메뉴 건너뛰기




Volumn 9, Issue 3, 2007, Pages 190-197

Mechanisms of aPL-mediated thrombosis: Effects of aPL on endothelium and platelets

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; APOLIPOPROTEIN E; ARACHIDONIC ACID; BETA2 GLYCOPROTEIN 1; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NUCLEAR FACTOR; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPASE A2; PHOSPHOLIPID ANTIBODY; THROMBOPLASTIN; THROMBOXANE; VASCULAR CELL ADHESION MOLECULE 1;

EID: 34250734572     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-007-0031-0     Document Type: Review
Times cited : (42)

References (50)
  • 1
    • 0023434038 scopus 로고
    • Syndrome of the black swan
    • Harris EN: Syndrome of the black swan. Br J Rheumatol 1987, 26:324-326.
    • (1987) Br J Rheumatol , vol.26 , pp. 324-326
    • Harris, E.N.1
  • 2
    • 0020599827 scopus 로고
    • Thrombosis in SLE: Striking associations with the presence of circulating lupus anticoagulant
    • Boey ML, Colaco CB, Gharavi AE, et al.: Thrombosis in SLE: striking associations with the presence of circulating lupus anticoagulant. Br Med J 1983, 287:1021-1023.
    • (1983) Br Med J , vol.287 , pp. 1021-1023
    • Boey, M.L.1    Colaco, C.B.2    Gharavi, A.E.3
  • 3
    • 1842783797 scopus 로고    scopus 로고
    • The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
    • McClain MT, Arbuckle MR, Heinlen LD, et al.: The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 2004, 50:1226-1232.
    • (2004) Arthritis Rheum , vol.50 , pp. 1226-1232
    • McClain, M.T.1    Arbuckle, M.R.2    Heinlen, L.D.3
  • 4
    • 0025102933 scopus 로고
    • Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: A model for autoimmune fetal loss
    • Branch DW, Dudley DJ, Mitchell MD, et al.: Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 1990, 163:210-216.
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 210-216
    • Branch, D.W.1    Dudley, D.J.2    Mitchell, M.D.3
  • 5
    • 0033586656 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    • Pierangeli SS, Colden-Stanfield M, Liu X, et al.: Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999, 99:1997-2000.
    • (1999) Circulation , vol.99 , pp. 1997-2000
    • Pierangeli, S.S.1    Colden-Stanfield, M.2    Liu, X.3
  • 6
    • 0037217897 scopus 로고    scopus 로고
    • Thrombogenicity of beta2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
    • Jankowski M, Vreys I, Wittevrongel C, et al.: Thrombogenicity of beta2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster. Blood 2003, 101:157-162.
    • (2003) Blood , vol.101 , pp. 157-162
    • Jankowski, M.1    Vreys, I.2    Wittevrongel, C.3
  • 7
    • 0037148520 scopus 로고    scopus 로고
    • C3 activation is required for anti-phospholipid antibody-induced fetal loss
    • Holers VM, Girardi G, Mo L, et al.: C3 activation is required for anti-phospholipid antibody-induced fetal loss. J Exp Med 2002, 195:211-220.
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1    Girardi, G.2    Mo, L.3
  • 8
    • 0036839070 scopus 로고    scopus 로고
    • Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis
    • Salmon JE, Girardi G, Holers VM: Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 2002, 61:46-50.
    • (2002) Ann Rheum Dis , vol.61 , pp. 46-50
    • Salmon, J.E.1    Girardi, G.2    Holers, V.M.3
  • 9
    • 22244485396 scopus 로고    scopus 로고
    • • Pierangeli SS, Girardi G, Vega-Ostertag ME, et al.: Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005, 52:2120-2124. This paper shows that complement activation (particularly C3 and C5) mediates induction of thrombosis and activation of endothelial cells by aPL.
    • • Pierangeli SS, Girardi G, Vega-Ostertag ME, et al.: Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005, 52:2120-2124. This paper shows that complement activation (particularly C3 and C5) mediates induction of thrombosis and activation of endothelial cells by aPL.
  • 10
    • 27144494245 scopus 로고    scopus 로고
    • 2-GPI requires a priming factor such as bacterial LPS and is complement dependent.
    • 2-GPI requires a priming factor such as bacterial LPS and is complement dependent.
  • 11
    • 0030897237 scopus 로고    scopus 로고
    • Endothelial cell target for antiphospholipid antibodies. Human polyclonal and monoclonal anti-b2glycoprotein I and induce endothelial cell activation
    • Del Papa N, Guidali L, Sala A, et al.: Endothelial cell target for antiphospholipid antibodies. Human polyclonal and monoclonal anti-b2glycoprotein I and induce endothelial cell activation. Arthritis Rheum 1997, 40:551-561.
    • (1997) Arthritis Rheum , vol.40 , pp. 551-561
    • Del Papa, N.1    Guidali, L.2    Sala, A.3
  • 12
    • 0028883356 scopus 로고
