BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response

European Journal of Immunology

Volumn 36, Issue 6, 2006, Pages 1572-1582

  Doody, Gina M ^a   Stephenson, Sophie ^a   Tooze, Reuben M ^a,b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

B cell; Cell differentiation; Gene regulation; Macrophage

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN INHIBITOR; PROTEIN KINASE R; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; CELL LINE; CONTROLLED STUDY; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RODENT; SIGNAL TRANSDUCTION; STRESS; UPREGULATION;

ANIMALS; B-LYMPHOCYTES; CYCLOHEXIMIDE; DITHIOTHREITOL; DNA-BINDING PROTEINS; EIF-2 KINASE; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; HELA CELLS; HL-60 CELLS; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; PROTEIN FOLDING; PROTEIN SYNTHESIS INHIBITORS; REPRESSOR PROTEINS; RNA, MESSENGER; SESQUITERPENES; SIGNAL TRANSDUCTION; THAPSIGARGIN; TRANSCRIPTION FACTORS;

EID: 33745381226     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535646     Document Type: Article

References (35)

1. Keller, A. D. and Maniatis, T., Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 1991. 5: 868-879.
2. Turner, C. A., Jr., Mack D. H. and Davis, M. M., Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Cell 1994. 77: 297-306.
3. Calame, K. L, Lin, K. I. and Thunyaplin, C., Regulatory mechanisms that determine the development and function of plasma cells. Annu. Rev. Immunol. 2003. 21: 205-230.
4. Chang, D. H., Angelin-Duclos, C. and Calame, K., BLIMP-1: trigger for differentiation of myeloid lineage. Nat. Immunol. 2000. 1: 169-176.
5. Gyory, I., Wu, J., Fejer, G., Seto, E. and Wright K. L., PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. Nat Immunol. 2004. 5: 299-308.
6. Williams, B. R., Signal integration via PKR. Sci. STKE 2002. 18: RE2.
7. Harding, H. P., Zhang, Y. and Ron, D., Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999. 397: 271-274.
8. Harding, H. P., Calfon, M., Urano, F., Novoa, I. and Ron, D., Transcriptional and translational control in the mammalian unfolded protein response. Annu. Rev. Cell Dev. Biol. 2002. 18: 575-599.
9. Jiang, H. Y., Wek, S. A., McGrath, B. C., Scheuner, D., Kaufman, R. J., Cavener, D. R. and Wek, R. C., Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol. Cell Biol. 2003. 23: 5651-5663.
10. Deng, J., Lu, P. D., Zhang, Y., Scheuner, D., Kaufman, R. J., Sonenberg, N., Harding, H. P. and Ron, D., Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol. Cell Biol. 2004. 24: 10161-10168.
11. Iwakoshi, N. N., Lee, A. H. and Glimcher, L. H., The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol. Rev. 2003. 194: 29-38.
12. Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M. et al., The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol. 2003. 5: 781-792.
13. Gotoh, T., Oyadomari, S., Mori, K. and Mori, M., Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem. 2002. 277: 12343-12350.
14. Zhou, J., Lhotak, S., Hilditch, B. A. and Austin, R. C., Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 2005. 111: 1814-1821.
15. Calfon, M., Zeng, H., Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., Clark, S. G. and Ron, D., IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002.415: 92-96.
16. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. and Mori, K., XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001. 107: 881-891.
17. Shaffer, A. L., Shapiro-Shelef, M., Iwakoshi, N. N., Lee, A. H., Qian, S. B., Zhao, H., Yu, X. et al., XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 2004. 21: 81-93.
18. Iwakoshi, N. N., Lee, A. H., Vallabhajosyula, P., Otipoby, K. L, Rajewsky, K. and Glimcher, L. H., Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 2003. 4: 321-329.
19. Kuznetsov, G., Brostrom, M. A. and Brostrom, C. O., Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol. J. Biol. Chem. 1992. 267: 3932-3939.
20. Reimold, A. M., Ponath, P. D., Li, Y. S., Hardy, R. R., David, C. S., Strominger, J. L. and Glimcher, L. H., Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J. Exp. Med. 1996. 183: 393-401.
21. Gyory I., Fejer, G., Ghosh, N., Seto, E. and Wright, K. L., Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J. Immunol. 2003. 170: 3125-3133.
22. Chang, D. H., Cattoretti, G. and Calame, K. L., The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development. Mech. Dev. 2002. 117: 305-309.
23. Lee, A. H., Iwakoshi, N. N. and Glimcher, L. H., XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell Biol. 2003. 23: 7448-7459.
24. Novoa, I., Zhang, Y., Zeng, H., Jungreis, R., Harding, H. P. and Ron, D., Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 2003. 22: 1180-1187
25. Lyss, G., Knorre, A., Schmidt, T. J., Pahl, H. L. and Merfort, I., The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J. Biol. Chem. 1998. 273: 33508-33516.
26. Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R., Schapira, M. and Ron, D., Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000. 6: 1099-1108.
27. Johnson, K, Shapiro-Shelef, M., Tunyaplin, C. and Calame, K., Regulatory events in early and late B-cell differentiation. Mol Immunol. 2005. 42: 749-761.
28. Kallies, A., Hasbold, J., Tarlinton, D. M., Dietrich, W., Corcoran, L. M., Hodgkin, P. D. and Nutt, S. L., Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J. Exp. Med. 2004. 200: 967-977
29. Gass, J. N., Gifford, N. M. and Brewer, J. W., Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J. Biol. Chem 2002. 277. 49047-49054.
30. Zhang, K, Wong, H. N., Song, B., Miller, C. N., Scheuner, D. and Kaufman, R. J., The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 2005. 115: 268-281.
31. Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A. and Locati, M., The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004. 25: 677-686.
32. Shaffer, A. L, Lin, K.I., Kuo, T. C., Yu, X, Hurt, E. M., Rosenwald, A., Giltnane, J. M. et al., Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002. 17:51-62.
33. Shaffer, A. L, Yu, X, He, Y., Boldrick, J., Chan, E. P. and Staudt, L.M., BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000. 13: 199-212.
34. Toney, L. M, Cattoretti, G., Graf, J. A., Merghoub, T., Pandolfi, P. P., Dalla-Favera, R., Ye, B. H. and Dent, A. L., BCL-6 regulates chemokine gene transcription in macrophages. Nat. Immunol. 2000. 1: 214-220.
35. Follows, G. A., Tagoh, H., Lefevre, P., Hodge, D., Morgan, G. J. and Bonifer, C., Epigenetic consequences of AML1-ETO action at the human c-FMS locus. EMBO J. 2003. 22: 2798-2809.