Aggregation behavior of self-assembling polylactide/poly(ethylene glycol) micelles for sustained drug delivery

International Journal of Pharmaceutics

Volumn 394, Issue 1-2, 2010, Pages 43-49

  Yang, Liu ^a,b   Qi, Xu ^b   Liu, Pei ^b   El Ghzaoui, Abdelslam ^a   Li, Suming ^a,b  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b FUDAN UNIVERSITY   (China)

Author keywords

Aggregation number; Micelle; Poly(ethylene glycol); Polylactide; Second virial coefficient; Stereocomplexation

Indexed keywords

COPOLYMER; MACROGOL; MACROGOL 2000; MACROGOL 5000; POLYLACTIDE; POLYMER; UNCLASSIFIED DRUG; DRUG CARRIER; MACROGOL DERIVATIVE; MICELLE; POLYESTER; SOLVENT; WATER;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; HYDROPHOBICITY; LIGHT SCATTERING; MICELLE; MOLECULAR WEIGHT; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; CHEMICAL PHENOMENA; CHEMISTRY; GEL CHROMATOGRAPHY; LIGHT; PROCEDURES; RADIATION SCATTERING; TEMPERATURE;

CHROMATOGRAPHY, GEL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HYDROPHOBICITY; LIGHT; MICELLES; MOLECULAR WEIGHT; POLYESTERS; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION; SOLVENTS; TEMPERATURE; WATER; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;

EID: 77953691198     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.04.030     Document Type: Article

References (54)

