Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration

Histochemistry and Cell Biology

Volumn 132, Issue 2, 2009, Pages 169-179

  Zhang, Baohua ^a,b   Zhou, Zhi ^a,b   Lin, Haiyan ^a   Lv, Xiaoyin ^a,b   Fu, Jiejun ^a,b   Lin, Ping ^a,c   Zhu, Cheng ^a   Wang, Hongmei ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Hydatidiform moles; MMP; PPM1A; TIMP; Trophoblast invasion

Indexed keywords

GELATINASE B; MATRIGEL; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1A; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; ENZYME PRECURSOR; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2C; PRO MATRIX METALLOPROTEINASE 9; PRO-MATRIX METALLOPROTEINASE 9;

ARTICLE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CYTOTROPHOBLAST; DOWN REGULATION; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDATIDIFORM MOLE; IMMUNOCYTOCHEMISTRY; PLACENTA; PLACENTA VILLUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCTION; TROPHOBLAST; WESTERN BLOTTING; ZYMOGRAPHY; BIOSYNTHESIS; CELL MOTION; CELL PROLIFERATION; ENZYMOLOGY; GENE SILENCING; GENETICS; PHYSIOLOGY; PREGNANCY;

CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; ENZYME PRECURSORS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MATRIX METALLOPROTEINASE 9; PHOSPHOPROTEIN PHOSPHATASES; PLACENTATION; PREGNANCY; RNA, SMALL INTERFERING; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TROPHOBLASTS;

EID: 70349261403     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-009-0601-5     Document Type: Article

References (49)

