Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4080-4084

  Lee, Yeon Sun ^a   Fernandes, Steve ^a   Kulkarani, Vinod ^a   Mayorov, Alexander ^a   Davis, Peg ^b   Ma, Shou wu ^b   Brown, Kathy ^c   Gillies, Robert J ^c   Lai, Josephine ^b   Porreca, Frank ^b   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cholecystokinin receptors; Melanocortin receptors; Opioid receptors; Peptides

Indexed keywords

ANALGESIC AGENT; CHOLECYSTOKININ RECEPTOR; MELANOCORTIN RECEPTOR; OPIATE RECEPTOR; PEPTIDE DERIVATIVE; RESIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; MICROWAVE RADIATION; NONHUMAN; PAIN; PHARMACOPHORE; RAT; SOLID PHASE SYNTHESIS; TOPOGRAPHY;

ANALGESICS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; LIGANDS; MASS SPECTROMETRY; MODELS, MOLECULAR; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, MELANOCORTIN; RECEPTORS, OPIOID;

EID: 77953869201     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.078     Document Type: Article

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