Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1802, Issue 7-8, 2010, Pages 649-658

  McGreal, Eamon P ^a   Davies, Philip L ^a   Powell, Wendy ^a   Rose John, Stefan ^c   Spiller, O Bradley ^a   Doull, Iolo ^b   Jones, Simon A ^a   Kotecha, Sailesh ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b CHILDREN S HOSPITAL FOR WALES   (United Kingdom)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Cystic fibrosis; Cytokine; IL 6; Inflammation; Neutrophil; Protease

Indexed keywords

CATHEPSIN G; ELASTASE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOBLASTIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYPOTHESIS; INFANT; LUNG DISEASE; LUNG LAVAGE; MOLECULAR INTERACTION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SCHOOL CHILD; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADULT; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYSTIC FIBROSIS; HUMANS; INFANT; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LEUKOCYTE ELASTASE; NEUTROPHILS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, INTERLEUKIN-6; SERINE PROTEASES; SOLUBILITY;

EID: 77953809342     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2010.04.005     Document Type: Article

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