1. A Altieri S Franceschi J Ferlay J Smith C La Vecchia 2003 Epidemiology and aetiology of gestational trophoblastic diseases Lancet Oncol 4 670 678 14602247 10.1016/S1470-2045(03)01245-2 (Pubitemid 37407434)
2. P Balaram S Alex B Panikkar TN Rajalekshmi 2004 Adhesion-related proteins E-cadherin, P-cadherin, CD44, and CD44v6, and antimetastatic protein nm23H1 in complete hydatidiform moles in relation to invasion potential Int J Gynecol Cancer 14 532 539 15228429 10.1111/j.1048-891x.2004.014316.x 1:STN:280:DC%2BD2czislegtA%3D%3D (Pubitemid 38747436)
3. P Bischof I Irminger-Finger 2005 The human cytotrophoblastic cell, a mononuclear chameleon Int J Biochem Cell Biol 37 1 16 15381142 10.1016/j.biocel.2004.05.014 1:CAS:528:DC%2BD2cXnslKgsrk%3D (Pubitemid 39286016)
4. P Bischof K Truong A Campana 2003 Regulation of trophoblastic gelatinases by proto-oncogenes Placenta 24 155 163 12566242 10.1053/plac.2002.0890 1:CAS:528:DC%2BD3sXptlOmuw%3D%3D (Pubitemid 37184711)
5. S Bu B Kapanadze T Hsu M Trojanowska 2008 Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway J Biol Chem 283 19593 19602 18482992 10.1074/jbc.M802417200 1:CAS:528:DC%2BD1cXotF2ktrw%3D
6. M Cohen P Bischof 2007 Factors regulating trophoblast invasion Gynecol Obstet Invest 64 126 130 17934306 10.1159/000101734 (Pubitemid 47574869)
7. M Cohen A Meisser P Bischof 2006 Metalloproteinases and human placental invasiveness Placenta 27 783 793 16249026 10.1016/j.placenta.2005.08.006 1:CAS:528:DC%2BD28XlvF2mu7w%3D (Pubitemid 43905919)
8. M Cohen C Wuillemin O Irion P Bischof 2008 Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells Hum Reprod 23 2273 2281 18635530 10.1093/humrep/den264 1:CAS:528:DC%2BD1cXhtFCiu7bF
9. X Duan YY Liang XH Feng X Lin 2006 Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway J Biol Chem 281 36526 36532 16931515 10.1074/jbc.M605169200 1:CAS:528:DC%2BD28Xht1eltrrE (Pubitemid 46042119)
10. C Ferretti L Bruni V Dangles-Marie AP Pecking D Bellet 2007 Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts Hum Reprod Update 13 121 141 17068222 10.1093/humupd/dml048 1:CAS:528:DC%2BD2sXhvFWlsrw%3D (Pubitemid 46323191)
11. JS Fitzgerald S Busch T Wengenmayer K Foerster T de la Motte TG Poehlmann UR Markert 2005 Signal transduction in trophoblast invasion Chem Immunol Allergy 88 181 199 16129946 10.1159/000087834 1:CAS:528:DC%2BD2MXht1CmsbzN (Pubitemid 43094385)
12. JS Fitzgerald TG Poehlmann E Schleussner UR Markert 2008 Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum Reprod Update 14 335 344 18424427 10.1093/humupd/dmn010 1:CAS:528:DC%2BD1cXnt1SksL0%3D (Pubitemid 351858973)
13. M Gallego DM Virshup 2005 Protein serine/threonine phosphatases: life, death, and sleeping Curr Opin Cell Biol 17 197 202 15780597 10.1016/j.ceb.2005. 01.002 1:CAS:528:DC%2BD2MXisVCqtbk%3D (Pubitemid 40380944)
14. MC Hall DA Young JG Waters AD Rowan A Chantry DR Edwards IM Clark 2003 The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1 J Biol Chem 278 10304 10313 12525489 10.1074/jbc.M212334200 1:CAS:528: DC%2BD3sXitVCrs7o%3D (Pubitemid 36800292)
15. K Hammani A Blakis D Morsette AM Bowcock C Schmutte P Henriet YA DeClerck 1996 Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene J Biol Chem 271 25498 25505 8810321 10.1074/jbc.271.41.25498 1:CAS:528:DyaK28Xmt1emurs%3D (Pubitemid 26337925)
16. M Hanada T Kobayashi M Ohnishi S Ikeda H Wang K Katsura Y Yanagawa A Hiraga R Kanamaru S Tamura 1998 Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells FEBS Lett 437 172 176 9824284 10.1016/S0014-5793(98)01229-0 1:CAS:528:DyaK1cXntFSjtL8%3D (Pubitemid 28511151)
17. SE Hoegy HR Oh ML Corcoran WG Stetler-Stevenson 2001 Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibition J Biol Chem 276 3203 3214 11042184 10.1074/jbc.M008157200 1:CAS:528:DC%2BD3MXhtFWjurw%3D
