메뉴 건너뛰기




Volumn 16, Issue 8, 1996, Pages 569-576

Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHIMERIC PROTEIN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ANTAGONIST; LYSINE; MUTANT PROTEIN; PHENYLALANINE; RECEPTOR BLOCKING AGENT; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

EID: 0029794317     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.1996.16.569     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 0027421831 scopus 로고
    • Interleukin-6 in biology and medicine
    • AKIRA, S., TAGA, T., and KISHIMOTO, T. (1993). Interleukin-6 in biology and medicine. Adv. Immunol. 54, 1-78.
    • (1993) Adv. Immunol. , vol.54 , pp. 1-78
    • Akira, S.1    Taga, T.2    Kishimoto, T.3
  • 3
    • 0024393839 scopus 로고
    • Interleukin-6 (IL-6) triggers the association of its receptor (IL-6R) with a possible signal transducer, gp130
    • TAGA, T., HIBI, M., HIRATA, Y., YAMASAKI, K., YASUKAWA, K., MATSUDA, T., HIRANO, T., and KISHIMOTO, T. (1989). Interleukin-6 (IL-6) triggers the association of its receptor (IL-6R) with a possible signal transducer, gp130. Cell 58, 573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3    Yamasaki, K.4    Yasukawa, K.5    Matsuda, T.6    Hirano, T.7    Kishimoto, T.8
  • 4
    • 0025630163 scopus 로고
    • Molecular cloning and expression of an IL-6 signal transducer, gp130
    • HIBI, M., MURAKAMI, M., SAITO, M., HIRANO, T., TAGA, T., and KISHIMOTO, T. (1990). Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63, 1149-1157.
    • (1990) Cell , vol.63 , pp. 1149-1157
    • Hibi, M.1    Murakami, M.2    Saito, M.3    Hirano, T.4    Taga, T.5    Kishimoto, T.6
  • 5
    • 0026721190 scopus 로고
    • The hepatic interleukin-6 receptor: Downregulation of the interleukin-6 binding subunit (gp80) by its ligand
    • ZOHLNHÖFER, D., GRAEVE, L., ROSE-JOHN, S., SCHOOLTINK, H., DITTRICH, E., and HEINRICH, P.C. (1992). The hepatic interleukin-6 receptor: Downregulation of the interleukin-6 binding subunit (gp80) by its ligand. FEBS Lett. 306, 219-222.
    • (1992) FEBS Lett. , vol.306 , pp. 219-222
    • Zohlnhöfer, D.1    Graeve, L.2    Rose-John, S.3    Schooltink, H.4    Dittrich, E.5    Heinrich, P.C.6
  • 6
    • 0027199126 scopus 로고
    • II-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase
    • MURAKAMI, M., HIBI, M., NAKAGAWA, T., YASUKAWA, Y., YAMANISHI, K., TAGA, T., and KISHIMOTO, T. (1993). II-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260, 1808-1810.
    • (1993) Science , vol.260 , pp. 1808-1810
    • Murakami, M.1    Hibi, M.2    Nakagawa, T.3    Yasukawa, Y.4    Yamanishi, K.5    Taga, T.6    Kishimoto, T.7
  • 7
    • 0028064835 scopus 로고
    • High affinity interleukin-6 receptor is a haxameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp130
    • WARD, L.D., HOWLETT, G.J., DISCOLO, G., YASUKAWA, K., HAMMACHER, A., MORITZ, R.L., and SIMPSON, R.J. (1994). High affinity interleukin-6 receptor is a haxameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp130. J. Biol. Chem. 269, 23286-23289.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23286-23289
    • Ward, L.D.1    Howlett, G.J.2    Discolo, G.3    Yasukawa, K.4    Hammacher, A.5    Moritz, R.L.6    Simpson, R.J.7
  • 10
    • 0025102756 scopus 로고
    • Hematopoietic receptors and helical cytokines
    • BAZAN, J.F. (1990). Hematopoietic receptors and helical cytokines. Immunol. Today 11, 350-354.
    • (1990) Immunol. Today , vol.11 , pp. 350-354
    • Bazan, J.F.1
  • 14
    • 0024361204 scopus 로고
    • Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28
    • BRAKENHOFF, J.P.J., HART, M., and AARDEN, L.A. (1989). Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28. J. Immunol. 143, 1175-1182.
