Genomewide screening for novel genetic variations associated with ciprofloxacin resistance in Bacillus anthracis

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 7, 2010, Pages 2787-2792

  Serizawa, Masakuni ^a   Sekizuka, Tsuyoshi ^a   Okutani, Akiko ^a   Banno, Satomi ^a   Sata, Tetsutaro ^a   Inoue, Satoshi ^a   Kuroda, Makoto ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING);

ARTICLE; BACILLUS ANTHRACIS; BACTERIAL STRAIN; CELL POPULATION; ESSENTIAL GENE; GENETIC SCREENING; GENETIC VARIABILITY; INDEL MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; DRUG EFFECTS; GENETIC ASSOCIATION; GENETICS; MOLECULAR GENETICS; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BACILLUS ANTHRACIS; CIPROFLOXACIN; DRUG RESISTANCE, BACTERIAL; GENETIC VARIATION; GENOME, BACTERIAL; GENOME-WIDE ASSOCIATION STUDY; MOLECULAR SEQUENCE DATA; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77953752178     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01405-09     Document Type: Article

References (28)

1. Bao, H., H. Guo, J. Wang, R. Zhou, X. Lu, and S. Shi. 2009. MapView: visualization of short reads alignment on a desktop computer. Bioinformatics 25:1554-1555.
2. Bast, D. J., A. Athamna, C. L. Duncan, J. C. de Azavedo, D. E. Low, G. Rahav, D. Farrell, and E. Rubinstein. 2004. Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance. J. Antimicrob. Chemother. 54:90-94.
3. Beecher, D. J. 2006. Forensic application of microbiological culture analysis to identify mail intentionally contaminated with Bacillus anthracis spores. Appl. Environ. Microbiol. 72:5304-5310.
4. Bentley, D. R., S. Balasubramanian, H. P. Swerdlow, G. P. Smith, J. Milton, C. G. Brown, K. P. Hall, D. J. Evers, C. L. Barnes, H. R. Bignell, J. M. Boutell, J. Bryant, R. J. Carter, R. Keira Cheetham, A. J. Cox, D. J. Ellis, M. R. Flatbush, N. A. Gormley, S. J. Humphray, L. J. Irving, M. S. Karbelashvili, S. M. Kirk, H. Li, X. Liu, K. S. Maisinger, L. J. Murray, B. Obradovic, T. Ost, M. L. Parkinson, M. R. Pratt, I. M. Rasolonjatovo, M. T. Reed, R. Rigatti, C. Rodighiero, M. T. Ross, A. Sabot, S. V. Sankar, A. Scally, G. P. Schroth, M. E. Smith, V. P. Smith, A. Spiridou, P. E. Torrance, S. S. Tzonev, E. H. Vermaas, K. Walter, X. Wu, L. Zhang, M. D. Alam, C. Anastasi, I. C. Aniebo, D. M. Bailey, I. R. Bancarz, S. Banerjee, S. G. Barbour, P. A. Baybayan, V. A. Benoit, K. F. Benson, C. Bevis, P. J. Black, A. Boodhun, J. S. Brennan, J. A. Bridgham, R. C. Brown, A. A. Brown, D. H. Buermann, A. A. Bundu, J. C. Burrows, N. P. Carter, N. Castillo, E. C. M. Chiara, S. Chang, R. Neil Cooley, N. R. Crake, O. O. Dada, K. D. Diakoumakos, B. Dominguez-Fernandez, D. J. Earnshaw, U. C. Egbujor, D. W. Elmore, S. S. Etchin, M. R. Ewan, M. Fedurco, L. J. Fraser, K. V. Fuentes Fajardo, W. Scott Furey, D. George, K. J. Gietzen, C. P. Goddard, G. S. Golda, P. A. Granieri, D. E. Green, D. L. Gustafson, N. F. Hansen, K. Harnish, C. D. Haudenschild, N. I. Heyer, M. M. Hims, J. T. Ho, A. M. Horgan, et al. 2008. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456:53-59.
5. Chattopadhyay, S., S. J. Weissman, V. N. Minin, T. A. Russo, D. E. Dykhuizen, and E. V. Sokurenko. 2009. High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection. Proc. Natl. Acad. Sci. U. S. A. 106:12412-12417.
6. CLSI. 2008. Performance standards for antimicrobial susceptibility testing; 18th informational supplement. M100-S18. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Grkovic, S., M. H. Brown, and R. A. Skurray. 2002. Regulation of bacterial drug export systems. Microbiol. Mol. Biol. Rev. 66:671-701.
8. Grohs, P., I. Podglajen, and L. Gutmann. 2004. Activities of different fluoroquinolones against Bacillus anthracis mutants selected in vitro and harboring topoisomerase mutations. Antimicrob. Agents Chemother. 48:3024-3027.
9. Inglesby, T. V., T. O'Toole, D. A. Henderson, J. G. Bartlett, M. S. Ascher, E. Eitzen, A. M. Friedlander, J. Gerberding, J. Hauer, J. Hughes, J. McDade, M. T. Osterholm, G. Parker, T. M. Perl, P. K. Russell, and K. Tonat. 2002. Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA 287:2236-2252.