18. K Isaka S Usuda H Ito Y Sagawa H Nakamura H Nishi Y Suzuki YF Li M Takayama 2003 Expression and activity of matrix metalloproteinase 2 and 9 in human trophoblasts Placenta 24 53 64 12495660 10.1053/plac.2002.0867 1:CAS:528:DC%2BD38Xps1Sjsbo%3D (Pubitemid 37184696)
19. RL Jones JK Findlay LA Salamonsen 2006 The role of activins during decidualisation of human endometrium Aust N Z J Obstet Gynaecol 46 245 249 16704482 10.1111/j.1479-828X.2006.00581.x (Pubitemid 44056735)
20. ED Karagiannis AS Popel 2004 A theoretical model of type I collagen proteolysis by matrix metalloproteinase (MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor of metalloproteinase 2 J Biol Chem 279 39105 39114 15252025 10.1074/jbc.M403627200 1:CAS:528:DC%2BD2cXnt1yjtrw%3D (Pubitemid 39296073)
21. P Kaufmann S Black B Huppertz 2003 Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia Biol Reprod 69 1 7 12620937 10.1095/biolreprod.102.014977 1:CAS:528:DC%2BD3sXkvFCnsbY%3D (Pubitemid 36806800)
22. S Knoeller E Lim L Aleta K Hertwig JW Dudenhausen PC Arck 2003 Distribution of immunocompetent cells in decidua of controlled and uncontrolled (choriocarcinoma/hydatidiform mole) trophoblast invasion Am J Reprod Immunol 50 41 47 14506927 10.1034/j.1600-0897.2003.00046.x 1:STN:280:DC%2BD3svltF2nuw%3D%3D (Pubitemid 36805763)
23. YC Kou L Shao HH Peng R Rosetta D del Gaudio AF Wagner TK Al-Hussaini IB Van den Veyver 2008 A recurrent intragenic genomic duplication, other novel mutations in NLRP7 and imprinting defects in recurrent biparental hydatidiform moles Mol Hum Reprod 14 33 40 18039680 10.1093/molehr/gam079 1:CAS:528:DC%2BD1cXlsV2nurk%3D (Pubitemid 351267224)
24. HL LaMarca PR Dash K Vishnuthevan E Harvey DE Sullivan CA Morris GS Whitley 2008 Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases Hum Reprod 23 1733 1741 18487214 10.1093/humrep/den178 1:CAS:528:DC%2BD1cXoslGqurw%3D (Pubitemid 352020009)
25. T Lammers P Peschke V Ehemann J Debus B Slobodin S Lavi P Huber 2007 Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity Mol Cancer 6 65 17941990 10.1186/1476-4598-6-65 (Pubitemid 350226876)
26. B Lifschitz-Mercer Y Sheinin D Ben-Meir L Bramante-Schreiber L Leider-Trejo S Karby NI Smorodinsky S Lavi 2001 Protein phosphatase 2Calpha expression in normal human tissues: an immunohistochemical study Histochem Cell Biol 116 31 39 11479720 1:CAS:528:DC%2BD3MXltlGqtLg%3D
27. X Lin X Duan YY Liang Y Su KH Wrighton J Long M Hu CM Davis J Wang FC Brunicardi Y Shi YG Chen A Meng XH Feng 2006 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling Cell 125 915 928 16751101 10.1016/j.cell.2006.03.044 1:CAS:528:DC%2BD28Xls1Shtrw%3D (Pubitemid 43795197)
28. J Melendez-Zajgla L Del Pozo G Ceballos V Maldonado 2008 Tissue inhibitor of metalloproteinases-4. The road less traveled Mol Cancer 7 85 19025595 10.1186/1476-4598-7-85
29. ER Norwitz DJ Schust SJ Fisher 2001 Implantation and the survival of early pregnancy N Engl J Med 345 1400 1408 11794174 10.1056/NEJMra000763 1:CAS:528:DC%2BD3MXot1aqu74%3D (Pubitemid 34940730)
30. RJ Oldt 3rd RJ Kurman M Shih Ie 2002 Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin Am J Pathol 161 1033 1037 12213732 1:CAS:528:DC%2BD38XnsFOis7w%3D
31. P Paiva LA Salamonsen U Manuelpillai E Dimitriadis 2008 Interleukin 11 inhibits human trophoblast invasion indicating a likely role in the decidual restraint of trophoblast invasion during placentation Biol Reprod 80 2 302 310 18987331 10.1095/biolreprod.108.071415
32. ZJ Pang JG Zhou LP Huang 2008 Interleukin-10 may participate in regulating trophoblast invasion in human placentae throughout gestation Am J Reprod Immunol 60 19 25 18593434 10.1111/j.1600-0897.2008.00586.x 1:CAS:528:DC%2BD1cXpt1eju70%3D (Pubitemid 351858399)
