Inhibition of inducible nitric oxide synthase worsens liver damage regardless of lipopolysaccharide treatment in small-for-size liver transplantation

Transplant Immunology

Volumn 23, Issue 1-2, 2010, Pages 6-11

  Hu, MingZheng ^a   Wang, ZhilLiang ^a   Rao, JianHua ^a   Cao, Yang ^a   Jiang, WeiWei ^a   Zhang, Feng ^a   Li, XiangCheng ^a   Wang, XueHao ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Inducible nitric oxide synthase; Ischemia reperfusion injury; Liver transplantation; Rat; Small for size

Indexed keywords

AMINOGUANIDINE; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; TRANSCRIPTION FACTOR RELA; IMMUNOLOGICAL ADJUVANT; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; LIVER DYSFUNCTION; LIVER INJURY; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SMALL FOR SIZE LIVER TRANSPLANTATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; LIVER; LIVER DISEASES; METABOLISM; ORGAN SIZE; PATHOLOGY; SPRAGUE DAWLEY RAT; STANDARD; SURVIVAL RATE; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BLOTTING, WESTERN; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; RNA, MESSENGER; SURVIVAL RATE;

EID: 77953807604     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.02.001     Document Type: Article

References (37)

1. Kiuchi T., Tanaka K., Ito T., Oike F., Ogura Y., Fujimoto Y., et al. Small-for-size graft in living donor liver transplantation: how far should we go?. Liver Transpl 2003, 9:S29-S35.
2. Liang T.B., Man K., Kin-Wah Lee T., Hong-Teng Tsui S., Lo C.M., Xu X., et al. Distinct intragraft response pattern in relation to graft size in liver transplantation. Transplantation 2003, 75:673-678.
3. Yang Z.F., Tsui T.Y., Ho D.W., Tang T.C., Fan S.T. Heme oxygenase-1 potentiates the survival of small-for-size liver graft. Liver Transpl 2004, 10:784-793.
4. Yang Z.F., Ho D.W., Ngai P., Lau C.K., Zhao Y., Poon R.T., et al. Antiinflammatory properties of IL-10 rescue small-for-size liver grafts. Liver Transpl 2007, 13:558-565.
5. Kim J.S., Ohshima S., Pediaditakis P., Lemasters J.J. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology 2004, 39:1533-1543.
6. Yagnik G.P., Takahashi Y., Tsoulfas G., Reid K., Murase N., Geller D.A. Blockade of the l-arginine/NO synthase pathway worsens hepatic apoptosis and liver transplantation preservation injury. Hepatology 2002, 36:573-581.
7. Man K., Lee T.K., Liang T.B., Lo C.M., Fung P.C., Tsui S.H., et al. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg 2004, 240:159-168.
8. Shah V., Kamath P.S. Nitric oxide in liver transplantation: pathobiology and clinical implications. Liver Transpl 2003, 9:1-11.
9. Filos K.S., Kirkilesis I., Spiliopoulou I., Scopa C.D., Nikolopoulou V., Kouraklis G., et al. Bacterial translocation, endotoxemia and apoptosis following Pringle maneuver in rats. Injury 2004, 35:35-43.
10. Kamada N., Calne R.Y. A surgical experience with five hundred thirty liver transplants in the rat. Surgery 1983, 93:64-69.
11. Yao A., Li X., Pu L., Zhong J., Liu X., Yu Y., et al. Impaired hepatic regeneration by ischemic preconditioning in a rat model of small-for-size liver transplantation. Transpl Immunol 2007, 18:37-43.
12. Yu Y., Yao A.H., Chen N., Pu L.Y., Fan Y., Lv L., et al. Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration. Mol Ther 2007, 15:1382-1389.
13. Misko T.P., Moore W.M., Kasten T.P., Nickols G.A., Corbett J.A., Tilton R.G., et al. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur J Pharmacol 1993, 233:119-125.
14. Varadarajan R., Golden-Mason L., Young L., McLoughlin P., Nolan N., McEntee G., et al. Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation. Transplantation 2004, 78:250-256.
15. Koti R.S., Tsui J., Lobos E., Yang W., Seifalian A.M., Davidson B.R. Nitric oxide synthase distribution and expression with ischemic preconditioning of the rat liver. FASEB 2005, 19:1155-1157.
