Drinking water with red beetroot food color antagonizes esophageal carcinogenesis in n-nitrosomethylbenzylamine-treated rats

Journal of Medicinal Food

Volumn 13, Issue 3, 2010, Pages 733-739

  Lechner, John F ^a,b   Wang, Li Shu ^a   Rocha, Claudio M ^a   Larue, Bethany ^a   Henry, Cassandra ^a   McIntyre, Colleen M ^a   Riedl, Kenneth M ^c   Schwartz, Steven J ^c   Stoner, Gary D ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN MAINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

esophageal carcinogenesis; rat; red beetroot dye

Indexed keywords

CD34 ANTIGEN; CD45 ANTIGEN; DRINKING WATER; KI 67 ANTIGEN; N BENZYL N METHYLNITROSAMINE; OXYGEN RADICAL;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BEETROOT; CARCINOGENESIS; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; FOOD COLOR; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; NICK END LABELING; NONHUMAN; PAPILLOMA; PRECANCER; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD34; ANTIGENS, CD45; APOPTOSIS; BETA VULGARIS; CELL PROLIFERATION; DIMETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; ESOPHAGEAL NEOPLASMS; FOOD COLORING AGENTS; HUMANS; MALE; PLANT EXTRACTS; PLANT ROOTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; WATER;

ANIMALIA; RATTUS;

EID: 77953771406     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2008.0280     Document Type: Article

References (39)

1. Stoner GD, Siglin JC, Morse MA, Desai DH, Amin SG, Kresty LA, Toburen AL, Heffner EM, Francis DJ: Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate. Carcinogenesis 1995;16:2473-2476.
2. Siglin JC, Barch DH, Stoner GD: Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats. Carcinogenesis 1995;16: 1101-1106.
3. Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, Gupta A, Blackwood M, Stoner GD: Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 2001;61:6112-6119.
4. Stoner GD, Chen T, Kresty LA, Aziz RM, Reinemann T, Nines R: Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer 2006;54:33-46.
5. Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF: Cancer prevention with freeze-dried berries and berry components. Semin Cancer Biol 2007;17:403-410.
6. Stoner GD, Wang LS, Chen T: Chemoprevention of esophageal squamous cell carcinoma. Toxicol Appl Pharmacol 2007;224: 337-349.
7. Pavlov A, Kovatcheva P, Tuneva D, Ilieva M, Bley T: Radical scavenging activity and stability of betalains from Beta vulgaris hairy root culture in simulated conditions of human gastrointestinal tract. Plant Foods Hum Nutr 2005;60:43-47.
8. Kapadia GJ, Tokuda H, Konoshima T, Nishino H: Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett 1996;100:211-214.
9. Kapadia GJ, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H: Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Pharmacol Res 2003;47:141-148.
10. Kanner J, Harel S, Granit R: Betalains-a new class of dietary cationized antioxidants. J Agric Food Chem 2001;49:5178-5185.
11. Gliszczyńska-Swigło A, Szymusiak H, Malinowska P: Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity. Food Addit Contam 2006;23:1079-1087.
12. Allegra M, Tesoriere L, Livrea MA: Betanin inhibits the myeloperoxidase=nitrite-induced oxidation of human low-density lipoproteins. Free Radic Res 2007;41:335-341.
13. Moreno DA, García-Viguera C, Gil JI, Gil-Izquierdo A: Betalains in the era of global agri-food science, technology and nutritional health. Phytochem Rev 2008;7:261-280.
14. Castro R, Rivera I, Martins C, Struys EA, Jansen EE, Clode N, Graça LM, Blom HJ, Jakobs C, de Almeida IT: Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J Mol Med 2005;83:831-836.
15. Zeisel SH, Mar MH, Howe JC, Holden JM: Concentrations of choline-containing compounds and betaine in common foods. J Nutr 2003;133:1302-1307.
16. Craig SA: Betaine in human nutrition. Am J Clin Nutr 2004;80: 539-549.
17. Ueland PM, Holm PI, Hustad S: Betaine: a key modulator of onecarbon metabolism and homocysteine status. Clin Chem Lab Med 2005;43:1069-1075.
18. Feinberg AP, Ohlsson R, Henikoff S: The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006;7:21-33.
19. Kisseljova NP, Kisseljov FL: DNA demethylation and carcinogenesis. Biochemistry (Mosc) 2005;70:743-752.
20. Castellar MR, Obon JM, Fernandez-Lopez JA: The isolation and properties of a concentrated red-purple betacyanin food colourant from Oluntia stricta fruits. J Sci Food Agric 2006; 86:122-128.
21. Stoner GD, Gupta A: Etiology and chemoprevention of esophageal squamous cell carcinoma. Carcinogenesis 2001;22:1737-1746. (Pubitemid 33064837)
22. Stintzing FC, Stintzing AS, Carle R, Frei B, Wrolstad RE: Color and antioxidant properties of cyanidin-based anthocyanin pigments. J Agric Food Chem 2002;50:6172-6181.
23. Abdalla SI, Sanderson IR, Fitzgerald RC: Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. Carcinogenesis 2005;26:1627-1633.
24. Knaapen AM, Güngör N, Schins RP, Borm PJ, Van Schooten FJ: Neutrophils and respiratory tract DNA damage and mutagenesis: a review. Mutagenesis 2006;21:225-236.
25. Ben-Baruch A: Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators. Semin Cancer Biol 2006;16:38-52.
26. Murakami A, Ohigashi H: Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 2007;121:2357-2363.
27. Holmes N: CD45: all is not yet crystal clear. Immunology 2006; 117:145-155.
28. Zou DM, Brewer M, Garcia F, Feugang JM, Wang J, Zang R, Liu H, Zou C: Cactus pear: a natural product in cancer chemoprevention. Nutr J 2005;4:25-33.
29. Uzzan B, Nicolas P, Cucherat M, Perret GY: Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. Cancer Res 2004;64: 2941-12455
30. Blanchetot C, Boonstra J: The ROS-NOX connection in cancer and angiogenesis. Crit Rev Eukaryot Gene Expr 2008;18:35-45.
31. Sreekanth D, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P: Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia cell line-K562. Phytomedicine 2007; 14:739-746.
32. Droge W: Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
33. Lundberg AS, Weinberg RA: Control of the cell cycle and apoptosis. Eur J Cancer 1999;35:1886-1894.
34. Halliwell B: Oxidative stress and cancer: have we moved forward? Biochem J 2007;401:1-11.
35. Pogribny IP, Ross SA, Wise C, Pogribna M, Jones EA, Tryndyak VP, James SJ, Dragan YP, Poirier LA: Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 2006;593:80-87.
36. Craig SA: Betaine in human nutrition. Am J Clin Nutr 2004;80: 539-549.
37. Ueland PM, Holm PI, Hustad S: Betaine: a key modulator of onecarbon metabolism and homocysteine status. Clin Chem Lab Med 2005;43:1069-1075.
38. Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C: Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 2008;87:424-430.
39. WHO Food Additives Series 22. www.inchem.org=documents= jecfa=jecmono=v22je08.htm (accessed July 2007).