Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma

Oncology Reports

Volumn 15, Issue 4, 2006, Pages 757-763

  Suwa, Tatsuhiko ^a   Saio, Masanao ^a   Umemura, Naoki ^a   Yamashita, Tomomi ^a   Toida, Makoto ^a   Shibata, Toshiyuki ^a   Takami, Tsuyoshi ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Immunohistochemical double staining; Ki 67; Oral squamous cell carcinoma; Radiation; Tumor infiltrating T cells

Indexed keywords

CD8 ANTIGEN; KI 67 ANTIGEN;

AGED; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; HUMAN; MALE; MIDDLE AGED; MOUTH TUMOR; PATHOLOGY; PREOPERATIVE CARE; RADIATION EXPOSURE; REGRESSION ANALYSIS; SQUAMOUS CELL CARCINOMA; TUMOR ASSOCIATED LEUKOCYTE;

AGED; AGED, 80 AND OVER; ANTIGENS, CD8; CARCINOMA, SQUAMOUS CELL; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; HUMANS; KI-67 ANTIGEN; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PREOPERATIVE CARE; REGRESSION ANALYSIS;

EID: 33746401621     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.4.757     Document Type: Article

References (37)

1. Chen L, Linsley PS and Hellstrom KE: Costimulation of T cells for tumor immunity. Immunol Today 14: 483-486, 1993. (Pubitemid 23300998)
2. Ando H, Saio M, Ohe N, et al : B7.1 immunogene therapy effectively activates CD(4+) tumor-infiltrating lymphocytes in the central nervous system in comparison with B7.2 gene therapy. Int J Oncol 20: 807-812, 2002.
3. + tumor-infiltrating lymphocytes in the central nervous system: prevention of parental tumor growth in the subcutaneous environment. J Neurosurg 97: 432-440, 2002.
4. Stinchcombe JC, Page LJ and Griffiths GM: Secretory lysosome biogenesis in cytotoxic T lymphocytes from normal and Chediak Higashi syndrome patients. Traffic 1: 435-444, 2000.
5. Onaitis M, Kalady MF, Pruitt S and Tyler DS: Dendritic cell gene therapy. Surg Oncol Clin N Am 11: 645-660, 2002. (Pubitemid 35210172)
6. Coyle AJ and Gutierrez-Ramos JC: The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat Immunol 2: 203-209, 2001. (Pubitemid 33705995)
7. Ridge JP, Di Rosa F and Matzinger P: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393: 474-478, 1998. (Pubitemid 128728267)
8. Schoenberger SP, Toes RE, van der Voort EI, Offringa R and Melief CJ: T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393: 480-483, 1998.
9. Unitt E, Rushbrook SM, Marshall A, et al : Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41: 722-730, 2005. (Pubitemid 40462933)
10. Nakano O, Sato M, Naito Y, et al : Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61: 5132-5136, 2001. (Pubitemid 32681545)
11. + T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 58: 3491-3494, 1998.
12. Key G, Becker MH, Baron B, Duchrow M, Schluter C, Flad HD, and Gerdes J: New Ki-67-equivalent murine monoclonal antibodies (MIB 1-3) generated against bacterially expressed parts of the Ki-67 cDNA containing three 62 base pair repetitive elements encoding for the Ki-67 epitope. Lab Invest 68: 629-636, 1993. (Pubitemid 23202791)
13. Marsland BJ, Battig P, Bauer M, et al : CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 22: 493-505, 2005. (Pubitemid 40545114)
14. Trapani JA and Sutton VR: Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr Opin Immunol 15: 533-543, 2003. (Pubitemid 37130194)
15. Trapani JA, Davis J, Sutton VR and Smyth MJ: Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Curr Opin Immunol 12: 323-329, 2000. (Pubitemid 30240543)
16. Sakakura K, Chikamatsu K, Sakurai T, Takahashi K, Murata T, Oriuchi N and Furuya N: Infiltration of dendritic cells and NK cells into the sentinel lymph node in oral cavity cancer. Oral Oncol 41: 89-96, 2005. (Pubitemid 39647125)
17. Leong SP, Peng M, Zhou YM, Vaquerano JE and Chang JW: Cytokine profiles of sentinel lymph nodes draining the primary melanoma. Ann Surg Oncol 9: 82-87, 2002. (Pubitemid 34262902)
