A morphological study of diffuse axonal injury in a rat model by lateral head rotation trauma

Acta Neurologica Belgica

Volumn 110, Issue 1, 2010, Pages 49-56

  Xiaosheng, He ^a   Guitao, Yang ^a   Xiang, Zhang ^a   Zhou, Fei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Animal model; Diffuse axonal injury (DAI); Morphological study; NF68

Indexed keywords

MYELIN; NEUROFILAMENT 68 PROTEIN; NEUROFILAMENT PROTEIN; UNCLASSIFIED DRUG; NEUROFILAMENT PROTEIN NF 68;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AXOPLASM; BRAIN TISSUE; CONTROLLED STUDY; DEVICE; DIFFUSE AXONAL INJURY; ELECTRON MICROSCOPY; HEAD INJURY; INJURY SEVERITY; LATERAL HEAD ROTATION TRAUMA; MALE; MEDULLA OBLONGATA; MICROSCOPY; MICROTUBULE; MITOCHONDRION; MORPHOLOGY; NERVE FIBER; NEUROFILAMENT; NONHUMAN; RAT; SURVIVAL TIME; SWELLING; ANIMAL; DISEASE MODEL; METABOLISM; METHODOLOGY; PATHOLOGY; ROTATION; SPRAGUE DAWLEY RAT; TIME; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; AXONS; CRANIOCEREBRAL TRAUMA; DIFFUSE AXONAL INJURY; DISEASE MODELS, ANIMAL; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEUROFILAMENT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; ROTATION; TIME FACTORS;

EID: 77953694869     PISSN: 03009009     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Adams JH, Doyle D, Ford I. et al. Diffuse axonal injury in head injury: 'definition' diagnosis and grading. Histopathology. 1989;15:49-59.
2. Adams JH, Graham DI, Gennarelli TA. et al. Diffuse axonal injury in non-missile head injury. J Neurol Neurosurg Psychiatry. 1991;54:481-483.
3. Bennett M, O'Brien DP, Phillips JP. et al. injury admitted to a neurosurgical unit. Ir Med J. 1995;88:59-62.
4. Christman CW, Grady MS, Walker SA. et al. Ultrastuctural studies of diffuse axonal injury in humans. J Neurotrauma. 1994;11:173-186.
5. Gennarelli TA. Mechanisms of brain injury. J Emerg Med. 1993;11:5-11.
6. Gentleman SM, Roberts GW, Gennarelli TA. et al. Axonal injury:a universal consequence of fatal closed head injury? Acta Neuropathol. 1995;89:537-543.
7. Grady MS, McLaughlin MR, Christman CW. et al. Valadka AB, Fligner CL, Povlishock JT. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol. 1993;52:143-152.
8. Graham DI, McIntosh TK, Maxwell WL. et al. Recent advances in neurotrauma. J Neuropathol Exp Neurol. 2000;59:641-653.
9. Jafari SS, Maxwell WL, Neilson M. et al. Graham DI. Axonal cytoskeletal changes after non-disruptive axonal injury. J Neurocytol. 1997;26:207-221.
10. Jafari SS, Nielson M, Graham DI. et al. Axonal cyto - skeletal changes after nondisruptive axonal injury. II. Intermediate sized axons. J Neurotrauma. 1998;15:955-966.
11. Kampfl A, Posmantur RM, Zhao X. et al. Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: a review and update. J Neurotrauma. 1997;14:121-134.
12. Levi L, Guilburd JN, Lemberger A. et al. Soustiel JF, Feinsod M. Diffuse axonal injury: Analysis of 100 patients with radiological signs. Neurology. 1990;27:429-432.
13. Maxwell WL. Histopathological changes at central nodes of Ranvier after stretch injury. Micro Res Tech. 1996;34:522-535.
14. Maxwell WL, Domleo A, McColl G. et al. Post-acute alterations in the axonal cytoskeleton after traumatic axonal injury. J Neurotrauma. 2003;20:151-168.
15. McCracken E, Hunter AJ, Patel S. et al. Calpain activation and cytoskeletal protein breakdown in the corpus callosum in head-injured patients. J Neurotrauma. 1999;16:749-761.
16. Posmantur R, Hayes RL, Dixon CE. et al. Neurofilament 68 and Neurofilament. 200 protein levels decrease after traumatic brain injury. J Neurotrauma. 1994;11:533-545.
17. Povlishock JT. Traumatically induced axonal injury: pathogenesis and pathobiological implication. Brain Pathol. 1992;2:1-12.
18. Ross DT, Meaney DF, Sabol MK. et al. Distribution of forbrain diffuse axonal injury following closed head injury in miniature swine. Exp Neurol. 1994;126:291-299.
19. Schlaepfer WW. Neurofilaments:structure, metabolism and implication in disease. J Neuropathol Exp Neurol. 1987;46:117-129
20. Slanzinski T, Johnson MC. Severe diffuse axonal injury in adults and children. J Neurosci Nurs. 1994;26:151-154.
21. Xiao-sheng H, Sheng-yu Y, Xiang Z. et al. Diffuse axonal injury due to lateral head rotation in a rat model. J Neurosurg. 2000;93:626-633.
22. Xiaosheng H, Xiang Z, Zhou F, Luoan F. et al. Calcium overloading in traumatic axonal injury by lateral head rotation: morphological evidence in rat model. J Clin Neurosci. 2004;11:402-407.