Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults

Journal of Clinical Pharmacology

Volumn 37, Issue 2, 1997, Pages 116-122

  White, Laura M ^a,c   Gardner, Stephanie F ^a   Gurley, Bill J ^a   Marx, Michael A ^a,b   Wang, Pei Ling ^a   Estes, Mark ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPHEDRINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD PRESSURE MONITORING; CLINICAL ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG ABSORPTION; DRUG USE; EPHEDRA; EUPHORIA; FEMALE; HEART INFARCTION; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSOMNIA; MALE; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; SEIZURE; STROKE;

EID: 0030937183     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1997.tb04769.x     Document Type: Article

References (15)

1. Tyler VE, Brady LR, Roberts JE: Pharmacognosy. Ninth Edition. Philadelphia: Lea & Febiger, 1988.
2. Cowley G: Herbal warning. Newsweek May 6, 1996:60-68.
3. FDA Statement on Street Drugs Containing Botanical Ephedrine. United States Department of Health and Human Services: Food and Drug Administration, April 10, 1996.
4. Nieder M, Jaeger H: Sensitive quantification of pseudoephedrine in human plasma and urine by high-performance liquid chromatography. J Chromatogr 1988;424:73-82.
5. Sagara K, Oshima T, Misake T: A simultaneous determination of norephedrine, pseudoephedrine, ephedrine, and methylephedrine in ephedra herb and oriental pharmaceutical preparations by ion-pair high performance liquid chromatography. Chem Pharm Bull 1983;31:2359-2365.
6. Zhang JS, Tian Z, Lou ZC: Quality evaluation of twelve species of Chinese Ephedra (ma-huang). Acta Pharm Sinica 1989;24:865-871.
7. van de Borne P, Tielemans C, Collart F, Vanherweghem J, Degaute J: Twenty-four-hour blood pressure and heart rate patterns in chronic hemodialysis patients. Am J Kidney Dis 1993;22:419-425.
8. Pickup ME, May CS, Senadagrie RS, Patterson JW: The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. Br J Clin Pharmac 1976;3:123-134.
9. Lu DR, Mao F: An interactive program for pharmacokinetic modeling. J Pharm Sci 1993;82:537-542.
10. Wilkinson GR, Beckett AH: Absorption, metabolism and excretion of the ephedrines in man II: pharmacokinetics. J Pharm Sci 1968;57:1933-38.
11. Kanfer I, Dowse R, Vuma V: Pharmacokinetics of oral decongestants. Pharmacotherapy 1993;13(suppl):116S-128S.
12. Vanakoski J, Stromberg C, Seppala T: Effects of a sauna on the pharmacokinetics of midazolam and ephedrine in healthy young women. Eur J Clin Pharmacol 1993;45:377-381.
13. Stromberg C, Vanakoski J, Olkkola KT, Lindquist A, Seppala T, Laitinen LA: Exercise alters the pharmacokinetics of midazolam. Clin Pharmacol Ther 1992;51:527-532.
14. Kelly HW, O'Connell MB: Asthma products. In, Covington TR, (ed.): Handbook of Nonprescription Drugs. Tenth Edition. Washington, DC: American Pharmaceutical Association, 1993:117-134.
15. New York Health Department bans sale of 20 ephedrine products. F-D-C Reports, The Tan Sheet June 3, 1996 3:4:13.