Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) γ/δ and the D1 dopamine receptor: Regulation of PKC-mediated receptor phosphorylation

Molecular Pharmacology

Volumn 78, Issue 1, 2010, Pages 69-80

  Rex, Elizabeth B ^a   Rankin, Michele L ^a   Yang, Yu ^b   Lu, Quansheng ^b   Gerfen, Charles R ^c   Jose, Pedro A ^b   Sibley, David R ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b CHILDREN S RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLIC AMP; DOPAMINE 1 RECEPTOR; PROTEIN KINASE C; PROTEIN RANBP 10; PROTEIN RANBP 9; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CYCLIC AMP; CYTOSKELETAL PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RATS; RECEPTORS, DOPAMINE D1;

EID: 77953769193     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.063727     Document Type: Article

References (46)

1. Bermak JC, Li M, Bullock C, and Zhou QY (2001) Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat Cell Biol 3:492-498.
2. Besson A, Wilson TL, and Yong VW (2002) The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. J Biol Chem 277:22073-22084.
3. Csukai M, Chen CH, De Matteis MA, and Mochly-Rosen D (1997) The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J Biol Chem 272:29200-29206. (Pubitemid 27498211)
4. Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, Fabbri M, Pardi R, and Bianchi E (2004) RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. J Biol Chem 279:13027-13034.
5. D'Souza MS, Ikegami A, Olsen CM, and Duvauchelle CL (2003) Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors. Pharmacol Biochem Behav 76:335-342.
6. El-Ghundi M, George SR, Drago J, Fletcher PJ, Fan T, Nguyen T, Liu C, Sibley DR, Westphal H, and O'Dowd BF (1998) Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior. Eur J Pharmacol 353:149-158.
7. Free RB, Hazelwood LA, Cabrera DM, Spalding HN, Namkung Y, Rankin ML, and Sibley DR (2007) D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin. J Biol Chem 282:21285-21300.
8. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, and Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27:107-144.
9. Gardner B, Liu ZF, Jiang D, and Sibley DR (2001) The role of phosphorylation/dephosphorylation in agonist-induced desensitization of D1 dopamine receptor function: evidence for a novel pathway for receptor dephosphorylation. Mol Pharmacol 59:310-321. (Pubitemid 32108565)
10. Gong S, Doughty M, Harbaugh CR, Cummins A, Hatten ME, Heintz N, and Gerfen CR (2007) Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J Neurosci 27:9817-9823.
11. Haase A, Nordmann C, Sedehizade F, Borrmann C, and Reiser G (2008) RanBPM, a novel interaction partner of the brain-specific protein p42(IP4)/centaurin alpha-1. J Neurochem 105:2237-2248.
12. +-ATPase. J Biol Chem 283:36441-36453.
13. Heydorn A, Søndergaard BP, Hadrup N, Holst B, Haft CR, and Schwartz TW (2004) Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting. FEBS Lett 556:276-280.
14. Holder N and Klein R (1999) Eph receptors and ephrins: effectors of morphogenesis. Development 126:2033-2044.
15. Jiang D and Sibley DR (1999) Regulation of D(1) dopamine receptors with mutations of protein kinase phosphorylation sites: attenuation of the rate of agonist-induced desensitization. Mol Pharmacol 56:675-683.
16. Johnson WE and Sawyer SL (2009) Molecular evolution of the antiretroviral TRIM5 gene. Immunogenetics 61:163-176.
17. Kebabian JW, Britton DR, DeNinno MP, Perner R, Smith L, Jenner P, Schoenleber R, and Williams M (1992) A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol 229:203-209.
18. Kohout TA and Lefkowitz RJ (2003) Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Mol Pharmacol 63:9-18.
19. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé D, and Schächtele C (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö6976. J Biol Chem 268:9194-9197.
20. Mason JN, Kozell LB, and Neve KA (2002) Regulation of dopamine D(1) receptor trafficking by protein kinase A-dependent phosphorylation. Mol Pharmacol 61: 806-816.
