Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival

Liver Transplantation

Volumn 12, Issue 4, 2006, Pages 621-627

  Xu, Xiao ^a   Man, Kwan ^a   Zheng, Shu Sen ^a   Liang, Ting Bo ^b   Lee, Terence K ^a   Ng, Kevin T ^a   Fan, Sheung Tat ^a   Lo, Chung Mau ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; BLOOD SAMPLING; CONTROLLED STUDY; DRUG MECHANISM; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER BLOOD FLOW; LIVER FUNCTION TEST; LIVER GRAFT; LIVER RESECTION; LIVER SIZE; LIVER TRANSPLANTATION; LOW DRUG DOSE; MALE; NICK END LABELING; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SURVIVAL RATE;

ANIMALS; BIOPSY; DNA PRIMERS; DNA PROBES; ENDOTHELIN-1; GENE EXPRESSION PROFILING; GLUCAGON; GRAFT SURVIVAL; LIVER; LIVER TRANSPLANTATION; MALE; MODELS, ANIMAL; ORGAN SIZE; RATS; RATS, INBRED LEW; SOMATOSTATIN; STRESS, MECHANICAL; TRANSPLANTATION, ISOGENEIC;

EID: 33645552213     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.20630     Document Type: Article

References (26)

1. Man K, Lo CM, Ng IO, Wong YC, Qin LF, Fan ST, Wong J. Liver transplantation in rats using small-for-size grafts: A study of hemodynamic and morphological changes. Arch Surg 2001; 136:280-285.
2. Man K, Lo CM, Lee TK, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA nitcroarray in small-for-size liver grafts. Liver Transpl 2003;9:425-432.
3. Liang TB, Man K, Kin-Wah LT, Hong-Teng TS, Lo CM, Xu X et al. Distinct intragraft response pattern in relation to graft size in liver transplantation. Transplantation 2003: 75:673-678.
4. Man K, Lee TK, Liang TB, Lo CM, Fung PC, Tsui SH, et al. FK 409 ameliorates small-for-size liver graft Injury by attenuation of portal hypertension and down-regulation of Egr- 1 pathway. Ann Surg 2004;240:159-168.
5. Zhao Y, Man K, Lo CM, Ng KT, LI XL, Sun CK, et al. Attenuation of small-for-size liver graft Injury by FTY720: Significance of cell-survival Akt signaling pathway. Am J Transplant 2004;4:1399-1407.
6. Man K, Fan ST, Lo CM, Liu CL, Fung PC, Liang TB, et al. Graft injury in relation to graft size in right lobe live donor liver transplantation: A study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003;237:256-264.
7. Zhang JX, Pegoli W Jr, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994;266:G624-G632.
8. Cirera I, Feu F, Luca A, Garcia-Pagan JC, Fernandez M, Escorsell A, et al. Effects of bolus Injections and continuous infusions of somatostatin and placebo in patients with cirrhosis: A double-blind hemodynamic investigation. Hepatology 1995;22:106-111.
9. Bosch J, Kravetz D, Rodes J. Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: Comparison with vasopressin. Gastroenterology 1981;80:518-525.
10. Sonnenberg GE, Keller U. Perruchoud A, Burckhardt D, Gyr K. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology 1981;80:526-532.
11. Matrella E, Valatas V, Notas G, Roumpaki H, Xidakis C, Hadzidakis A. et al. Bolus somatostatin but not octreotide reduces hepatic sinusoidal pressure by a NO-independent mechanism in chronic liver disease. Aliment Pharmacol Ther 2001; 15:857-864.
12. Morris JB, Guerrero NH, Furth EE, Stellato TA. Somatostatin attenuates ischemic intestinal injury. Am J Surg 1993; 165:676-680.
13. Ferrer JV, Ariceta J, Guerrero D, Balen E, Herrera J, Lera JM. Prevention by somatostatine and N-acetylcisteine of multiorgan failure mediated by oxidative stress after intestinal ischemia. Transplant Proc 1999;31:2570-2571.
14. Reynaert H, Vaeyens F. Qin H. Hellemans K, Chatterjee N, Winand D. et al. Somatostatin suppresses endothelin-1-induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1. Gastroenterology 2001;121: 915-930.
15. Lo CM, Liu CL, Fan ST. Portal hyperperfusion injury as the cause of primary nonfunction in a small-for-size liver graft-successftil treatment with splenic artery ligation. Liver Transpl 2003:9:626-628.
16. Ito T, Kiuchi T, Yamamoto H, Oike F, Ogura Y, Fujimoto Y, et al. Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications. Transplantation 2003;75:1313-1317.
17. Troisi P, Cammu G, Militerno G, De Baerdemaeker L, Decruyenaere J, Hoste E, et al. Modulation of portal graft inflow: A necessity in adult living-donor liver transplantation? Ann Surg 2003;237:429-436.
18. Takada Y, Ueda M, Ishikawa Y, Fujimoto Y, Miyauchi H, Ogura Y, et al. End-to-side portocaval shunting for a small-for-size graft in living donor liver transplantation. Liver Transpl 2004; 10:807-810.
19. Kravetz D, Bosch J, Arderiu. MT, Pizcueta MP, Casamit-Jana R, Rivera F, et al. Effects of somatostatin on splanchnic hemodynamics and plasma glucagon in portal hypertensive rats. Am J Physiol 1988,254:G322-G328.
20. Schwartz SM. A protective player in the vascular response to injury. Nat Med 2001;7:656-657.
21. Coito AJ, Buelow R, Shen XD, Amersi F, Moore C, Volk HD, et al. Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury. Transplantation 2002;74:96-102.
22. Sass G, Koerber K, Bang R, Guehring H, Tiegs G. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. J Clin Invest 2001;107:439-447.
23. Arvelo MB, Cooper JT, Longo C, Daniel S, Grey ST, Mahiou J, et al. A20 protects mice from D-galactosaniine/lipopoly-saccharide acute toxic lethal hepatitis. Hepatology 2002; 35:535-543.
24. Gao W, Bentley RC, Madden JF, Clavien PA. Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 1998;27:1652-1660.
25. Mearadji A, Breeman W, Hofland L, van Koetsveld P, Marquet R, Jeekel J, et al. Somatostatin receptor gene therapy combined with targeted therapy with radiolabeled octreotide: A new treatment for liver metastases. Ann Surg 2002;236:722-728; discussion 728-729.
26. Lasfer M, Vadrot N, Schally AV, Nagy A, Halmos G, Pessayre D, et al. Potent induction of apoptosis in human hepatoma cell lines by targeted cytotoxic somatostatin analogue AN-238. J Hepatol 2005;42:230-237.