Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions

Archives of Biochemistry and Biophysics

Volumn 499, Issue 1-2, 2010, Pages 32-39

  Byun, Sangwon ^a   Tortorella, Micky D ^b   Malfait, Anne Marie ^c   Fok, Kam ^b   Frank, Eliot H ^d   Grodzinsky, Alan J ^a,d,e  

^a USA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c RUSH UNIVERSITY MEDICAL CENTER   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

ADAMTS 4 5; Cartilage; Donnan partitioning; Glycosaminoglycan; Intra tissue transport; PACE4

Indexed keywords

ENZYME INHIBITOR; GLYCOSAMINOGLYCAN; PAIRED AMINO ACID CONVERTING ENZYME 4; PF PEP; SERINE PROTEINASE; UNCLASSIFIED DRUG; OLIGOPEPTIDE; PCSK6 PROTEIN, RAT; PROTEINASE INHIBITOR; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT; RECOMBINANT PROTEIN;

ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BINDING COMPETITION; CALF (BOVINE); CONTROLLED STUDY; COW; DRUG DIFFUSION; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STATIC ELECTRICITY; SURFACE CHARGE; SYNOVIAL FLUID; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CATTLE; CHEMISTRY; DRUG ANTAGONISM; IN VITRO STUDY; KINETICS; METABOLISM; RAT;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARTILAGE, ARTICULAR; CATTLE; GLYCOSAMINOGLYCANS; IODINE RADIOISOTOPES; KINETICS; MODELS, BIOLOGICAL; OLIGOPEPTIDES; PROPROTEIN CONVERTASES; PROTEASE INHIBITORS; RADIOPHARMACEUTICALS; RATS; RECOMBINANT PROTEINS; STATIC ELECTRICITY;

EID: 77953718590     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2010.04.019     Document Type: Article

References (59)

