A new method for the stereoselective construction of angular methyl group of fuzed cyclic ethers

Tetrahedron Letters

Volumn 51, Issue 30, 2010, Pages 3960-3961

  Kadota, Isao ^a   Kishi, Takayuki ^a   Fujisawa, Yuka ^a   Yamagami, Yuji ^a   Takamura, Hiroyoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Angular methyl group; Fuzed cyclic ethers; Marine polycyclic ethers; Mixed thioacetals

Indexed keywords

BENZYLIDENE DERIVATIVE; ETHER DERIVATIVE; METHYL GROUP; THIOACETALDEHYDE;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; METHYLATION; QUANTUM YIELD; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 77953683513     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.05.109     Document Type: Article

References (15)

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14. 3) δ 4.00-3.92 (m, 1H), 3.76 (ddd, J = 11.5, 11.5, 2.5 Hz, 1H), 3.75-3.70 (m, 1H), 3.36 (ddd, J = 12.4, 11.2, 2.2 Hz, 1H), 3.21-3.19 (m, 1H), 2.04-1.66 (m, 5H), 1.45-1.23 (m, 3H), 1.16 (s, 3H).
15. The substrates 7-10 were prepared from the corresponding hemiacetals by the same procedure described in the Scheme 2. The mixed thioacetal 11 was synthesized from a hydroxy dithioacetal by using the Nicolaou's protocol, see Ref. 4a.