16. Huk I., Nanobashvili J., Neumayer C., Punz A., Mueller M., Afkhampour K., et al. l-Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 1997, 96:667-675.
17. Kurose I., Wolf R., Grisham M.B., Granger D.N. Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide. Circ Res 1994, 74:376-382.
18. Radomski M.W., Palmer R.M., Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987, 2:1057-1058.
19. Cottart C.H., Do L., Blanc M.C., Vaubourdolle M., Descamps G., Durand D., et al. Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat. Hepatology 1999, 29:809-813.
20. Hur G.M., Ryu Y.S., Yun H.Y., Jeon B.H., Kim Y.M., Seok J.H, et al. Hepatic ischemia/reperfusion in rats induces iNOS gene transcription by activation of NF-κB. Biochem Biophys Res Commun 1999, 261:917-922.
21. Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem J 1994, 298(Pt.2):249-258.
22. Xu X., Man K., Zheng S.S., Liang T.B., Lee T.K, Ng K.T., et al. Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival. Liver Transpl 2006, 12:621-627.
23. Song J., Zhang Y.W., Yao A.H., Yu Y., Hua Z.Y., Pu L.Y., et al. Adenoviral cardiotrophin-1 transfer improves survival and early graft function after ischemia and reperfusion in rat small-for-size liver transplantation model. Transpl Int 2008, 21:372-383.
24. Loureiro-Silva M.R., Cadelina G.W., Iwakiri Y., Groszmann R.J. A liver-specific nitric oxide donor improves the intra-hepatic vascular response to both portal blood flow increase and methoxamine in cirrhotic rats. J Hepatology 2003, 39:940-946.
25. Fiorucci S., Antonelli E., Brancaleone V., Sanpaolo L., Orlandi S., Distrutti E., et al. NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver. J Hepatology 2003, 39:932-939.
26. Sakamoto S., Okanoue T., Itoh Y., Sakamoto K., Nishioji K., Nakagawa Y., et al. Intercellular adhesion molecule-1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rat. Hepatology 1997, 26:658-663.
27. Ohtsuka M., Miyazaki M., Kubosawa H., Kondo Y., Ito H., Shimizu H., et al. Role of neutrophils in sinusoidal endothelial cell injury after extensive hepatectomy in cholestatic rats. J Gastroenterol Hepatol 2000, 15:880-886.
28. Yee S.B., Hanumegowda U.M., Hotchkiss J.A., Ganey P.E., Roth R.A. Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure. Toxicol Sci 2003, 72:43-56.
29. Farhood A., McGuire G.M., Manning A.M., Miyasaka M., Smith C.W., Jaeschke H. Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J Leukoc Biol 1995, 57:368-374.
30. Kobayashi A., Imamura H., Isobe M., Matsumaya Y., Soeda J., Matsunga K., et al. Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver. Am J Physiol Gastrointest Liver Physiol 2001, 281:G577-G585.
31. El-Wahsh M., Seifalian A.M., Fuller B.J., Rolles K., Davidson B.R., et al. Induction of adhesion molecule expression in liver ischaemia-reperfusion injury is associated with impaired hepatic parenchymal microcirculation. Br J Surg 2004, 91:1034-1039.
32. Kaizu T., Ikeda A., Nakao A., Takahashi Y., Tsung A., Kohmoto J., et al. Donor graft adenoviral iNOS gene transfer ameliorates rat liver transplant preservation injury and improves survival. Hepatology 2006, 43:464-473.
33. Kone B.C., Schwöbel J., Turner P., Mohaupt M.G., Cangro C.B. Role of NF-κB in the regulation of inducible nitric oxide synthase in an MTAL cell line. Am J Physiol 1995, 269(5 Pt 2):F718-F729.
34. Ledebur H.C., Parks T.P. Transcriptional of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. J Biol Chem 1995, 270:933-943.
35. Araindan N., Mohan S., Herman T.S., Natarajan M. Nitric oxide-mediated inhibition of NF-κB regulates hyperthermia-induced apoptosis. J Cell Biochem 2009, 106:999-1009.
36. Waldow T., Witt W., Weber E., Matschke K. Nitric oxide donor-induced persistent inhibition of cell adhesion protein expression and NF-κB activation in endothelial cells. Nitric Oxide 2006, 15:103-113.
37. Tsuchihashi S., Kaldas F., Chida N., Sudo Y., Tamura K., Zhai Y., et al. FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation. Am J Transplant 2006, 6:2013-2022.