1. Malfait A.M., Arner E.C., Song R.H., Alston J.T., Markosyan S., Staten N., Yang Z., Griggs D.W., Tortorella M.D. Arch. Biochem. Biophys. 2008, 478:43-51.
2. Tortorella M.D., Burn T.C., Pratta M.A., Abbaszade I., Hollis J.M., Liu R., Rosenfeld S.A., Copeland R.A., Decicco C.P., Wynn R., Rockwell A., Yang F., Duke J.L., Solomon K., George H., Bruckner R., Nagase H., Itoh Y., Ellis D.M., Ross H., Wiswall B.H., Murphy K., Hillman M.C., Hollis G.F., Newton R.C., Magolda R.L., Trzaskos J.M., Arner E.C. Science 1999, 284:1664-1666.
3. Abbaszade I., Liu R.Q., Yang F., Rosenfeld S.A., Ross O.H., Link J.R., Ellis D.M., Tortorella M.D., Pratta M.A., Hollis J.M., Wynn R., Duke J.L., George H.J., Hillman M.C., Murphy K., Wiswall B.H., Copeland R.A., Decicco C.P., Bruckner R., Nagase H., Itoh Y., Newton R.C., Magolda R.L., Trzaskos J.M., Hollis G.F., Arner E.C., Burn T.C. J. Biol. Chem. 1999, 274:23443-23450.
4. Tortorella M.D., Arner E.C., Hills R., Gormley J., Fok K., Pegg L., Munie G., Malfait A.M. Arch. Biochem. Biophys. 2005, 444:34-44.
5. Wang P., Tortorella M., England K., Malfait A.M., Thomas G., Arner E.C., Pei D. J. Biol. Chem. 2004, 279:15434-15440.
6. Caterson B., Flannery C.R., Hughes C.E., Little C.B. Matrix Biol. 2000, 19:333-344.
7. Tortorella M.D., Pratta M., Liu R.Q., Austin J., Ross O.H., Abbaszade I., Burn T., Arner E. J. Biol. Chem. 2000, 275:18566-18573.
8. Lark M.W., Gordy J.T., Weidner J.R., Ayala J., Kimura J.H., Williams H.R., Mumford R.A., Flannery C.R., Carlson S.S., Iwata M., Sandy J.D. J. Biol. Chem. 1995, 270:2550-2556.
9. Arner E.C., Hughes C.E., Decicco C.P., Caterson B., Tortorella M.D. Osteoarthr. Cartilage 1998, 6:214-228.
10. Sandy J.D., Flannery C.R., Neame P.J., Lohmander L.S. J. Clin. Invest. 1992, 89:1512-1516.
11. Lohmander L.S., Neame P.J., Sandy J.D. Arthritis Rheum. 1993, 36:1214-1222.
12. Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., Flannery C.R., Peluso D., Kanki K., Yang Z., Majumdar M.K., Morris E.A. Nature 2005, 434:644-648.
13. Maroudas A. Biophys. J. 1968, 8:575-595.
14. Buckwalter J.A., Mankin H.J., Grodzinsky A.J. Instr. Course Lect. 2005, 54:465-480.
15. Maroudas A. Physicochemical Properties of Articular Cartilage 1979, Pitman, Tunbridge Well, England. second ed.
16. Nimer E., Schneiderman R., Maroudas A. Biophys. Chem. 2003, 106:125-146.
17. Schneiderman R., Snir E., Popper O., Hiss J., Stein H., Maroudas A. Arch. Biochem. Biophys. 1995, 324:159-172.
18. Garcia A.M., Szasz N., Trippel S.B., Morales T.I., Grodzinsky A.J., Frank E.H. Arch. Biochem. Biophys. 2003, 415:69-79.
19. Tokunou T., Miller R., Patwari P., Davis M.E., Segers V.F., Grodzinsky A.J., Lee R.T. FASEB J. 2008, 22:1886-1893.
20. R. Miller, A.J. Grodzinsky, K. Cummings, R.T. Lee, P. Patwari, Intra-Articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6-9, 2010.
21. van den Berg W.B., van de Putte L.B.A., Zwarts W.A., Joosten L.A. J. Clin. Invest. 1984, 74:1850-1859.
22. van den Berg W.B., van de Putte L.B.A. Am. J. Pathol. 1985, 121:224-234.
23. van den Berg W.B., van Lent P.L.E.M., van de Putte L.B.A., Zwarts W.A. Clin. Immunol. Immunopathol. 1986, 39:187-197.
24. Bhakta N.R., Garcia A.M., Frank E.H., Grodzinsky A.J., Morales T.I. J. Biol. Chem. 2000, 275:5860-5866.
25. Bennett G.L., Horuk R. Methods Enzymol. 1997, 288:134-148.
26. Sah R.L.Y., Kim Y.J., Doong J.Y.H., Grodzinsky A.J., Plaas A.H.K., Sandy J.D. J. Orthop. Res. 1989, 7:619-636.
27. Garcia A.M., Lark M.W., Trippel S.B., Grodzinsky A.J. J. Orthop. Res. 1998, 16:734-742.
28. Nussbaum J.H., Grodzinsky A.J. J. Membr. Sci. 1981, 8:193-219.
29. Garcia A.M., Frank E.H., Grimshaw P.E., Grodzinsky A.J. Arch. Biochem. Biophys. 1996, 333:317-325.
30. Maroudas A., Bullough P., Swanson S.A.V., Freeman M.A.R. J. Bone Joint Surg. Br. 1968, 50B:166-177.
31. Basser P.J., Schneiderman R., Bank R.A., Wachtel E., Maroudas A. Arch. Biochem. Biophys. 1998, 351:207-219.
32. Venn M., Maroudas A. Ann. Rheum. Dis. 1977, 36:121-129.
33. Frank E.H., Grodzinsky A.J. J. Biomech. 1987, 20:615-627.
34. Crank J. The Mathematics of Diffusion 1979, Clarendon Press, Oxford. second ed.
35. Eisenberg S.R., Grodzinsky A.J. J. Orthop. Res. 1985, 3:148-159.
36. Torzilli P.A., Arduino J.M., Gregory J.D., Bansal M. J. Biomech. 1997, 30:895-902.
37. Frank E.H., Grodzinsky A.J., Koob T.J., Eyre D.R. J. Orthop. Res. 1987, 5:497-508.
38. Burstein D., Gray M.L., Hartman A.L., Gipe R., Foy B.D. J. Orthop. Res. 1993, 11:465-478.
39. Foy B.D., Blake J. J. Magn. Reson. 2001, 148:126-134.
40. Xia Y., Farquhar T., Burtonwurster N., Verniersinger M., Lust G., Jelinski L.W. Arch. Biochem. Biophys. 1995, 323:323-328.
41. Maroudas A. Biorheology 1975, 12:233-248.
42. Maroudas A. Biophys. J. 1970, 10:365-379.
43. Maroudas A. J. Anat. 1976, 122:335-347.
44. Ogston A.G. Trans. Faraday Soc. 1958, 54:1754-1757.
45. Johnson E.M., Deen W.M. J. Colloid Interface Sci. 1996, 178:749-756.
46. Simkin P.A., Nilson K.L. Clin. Rheum. Dis. 1981, 7:99-129.
47. Owen S.G., Francis H.W., Roberts M.S. Br. J. Clin. Pharmacol. 1994, 38:349-355.
48. Leddy H.A., Guilak F. Ann. Biomed. Eng. 2003, 31:753-760.
49. Quinn T.M., Kocian P., Meister J.J. Arch. Biochem. Biophys. 2000, 384:327-334.
50. Quinn T.M., Morel V., Meister J.J. J. Biomech. 2001, 34:1463-1469.
51. Evans R.C., Quinn T.M. Arch. Biochem. Biophys. 2005, 442:1-10.
52. Lotke P.A., Granda J.L. Arthritis Rheum. 1972, 15:302-308.
53. Lotke P.A., Granda J.L. Surg. Forum 1971, 22:449-450.
54. Evans R.C., Quinn T.M. J. Biomech. 2006, 39:1048-1055.
55. Evans R.C., Quinn T.M. Biophys. J. 2006, 91:1541-1547.
56. O'hara B.P., Urban J.P.G., Maroudas A. Ann. Rheum. Dis. 1990, 49:536-539.
57. Torzilli P.A. Med. Biol. Eng. Comput. 1993, 31:S93-S98.
58. Serrat M.A., Williams R.M., Farnum C.E. J. Appl. Physiol. 2009, 106:2016-2025.
59. Buschmann M.D., Grodzinsky A.J. J. Biomech. Eng. 1995, 117:179-192.