18. Shintani S, Mihara M, Nakahara Y, et al: Apoptosis and p53 are associated with effect of preoperative radiation in oral squamous cell carcinomas. Cancer Lett 154: 71-77, 2000. (Pubitemid 30229911)
19. Doi R, Makino T, Adachi H, Ryoke K and Ito H: Pre-operative radio-chemotherapy enhances apoptotic cell death in oral squamous cell carcinoma. J Oral Pathol Med 27: 382-387, 1998. (Pubitemid 28407834)
20. Fonteneau JF, Kavanagh DG, Lirvall M, Sanders C, Cover TL, Bhardwaj N and Larsson M: Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 102: 4448-4455, 2003. (Pubitemid 37494109)
21. Feinmesser M, Okon E, Schwartz A, et al : Histologic and immunohistochemical characterization of tumor and inflammatory infiltrates in oral squamous cell carcinomas treated with local multikine immunotherapy: the macrophage at the front line. Eur Arch Otorhinolaryngol 261: 359-368, 2004. (Pubitemid 39141440)
22. Timar J, Ladanyi A, Forster-Horvath C, et al : Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial. J Clin Oncol 23: 3421-3432, 2005.
23. Kokemueller H, Brachvogel P, Eckardt A and Hausamen JE: Neck dissection in oral cancer - clinical review and analysis of prognostic factors. Int J Oral Maxillofac Surg 31: 608-614, 2002.
24. Nemeth Z, Somogyi A, Takacsi-Nagy Z, Barabas J, Nemeth G and Szabo G: Possibilities of preventing osteoradionecrosis during complex therapy of tumors of the oral cavity. Pathol Oncol Res 6: 53-58, 2000. (Pubitemid 30262780)
25. Lee N, Xia P, Fischbein NJ, Akazawa P, Akazawa C and Quivey JM: Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Oncol Biol Phys 57: 49-60, 2003. (Pubitemid 36959738)
26. Harada M, Tamada K, Abe K, et al: Systemic administration of interleukin-12 can restore the anti-tumor potential of B16 melanoma-draining lymph node cells impaired at a late tumor-bearing state. Int J Cancer 75: 400-405, 1998. (Pubitemid 28100043)
27. Cortesina G, De Stefani A, Giovarelli M, Barioglio MG, Cavallo GP, Jemma C and Forni G: Treatment of recurrent squamous cell carcinoma of the head and neck with low doses of interleukin-2 injected perilymphatically. Cancer 62: 2482-2485, 1988. (Pubitemid 19006426)
28. Andreadis C, Vahtsevanos K, Sidiras T, Thomaidis I, Antoniadis K and Mouratidou D: 5-Fluorouracil and cisplatin in the treatment of advanced oral cancer. Oral Oncol 39: 380-385, 2003. (Pubitemid 36379346)
29. Adema GJ, De Vries IJ, Punt CJ and Figdor CG: Migration of dendritic cell based cancer vaccines: in vivo veritas? Curr Opin Immunol 17: 170-174, 2005. (Pubitemid 40343104)
30. Fong L, Brockstedt D, Benike C, Breen JK, Strang G, Ruegg CL and Engleman EG: Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy. J Immunol 167: 7150-7156, 2001. (Pubitemid 33144213)
31. Peterson AC, Harlin H and Gajewski TF: Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma. J Clin Oncol 21: 2342-2348, 2003. (Pubitemid 46628465)
32. Colnot DR, Roos JC, De Bree R, et al: Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 52: 576-582, 2003. (Pubitemid 37056133)
33. Borjesson PK, Postema EJ, De Bree R, Roos JC, Leemans CR, Kairemo KJ and van Dongen GA: Radioimmunodetection and radioimmunotherapy of head and neck cancer. Oral Oncol 40: 761-772, 2004. (Pubitemid 39061090)
34. Postema EJ, Borjesson PK, Buijs WC, et al: Dosimetric analysis of radioimmunotherapy with 186Re-labeled bivatuzumab in patients with head and neck cancer. J Nucl Med 44: 1690-1699, 2003. (Pubitemid 39663345)
35. Ghobrial I and Witzig T: Radioimmunotherapy: a new treatment modality for B-cell non-Hodgkin's lymphoma. Oncology 18: 623-640, 2004.
36. Santin AD: Lymph node metastases: the importance of the microenvironment. Cancer 88: 175-179, 2000.
37. Mazo IB, Honczarenko M, Leung H, et al: Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22: 259-270, 2005. (Pubitemid 40255716)