    • (1989) J. Immunol. , vol.143 , pp. 1175-1182
    • Brakenhoff, J.P.J.1    Hart, M.2    Aarden, L.A.3
  • 16
    • 0025134958 scopus 로고
    • The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity
    • KRÜTTGEN, A., ROSE-JOHN, S., DUFHUES, G., BENDER, S., LÜTTICKEN, C., FREYER, P., and HEINRICH, P.C. (1990). The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity. FEBS Lett. 273, 95-98.
    • (1990) FEBS Lett. , vol.273 , pp. 95-98
    • Krüttgen, A.1    Rose-John, S.2    Dufhues, G.3    Bender, S.4    Lütticken, C.5    Freyer, P.6    Heinrich, P.C.7
  • 17
    • 0025819125 scopus 로고
    • Evidence for the importance of a positive charge and an α-helical structure of the C-terminus for biological activity of human IL-6
    • LÜTTICKEN, C., KRÜTTGEN, A., MÖLLER, C., HEINRICH, P.C., and ROSE-JOHN, S. (1991). Evidence for the importance of a positive charge and an α-helical structure of the C-terminus for biological activity of human IL-6. FEBS Lett. 282, 265-267.
    • (1991) FEBS Lett. , vol.282 , pp. 265-267
    • Lütticken, C.1    Krüttgen, A.2    Möller, C.3    Heinrich, P.C.4    Rose-John, S.5
  • 18
    • 0026769413 scopus 로고
    • Identification of a receptor binding site in the carboxyl terminus of human interleukin-6
    • LEEBECK, F.W.G., KARIYA, K., SCHWABE, M., and FOWLKES, D.M. (1992). Identification of a receptor binding site in the carboxyl terminus of human interleukin-6. J. Biol. Chem. 267, 14832-14383.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14832-114383
    • Leebeck, F.W.G.1    Kariya, K.2    Schwabe, M.3    Fowlkes, D.M.4
  • 19
    • 0026598960 scopus 로고
    • Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
    • DE VOS, A.M., ULTSCH, M., and KOSSIAKOFF, A.A. (1992). Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 255, 306-312.
    • (1992) Science , vol.255 , pp. 306-312
    • De Vos, A.M.1    Ultsch, M.2    Kossiakoff, A.A.3
  • 20
    • 0028202123 scopus 로고
    • Generation of interleukin-6 receptor antagonists by molecular-modelling guided mutagenesis of residues important for gp130 activation
    • SAVINO, R., LAHM, A., SALVATI, A.L., CIAPPONI, L., SPORENO, E., ALTAMURA, S., PAONESSA, G., TONIATTI, C., and CILIBERTO, G. (1994). Generation of interleukin-6 receptor antagonists by molecular-modelling guided mutagenesis of residues important for gp130 activation. EMBO J. 13, 1357-1367.
    • (1994) EMBO J. , vol.13 , pp. 1357-1367
    • Savino, R.1    Lahm, A.2    Salvati, A.L.3    Ciapponi, L.4    Sporeno, E.5    Altamura, S.6    Paonessa, G.7    Toniatti, C.8    Ciliberto, G.9
  • 26
    • 0028018978 scopus 로고
    • Development of an interleukin (IL)-6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells
    • DE HON, F.D., EHLERS, M., ROSE-JOHN, S., EBELING, S.B., KLAASSE BOS, H., AARDEN, L.A., and BRAKENHOFF, J.P.J. (1994). Development of an interleukin (IL)-6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells. J. Exp. Med. 180, 2395-2398.
    • (1994) J. Exp. Med. , vol.180 , pp. 2395-2398
    • De Hon, F.D.1    Ehlers, M.2    Rose-John, S.3    Ebeling, S.B.4    Klaasse Bos, H.5    Aarden, L.A.6    Brakenhoff, J.P.J.7
  • 27
    • 0025308827 scopus 로고
    • Brain alpha-bungaro toxin binding protein cDNAs and Mabs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
    • SCHOEPFER, R., CONROY, W.G., WHITING, P., GORE, M., and LINDSTROM, J. (1990). Brain alpha-bungaro toxin binding protein cDNAs and Mabs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily. Neuron 5, 393-397.
    • (1990) Neuron , vol.5 , pp. 393-397
    • Schoepfer, R.1    Conroy, W.G.2    Whiting, P.3    Gore, M.4    Lindstrom, J.5
  • 28
    • 0027303256 scopus 로고
    • Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules: Involvement of two separate domains in receptor binding
    • VAN DAM, M., MÜLLBERG, J., SCHOOLTINK, H., STOYAN, T., HEINRICH, P.C., and ROSE-JOHN, S. (1992). Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules: Involvement of two separate domains in receptor binding. J. Biol. Chem. 268, 15285-15290.
