Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury

Molecular Pain

Volumn 4, Issue , 2008, Pages

  Xie, Weijiao ^a   Matsumoto, Misaki ^a   Chun, Jerold ^b   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR I; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ABETA FIBER; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MOUSE; NERVE CONDUCTION; NERVE FIBER; NERVE STIMULATION; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SCIATIC NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; WILD TYPE; ANIMAL; DEMYELINATING DISEASE; INJURY; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; POSTERIOR HORN CELL; SCIATIC NEUROPATHY; SPINAL GANGLION; SPINAL NERVE; SYNAPTIC TRANSMISSION;

ANIMALS; DEMYELINATING DISEASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; MICE; PHOSPHORYLATION; POSTERIOR HORN CELLS; RECEPTORS, LYSOPHOSPHATIDIC ACID; SCIATIC NERVE; SCIATIC NEUROPATHY; SIGNAL TRANSDUCTION; SPINAL NERVES; SYNAPTIC TRANSMISSION;

EID: 57649243710     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-4-46     Document Type: Article

References (18)

1. Bridges D Thompson SWN Rice ASC Mechanisms of neuropathic pain Br J Anaesth 2001, 87(1):12-26. 10.1093/bja/87.1.12 11460801
2. Ueda H Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms Pharmacology & Therapeutics 2006, 109(1-2):57-77. 10.1016/j.pharmthera.2005.06.003 16023729
3. Woolf CJ Shortland P Coggeshall RE Peripheral nerve injury triggers central sprouting of myelinated afferents Nature 1992, 355(6355):75-78. 10.1038/355075a0 1370574
4. Okamoto M Baba H Goldstein PA Higashi H Shimoji K Yoshimura M Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury J Physiol 2001, 532(Pt 1):241-250. 2278535 11283238 10.1111/j.1469-7793.2001.0241g.x
5. Ueda H Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination Molecular Pain 2008, 4 (1):11. 2365930 18377664 10.1186/1744-8069-4-11
6. Ji R-R Baba H Brenner GJ Woolf CJ Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity Nat Neurosci 1999, 2(12):1114-1119. 10.1038/16040 10570489
7. Dai Y Iwata K Fukuoka T Kondo E Tokunaga A Yamanaka H Tachibana T Liu Y Noguchi K Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization J Neurosci 2002, 22(17):7737-7745. 12196597
8. Matsumoto M Xie W Ma L Ueda H Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury Mol Pain 2008, 4:25. 2488330 18620588 10.1186/1744-8069-4-25
9. Wang H Dai Y Fukuoka T Yamanaka H Obata K Tokunaga A Noguchi K Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury European Journal of Neuroscience 2004, 19(4):884-890. 10.1111/ j.0953-816X.2004.03203.x 15009135
10. Inoue M Rashid MH Fujita R Contos JJA Chun J Ueda H Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling Nat Med 2004, 10(7):712-718. 10.1038/nm1060 15195086
11. Inoue M Ma L Aoki J Chun J Ueda H Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain Mol Pain 2008, 4:6. 2277392 18261210 10.1186/ 1744-8069-4-6
12. Inoue M Xie W Matsushita Y Chun J Aoki J Ueda H Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid Neuroscience 2008, 152(2):296-298. 10.1016/ j.neuroscience.2007.12.041 18280050
13. Contos JJA Fukushima N Weiner JA Kaushal D Chun J Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior Proceedings of the National Academy of Sciences 2000, 97(24):13384-13389. 10.1073/pnas.97.24.13384
14. Zimmermann M Ethical guidelines for investigations of experimental pain in conscious animals Pain 1983, 16(2):109-110. 10.1016/ 0304-3959(83)90201-4 6877845
15. Rosen LB Ginty DD Weber MJ Greenberg ME Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras Neuron 1994, 12(6):1207-1221. 10.1016/0896-6273(94)90438-3 8011335
16. Isaac JT Ashby M McBain CJ The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity Neuron 2007, 54(6):859-871. 10.1016/j.neuron.2007.06.001 17582328
17. Todd A Koerber H Neuroanatomical substrates of spinal nociception Wall and Melzack's Textbook of Pain Philadelphia: Elsevier McMahon SB, Koltzenburg M 5 2006:73-90.
18. Furue H Katafuchi T Yoshimura M Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal horn Neuroscience Research 2004, 48(4):361-368. 10.1016/j.neures.2003.12.005 15041189