Iron Overload: Predictor of Adverse Outcome in Hematopoietic Stem Cell Transplantation

Transplantation Proceedings

Volumn 42, Issue 5, 2010, Pages 1841-1848

  Sucak, G T ^a   Yegin, Z A ^a   Ozkurt Z N ^a   Aki, S Z ^a   Yagci M ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN;

ADOLESCENT; ADULT; ADVERSE OUTCOME; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; COMORBIDITY; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; INFECTIOUS COMPLICATION; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURVIVAL RATE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD34; FEMALE; FERRITINS; FOLLOW-UP STUDIES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IRON; IRON OVERLOAD; MALE; MIDDLE AGED; PNEUMONIA; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; TRANSFERRIN; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 77953671391     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.11.049     Document Type: Article

References (41)

1. Majhail N.S., Lazarus H.M., and Burns L.J. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant 41 (2008) 997
2. Witte T. The role of iron in patients after bone marrow transplantation. Blood Rev 22 suppl 2 (2008) S22
3. Rizzo J.D., Wingard J.R., Tichelli A., et al. Recommended screening and preventive practices for long term survivors after hematopoietic cell transplantation: Joint recommendations of the European group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 12 (2006) 138
4. Socie G., Salooja N., Cohen A., et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 101 (2003) 3373
5. Strasser S.I., Kowdley K.V., Sale G.E., et al. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 22 (1998) 167
6. Gordon L.I., Brown S.G., Tallman M.S., et al. Sequential changes in serum iron and ferritin in patients undergoing high dose chemotherapy and radiation with autologous bone marrow transplantation: possible implications for treatment related toxicity. Free Rad Biol Med 18 (1995) 383
7. Altes A., Remacha A.F., Sadra P., et al. Early clinical impact of iron overload in stem cell transplantation: a prospective study. Ann Hematol 86 (2007) 443
8. Dürken M., Nielsen P., Knobel S., et al. Non-transferrin-bound iron in serum of patients receiving bone marrow transplants. Free Rad Biol Med 22 (1997) 1159
9. Sahlstedt L., Ebeling F., Bonsdorff L.V., et al. Non-transferin-bound iron during allogeneic stem cell transplantation. Br J Haematol 113 (2001) 836
10. Armand P., Kim H.T., Cutler C.S., et al. Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood 109 (2007) 4586
11. Malcovati L. Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes. Leuk Res 31 suppl 3 (2007) S2
12. Majhail N.S., DeFor T., Lazarus H.M., et al. Iron overload after autologous hematopoieitc stem cell transplantation. Leuk Res 33 (2009) 578
13. Harrison P., Neilson J.R., Marwah S.S., et al. Role of non-transferrin-bound iron in iron overload and liver dysfunction in long term survivors of acute leukaemia and bone marrow transplantation. J Clin Pathol 49 (1996) 853
14. Ascioglu S., Rex J.H., de Pauw B., et al. Invasive Fungal Infections Cooperative Group of the European Organization for Research and Treatment of Cancer; Mycoses Study Group of the National Institute of Allergy and Infectious Diseases: Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 34 (2002) 7
15. Przepiorka D., Weisdorf D., Martin P., et al. Consensus conference on acute GVHD grading. Bone Marrow Transplant 15 (1995) 825
16. McDonald G.B., Hinds M.S., Fisher L.D., et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Int Med 118 (1993) 255
17. Mahindra A., Bolwell B., Sobecks R., et al. Elevated ferritin is associated with relapse after autologous hematopoietic stem cell transplantation for lymphoma. Biol Blood Marrow Transplant 14 (2008) 1239
18. Pullarkat V., Blanchard S., Tegtmeier B., et al. Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 42 (2008) 799
19. Altes A., Remacha A.F., Sureda A., et al. Iron overload might increase transplant related mortality in hematopoietic stem cell transplantation. Bone Marrow Transplant 29 (2002) 987
20. Altes A., Remacha A.F., Sarda P., et al. Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis. Bone Marrow Transplant 34 (2004) 505
21. Dürken M., Herrnring C., Finckh B., et al. Impaired plasma antioxidative defense and increased non-transferrin-bound iron during high dose chemotherapy and radiochemotherapy preceding bone marrow transplantation. Free Rad Biol Med 28 (2000) 887
22. Evens A.M., Mehta J., and Gordon L.I. Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplant 34 (2004) 561
23. Maertens J., Demuynck H., Verbeken E.K., et al. Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 24 (1999) 307
24. Bullen J.J., Rogers H.J., Spalding P.B., et al. Natural resistance, iron and infection: a challenge for clinical medicine. J Med Microbiol 55 (2006) 251
25. Marx J.J.M. Iron and infection: competition between host and microbes for a precious element. Best Pract Res Clin Haematol 15 (2002) 411
26. Miceli M.H., Dong L., Grazziutti M.L., et al. Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: a study of 367 myeloma patients. Bone Marrow Transplant 37 (2006) 857
27. Reyes H.M., Tingle E.J., Fenves A.Z., et al. Pulmonary invasive mucormycosis in a patient with secondary iron overload following deferoxamine therapy. Proc (Bayl Univ Med Cent) 21 (2008) 378
28. Weinberg ED. Iron loading and disease surveillance. Emerg Infect Dis 5 (1999) 346
29. Alexander J., Limaye A.P., Ko C.W., et al. Association of hepatic iron overload with invasive fungal infection in liver transplant recipients. Liver Transplant 12 (2006) 1799
30. Brandhagen D.J., Alvarez W., Therneau T.M., et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 31 (2000) 456
31. Kontoyiannis D.P., Chamilos G., Lewis R.E., et al. Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation. Cancer 110 (2007) 1303
32. Platzbecker U., Bornhauser M., Germing U., et al. Red blood cell transfusion dependence and outcome after allogeneic peripheral blood stem cell transplantation in patients with de novo myelodysplastic syndrome (MDS). Biol Blood Marrow Transplant 14 (2008) 1217
33. Kamble R., and Mims M. Iron overload in long term survivors of hematopoietic transplantation. Bone Marrow Transplant 37 (2006) 805
34. Morado M., Ojeda E., Garcia-Bustos J., et al. Serum ferritin as risk factor for veno-occlusive disease of the liver: prospective cohort study. Hematology 4 (2000) 505
35. Sucak G.T., Aki Z.S., Yaǧci M., et al. Treatment of sinusoidal obstruction syndrome with defibrotide: a single-center experience. Transplant Proc 39 (2007) 1558
36. Gaziev J., Sodani P., Polchi P., et al. Bone marrow transplantation in adults with thalassemia. Ann N Y Acad Sci 1054 (2005) 196
37. Bhatia M., and Walters M.C. Hematopoietic cell transplantation for thalassemia and sickle cell disease: past, present and future. Bone Marrow Transplant 41 (2008) 109
38. Knovich M.A., Storey J.A., Coffman L.G., et al. Ferritin for the clinician. Blood Rev 23 (2008) 95
39. Armand P., Kim H.T., Cutler C.S., et al. A prognostic score for patients with acute leukemia or myelodysplastic syndromes undergoing allogeneic stem cell transplantation. Biol Blood Marrow Transplant 14 (2008) 28
40. Kamble R.T., Selby G.B., Mims M., et al. Iron overload manifesting as apparent exacerbation of hepatic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 12 (2006) 506
41. Sucak G.T., Yegin Z.A., Ozkurt Z.N., et al. The role of liver biopsy in the workup of liver dysfunction late after SCT: is the role of iron overload underestimated?. Bone Marrow Transplant 42 (2008) 461