PU.1 regulates positive regulatory domain I-binding factor 1/Blimp-1 transcription in lymphoma cells

Journal of Immunology

Volumn 183, Issue 9, 2009, Pages 5778-5787

  Desai, Shruti ^a,b   Bolick, Sophia C E ^a,c,d   Maurin, Michelle ^a   Wright, Kenneth L ^a,b,c  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; MESSENGER RNA; TRANSCRIPTION FACTOR PU 1; TRANSDUCIN;

ARTICLE; B LYMPHOCYTE; CELL LINE; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOMA CELL; MYELOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FOOTPRINTING; PROTEIN LOCALIZATION;

ANTIBODIES, ANTI-IDIOTYPIC; BURKITT LYMPHOMA; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; HUMANS; IMMUNOGLOBULIN M; MULTIPLE MYELOMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, B-CELL; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 77953798195     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901120     Document Type: Article

References (48)

1. Keller, A. D., and T. Maniatis. 1991. Identification and characterization of a novel repressor of β-interferon gene expression. Genes Dev. 5: 868-879.
2. Turner, C. A., Jr., D. H. Mack, and M. M. Davis. 1994. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 77: 297-306.
3. Shapiro-Shelef, M., K. I. Lin, L. J. McHeyzer-Williams, J. Liao, M. G. McHeyzer-Williams, and K. Calame. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607-620.
4. Piskurich, J. F., K. I. Lin, Y. Lin, Y. Wang, J. P. Ting, and K. Calame. 2000. BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Nat. Immunol. 1: 526-532.
5. Ghosh, N., I. Gyory, G. Wright, J. Wood, and K. L. Wright. 2001. Positive regulatory domain I binding factor 1 silences class II transactivator expression in multiple myeloma cells. J. Biol. Chem. 276: 15264-15268.
6. Lin, Y., K. Wong, and K. Calame. 1997. Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276: 596-599.
7. Lin, K. I., C. Angelin-Duclos, T. C. Kuo, and K. Calame. 2002. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol. Cell Biol. 22: 4771-4780.
8. Shaffer, A. L., K. I. Lin, T. C. Kuo, X. Yu, E. M. Hurt, A. Rosenwald, J. M. Giltnane, L. Yang, H. Zhao, K. Calame, and L. M. Staudt. 2002. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17: 51-62.
9. Doody, G. M., S. Stephenson, and R. M. Tooze. 2006. BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response. Eur. J. Immunol. 36: 1572-1582.
10. Benhamou, L. E., P. A. Cazenave, and P. Sarthou. 1990. Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells. Eur. J. Immunol. 20: 1405-1407.
11. Carey, G. B., and D. W. Scott. 2001. Role of phosphatidylinositol 3-kinase in anti-IgM- and anti-IgD-induced apoptosis in B cell lymphomas. J. Immunol. 166: 1618-1626. (Pubitemid 32114642)
12. Hasbold, J., and G. G. Klaus. 1990. Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas. Eur. J. Immunol. 20: 1685-1690.
13. Kaptein, J. S., C. K. Lin, C. L. Wang, T. T. Nguyen, C. I. Kalunta, E. Park, F. S. Chen, and P. M. Lad. 1996. Anti-IgM-mediated regulation of c-myc and its possible relationship to apoptosis. J. Biol. Chem. 271: 18875-18884.
14. Zupo, S., L. Isnardi, M. Megna, R. Massara, F. Malavasi, M. Dono, E. Cosulich, and M. Ferrarini. 1996. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood 88: 1365-1374.
15. Lee, S. C., A. Bottaro, and R. A. Insel. 2003. Activation of terminal B cell differentiation by inhibition of histone deacetylation. Mol. Immunol. 39: 923-932.
16. Knodel, M., A. W. Kuss, D. Lindemann, I. Berberich, and A. Schimpl. 1999. Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family. Eur. J. Immunol. 29: 2988-2998.
17. Messika, E. J., P. S. Lu, Y. J. Sung, T. Yao, J. T. Chi, Y. H. Chien, and M. M. Davis. 1998. Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. J. Exp. Med. 188: 515-525.
18. Garcia, J. F., G. Roncador, J. F. Garcia, A. I. Sanz, L. Maestre, E. Lucas, S. Montes-Moreno, R. Fernandez Victoria, J. L. Martinez-Torrecuadrara, T. Marafioti, D. Y. Mason, and M. A. Piris. 2006. PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. Haematologica 91: 467-474.
19. Pasqualucci, L., M. Compagno, J. Houldsworth, S. Monti, A. Grunn, S. V. Nandula, J. C. Aster, V. V. Murty, M. A. Shipp, and R. Dalla-Favera. 2006. Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. J. Exp. Med. 203: 311-317.
20. Tam, W., M. Gomez, A. Chadburn, J. W. Lee, W. C. Chan, and D. M. Knowles. 2006. Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. Blood 107: 4090-4100.
21. Gyory, I., G. Fejer, N. Ghosh, E. Seto, and K. L. Wright. 2003. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J. Immunol. 170: 3125-3133.
22. Borson, N. D., M. Q. Lacy, and P. J. Wettstein. 2002. Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. Blood 100: 4629-4639.