1. Alexandridis P., Hatton T.A. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloid Surf. A: Physicochem. Eng. Aspects 1995, 96:1-46.
2. Altinok H., Nixon S.K., Gorry P.A., Attwood D., Booth C., Kelarakis A., Havredaki V. Micellisation and gelation of diblock copolymers of ethylene oxide and propylene oxide in aqueous solution, the effect of P-block length. Colloid Surf. B: Biointerfaces 1999, 16:73-91.
3. Brown W., Schillen K., Almgren M., Hvidt S., Bahadur P. Micelle and gel formation in a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) triblock copolymer in water solution: dynamic and static light scattering and oscillatory shear measurements. J. Phys. Chem. 1991, 95:1850-1858.
4. Burt H.M., Zhang X., Toleikis P., Embree L., Hunter W.L. Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloid Surf. B: Biointerfaces 1999, 16:161-171.
5. Castro E., Barbosa S., Juarez J., Taboada P., Katime I.A., Mosquera V. Influence of external factors on the micellization process and aggregate structure of poly(oxy)styrene-poly(oxy)ethylene block copolymers. J. Phys. Chem. B 2008, 112:5296-5304.
6. 1H NMR relaxation studies of the micellization of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution. Macromolecules 1996, 29:170-178.
7. Colombani O., Ruppel M., Burkhardt M., Drechsler M., Schumacher M., Gradzielski M., Schweins R., Muller A.H.E. Structure of micelles of poly(n-butyl acrylate)-block-poly(acrylic acid) diblock copolymers in aqueous solution. Macromolecules 2007, 40:4351-4362.
8. Dimitrov P., Jamroz-Piegza M., Trzebicka B., Dworak A. The influence of hydrophobic substitution on self-association of poly(ethylene oxide)-b-poly(n-alkyl glycidyl carbamate)s-b-poly(ethylene oxide) triblock copolymers in aqueous media. Polymer 2007, 48:1866-1874.
9. Dimitrov P., Utrata-Wesolek A., Rangelov S., Walach W., Trzebicka B., Dworak A. Synthesis and self-association in aqueous media of poly(ethylene oxide)/poly(ethyl glycidyl carbamate) amphiphilic block copolymers. Polymer 2006, 47:4905-4915.
10. Forster S., Zisenis M., Wenz E., Antonietti M. Micellization of strongly segregated block copolymers. J. Chem. Phys. 1996, 104:9956-9970.
11. Garnier S., Laschewsky A. Non-ionic amphiphilic block copolymers by RAFT-polymerization and their self-organization. Colloid Polym. Sci. 2006, 284:1243-1254.
12. Garstens M.G., van Nostrum C.F., Ramzi A., Meeldijk J.D., Verrijk R., de Leede L.G.J., Crommelin D.J.A., Hennink W.E. Poly(ethylene glycol)-oligo(l-lactate)s with monodisperse hydrophobic blocks: preparation, characterisation and behaviour in water. Langmuir 2005, 21:11446-11454.
13. Giacomelli F.C., Riegel I.C., Petzhold C.L., da Silveira N.P., Stepanek P. Aggregation behavior of a new series of ABA triblock copolymers bearing short outer A blocks in B-selective solvent: from free chains to bridged micelles. Langmuir 2009, 25:731-738.
14. Hagan S.A., Coombes A.G.A., Garnett M.C., Dunn S.E., Davies M.C., Illum L., Davis S.S. Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. 1. characterization of water dispersible micelle-forming systems. Langmuir 1996, 12:2153-2161.
15. Hamaguchi T., Matsumura Y., Suzuki M., Shimizu K., Goda R., Nakamura I., Nakatomi I., Yokoyama M., Kataoka K., Kakizoe T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer 2005, 92:1240-1246.
16. Hussain H., Mya K.Y., He C. Self-assembly of brush-like poly[poly(ethylene glycol) methyl ether methacrylate] synthesized via aqueous atom transfer radical polymerization. Langmuir 2008, 24:13279-13286.
17. Hussain H., Tan B.H., Gudipati C.S., Liu Y., He C.B., Davis T.P. Synthesis and self-assembly of poly(styrene)-b-poly(N-vinylpyrrolidone) Amphiphilic diblock copolymers made via a combined ATRP and MADIX approach. J. Polym. Sci. Part A: Polym. Chem. 2008, 46:5604-5615.
18. Iijima M., Nagasaki Y., Okada T., Kato M., Kataoka K. Core-polymerized reactive micelles from heterotelechelic amphiphilic block copolymers. Macromolecules 1999, 32:1140-1146.
19. Inoue T., Chen G., Nakamae K., Hoffman A.S. An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs. J. Control. Release 1998, 51:221-229.
20. Jeong B., Bae Y.H., Kim S.W. Biodegradable thermosensitive micelles of PEG-PLGA-PEG triblock copolymers. Colloid Surf. B: Biointerfaces 1999, 16:185-193.
21. Jie P., Venkatraman S.S., Min F., Freddy B.Y.C., Huat G.L. Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier. J. Control. Release 2005, 110:20-33.
22. Jones M.C., Leroux J.C. Polymeric micelles-a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm. 1999, 48:101-111.
23. Kang N., Perron M.E., Prud'homme R.E., Zhang Y., Gaucher G., Leroux J.C. Stereocomplex block copolymer micelles: core-shell nanostructures with enhanced stability. Nano Lett. 2005, 5:315-319.
24. Kim J.H., Nagasaki Y., Kataoka K. Preparation and core-polymerization of MePEG/PDLLA block copolymer micelle (I). J. Ind. Eng. Chem. 1998, 4:244-250.
25. Kim S.Y., Kim J.H., Kim D., An J.H., Lee D.S., Kim S.C. Drug-releasing kinetics of MPEG/PLLA block copolymer micelles with different PLLA block lengths. J. Appl. Polym. Sci. 2001, 82:2599-2605.
26. Kwon G.S., Okano T. Polymeric micelles as new drug carriers. Adv. Drug Deliv. Rev. 1996, 21:107-116.
27. La S.B., Okano T., Kataoka K. Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly(β-benzyl l-aspartate) block copolymer micelles. J. Pharm. Sci. 1996, 85:85-90.