21. McLean SL, Idris NF, Woolley ML, and Neill JC (2009) D(1)-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia. Eur Neuropsychopharmacol 19:440-450.
22. Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG, Blumberg PM, Pierce JH, and Mushinski JF (1993) Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268:6090-6096.
23. Missale C, Nash SR, Robinson SW, Jaber M, and Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78:189-225.
24. Murrin LC and Talbot JN (2007) RanBPM, a scaffolding protein in the immune and nervous systems. J Neuroimmune Pharmacol 2:290-295.
25. Okada H, Tajima A, Shichiri K, Tanaka A, Tanaka K, and Inoue I (2008) Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. PLoS Genet 4:e26.
26. Piontek J and Brandt R (2003) Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development. J Biol Chem 278:38970-38979.
27. Price KL and Middaugh LD (2004) The dopamine D1 antagonist reduces ethanol reward for C57BL/6 mice. Alcohol Clin Exp Res 28:1666-1675.
28. Rankin ML, Marinec PS, Cabrera DM, Wang Z, Jose PA, and Sibley DR (2006) The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. Mol Pharmacol 69:759-769.
29. Rex EB, Rankin ML, Ariano MA, and Sibley DR (2008) Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner. Neuropsychopharmacology 33:2900-2911.
30. Rodriguez MM, Ron D, Touhara K, Chen CH, and Mochly-Rosen D (1999) RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro. Biochemistry 38:13787-13794.
31. Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, and Mochly-Rosen D (1994) Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci USA 91:839-843. (Pubitemid 24048462)
32. Ron D, Jiang Z, Yao L, Vagts A, Diamond I, and Gordon A (1999) Coordinated movement of RACK1 with activated betaIIPKC. J Biol Chem 274:27039-27046. (Pubitemid 129520228)
33. Schneider JS, Sun ZQ, and Roeltgen DP (1994) Effects of dihydrexidine, a full dopamine D-1 receptor agonist, on delayed response performance in chronic low dose MPTP-treated monkeys. Brain Res 663:140-144.
34. Schulze H, Dose M, Korpal M, Meyer I, Italiano JE Jr, and Shivdasani RA (2008) RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem 283:14109-14119.
35. Seebahn A, Rose M, and Enz R (2008) RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. FEBS Lett 582:2453-2457.
36. Staudinger J, Lu J, and Olson EN (1997) Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem 272:32019-32024.
37. Stebbins EG and Mochly-Rosen D (2001) Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C. J Biol Chem 276:29644-29650.
38. Stempka L, Schnölzer M, Radke S, Rincke G, Marks F, and Gschwendt M (1999) Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J Biol Chem 274:8886-8892.
39. Suh YH, Pelkey KA, Lavezzari G, Roche PA, Huganir RL, McBain CJ, and Roche KW (2008) Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. Neuron 58: 736-748.
40. Talbot JN, Skifter DA, Bianchi E, Monaghan DT, Toews ML, and Murrin LC (2009) Regulation of mu opioid receptor internalization by the scaffold protein RanBPM. Neurosci Lett 466:154-158.
41. Tiberi M, Nash SR, Bertrand L, Lefkowitz RJ, and Caron MG (1996) Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. J Biol Chem 271:3771-3778.
42. Wang D, Li Z, Schoen SR, Messing EM, and Wu G (2004) A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Biochem Biophys Res Commun 313:320-326.
43. Watts VJ and Neve KA (1996) Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors. Mol Pharmacol 50:966-976.
44. Yu P, Asico LD, Luo Y, Andrews P, Eisner GM, Hopfer U, Felder RA, and Jose PA (2006) D1 dopamine receptor hyperphosphorylation in renal proximal tubules in hypertension. Kidney Int 70:1072-1079.
45. Zemskov EA, Jana NR, Kurosawa M, Miyazaki H, Sakamoto N, Nekooki M, and Nukina N (2003) Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease. J Neurochem 87:395-406.
46. Zeng C, Armando I, Luo Y, Eisner GM, Felder RA, and Jose PA (2008) Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol 294:H551-H569.