S ^c   Esterman, A J ^d   Went, P ^b   Oertli, D ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b TRIEMLI HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Oesophageal adenocarcinoma; Regulatory T cells; Survival; Tumour infiltrating lymphocytes

Indexed keywords

BASILIXIMAB; CD3 ANTIBODY; CD4 ANTIBODY; CISPLATIN; FLUOROURACIL; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; ESOPHAGEAL ADENOCARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL; SURVIVAL TIME; TUMOR ASSOCIATED LEUKOCYTE;

ADENOCARCINOMA; ADULT; AGED; CHEMOTHERAPY, ADJUVANT; ESOPHAGEAL NEOPLASMS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY, ADJUVANT; RESEARCH DESIGN; SURVIVAL ANALYSIS; T-LYMPHOCYTES, REGULATORY;

EID: 77953911309     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2010.05.012     Document Type: Article

References (31)

1. Falk J., Carstens H., Lundell L., and Albersson M. Incidence of carcinoma of the oesophagus and gastric cardia. Changes over time and geographical differences. Acta Oncologica 46 (2007) 1070-1074
2. Hulscher J.B., van Sandick J.W., de Boer A.G., et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the oesophagus. N Engl J Med 347 (2002) 1662-1669
3. Lerut T., Nafteux P., Moons J., et al. Three-field lymphadenectomy for carcinoma of the oesophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival and outcome. Ann Surg 240 (2004) 962-974
4. Toes R.E., Ossendorp F., Offringa R., and Melief C. CD4 T cells and their role in antitumor responses. J Exp Med 189 (1999) 753-756
5. Ossendorp F., Toes R.E., Offringa R., van der Burg S.H., and Melief C.J. Importance of CD4+ T helper responses in tumour immunity. Immunol Lett 15 (2000) 75-79
6. Zhang L., Conejo-Gracia J.R., Katsaros D., et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348 (2003) 203-213
7. Sato E., Olson S.H., Ahn J., et al. Intraepithelial CD8+ tumour-infiltrating lymphocytes and a high CD8/regulatory T cell ratio are associated with favourable prognosis in ovarian cancer. Proc Natl Acad Sci 102 (2005) 18538-18543
8. Clarke S.L., Betts G.J., Plant A., et al. CD4+CD25+FoxP3+ regulatory T cells suppress anti-tumour responses in patients with colorectal cancer. PloS One 1 (2006) e129
9. Fukunaga A., Miyamoto M., Cho Y., et al. CD8+ tumour-infiltrating lymphocytes together with CD4+ tumour-infiltration lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas 28 (2004) e26-e31
10. Cho Y., Miyamoto M., Kato K., et al. CD4+ and CD8+ T cells cooperate to improve prognosis of patients with oesophageal squamous cell carcinoma. Cancer Res 63 (2003) 1555-1559
11. Schumacher K., Haensch W., Roefzaad C., and Schlag P.M. Prognostic significance of activated CD8+ T cell infiltrations in oesophageal carcinomas. Cancer Res 61 (2001) 3932-3936
12. Ikeguchi M., Saito H., Katano K., Tsujitani S., Maeta M., and Kaibara N. Correlation between the lymphocytic infiltration of tumours and the proliferative activity of cancer cells from surgically treated oesophageal carcinoma. Oncology 54 (1997) 311-317
13. Sasada T., Kimura M., Yoshida Y., Kanai M., and Takabayashi A. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies. Cancer 98 (2003) 1089-1099
14. Roncador G., Brown P.J., Maestre L., et al. Analysis of FoxP3 protein expression in human CD4+CD25+ regulatory T cells at single-cell level. Eur J Immunol 35 (2005) 1681-1691
15. Fontenot J.D., Gavin M.A., and Rudensky A.Y. FoxP3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
16. Curiel T.J., Coukos G., Zou L., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10 (2004) 942-949
17. Badoual C., Hans S., Rodriguez J., et al. Prognostic value of tumour-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res 12 (2006) 465-472
18. Yoshioka T., Miyamoto M., Cho Y., et al. Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell cancer. Br J Cancer 98 (2008) 1258-1263
19. Zingg U., Montani M., Frey D.M., Dirnhofer S., Went P., and Oertli D. Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancer. Eur J Surg Oncol (2009 Jul 23) [Epub ahead of print]
20. Mandard A.M., Dalibard F., Mandard J.C., et al. Pathologic assessment of tumour regression after preoperative chemoradiotherapy of oesophageal carcinoma. Cancer 73 (1994) 2680-2688
21. Siewert J.R., and Stein H.J. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg 85 (1998) 1457-1459
22. + regulatory T cells with improved survival in germinal center-like large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica 93 (2008) 193-200
23. Galon J., Costes A., Sanchez-Cabo F., et al. Type, density, and location of immune cells within human colorectal tumours predict clinical outcome. Science 313 (2006) 1960-1964
24. Kono K., Kawaida H., Takahashi A., et al. CD4(+)CD25high regulatory T cells increase with tumour stage in patients with gastric and oesophageal cancers. Cancer Immunol Immunother 55 (2006) 1064-1071
25. Grabenbauer G.G., Lahmer G., Distel L., and Niedobitek G. Tumour-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. Clin Cancer Res 12 (2006) 3355-3360
26. Shevach E.M. CD4+CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2 (2002) 389-400
27. Ichihara F., Kono K., Takahashi A., Kawaida H., Sugai H., and Fujii H. Increased populations of regulatory T cells in peripheral blood and tumour-infiltrating lymphocytes in patients with gastric and oesophageal cancers. Clin Cancer Res 9 (2003) 4404-4408
28. Yamamoto T., Kimura T., Ueta E., Tatemoto Y., and Osaki T. Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns. Oncology 64 (2003) 407-415
29. Suwa T., Saio M., Umemura N., et al. Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumour-infiltrating T-cells in oral squamous cell carcinoma. Oncol Rep 15 (2006) 757-763
30. Schaue D., Comin-Anduix B., Ribas A., et al. T-cell responses to surviving in cancer patients undergoing radiation therapy. Clin Cancer Res 14 (2008) 4883-4890
31. Tzankov A., Bourgau C., Kaiser A., et al. Rare expression of T-cell markers in classical Hodgkin's lymphoma. Mod Pathol 8 (2005) 1542-1549