10. Ito, H., H. Yoshida, M. Bogaki-Shonai, T. Niga, H. Hattori, and S. Nakamura. 1994. Quinolone resistance mutations in the DNA gyrase gyrA and gyrB genes of Staphylococcus aureus. Antimicrob. Agents Chemother. 38:2014-2023.
11. Ley, T. J., E. R. Mardis, L. Ding, B. Fulton, M. D. McLellan, K. Chen, D. Dooling, B. H. Dunford-Shore, S. McGrath, M. Hickenbotham, L. Cook, R. Abbott, D. E. Larson, D. C. Koboldt, C. Pohl, S. Smith, A. Hawkins, S. Abbott, D. Locke, L. W. Hillier, T. Miner, L. Fulton, V. Magrini, T. Wylie, J. Glasscock, J. Conyers, N. Sander, X. Shi, J. R. Osborne, P. Minx, D. Gordon, A. Chinwalla, Y. Zhao, R. E. Ries, J. E. Payton, P. Westervelt, M. H. Tomasson, M. Watson, J. Baty, J. Ivanovich, S. Heath, W. D. Shannon, R. Nagarajan, M. J. Walter, D. C. Link, T. A. Graubert, J. F. DiPersio, and R. K. Wilson. 2008. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456:66-72.
12. Li, H., J. Ruan, and R. Durbin. 2008. Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 18:1851-1858.
13. Markham, P. N., and A. A. Neyfakh. 2001. Efflux-mediated drug resistance in Gram-positive bacteria. Curr. Opin. Microbiol. 4:509-514.
14. Markham, P. N., E. Westhaus, K. Klyachko, M. E. Johnson, and A. A. Neyfakh. 1999. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus. Antimicrob. Agents Chemother. 43:2404-2408.
15. Mock, M., and A. Fouet. 2001. Anthrax. Annu. Rev. Microbiol. 55:647-671.
16. Ng, E. Y., M. Trucksis, and D. C. Hooper. 1994. Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob. Agents Chemother. 38:1345-1355.
17. Orth, P., D. Schnappinger, W. Hillen, W. Saenger, and W. Hinrichs. 2000. Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat. Struct. Biol. 7:215-219.
18. Price, L. B., A. Vogler, T. Pearson, J. D. Busch, J. M. Schupp, and P. Keim. 2003. In vitro selection and characterization of Bacillus anthracis mutants with high-level resistance to ciprofloxacin. Antimicrob. Agents Chemother. 47:2362-2365.
19. Ramos, J. L., M. Martinez-Bueno, A. J. Molina-Henares, W. Teran, K. Watanabe, X. Zhang, M. T. Gallegos, R. Brennan, and R. Tobes. 2005. The TetR family of transcriptional repressors. Microbiol. Mol. Biol. Rev. 69:326-356.
20. Rasko, D. A., M. R. Altherr, C. S. Han, and J. Ravel. 2005. Genomics of the Bacillus cereus group of organisms. FEMS Microbiol. Rev. 29:303-329.
21. Read, T. D., S. L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E. Holtzapple, J. D. Busch, K. L. Smith, J. M. Schupp, D. Solomon, P. Keim, and C. M. Fraser. 2002. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science 296:2028-2033.
22. Ruiz, J. 2003. Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection. J. Antimicrob. Chemother. 51:1109-1117.
23. Schmitz, F. J., P. G. Higgins, S. Mayer, A. C. Fluit, and A. Dalhoff. 2002. Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance. Eur. J. Clin. Microbiol. Infect. Dis. 21:647-659.
24. Sokurenko, E. V., D. L. Hasty, and D. E. Dykhuizen. 1999. Pathoadaptive mutations: gene loss and variation in bacterial pathogens. Trends Microbiol. 7:191-195.
25. Sreedharan, S., M. Oram, B. Jensen, L. R. Peterson, and L. M. Fisher. 1990. DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. J. Bacteriol. 172:7260-7262.
26. Srivatsan, A., Y. Han, J. Peng, A. K. Tehranchi, R. Gibbs, J. D. Wang, and R. Chen. 2008. High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies. PLoS Genet. 4:e1000139.
27. Swartz, M. N. 2001. Recognition and management of anthrax - an update. N. Engl. J. Med. 345:1621-1626.
28. Wang, J., W. Wang, R. Li, Y. Li, G. Tian, L. Goodman, W. Fan, J. Zhang, J. Li, Y. Guo, B. Feng, H. Li, Y. Lu, X. Fang, H. Liang, Z. Du, D. Li, Y. Zhao, Y. Hu, Z. Yang, H. Zheng, I. Hellmann, M. Inouye, J. Pool, X. Yi, J. Zhao, J. Duan, Y. Zhou, J. Qin, L. Ma, G. Li, G. Zhang, B. Yang, C. Yu, F. Liang, W. Li, S. Li, P. Ni, J. Ruan, Q. Li, H. Zhu, D. Liu, Z. Lu, N. Li, G. Guo, J. Ye, L. Fang, Q. Hao, Q. Chen, Y. Liang, Y. Su, A. San, C. Ping, S. Yang, F. Chen, L. Li, K. Zhou, Y. Ren, L. Yang, Y. Gao, G. Yang, Z. Li, X. Feng, K. Kristiansen, G. K. Wong, R. Nielsen, R. Durbin, L. Bolund, X. Zhang, and H. Yang. 2008. The diploid genome sequence of an Asian individual. Nature 456:60-65.