Acute effects of ephedra on autonomic nervous modulation in healthy young adults

Clinical Pharmacology and Therapeutics

Volumn 88, Issue 1, 2010, Pages 39-44

  Chen, W L ^a,b,c   Tsai, T H ^a,d   Yang, C C H ^a,d   Kuo, T B J ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c CATHAY GENERAL HOSPITAL   (Taiwan)

^d TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EPHEDRA EXTRACT; PLACEBO;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARASYMPATHETIC TONE; POWER SPECTRUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYMPATHETIC TONE; VOLUNTEER;

ADULT; ALGORITHMS; AUTONOMIC NERVOUS SYSTEM; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; EPHEDRA; FEMALE; FOURIER ANALYSIS; HEART RATE; HEMODYNAMICS; HUMANS; MALE; YOUNG ADULT;

EID: 77953809883     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2010.66     Document Type: Article

References (24)

1. Mehendale, S.R., Bauer, B.A. & yuan, C.S. Ephedra-containing dietary supplements in the US versus ephedra as a Chinese medicine. Am. J. Chin. Med. 32, 1-10 (2004).
2. Andraws, R., Chawla, P. & Brown, D.L. Cardiovascular efects of ephedra alkaloids: a comprehensive review. Prog. Cardiovasc. Dis. 47, 217-225 (2005).
3. Haller, C.A. & Benowitz, N.L. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N. Engl. J. Med. 343, 1833-1838 (2000).
4. Haller, C.A., Meier, K.H. & Olson, K.R. Seizures reported in association with use of dietary supplements. Clin. Toxicol. (Phila). 43, 23-30 (2005).
5. Holstege, C.P., Mitchell, K., Barlotta, K. & Furbee, R.B. Toxicity and drug interactions associated with herbal products: ephedra and St. john's Wort. Med. Clin. North Am. 89, 1225-1257 (2005).
6. McBride, B.F., Karapanos, A.K., Krudysz, A., Kluger, J., Coleman, C.I. & White, C.M. Electrocardiographic and hemodynamic efects of a multicomponent dietary supplement containing ephedra and cafeine: a randomized controlled trial. JAMA 291, 216-221 (2004).
7. Haller, C.A., jacob, P. & Benowitz, N.L. Short-term metabolic and hemodynamic efects of ephedra and guarana combinations. Clin. Pharmacol. Ther. 77, 560-571 (2005).
8. Vukovich, M.D., Schoorman, R., Heilman, C., jacob, P. 3rd & Benowitz, N.L. Cafeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure. Clin. Exp. Pharmacol. Physiol. 32, 47-53 (2005).
9. Caron, M.F., Dore, D.D., Min, B., Kluger, J., Boguk, I. & White, C.M. Electrocardiographic and blood pressure efects of the ephedra-containing TrimSpa thermogenic herbal compound in healthy volunteers. Pharmacotherapy 26, 1241-1246 (2006).
10. Howden, R. et al. Ephedrine plus cafeine causes age-dependent cardiovascular responses in Fischer 344 rats. Am. J. Physiol. Heart Circ. Physiol. 288, H2219-H2224 (2005).
11. Nyska, A. et al. Acute hemorrhagic myocardial necrosis and sudden death of rats exposed to a combination of ephedrine and cafeine. Toxicol. Sci. 83, 388-396 (2005).
12. Dunnick, J.K., Kissling, G., Gerken, D.K., Vallant, M.A. & Nyska, A. Cardiotoxicity of Ma Huang/cafeine or ephedrine/cafeine in a rodent model system. Toxicol. Pathol. 35, 657-664 (2007).
13. Pomeranz, B. et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am. J. Physiol. 248, H151-H153 (1985).
14. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 1043-1065 (1996).
15. Kleiger, R.E., Stein, P.K. & Bigger, J.T. jr. Heart rate variability: measurement and clinical utility. Ann. Noninvasive Electrocardiol. 10, 88-101 (2005).
16. White, L.M., Gardner, S.F., Gurley, B.J., Marx, M.A., Wang, P.L. & Estes, M. Pharmacokinetics and cardiovascular efects of ma-huang (Ephedra sinica) in normotensive adults. J. Clin. Pharmacol. 37, 116-122 (1997).
17. Gardner, S.F., Franks, A.M., Gurley, B.J., Haller, C.A., Singh, B.K. & Mehta, J.L. Efect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers. Am. J. Cardiol. 91, 1510-1513, A9 (2003).
18. Curtis, B.M. & O'Keefe, J.H. jr. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fght or fight. Mayo Clin. Proc. 77, 45-54 (2002).
19. Boozer, C.N., Nasser, J.A., Heymsfeld, S.B., Wang, V., Chen, G. & Solomon, J.L. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int. J. Obes. Relat. Metab. Disord. 25, 316-324 (2001).
20. Boozer, C.N. et al. Herbal ephedra/cafeine for weight loss: a 6-month randomized safety and efcacy trial. Int. J. Obes. Relat. Metab. Disord. 26, 593-604 (2002).
21. Soni, M.G., Carabin, I.G., Grifths, J.C. & Burdock, G.A. Safety of ephedra: lessons learned. Toxicol. Lett. 150, 97-110 (2004).
22. Betz, J.M., Gay, M.L., Mossoba, M.M., Adams, S. & Portz, B.S. Chiral gas chromatographic determination of ephedrine-type alkaloids in dietary supplements containing Má Huáng. J. AOAC Int. 80, 303-315 (1997).
23. Gurley, B.J., Gardner, S.F. & Hubbard, M.A. Content versus label claims in ephedra-containing dietary supplements. Am. J. Health. Syst. Pharm. 57, 963-969 (2000).
24. Su, C.F., Kuo, T.B., Kuo, J.S., Lai, H.y. & Chen, H.I. Sympathetic and parasympathetic activities evaluated by heart-rate variability in head injury of various severities. Clin. Neurophysiol. 116, 1273-1279 (2005).