23. Garrone, P., E. M. Neidhardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182: 1265-1273.
24. Kuchtey, J., M. Pennini, R. K. Pai, and C. V. Harding. 2003. CpG DNA induces a class II transactivator-independent increase in class II MHC by stabilizing class II MHC mRNA in B lymphocytes. J. Immunol. 171: 2320-2325. (Pubitemid 37025537)
25. Wuarin, J., and U. Schibler. 1994. Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing. Mol. Cell Biol. 14: 7219-7225.
26. Couronne, O., A. Poliakov, N. Bray, T. Ishkhanov, D. Ryaboy, E. Rubin, L. Pachter, and I. Dubchak. 2003. Strategies and tools for whole-genome alignments. Genome Res. 13: 73-80.
27. Ghosh, N., J. F. Piskurich, G. Wright, K. Hassani, J. P. Ting, and K. L. Wright. 1999. A novel element and a TEF-2-like element activate the major histocompatibility complex class II transactivator in B-lymphocytes. J. Biol. Chem. 274: 32342-32350.
28. Pfeifer, G. P., R. L. Tanguay, S. D. Steigerwald, and A. D. Riggs. 1990. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. Genes Dev. 4: 1277-1287.
29. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA pol II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11: 1475-1488.
30. Lin, Y., K.-K. Wong, and K. Calame. 1997. Repression of c-myc Transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276: 596-599.
31. Dani, C., J. M. Blanchard, M. Piechaczyk, S. El Sabouty, L. Marty, and P. Jeanteur. 1984. Extreme instability of myc mRNA in normal and transformed human cells. Proc. Natl. Acad. Sci. USA 81: 7046-7050.
32. Sharova, L. V., A. A. Sharov, T. Nedorezov, Y. Piao, N. Shaik, and M. S. Ko. 2009. Database for mRNA half-life of 19,977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res. 16: 45-58.
33. Tunyaplin, C., M. A. Shapiro, and K. L. Calame. 2000. Characterization of the B lymphocyte-induced maturation protein-1 (Blimp-1) gene, mRNA isoforms and basal promoter. Nucleic Acids Res. 28: 4846-4855.
34. Parekh, S., J. M. Polo, R. Shaknovich, P. Juszczynski, P. Lev, S. M. Ranuncolo, Y. Yin, U. Klein, G. Cattoretti, R. Dalla Favera, M. A. Shipp, and A. Melnick. 2007. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood 110: 2067-2074.
35. Tunyaplin, C., A. L. Shaffer, C. D. Angelin-Duclos, X. Yu, L. M. Staudt, and K. L. Calame. 2004. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173: 1158-1165.
36. Mora-Lopez, F., N. Pedreno-Horrillo, L. Delgado-Perez, J. A. Brieva, and A. Campos-Caro. 2008. Transcription of PRDM1, the master regulator for plasma cell differentiation, depends on an SP1/SP3/EGR-1 GC-box. Eur. J. Immunol. 38: 2316-2324.
37. Vasanwala, F. H., S. Kusam, L. M. Toney, and A. L. Dent. 2002. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J. Immunol. 169: 1922-1929.
38. Linderson, Y., D. Eberhard, S. Malin, A. Johansson, M. Busslinger, and S. Pettersson. 2004. Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes. EMBO Rep. 5: 291-296.
39. Yamamoto, H., F. Kihara-Negishi, T. Yamada, Y. Hashimoto, and T. Oikawa. 1999. Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. Oncogene 18: 1495-1501.
40. Shapiro-Shelef, M., and K. Calame. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5: 230-242.
41. Lotz, C., S. A. Mutallib, N. Oehlrich, U. Liewer, E. A. Ferreira, M. Moos, M. Hundemer, S. Schneider, S. Strand, C. Huber, H. Goldschmidt, and M. Theobald. 2005. Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. J. Immunol. 175: 1301-1309.
42. Ohkubo, Y., M. Arima, E. Arguni, S. Okada, K. Yamashita, S. Asari, S. Obata, A. Sakamoto, M. Hatano, J. O-Wang, M. Ebara, H. Saisho, and T. Tokuhisa. 2005. A role for c-fos/activator protein 1 in B lymphocyte terminal differentiation. J. Immunol. 174: 7703-7710.
43. Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573-1577. (Pubitemid 24986727)
44. Tatetsu, H., S. Ueno, H. Hata, Y. Yamada, M. Takeya, H. Mitsuya, D. G. Tenen, and Y. Okuno. 2007. Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. Cancer Res. 67: 5328-5336.
45. Suzuki, M., T. Yamada, F. Kihara-Negishi, T. Sakurai, and T. Oikawa. 2003. Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-mediated transcriptional repression. Oncogene 22: 8688-8698.
46. Shaffer, A. L., X. Yu, Y. He, J. Boldrick, E. P. Chan, and L. M. Staudt. 2000. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 13: 199-212.
47. Ochiai, K., Y. Katoh, T. Ikura, Y. Hoshikawa, T. Noda, H. Karasuyama, S. Tashiro, A. Muto, and K. Igarashi. 2006. Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J. Biol. Chem. 281: 38226-38234.
48. Genetta, T., D. Ruezinsky, and T. Kadesch. 1994. Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer. Mol. Cell Biol. 14: 6153-6163.