The influence of protonation ratio on properties of carboxymethyl starch excipient at various substitution degrees: Structural insights and drug release kinetics

International Journal of Pharmaceutics

Volumn 394, Issue 1-2, 2010, Pages 75-84

  Assaad, Elias ^a   Mateescu, Mircea Alexandru ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

Carboxymethyl starch; Degree of substitution; Drug delivery; Excipient; Monolithic tablet; Protonation ratio

Indexed keywords

CARBOXYMETHYL STARCH; EXCIPIENT; PARACETAMOL; UNCLASSIFIED DRUG; DELAYED RELEASE FORMULATION; PROTON; STARCH; TABLET;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STORAGE; HYDROGEN BOND; INTESTINE FLUID; PH; PRIORITY JOURNAL; PROTON TRANSPORT; STOMACH JUICE; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; SUSTAINED RELEASE PREPARATION; TABLET HARDNESS; ANALOGS AND DERIVATIVES; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG STABILITY; INTESTINAL SECRETIONS; KINETICS; METABOLISM; SOLUBILITY; TABLET;

ACETAMINOPHEN; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; GASTRIC JUICE; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; KINETICS; PROTONS; SOLUBILITY; STARCH; TABLETS;

EID: 77953689091     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.04.037     Document Type: Article

References (25)

1. Barba A.A., d'Amore M., Chirico S., Lamberti G., Titomanlio G. Swelling of cellulose derivative (HPMC) matrix systems for drug delivery. Carbohydr. Polym. 2009, 78:469-474.
2. Brouillet F., Bataille B., Cartilier L. High-amylose sodium carboxymethyl starch matrices for oral, sustained drug-release: formulation aspects and in vitro drug-release evaluation. Int. J. Pharm. 2008, 356:52-60.
3. Calinescu C., Mulhbacher J., Nadeau E., Fairbrother J.M., Mateescu M.A. Carboxymethyl high amylose starch (CM-HAS) as excipients for Escherichia coli oral formulations. Eur. J. Pharm. Biopharm. 2005, 60:53-60.
4. Calinescu C., Nadeau E., Mulhbacher J., Fairbrother J.M., Mateescu M.A. Carboxymethyl high amylose starch for F4 fimbriae gastro-resistant oral formulation. Int. J. Pharm. 2007, 343:18-25.
5. Chen J., Jane J. Properties of granular cold-water-soluble starches prepared by alcoholic-alkaline treatments. Cereal Chem. 1994, 71:623-626.
6. Chiu C., Solarek D. Modification of starches. Starch: Chemistry and Technology 2009, 629-648. Elsevier, New York. J. BeMiller, R. Whistler (Eds.).
7. Colombo P., Bettini R., Catellani P.L., Santi P., Peppas N.A. Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug. Eur. J. Pharm. Sci. 1999, 9:33-40.
8. Edge S., Belu A.M., Potter U.J., Steele D.F., Young P.M., Price R., Staniforth J.N. Chemical characterisation of sodium starch glycolate particles. Int. J. Pharm. 2002, 240:67-78.
9. Harada T., Sato H., Hirashima Y., Igarashi K., Suzuki A., Goto M., Kawamura N., Tokita M. Swelling behavior of poly(sodium acrylate) gels crosslinked by aluminum ions. Colloids Surf., B 2004, 38:209-212.
10. Heinze T., Koschella A. Carboxymethyl ethers of cellulose and starch: a review. Macromol. Symp. 2005, 223:13-39.
11. Ispas-Szabo P., De Koninck P., Calinescu C., Mateescu M.A. Novel carboxymethyl starch excipients for oral dosage forms. Proceedings of the 34th Annual Meeting and Exposition of the Controlled Release Society 2007.
12. Ispas-Szabo P., Ravenelle F., Hassan I., Preda M., Mateescu M.A. Structure-properties relationship in cross-linked high-amylose starch for use in controlled drug release. Carbohydr. Res. 2000, 323:163-175.
13. Kavanagh N., Corrigan O.I. Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices-influence of agitation rate and dissolution medium composition. Int. J. Pharm. 2004, 279:141-152.
14. Lemieux M., Gosselin P., Mateescu M.A. Influence of drying method of carboxymethyl high amylose starch (CM-HAS) derivatives on physical properties and drug release profiles. 2007 AAPS Annual Meeting and Exposition 2007.
15. Lemieux M., Gosselin P., Mateescu M.A. Carboxymethyl high amylose starch as excipient for controlled drug release: mechanistic study and the influence of degree of substitution. Int. J. Pharm. 2009, 382:172-182.
16. Mulhbacher J., Ispas-Szabo P., Mateescu M.A. Cross-linked high amylose starch derivatives for drug release. II. Swelling properties and mechanistic study. Int. J. Pharm. 2004, 278:231-238.
17. Mulhbacher, J., Mateescu, M.A., Calinescu, C., 2004b. Composition comprising polymeric material and uses thereof. US Patent Application, priority 60/542,299.
18. Peppas N.A. Analysis of Fickian and no-Fickian drug release from polymers. Pharm. Acta Helv. 1985, 60:110-111.
19. Rowe R.C., Sheskey P.J., Owen S.C. Handbook of Pharmaceutical Excipients 2006, Pharmaceutical Press, London. 5th ed.
20. Silverstein R.M., Webster F.X., Kiemle D.J. Spectrometric Identification of Organic Compounds 2005, John Willey & Sons, pp. 82-110. 7th ed.
21. Stojanovic Z., Jeremic K., Jovanovic S., Lechner M.D. A comparison of some methods for the determination of the degree of substitution of carboxymethyl starch. Starch-Stärke 2005, 57:79-83.
22. US Pharmacopeia National Formulary U.S.P. XXIV, NF XIX, 2000. United States Pharmacopeial Convention Inc., Rockville, MD.
23. Wei L., Cai C., Lin J., Chen T. Dual-drug delivery system based on hydrogel/micelle composites. Biomaterials 2009, 30:2606-2613.
24. Yang C.Q. FT-IR spectroscopy study of the ester crosslinking mechanism of cotton cellulose. Text. Res. J. 1991, 61:433-440.
25. Zoldakova A., Srokova I., Sasinkova V., Hirsch J., Ebringerova A. Biosurfactants based on partially esterified O-(carboxymethyl)starch. Chem. Pap. 2005, 59:362-367.