Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis

Bone Marrow Transplantation

Volumn 34, Issue 6, 2004, Pages 505-509

  Altes, A ^a,b   Remacha, A F ^a   Sarda, P ^a   Sancho, F J ^a   Sureda, A ^a   Martino, R ^a   Briones, J ^a   Brunet, S ^a   Canals, C ^a   Sierra, J ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b HOSPITAL DE L ESPERIT SANT   (Spain)

Author keywords

Aspergillosis; HSCT; Iron overload; TRM

Indexed keywords

CYCLOSPORIN; IRON; METHOTREXATE;

ACUTE LEUKEMIA; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; ASPERGILLOSIS; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CANCER MORTALITY; CAUSE OF DEATH; CHRONIC MYELOID LEUKEMIA; CONFIDENCE INTERVAL; DISEASE ASSOCIATION; DISEASE SEVERITY; DRY WEIGHT; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IRON OVERLOAD; LIVER HEMOSIDEROSIS; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; MYELODYSPLASTIC SYNDROME; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE;

ADULT; AGED; ASPERGILLOSIS; FEMALE; HUMANS; IRON OVERLOAD; LEUKEMIA; LIVER DISEASES; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RETROSPECTIVE STUDIES; SPAIN; STEM CELL TRANSPLANTATION;

EID: 4644309319     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704628     Document Type: Article

References (36)

1. Lucarelli G, Galimberti M, Polchi P et al. Bone marrow transplantation in patients with thalassemia. N Engl J Med 1990; 322: 417-421.
2. Angelucci E, Muretto P, Nicolucci A et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 2002; 100: 17-21.
3. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992; 119: 598-620.
4. Carmine TC, Evans P, Bruchelt G et al. Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management. Cancer Lett 1995; 94: 219-226.
5. Bullen JJ. The significance of iron in infection. Rev Infect Dis 1981; 3: 1127-1138.
6. Brissot P, Bourel M, Herry D et al. Assessment of liver iron content in 271 patients: a reevaluation of direct and indirect methods. Gastroenterology 1981; 80: 557-565.
7. Barry M, Sherlock S. Measurement of liver-iron concentration in needle-biopsy specimens. Lancet 1971; 1: 100-103.
8. Gimferrer E, Sancho FX. Las hepatosiderosis. I. Planteamientos patogénicos y diagnósticos. Bio-Ferrum 1997; 2: 53-60.
9. Ascioglu S, Rex JH, de Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002; 34: 7-14.
10. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34: 1094-1097.
11. Przepiorka D, Weisdorf D, Martin P et al. 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant 1995; 15: 825-828.
12. Sullivan KM, Agura E, Anasetti C et al. Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol 1991; 28: 250-259.
13. Altès A, Remacha AF, Sureda A et al. Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation. Bone Marrow Transplant 2002; 29: 987-989.
14. Strasser SI, Kowdley KV, Sale GE, McDonald GB. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 1998; 22: 167-173.
15. Kornreich L, Horev G, Yaniv I et al. Iron overload following bone marrow transplantation in children: MR findings. Pediatr Radiol 1997; 27: 869-872.
16. Bothwell TH, MacPhail AP. Hereditary hemochromatosis: etiologic, pathologic and clinical aspects. Semin Hematol 1998; 35: 55-71.
17. Bradley SJ, Gosriwitana I, Srichairatanakool S et al. Non-transferrin-bound iron induced by myeloablative chemotherapy. Br J Haematol 1997; 99: 337-343.
18. Sahlstedt L, Ebeling F, Bonsdorff L et al. Non-transferrin-bound iron during allogeneic stem cell transplantation. Br J Haematol 2001; 113: 836-838.
19. Griffiths E, Williams P. The iron-uptake systems of pathogenic bacteria, fungi and protozoa. In: Bullen JJ, Griffiths E (eds.). Iron and Infection. John Wiley & Sons: Chichester, 1999; pp 87-212.
20. Boelaert JR, de Locht M, Van Cutsem J et al. Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. J Clin Invest 1993; 91: 1979-1986.
21. Gifford AHT, Klippenstein JR, Moore MM. Serum stimulates growth of and proteinase secretion by Aspergillus fumigatus. Infect Immun 2002; 70: 19-26.
22. Hissen AH, Chow JM, Pinto LJ, Moore MM. Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores. Infect Immun 2004; 72: 1402-1408.
23. Eisendle M, Oberegger H, Zadra I, Haas H. The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding 1-ornithine N 5-monooxigenase (sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 2003; 49: 359-375.
24. Abe F, Katoh T, Kaneko T, Hotchi M. Effects of endotoxin (lipopolysaccharides) on experimental aspergillosis in leukemic mice. Mycopathologia 1987; 99: 95-97.
25. Okawa Y, Murata Y, Suzuki M et al. Delayed lethal response to Aspergillus fumigatus infection in sarcoma 180 tumor-bearing mice. FEMS Immunol Med Microbiol 2002; 34: 113-117.
26. Yamada K, Zoarski GH, Rothman MI et al. An intracranial aspergilloma with low signal on T2-weighted images corresponding to iron accumulation. Neuroradiology 2001; 43: 559-561.
27. Iglesias-Osma C, Gonzalez-Villaron L, San Miguel JF et al. Iron metabolism and fungal infections in patients with haematological malignancies. J Clin Pathol 1995; 48: 223-225.
28. Maertens J, Demuynck H, Verbeken EK et al. Mucormycosis in allogeneic bone marrow transplant recipients: report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 1999; 24: 307-312.
29. Brandhagen DJ, Alvarez W, Therneau TM et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation. Hepatology 2000; 31: 456-460.
30. Husni RN, Gordon SM, Longworth DL et al. Cytomegalovirus infection is a risk factor for invasive aspergillosis in lung transplant recipients. Clin Infect Dis 1998; 26: 753-755.
31. George MJ, Snydman DR, Werner BG et al. The independent role of cytomegalovirus as a risk factor for invasive fungal disease in orthotopic liver transplant recipients. Boston center for liver transplantation CMVIG study group. Am J Med 1997; 103: 106-113.
32. Marr KA, Carter RA, Boeckh M et al. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 2002; 100: 4358-4366.
33. Grow WB, Moreb JS, Roque D et al. Late onset of invasive Aspergillus infection in bone marrow transplant patients at a university hospital. Bone Marrow Transplant 2002; 29: 15-19.
34. Fukuda T, Boeckh M, Carter RA et al. Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning. Blood 2003; 102: 827-833.
35. de la Serna J, Bornstein R, García-Bueno MJ, Lahuerta-Palacios JJ. Iron depletion by phlebotomy with recombinant erythropoietin prior to allogeneic transplantation to prevent liver toxicity. Bone Marrow Transplant 1999; 23: 95-97.
36. Sahlstedt L, von Bonsdorff L, Ebeling F et al. Effective binding of free iron by a single intravenous dose of human apotransferrin in haematological stem cell transplant patients. Br J Haematol 2002; 119: 547-553.