Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells

Journal of Ethnopharmacology

Volumn 130, Issue 1, 2010, Pages 13-18

  Zeng, Ke Wu ^a,b   Wang, Xue Mei ^b   Ko, Hyeonseok ^a   Yang, Hyun Ok ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b PEKING UNIVERSITY   (China)

Author keywords

Cobalt chloride; Modified Wu Zi Yan Zong granule; Neuroprotection; PC12 cells; Traditional Chinese medicine

Indexed keywords

CASPASE 3; CHINESE DRUG; COBALT CHLORIDE; CYTOCHROME C; HERBACEOUS AGENT; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WU ZI YAN ZONG; COBALT; NEUROPROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CHINESE MEDICINE; CONTROLLED STUDY; ENZYME INHIBITION; HERBAL MEDICINE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; PC12 CELL LINE; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; COBALT; DRUGS, CHINESE HERBAL; MEMBRANE POTENTIALS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; REACTIVE OXYGEN SPECIES;

EID: 77953812776     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.03.018     Document Type: Article

References (21)

1. Boulares A.H., Yakovlev A.G., Ivanova V., Stoica B.A., Wang G.P., Lyer S., Smulson M. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. The Journal of Biological Chemistry 1999, 274:22932-22940.
2. Chihab R., Ferry C., Koziel V., Monin P., Daval J.L. Sequential activation of activator protein-1-related transcription factors and JNK protein kinases may contribute to apoptotic death induced by transient hypoxia in developing brain neurons. Brain Research, Molecular Brain Research 1998, 63:105-120.
3. Chinese Pharmacopoeia The Pharmacopoeia Commission of PRC, vol. 2 2005, Chinese Pharmacopoeia, p. 364. 2005 edition.
4. Chung H.J., Kim E.H., Lee D.H., Seo S.H., Ju S.H., Lee D., Kim H.C., Park S.J. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 2007, 148:148-159.
5. Endres M., Wang Z.Q., Namura S., Waeber C., Moskowitz M.A. Ischemic brain injury is mediated by the activation of poly (ADP-ribose) polymerase. Journal of Cerebral Blood Flow & Metabolism 1997, 17:1143-1151.
6. Fu H., Wang X.M., Lui G.X., Xie C., Guo X.M., Li L., Yang J.X., Zhu W. Effects of modified Wu-Zi-Yan-Zong granule on memory ability and volume of hippocampus measured by MRI in patients with mild cognitive impairment. Chinese Journal of Integrated Traditional and Western Medicine 2006, 26:1066-1069.
7. Fu H., Wang X.M., Liu G.X., Zhu W., Li L., Yang J.X. The effect of Jiawei Wu-Zi-Yan-Zong granule on memory ability and level of serum beta-amyloid of mild cognitive impairment patients. Chinese Journal of Gerontology 2007, 27:715-717.
8. Hou R.C.W., Huang H.M., Tzen J.T.C., Jeng K.C.G. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. Journal of Neuroscience Research 2003, 74:123-133.
9. 2-induced apoptosis of rat PC12 cells. Neuroscience Letters 2004, 371:85-90.
10. 2-induced apoptosis. Brain Research Bulletin 2008, 76:579-585.
11. Junn E., Mouradian M.M. Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. Journal of Neurochemistry 2001, 78:374-383.
12. Li M.F., Li H., Wang X.M., Wang G.H. Determination of icariin in Jiawei Wu-Zi-Yan-Zong Pill by HPLC. Chinese Journal of Information on Traditional Chinese Medicine 2008, 15:51-52.
13. Martin B., Gill J., Regino P.P. Hypoxia ischemia-mediated cell death in neonatal rat brain. Neurochemical Research 2008, 33:2379-2389.
14. Rao R., Howard R. Vascular dementia: dead or alive?. International Journal of Geriatric Psychiatry 1998, 13:277-284.
15. Stefan I., Guido S., Michael S., Stanislaw K., John C.R., Mathias B. Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat. Brain Pathology 2006, 8:49-62.
16. Sundvall M.P., Wallina C., Gillanda E., Hallinb U., Wang X., Sandberga M., Karlssona J., Blomgren K., Hagberg H. Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. Developmental Brain Research 2000, 125:43-50.
17. 2 amino-terminal kinase 1 and stress-activated kinases p38 and p38 activation and confers neuroprotection in the pheochromocytoma PC12 model. Journal of Molecular Neuroscience 2004, 22:237-250.
18. Wang X.M., Fu H., Liu G.X., Song P., Tu P.F., Wang Y.H. Clinical study on treatment of mild cognitive impairment by modified Wu-Zi-Yan-Zong granule. Chinese Journal of Integrated Traditional and Western Medicine 2004, 24:392-395.
19. Yoshimura S., Banno Y., Nakashima S., Takenaka K., Sakai H., Nishimura Y., Sakai N., Shimizu S., Eguchi Y., Tsujimoto Y., Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. The Journal of Biological Chemistry 1998, 273:6921-6927.
20. Zou W.G., Yan M.D., Xu W.J., Huo H.R., Sun L.Y., Zheng Z.C., Liu X.Y. Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. Journal of Neuroscience Research 2001, 64:646-653.
21. Zou W.G., Zeng J.P., Zhuo M., Xu W.J., Sun L.Y., Wang J.X., Liu X.Y. Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. Journal of Neuroscience Research 2002, 67:837-843.