Single minded 2-s (SIM2-s) gene is expressed in human GBM cells and involved in GBM invasion

Cancer Biology and Therapy

Volumn 9, Issue 6, 2010, Pages 430-436

  He, Qiaowei ^a   Li, Gang ^a   Su, Yuhang ^a   Shen, Jie ^a   Liu, Qinglin ^a   Ma, Xiangyu ^a   Zhao, Peng ^a   Zhang, Jian ^b  

^a SHANDONG UNIVERSITY   (China)

^b Modern Research Center for Traditional Chinese Medicine   (China)

Author keywords

Cell invasion; ECM; GBM; MMP; SIM2 s; siRNA; TIMP

Indexed keywords

GELATINASE A; MESSENGER RNA; PROTEIN; RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ARTICLE; BRAIN TUMOR; CANCER INVASION; CANCER THERAPY; CHROMOSOME 21; COLON TUMOR; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE MAPPING; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS TUMOR; PROSTATE TUMOR; RNA INTERFERENCE; SIM2 S GENE;

EID: 77953708821     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.9.6.10892     Document Type: Article

References (36)

1. Ismail K, Paul JH. Animal models in the study of the biological function of genes on human chromosome 21 and their role in the pathophysiology of down syndrome. Hum Mol Genet 1997; 6:1713-27.
2. Roman C, Hamish SS, Chen H, Kudoh J, Rossier C, Minoshima S, et al. Cloning of two human homologs of the drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the down syndrome chromosomal region. Genome Res 1997; 7:615-24. (Pubitemid 27313610)
3. McGuire J, Coumailleau P, Whitelaw ML, Gustafsson JA, Poellinger L. The basic Helix-Loop-Helix/PAS factor sim is associated with hsp90. J Biol Chem 1996; 270:31353-7.
4. Nambu JR, Lewis JO, Wharton KA Jr, Crews ST. The drosophila single-minded gene encodes a helix-loophelix protein that acts as a master regulator of CNS midline development. Cell 1991; 67:1157-67.
5. Rachidi M, Lopes C, Charron G, Delezoide AL, Paly E, Bloch B, et al. Spatial and temporal localization during embryonic and fetal human development of the transcription factor SIM2 in brain regions altered in down syndrome. Int J Dev Neurosci 2005; 23:475-84.
6. Deyoung MP, Scheurle D, Damania H, Zylberberg C, Narayanan R. Down's syndrome-associated single minded gene as a novel tumor marker. Anticancer Res 2002; 22:3149-57.
7. DeYoung MP, Tress M, Narayanan R. Identification of down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. PNAS 2003; 100:4760-5.
8. Aleman MJ, DeYoung MP, Tress M, Keating P, Perry GW, Narayanan R. Inhibition of single minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells. PNAS 2005; 102:12765-70.
9. DeYoung MP, Tress M, Narayanan R. Down's syndrome-associated single minded 2 gene as a pancreatic cancer drug therapy target. Cancer Lett 2003; 200:25-31. (Pubitemid 37222355)
10. Halvorsen OJ, Rostad K, Øyan AM, Puntervoll H, Bø TH, Stordrange L, et al. Increased expression of SIM2-s protein is a novel marker of aggressive prostate cancer. Clin Cancer Res 2007; 13:892-7.
11. Kwak HI, Gustafson T, Metz RP, Laffin B, Schedin P, Porter WW. Inhibition of breast cancer growth and invasion by single-minded 2s. Carcinogenesis 2007; 28:259-66.
12. Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T, et al. Loss of singleminded-2s in the mouse mammary gland induces an epithelialmesenchymal transition associated with upregulation of slug and matrix metalloprotease 2. Mol Cell Biol 2008; 28:1936-46. (Pubitemid 351342625)
13. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, et al. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol 2009; 132:169-79.
14. Jin KL, Pak JH, Park JY, Choi WH, Lee JY, Kim JH, et al. Expression profile of histone deacetylases 1, 2 and 3 in ovarian cancer tissues. J Gynecol Oncol 2008; 19:185-90.
15. Liu JJ, Zhang Y, Guang WB, Yang HZ, Lin DJ, Xiao RZ. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. Int J Mol Sci 2008; 9:2265-77.
16. Li W, He H, Kuo CL, Gao Y, Kawakita T, Tseng SC. Basement membrane dissolution and reassembly by limbal corneal epithelial cells expanded on amniotic membrane. Invest Ophthalmol Vis Sci 2006; 47:2381-9.
17. McClung HM, Thomas SL, Osenkowski P, Toth M, Menon P, Raz A, et al. SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells. Neurosci Lett 2007; 419:172-7.
18. Hussaini IM, Trotter C, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, et al. Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Am J Pathol 2007; 170:356-65. (Pubitemid 47339213)
19. Zeng R, Chen YC, Zeng Z, Liu R, Qiang O, Jiang XF, et al. Small interfering RNA knockdown of mini-TyrRS and mini-TrpRS effects angiogenesis in human umbilical vein endothelial cells in hypoxic culture. Cytotechnology 2008; 56:219-31.
20. Ghiaur G, Ferkowicz MJ, Milsom MD, Bailey J, Witte D, Cancelas JA, et al. Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood 2008; 111:3313-21.
21. Wood JP, Lascaratos G, Bron AJ, Osborne NN. The influence of visible light exposure on cultured RGC-5 cells. Mol Vis 2007; 14:334-44.
22. Szeto MD, Chakraborty G, Hadley J, Rockne R, Muzi M, Alvord EC Jr, et al. Quantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed glioblastomas. Cancer Res 2009; 69:4502-9.
23. Chang C, Werb Z. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 2001; 11:37-43. (Pubitemid 33001442)
24. Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB, Berens ME. Molecular targets of glioma invasion. Cell Mol Life Sci 2007; 64:456-78.
25. Muenke M, Bone LJ, Mitchell HF, Hart I, Walton K, Hall-Johnson K, et al. Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. Am J Hum Genet 1995; 57:1074-9.
26. Chrast R, Scott HS, Madani R, Huber L, Wolfer DP, Prinz M, et al. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum Mol Genet 2000; 9:1853-64.
27. Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer and metastasis. Am J Physiol Cell Physiol 2005; 288:494-506.
28. Pflug BR, Reiter RE, Nelson JB. Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines. Prostate 1999; 40:269-73.
29. Williams TM, Hassan GS, Li J, Cohen AW, Medina F, Frank PG, et al. Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. J Biol Chem 2005; 280:25134-45. (Pubitemid 40934606)
30. Planchenault T, Costa S, Fages C, Riche D, Charrière-Bertrand C, Perzelova A, et al. Differential expression of laminin and fibronectin and of their related metalloproteinases in human glioma cell lines: relation to invasion. Neurosci Lett 2001; 299:140-4.
31. Yong VW, Krekoski CA, Forsyth PA, Bell R, Edwards DR. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci 1998; 21:75-80.
32. Choe G, Park JK, Jouben-Steele L, Kremen TJ, Liau LM, Vinters HV, et al. Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype. Clin Cancer Res 2002; 8:2894-901. (Pubitemid 35025737)
33. Tauro JR, Gemeinhart RA. Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes. Bioconjug Chem 2005; 16:1133-9.
34. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, et al. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol 2008; 10:254-64.
35. Levicar N, Nuttall RK, Lah TT. Proteases in brain tumour progression. Acta Neurochir (Wien) 2003; 145:825-38.
36. Chintala SK, Tonn JC, Rao JS. Matrix metalloproteinases and their biological function in human gliomas. Int J Dev Neurosci 1999; 17:495-502.