    • (1992) J. Biol. Chem. , vol.268 , pp. 15285-15290
    • Van Dam, M.1    Müllberg, J.2    Schooltink, H.3    Stoyan, T.4    Heinrich, P.C.5    Rose-John, S.6
  • 32
    • 0025859083 scopus 로고
    • Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector
    • ARCONE, R., PUCCI, P., ZAPPACOSTA, F., FONTAINE, V., MALORNI, A., MARINO, G., and CILIBERTO, G. (1991). Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector. Eur. J. Biochem. 198, 541-546.
    • (1991) Eur. J. Biochem. , vol.198 , pp. 541-546
    • Arcone, R.1    Pucci, P.2    Zappacosta, F.3    Fontaine, V.4    Malorni, A.5    Marino, G.6    Ciliberto, G.7
  • 34
    • 0025633094 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells
    • ZHANG, X.-G., BATAILLE, R., JOURDAN, M., SAELAND, S., BANCHEREAU, J., MANNONI, P., and KLEIN, B. (1990). Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells. Blood 76, 2599-2602.
    • (1990) Blood , vol.76 , pp. 2599-2602
    • Zhang, X.-G.1    Bataille, R.2    Jourdan, M.3    Saeland, S.4    Banchereau, J.5    Mannoni, P.6    Klein, B.7
  • 36
    • 0024418255 scopus 로고
    • Structure of the rat interleukin-6 gene and its expression in macrophage-derived cells
    • NORTHEMANN, W., BRACIAK, T.A., HATTORI, M., LEE, F., and FEY, G.H. (1989). Structure of the rat interleukin-6 gene and its expression in macrophage-derived cells. J. Biol. Chem. 264, 16072-16077.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16072-16077
    • Northemann, W.1    Braciak, T.A.2    Hattori, M.3    Lee, F.4    Fey, G.H.5
  • 37
    • 0028302118 scopus 로고
    • Roles of disulfide bonds in recombinant human interleukin-6 conformation
    • ROCK, F.L., LI, X., CHONG, P., IDA, N., and KLEIN, M. (1994). Roles of disulfide bonds in recombinant human interleukin-6 conformation. Biochemistry 33, 5146-5151.
    • (1994) Biochemistry , vol.33 , pp. 5146-5151
    • Rock, F.L.1    Li, X.2    Chong, P.3    Ida, N.4    Klein, M.5
  • 38
    • 0024403619 scopus 로고
    • High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis
    • CUNNINGHAM, B.C., and WELLS, J.A. (1989). High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244, 1081-1084.
    • (1989) Science , vol.244 , pp. 1081-1084
    • Cunningham, B.C.1    Wells, J.A.2
  • 39
    • 0027132013 scopus 로고
    • Comparison of a structural and a functional epitope
    • CUNNINGHAM, B.C., and WELLS, J.A. (1993). Comparison of a structural and a functional epitope. J. Mol. Biol. 234, 554-559.
    • (1993) J. Mol. Biol. , vol.234 , pp. 554-559
    • Cunningham, B.C.1    Wells, J.A.2
  • 40
    • 0025765004 scopus 로고
    • A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor
    • BASS, S.H., MULKERRIN, M.G., and WELLS, J.A. (1991). A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc. Natl. Acad. Sci. USA 88, 4498-4503.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4498-4503
    • Bass, S.H.1    Mulkerrin, M.G.2    Wells, J.A.3
  • 41
    • 0028916599 scopus 로고
    • A hot spot of binding energy in a hormone-receptor interface
    • CLACKSON, T., and WELLS, J.A. (1995). A hot spot of binding energy in a hormone-receptor interface. Science 267, 383-385.
    • (1995) Science , vol.267 , pp. 383-385
    • Clackson, T.1    Wells, J.A.2
  • 42
    • 0029161046 scopus 로고
    • Leucine-58 in the putative 5th-helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130
    • DE HON, F.D., KLAASSE BOS, H., EBELING, S.B., GRÖTZINGER, J., KURAPKAT, G., ROSE-JOHN, S., AARDEN, L.A., and BRAKENHOFF, J.P.J. (1995). Leucine-58 in the putative 5th-helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130. FEBS Lett. 369, 187-190.
    • (1995) FEBS Lett. , vol.369 , pp. 187-190
    • De Hon, F.D.1    Klaasse Bos, H.2    Ebeling, S.B.3    Grötzinger, J.4    Kurapkat, G.5    Rose-John, S.6    Aarden, L.A.7    Brakenhoff, J.P.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.