Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45α expression

Cancer Research

Volumn 67, Issue 13, 2007, Pages 6146-6154

  Chang, Qingshan ^a,b   Bhatia, Deepak ^a   Zhang, Yadong ^a,b   Meighan, Terry ^a   Castranova, Vince ^a   Shi, Xianglin ^a,b   Chen, Fei ^a,b,c  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; ELONGATION FACTOR 2; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; PROTEIN P70; RAPAMYCIN; S6 KINASE;

5' UNTRANSLATED REGION; ARSENIC POISONING; ARTICLE; CELL GROWTH; CISTRON; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNAL RIBOSOME ENTRY SITE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEOMICS; REGULATORY MECHANISM; REPORTER GENE; RNA SEQUENCE; SEQUENCE ANALYSIS; TIME; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ARSENIC; BASE SEQUENCE; CELL CYCLE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RIBOSOMES; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34447132923     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0867     Document Type: Article

References (50)

1. Hollander MC, Fornace AJ, Jr. Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a. Oncogene 2002;21:6228-33.
2. Chen F, Zhang Z, Leonard SS, Shi X. Contrasting roles of NF-κB and JNK in arsenite-induced p53-independent expression of GADD45α. Oncogene 2001;20:3585-9.
3. Smith ML, Chen IT, Zhan Q, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 1994;266:1376-80.
4. Wang XW, Zhan Q, Coursen JD, et al. GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A 1999;96:3706-11.
5. Kearsey JM, Coates PJ, Prescott AR, Warbrick E, Hall PA. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene 1995;11:1675-83.
6. Carrier F, Georgel PT, Pourquier P, et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 1999;19:1673-85.
7. Jin S, Antinore MJ, Lung FD, et al. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression. J Biol Chem 2000;275:16602-8.
8. Barreto G, Schafer A, Marhold J, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007;445:671-5.
9. Wang W, Nahta R, Huper G, Marks JR. TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. Mol Cancer Res 2004;2:442-52.
10. Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-5.
11. Marhin WW, Chen S, Facchini LM, Fornace AJ, Jr., Penn LZ. Myc represses the growth arrest gene gadd45. Oncogene 1997;14:2825-34.
12. Zheng L, Pan H, Li S, et al. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell 2000;6:757-68.
13. Chen F, Lu Y, Zhang Z, et al. Opposite effect of NF-κB and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite. J Biol Chem 2001;276:11414-9.
14. Zhang Y, Bhatia D, Xia H, Castranova V, Shi X, Chen F. Nucleolin links to arsenic-induced stabilization of GADD45α mRNA. Nucleic Acids Res 2006;34:485-95.
15. Lal A, Abdelmohsen K, Pullmann R, et al. Posttranscriptional derepression of GADD45α by genotoxic stress. Mol Cell 2006;22:117-28.
16. Lal A, Gorospe M. Egad, more forms of gene regulation: the gadd45a story. Cell Cycle 2006;5:1422-5.
17. Kitchin KT. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 2001;172:249-61.
18. Scott N, Hatlelid KM, MacKenzie NE, Carter DE. Reactions of arsenic(III) and arsenic(V) species with glutathione. Chem Res Toxicol 1993;6:102-6.
19. Chen F, Zhang Z, Bower J, et al. Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 2002;99:1990-5.
20. Shackelford D, Kenific C, Blusztajn A, Waxman S, Ren R. Targeted degradation of the AML1/MDS1/EVI1 oncoprotein by arsenic trioxide. Cancer Res 2006;66:11360-9.
21. Chen Z, Zhao WL, Shen ZX, et al. Arsenic trioxide and acute promyelocytic leukemia: clinical and biological. Curr Top Microbiol Immunol 2007;313:129-44.
22. Sherrill KW, Byrd MP, Van Eden ME, Lloyd RE. BCL-2 translation is mediated via internal ribosome entry during cell stress. J Biol Chem 2004;279:2906 6-74.
23. Zhang Y, Lu Y, Ding M, Castranova V, Shi X, Chen F. Deficiency in Ikkβ gene enhances arsenic-induced gadd45α expression. Mol Cell Biochem2005;279:163-8.
24. Zheng X, Zhang Y, Chen YQ, Castranova V, Shi X, Chen F. Inhibition of NF-κB stabilizes gadd45α mRNA. Biochem Biophys Res Commun 2005;329:95-9.
25. Gingras AC, Raught B, Gygi SP, et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 2001;15:2852-64.
26. Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 2005;433:477-80.
27. Debernardis D, Sire EG, De Feudis P, et al. p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel. Cancer Res 1997;57:870-4.
28. An W, Kim J , Roeder RG. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell 2004;117:735-48.
29. Tong T, Fan W, Zhao H, et al. Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation. Exp Cell Res 2001;269:64-72.
30. Hellen CU, Sarnow P. Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev 2001;15:1593-612.
31. Holcik M, Gordon BW, Korneluk RG. The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2. Mol Cell Biol 2003;23:280-8.
32. Han B, Zhang JT. Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol Cell Biol 2002;22:7372-84.
33. Marash L, Kimchi A. DAP5 and IRES-mediated translation during programmed cell death. Cell Death Differ 2005;12:554-62.
34. Jorgensen R, Merrill AR, Andersen GR. The life and death of translation elongation factor 2. Biochem Soc Trans 2006;34:1-6.
35. Lu H, Li W, Noble WS, Payan D, Anderson DC. Riboproteomics of the hepatitis C virus internal ribosomal entry site. J Proteome Res 2004;3:949-57.
36. Sonenberg N, Dever TE. Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol 2003;13:56-63.
37. Vagner S, Galy B, Pyronnet S. Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites. EMBO Rep 2001;2:893-8.
38. Komar AA, Hatzoglou M. Internal ribosome entry sites in cellular mRNAs: mystery of their existence. J Biol Chem2005;280:2 3425-8.
39. Pham FH, Sugden PH, Clerk A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ Res 2000;86:1252-8.
40. Jang SK, Pestova TV, Hellen CU, Witherell GW, Wimmer E. Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site. Enzyme 1990;44:292-309.
41. Jang SK. Internal initiation: IRES elements of picornaviruses and hepatitis c virus. Virus Res 2006;119:2-15.
42. Thoma C, Bergamini G, Galy B, Hundsdoerfer P, Hentze MW. Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell 2004;15:925-35.
43. Ray PS, Grover R, Das S. Two internal ribosome entry sites mediate the translation of p53 isoforms. EMBO Rep 2006;7:404-10.
44. Stein I, Itin A, Einat P, Skaliter R, Grossman Z, Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol Cell Biol 1998;18:3112-9.
45. Creancier L, Morello D, Mercier P, Prats AC. Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. J Cell Biol 2000;150:275-81.
46. Bernstein J, Sella O, Le SY, Elroy-Stein O. PDGF2/c-sis mRNA leader contains a differentiation-linked internal ribosomal entry site (D-IRES). J Biol Chem 1997;272:9356-62.
47. Lang KJ, Kappel A, Goodall GJ. Hypoxia-inducible factor-1α mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 2002;13:1792-801.
48. Coldwell MJ, Mitchell SA, Stoneley M, MacFarlane M, Willis AE. Initiation of Apaf-1 translation by internal ribosome entry. Oncogene 2000;19:899-905.
49. Chappell SA, LeQuesne JP, Paulin FE, et al. A mutation in the c-myc-IRES leads to enhanced internal ribosome entry in multiple myeloma: a novel mechanism of oncogene de-regulation. Oncogene 2000;19:4437-40.
50. Yoon A, Peng G, Brandenburger Y, et al. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science 2006;312:902-6.