Dual effects of α-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells

Science China Life Sciences

Volumn 53, Issue 5, 2010, Pages 590-597

  Lu, Ling Ling ^a   Gu, Li ^a   Liang, Yuan ^a   Sun, Xiao Hong ^a   Duan, Chun Li ^a   Yang, Hui ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Synuclein; Mitochondrial deficit; Oxidative stress; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; INSECTICIDE; OXYGEN; ROTENONE;

ARTICLE; CELL SURVIVAL; COMPARATIVE STUDY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION SWELLING; NERVE CELL; NEUROBLASTOMA; OXIDATIVE STRESS; PHYSIOLOGY; TIME; TUMOR CELL LINE; ULTRASTRUCTURE; DRUG EFFECTS; TOXICITY;

ALPHA-SYNUCLEIN; CELL LINE, TUMOR; CELL SURVIVAL; DOPAMINE; HUMANS; INSECTICIDES; MITOCHONDRIAL SWELLING; NEUROBLASTOMA; NEURONS; OXIDATIVE STRESS; OXYGEN; ROTENONE; TIME FACTORS; TRANSFECTION;

EID: 77953704399     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-010-0104-6     Document Type: Article

References (22)

1. Dauer W, Przedborski S. Parkinson's disease: Mechanisms and models. Neuron, 2003, 39: 889-909.
2. Halbach V B, Schober A, Krieglstein K. Genes, proteins, and neurotoxins involved in Parkinson's disease. Prog Neurobiol, 2004, 73: 151-177.
3. Sung J Y, Lee H J, Jeong E I, et al. α-Synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells. Neurosci Lett, 2007, 416: 289-293.
4. Conway K A, Lee S J, Rochet J C, et al. Acceleration of oligomerization, not fibrillization, is a shared property of both a-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy. Proc Natl Acad Sci USA, 2000, 97: 571-576.
5. Seo J H, Rah J C, Choi S H, et al. a-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB J, 2002, 16: 1826-1828.
6. Kaul S, Anantharam V, Kanthasamy A, et al. Wild-type α-synuclein interacts with pro-apoptotic proteins PKCδ and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Mol Brain Res, 2005, 1139: 137-152.
7. Di Monte D A. The environment and Parkinson's disease: Is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol, 2003, 2: 531-538.
8. Shimizu K, Matsubara K, Ohtaki K, et al. Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci Res, 2003, 46: 523-532.
9. Li A A, Mink P J, McIntosh L J, et al. Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease. J Occup Environ Med, 2005, 47: 1059-1087.
10. de Lau L M, Breteler M M. Epidemiology of Parkinson's disease. Lancet Neurol, 2006, 5: 525-535.
11. Jenner P. Parkinson's disease, pesticides and mitochondrial dopamine turnover following acute administration of rotenone to dysfunction. Trends Neurosci, 2001, 24: 245-247.
12. Thiffault C, Langston J W, Di Monte D A. Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Res, 2000, 885: 283-288.
13. Trounce I A, Kim Y L, Jun A S, et al. Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. Methods Enzymol, 1996, 264: 484-509.
14. Turrens J F, Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J, 1980, 191: 421-427.
15. Hsu L J, Sagara Y, Arroyo A, et al. Alpha-synuclein promotes mitochondrial deficit and oxidative stress. Am J Pathol, 2000, 157: 401-410.
16. Zhou W, Schaack J, Zawada W M, et al. Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture. Brain Res, 2002, 926: 42-50.
17. Zhang Y X, Yang H, Cai Q, et al. The influence of overexpression α-synuclein-egfp on formation of inclusion and mitochondrial ultrastructure in sh-sy5y cells in vitro. Chin J Neuroanat, 2003, 19: 251-256.
18. Zhang Y X, Zhang Z M, Yang H, et al. Overexpression of α-synuclein in SH-SY5Y cells in vitro leads to oxidative stress. Chin J Pathophysiology, 2005, 21: 1532-1535.
19. Zhang Y X, Zhang Z M, Yang H, et al. Overexpression of α-synuclein leads to autophagy in SH-SY5Y cells in vitro. Chin J Anat, 2005, 28: 258-260.
20. Brown T P, Rumsby P C, Capleton A C, et al. Pesticides and Parkinson's disease-is there a link? Environ Health Perspect, 2006, 114: 156-164.
21. Ding T T, Lee S J, Rochet J C, et al. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry, 2002, 41: 10209-10217.
22. Dev K K, Hofele K, Barbieri S, et al. α-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology, 2003, 45: 14-44.