Regulation of mu opioid receptor internalization by the scaffold protein RanBPM

Neuroscience Letters

Volumn 466, Issue 3, 2009, Pages 154-158

  Talbot, Jeffery N ^a   Skifter, Donald A ^a   Bianchi, Elisabetta ^b   Monaghan, Daniel T ^a   Toews, Myron L ^a   Murrin, L Charles ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

Arrestin; Internalization; Mu opioid receptor; RanBPM; Scaffold protein; Yeast two hybrid screen

Indexed keywords

ADENYLATE CYCLASE; ALPHA 1B ADRENERGIC RECEPTOR; BETA ARRESTIN 2; GREEN FLUORESCENT PROTEIN; MU OPIATE RECEPTOR; PROTEIN RANBPM; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERNALIZATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENYLATE CYCLASE; ARRESTINS; CELL LINE; CYCLIC AMP; CYTOSKELETAL PROTEINS; ENDOCYTOSIS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GREEN FLUORESCENT PROTEINS; HUMANS; NUCLEAR PROTEINS; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, OPIOID, MU; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 70350304034     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.09.048     Document Type: Article

References (32)

1. Arden J.R., Segredo V., Wang Z., Lameh J., and Sadee W. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. J. Neurochem. 65 (1995) 1636-1645
2. Bai D., Chen H., and Huang B.R. RanBPM is a novel binding protein for p75NTR. Biochem. Biophys. Res. Commun. 309 (2003) 552-557
3. Brannetti B., Zanzoni A., Montecchi-Palazzi L., Cesareni G., and Helmer-Citterich M. iSPOT: a web tool for the analysis and recognition of protein domain specificity. Comp. Funct. Genomics 2 (2001) 314-318
4. Bylund D.B., Deupree J.D., and Toews M.L. Radioligand-binding methods for membrane preparations and intact cells. Methods Mol. Biol. 259 (2004) 1-28
5. Coulter C.L., Happe H.K., and Murrin L.C. Dopamine transporter development in postnatal rat striatum: an autoradiographic study with [3H]WIN 35,428. Brain Res. Dev. Brain Res. 104 (1997) 55-62
6. Denti S., Sirri A., Cheli A., Rogge L., Innamorati G., Putignano S., Fabbri M., Pardi R., and Bianchi E. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. J. Biol. Chem. 279 (2004) 13027-13034
7. Feng G.J., Kellett E., Scorer C.A., Wilde J., White J.H., and Milligan G. Selective interactions between helix VIII of the human μ-opioid receptors and the C terminus of periplakin disrupt G protein activation. J. Biol. Chem. 278 (2003) 33400-33407
8. Fischer B.D., Miller L.L., Henry F.E., Picker M.J., and Dykstra L.A. Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959). Psychopharmacology (Berl.) 198 (2008) 271-278
9. Georgoussi Z., Leontiadis L., Mazarakou G., Merkouris M., Hyde K., and Hamm H. Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling. Cell Signal. 18 (2006) 771-782
10. Ideguchi H., Ueda A., Tanaka M., Yang J., Tsuji T., Ohno S., Hagiwara E., Aoki A., and Ishigatsubo Y. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Biochem. J. 367 (2002) 87-95
11. Kay B.K., Williamson M.P., and Sudol M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J. 14 (2000) 231-241
12. Keith D.E., Murray S.R., Zaki P.A., Chu P.C., Lissin D.V., Kang L., Evans C.J., and von Zastrow M. Morphine activates opioid receptors without causing their rapid internalization. J. Biol. Chem. 271 (1996) 19021-19024
13. Kovoor A., Nappey V., Kieffer B.L., and Chavkin C. Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta arrestin 2 in Xenopus oocytes. J. Biol. Chem. 272 (1997) 27605-27611
14. Kreps D.M., Whittle S.M., Hoffman J.M., and Toews M.L. Lysophosphatidic acid mimics serum-induced sensitization of cyclic AMP accumulation. FASEB J. 7 (1993) 1376-1380
15. Law P.Y., Wong Y.H., and Loh H.H. Molecular mechanisms and regulation of opioid receptor signaling. Annu. Rev. Pharmacol. Toxicol. 40 (2000) 389-430
16. Mikolajczyk M., Shi J., Vaillancourt R.R., Sachs N.A., and Nelson M. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. Biochem. Biophys. Res. Commun. 310 (2003) 14-18
17. Murrin L.C., and Talbot J.N. RanBPM, a scaffolding protein in the immune and nervous systems. J. Neuroimmune Pharmacol. 2 (2007) 290-295
18. Nakamura M., Masuda H., Horii J., Kuma K., Yokoyama N., Ohba T., Nishitani H., Miyata T., Tanaka M., and Nishimoto T. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. J. Cell Biol. 143 (1998) 1041-1052
19. Nielsen D.A., Ji F., Yuferov V., Ho A., Chen A., Levran O., Ott J., and Kreek M.J. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Mol. Psychiatry 13 (2008) 417-428
20. Nishitani H., Hirose E., Uchimura Y., Nakamura M., Umeda M., Nishii K., Mori N., and Nishimoto T. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. Gene 272 (2001) 25-33
21. Ogawa M., Miyakawa T., Nakamura K., Kitano J., Furushima K., Kiyonari H., Nakayama R., Nakao K., Moriyoshi K., and Nakanishi S. Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 14789-14794
22. Onoprishvili I., Andria M.L., Kramer H.K., Ancevska-Taneva N., Hiller J.M., and Simon E.J. Interaction between the μ opioid receptor and filamin A is involved in receptor regulation and trafficking. Mol. Pharmacol. 64 (2003) 1092-1100
23. Schultz J., Milpetz F., Bork P., and Ponting C.P. SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5857-5864
24. Seebahn A., Rose M., and Enz R. RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. FEBS Lett. 582 (2008) 2453-2457
25. Sternini C., Spann M., Anton B., Keith Jr. D.E., Bunnett N.W., von Zastrow M., Evans C., and Brecha N.C. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 9241-9246
26. Talbot J.N., Happe H.K., and Murrin L.C. Mu opioid receptor coupling to Gi/o proteins increases during postnatal development in rat brain. J. Pharmacol. Exp. Ther. 314 (2005) 596-602
27. von Zastrow M., Svingos A., Haberstock-Debic H., and Evans C. Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs. Curr. Opin. Neurobiol. 13 (2003) 348-353
28. Wang D., Li Z., Messing E.M., and Wu G. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J. Biol. Chem. 277 (2002) 36216-36222
29. Wang D., Li Z., Schoen S.R., Messing E.M., and Wu G. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Biochem. Biophys. Res. Commun. 313 (2004) 320-326
30. Wang J., Wang L., Zheng J., Anderson J.L., and Toews M.L. Identification of distinct carboxyl-terminal domains mediating internalization and down-regulation of the hamster alpha(1B)-adrenergic receptor. Mol. Pharmacol. 57 (2000) 687-694
31. Whistler J.L., Chuang H.H., Chu P., Jan L.Y., and von Zastrow M. Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23 (1999) 737-746
32. Whistler J.L., and von Zastrow M. Morphine-activated opioid receptors elude desensitization by beta arrestin. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9914-9919