FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation

American Journal of Transplantation

Volumn 6, Issue 9, 2006, Pages 2013-2022

  Tsuchihashi, S ^a   Kaldas, F ^a   Chida, N ^b   Sudo, Y ^b   Tamura, K ^c   Zhai, Y ^a   Qiao, B ^a   Busuttil, R W ^a   Kupiec Weglinski, J W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ASTELLAS PHARMA INC   (Japan)

^c ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

Ischemia reperfusion; Liver; Nitric oxide; Transplant

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CD3 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; ENDOTHELIN 1; FK 330; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PADGEM PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE; BIOSYNTHESIS; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; EX VIVO STUDY; GENE EXPRESSION; GRAFT SURVIVAL; HISTOLOGY; INFLAMMATION; LEUKOCYTE; LIVER CELL DAMAGE; LIVER GRAFT; LIVER ISCHEMIA; LIVER TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; NEUTROPHIL; NONHUMAN; ORGAN DONOR; PATHOPHYSIOLOGY; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CYTOKINES; ENZYME INHIBITORS; GRAFT SURVIVAL; IMMUNOENZYME TECHNIQUES; LIVER; LIVER TRANSPLANTATION; MALE; NITRIC OXIDE SYNTHASE TYPE II; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SURVIVAL RATE;

EID: 33746877898     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01435.x     Document Type: Article

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