28. Letchford K., Zastre J., Liggins R., Burt H. Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers. Colloid Surf. B: Biointerfaces 2004, 35:81-91.
29. Li S., Vert M. Synthesis, characterization, and stereocomplex-induced gelation of block copolymers prepared by ring-opening polymerization of l(d)-lactide in the presence of poly(ethylene glycol). Macromolecules 2003, 36:8008-8014.
30. Li X., Mya K.Y., Ni X., He C., Leong K.W., Li J. Dynamic and static light scattering studies on self-aggregation behavior of biodegradable amphiphilic poly(ethylene oxide)-polu[(R)-3-hydroxybutyrate]-poly(ethylene oxide) triblock copolymers in aqueous solution. J. Phys. Chem. B 2006, 110:5920-5926.
31. Liggins R.T., Burt H.M. Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. Adv. Drug Deliv. Rev. 2002, 54:191-202.
32. Liu L., Li C., Li X., Yuan Z., An Y., He B. Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers. J. Appl. Polym. Sci. 2001, 80:1976-1982.
33. Liu T., Kim K., Hsiao B.S., Chu B. Regular and irregular micelles formed by A LEL triblock copolymer in aqueous solution. Polymer 2004, 45:7989-7993.
34. Liu T., Zhou Z., Wu C., Nace V.M., Chu B., Schneider D.K. Self-assembly of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) (B6E46B6) triblock copolymer in aqueous solution. J. Phys. Chem. B 1997, 101:8808-8815.
35. n-type triblock copolymers in aqueous solution. J. Phys. Chem. B 1998, 102:2875-2882.
36. Mansur C.R.E., Oliveira C.M.F., Gonzalez G., Lucas E.F. Phase behavior of aqueous systems containg block copolymers of poly(ethylene oxide) and poly(propylene oxide). J. Appl. Polym. Sci. 1997, 66:1767-1772.
37. Matsumoto J., Nakada Y., Sakurai K., Nakamura T., Takahashi Y. Preparation of nanoparticles consisted of poly(l-lactide)-poly(ethylene glycol)-poly(l-lactide) and their evaluation in vitro. Int. J. Pharm. 1999, 185:93-101.
38. Mya K.Y., Li X., Chen L., Ni X., Li J., He C. Core-corona structure of cubic silsesquioxane-poly(ethylene oxide) in aqueous solution: fluorescence, light scattering, and TEM studies. J. Phys. Chem. B 2005, 109:9455-9462.
39. Nuopponen M., Ojala J., Tenhu H. Aggregation behaviour of well defined amphiphilic diblock copolymers with poly(N-isopropylacrylamide) and hydrophobic blocks. Polymer 2004, 45:3643-3650.
40. Paillet S., Grassl B., Desbrieres J. Rapid and quantitative determination of critical micelle concentration by automatic continuous mixing and static light scattering. Anal. Chim. Acta 2009, 636:236-241.
41. Pierri E., Avgoustakis K. Poly(lactide)-poly(ethylene glycol) micelles as a carrier for griseofulvin. J. Biomed. Mater. Res. 2005, 75A:639-647.
42. Pioge S., Fontaine L., Gaillard C., Nicol E., Pascual S. Self-assembling properties of well-defined poly(ethylene oxide)-b-poly(ethylene acrylate) diblock copolymers. Macromolecules 2009, 42:4262-4272.
43. Rijcken C.J.F., Veldhuis T.F.J., Ramzi A., Meeldijk J.D., van Nostrum C.F., Hennink W.E. Novel fast degradable thermosensitive polymeric micelles based on mPEG-block-poly(N-(2-hydroxyethyl)-methacrylamide-oligolactates). Biomacromolecules 2005, 6:2343-2351.
44. Riley T., Stolnik S., Heald C.R., Xiong C.D., Garnett M.C., Illum L., Davis S.S., Purkiss S.C., Barlow R.J., Gellert P.R. Physicochemical evaluation of nanoparticles assembled from poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) block copolymers as drug delivery vehicles. Langmuir 2001, 17:3168-3174.
45. Ruan G., Feng S.S. Prparation and characterization of poly(lactide acid)-poly(ethylene glycol)-poly(lactide acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. Biomaterials 2003, 24:5037-5044.
46. Savic R., Eisenberg A., Maysinger D. Block copolymer micelles as delivery vehicles of hydrophobic drugs: micelle-cell interactions. J. Drug Target. 2006, 14:343-355.
47. Schilli C.M., Zhang M., Rizzardo E., Thang S.H., Chong Y.K., Edwards K., Karlsson G., Muller A.H.E. A new double-responsive block copolymer synthesized via RAFT polymerization: poly(N-isopropylacrylamide)-block-poly(acrylic acid). Macromolecules 2004, 37:7861-7866.
48. Shuai X., Merdan T., Schaper A.K., Xi F., Kissel T. Core-cross-linked polymeric micelles as paclitaxel carriers. Bioconjug. Chem. 2004, 15:441-448.
49. Tanodekaew S., Pannu R., Heatley F., Attwood D., Booth C. Association and surface properties of diblock copolymers of ethylene oxide and dl-lactide in aqueous solution. Macromol. Chem. Phys. 1997, 198:927-944.
50. Wanka G., Hoffmann H., Ulbricht W. The aggregation behavior of poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers in aqueous solution. Colloid Polym. Sci. 1990, 268:101-117.
51. Yang L., Wu X., Liu F., Duan Y., Li S. Novel biodegradable polylactide/poly(ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs. Pharm. Res. 2009, 26:2332-2342.
52. Yang L., Zhao Z., Wei J., Ghzaoui A.E., Li S. Micelles formed by self-assembling of polylactide/poly(ethylene glycol) block copolymers in aqueoous solutions. J. Colloid Interface Sci. 2007, 314:470-477.
53. Yao J.H., Mya K.Y., Li X., Parameswaran M., Xu Q.H., Loh K.P., Chen Z.K. Light scattering and luminescence studies on self-aggregation behavior of amphiphilic copolymer micelles. J. Phys. Chem. B 2008, 112:749-755.
54. Zhou Z., Chu B. Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution. J. Colloid Interface Sci. 1988, 126:171-180.