33. P Petignat R Laurini F Goffin I Bruchim P Bischof 2006 Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta Int J Gynecol Cancer 16 1679 1684 16884384 10.1111/j.1525-1438.2006.00643.x 1:STN:280:DC%2BD28vmtFyrsA%3D%3D (Pubitemid 44060398)
34. Q Qiu M Yang BK Tsang A Gruslin 2004 EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways Reproduction 128 355 363 15333786 10.1530/rep.1.00234 1:CAS:528: DC%2BD2cXot1Kitb8%3D (Pubitemid 39242711)
35. EA Reynolds B DuBeshter P Katzman K Larson S Katzel C Glantz 2007 Expression of CD44, E-cadherin, and antimetastatic protein nm23-H1 in complete hydatidiform moles Gynecol Oncol 104 451 454 17027071 10.1016/j.ygyno.2006.08. 030 1:CAS:528:DC%2BD2sXpvVKitQ%3D%3D (Pubitemid 46135650)
36. NJ Sebire H Rees F Paradinas R Fisher M Foskett M Seckl E Newlands 2001 Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies Placenta 22 725 728 11597192 10.1053/plac.2001.0716 1:STN:280:DC%2BD3MrltF2qtg%3D%3D (Pubitemid 32982708)
37. DW Seo H Li L Guedez PT Wingfield T Diaz R Salloum BY Wei WG Stetler-Stevenson 2003 TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism Cell 114 171 180 12887919 10.1016/S0092-8674(03)00551- 8 1:CAS:528:DC%2BD3sXlvFCgu7k%3D (Pubitemid 36936911)
38. M Shih I.e 2007 Gestational trophoblastic neoplasia-pathogenesis and potential therapeutic targets Lancet Oncol 8 642 650 17613426 10.1016/S1470-2045(07)70204-8 (Pubitemid 46995636)
39. MK Siu ES Wong HY Chan HY Ngan KY Chan AN Cheung 2008 Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome Am J Pathol 173 1165 1172 18772339 10.2353/ajpath.2008. 080288 1:CAS:528:DC%2BD1cXht1CjtL%2FJ
40. M Takekawa T Maeda H Saito 1998 Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways EMBO J 17 4744 4752 9707433 10.1093/emboj/17.16.4744 1:CAS:528:DyaK1cXlslOrtLs%3D (Pubitemid 28377174)
41. A Tapia LA Salamonsen U Manuelpillai E Dimitriadis 2008 Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2 Hum Reprod 23 1724 1732 18492704 10.1093/humrep/den121 1:CAS:528:DC%2BD1cXoslGqu78%3D (Pubitemid 352020000)
42. H Wang Q Li L Shao C Zhu 2001 Expression of matrix metalloproteinase-2,- 9,-14, and tissue inhibitors of metalloproteinase-1,-2,-3 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy Biol Reprod 65 31 40 11420220 10.1095/biolreprod65.1.31 1:CAS:528:DC%2BD3MXkslWht78%3D
43. A Wang B Zhang H Huang L Zhang D Zeng Q Tao J Wang C Pan 2008 Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro BMC Cancer 8 182 18588710 10.1186/1471-2407-8-182 (Pubitemid 352003726)
44. M Wisniewska P Goettig K Maskos E Belouski D Winters R Hecht R Black W Bode 2008 Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex J Mol Biol 381 1307 1319 18638486 10.1016/j.jmb.2008.06.088 1:CAS:528:DC%2BD1cXps1KjsL0%3D
45. KH Wrighton D Willis J Long F Liu X Lin XH Feng 2006 Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling J Biol Chem 281 38365 38375 17035229 10.1074/jbc.M607246200 1:CAS:528:DC%2BD28Xht12msr7N (Pubitemid 46041960)
46. SK Wu BJ Wang Y Yang XH Feng XP Zhao DL Yang 2007 Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues World J Gastroenterol 13 4554 4559 17729405
47. Q Yang HX Wang YG Zhao HY Lin H Zhang HM Wang QX Sang C Zhu 2006 Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy Life Sci 78 2804 2811 16375928 10.1016/j.lfs.2005.11.016 1:CAS:528:DC%2BD28XjvValsbw%3D
48. T Yoshizaki H Maegawa K Egawa S Ugi Y Nishio T Imamura T Kobayashi S Tamura JM Olefsky A Kashiwagi 2004 Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes J Biol Chem 279 22715 22726 15016818 10.1074/jbc.M313745200 1:CAS:528:DC%2BD2cXjvF2rurg%3D (Pubitemid 38679472)
49. X Zhang HM Wang HY Lin GY Liu QL Li C Zhu 2004 Regulation of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) during mouse peri-implantation: role of nitric oxide Placenta 25 243 252 15028415 10.1016/j.placenta.2003.08.014 1:CAS:528:DC%2BD2cXitFKmtLo%3D (Pubitemid 38514932)