    • Activation of cultured vascular endothelial cells by antiphospholipid antibodies
    • Simantov E, LaSala J, Lo SK, et al.: Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995, 96:2211-2219.
    • (1995) J Clin Invest , vol.96 , pp. 2211-2219
    • Simantov, E.1    LaSala, J.2    Lo, S.K.3
  • 13
    • 0035793334 scopus 로고    scopus 로고
    • Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    • Pierangeli SS, Espinola RG, Liu X, Harris EN: Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 2001, 88:245-250.
    • (2001) Circ Res , vol.88 , pp. 245-250
    • Pierangeli, S.S.1    Espinola, R.G.2    Liu, X.3    Harris, E.N.4
  • 14
    • 0142166253 scopus 로고    scopus 로고
    • E-selectin mediated pathogenic effects of antiphospholipid antibodies
    • Espinola RG, Liu X, Colden-Stanfield M, et al.: E-selectin mediated pathogenic effects of antiphospholipid antibodies. J Thromb Haemost 2002, 1:843-848.
    • (2002) J Thromb Haemost , vol.1 , pp. 843-848
    • Espinola, R.G.1    Liu, X.2    Colden-Stanfield, M.3
  • 15
    • 0034085616 scopus 로고    scopus 로고
    • Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: Correlations with the severity of thrombosis
    • Kaplanski G, Cacoub P, Farnarier C, et al.: Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis. Arthritis Rheum 2000, 43:55-64.
    • (2000) Arthritis Rheum , vol.43 , pp. 55-64
    • Kaplanski, G.1    Cacoub, P.2    Farnarier, C.3
  • 16
    • 0033694198 scopus 로고    scopus 로고
    • Systemic endothelial cell markers in primary antiphospholipid syndrome
    • Williams FM, Parmar K, Hughes GR, Hunt BJ: Systemic endothelial cell markers in primary antiphospholipid syndrome. J Thromb Haemost 2000, 84:742-746.
    • (2000) J Thromb Haemost , vol.84 , pp. 742-746
    • Williams, F.M.1    Parmar, K.2    Hughes, G.R.3    Hunt, B.J.4
  • 17
    • 0030857363 scopus 로고    scopus 로고
    • Tissue factor in health and disease
    • Semerato N, Colucci M: Tissue factor in health and disease. Thromb Haemost 1997, 78:759-764.
    • (1997) Thromb Haemost , vol.78 , pp. 759-764
    • Semerato, N.1    Colucci, M.2
  • 18
    • 1842413134 scopus 로고    scopus 로고
    • Thrombosis in primary antiphospholipid syndrome: A pivotal role for monocyte tissue factor expression
    • Cuadrado MJ, Lopez-Pedrera C, Khamashta MA, et al.: Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression. Arthritis Rheum 1997, 40:834-841.
    • (1997) Arthritis Rheum , vol.40 , pp. 834-841
    • Cuadrado, M.J.1    Lopez-Pedrera, C.2    Khamashta, M.A.3
  • 19
    • 0031886679 scopus 로고    scopus 로고
    • The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome
    • Amengual O, Atsumi T, Khamashta MA, Hughes GR: The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb Haemost 1998, 79:276-281.
    • (1998) Thromb Haemost , vol.79 , pp. 276-281
    • Amengual, O.1    Atsumi, T.2    Khamashta, M.A.3    Hughes, G.R.4
  • 20
    • 0032700453 scopus 로고    scopus 로고
    • Increased levels of TF mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome
    • Dobado-Barrios M, Lopez-Perrara C, Velasco F, et al.: Increased levels of TF mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome. Thromb Haemost 1999, 82:1578-1582.
    • (1999) Thromb Haemost , vol.82 , pp. 1578-1582
    • Dobado-Barrios, M.1    Lopez-Perrara, C.2    Velasco, F.3
  • 21
    • 3242697048 scopus 로고    scopus 로고
    • Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    • Zhou H, Woldberg AS, Roubey RA: Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep. Blood 2004, 104:2353-2358.
    • (2004) Blood , vol.104 , pp. 2353-2358
    • Zhou, H.1    Woldberg, A.S.2    Roubey, R.A.3
  • 22
    • 14744275911 scopus 로고    scopus 로고
    • Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies
    • Forastiero RR, Martinuzzo ME, De Larranaga G: Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies. Lupus 2005, 14:129-136.
    • (2005) Lupus , vol.14 , pp. 129-136
    • Forastiero, R.R.1    Martinuzzo, M.E.2    De Larranaga, G.3
  • 23
    • 4043106414 scopus 로고    scopus 로고
    • NF-kappaB: Holy grail for rheumatoid arthritis
    • Firestein GS: NF-kappaB: Holy grail for rheumatoid arthritis. Arthritis Rheum 2004, 50:2381-2386.
    • (2004) Arthritis Rheum , vol.50 , pp. 2381-2386
    • Firestein, G.S.1
  • 24
    • 0030783156 scopus 로고    scopus 로고
    • The search for physiological substrates of MAP and SAP kinases in mammalian cells
    • Cohen P: The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 1997, 7:353-358.
    • (1997) Trends Cell Biol , vol.7 , pp. 353-358
    • Cohen, P.1
  • 25
    • 0036847630 scopus 로고    scopus 로고
    • NF-kappaB is an essential intermediate in the activation of endothelial cells by anti-beta2glycoprotein I antibodies
    • Dunoyer-Geindre S, de Moerloose P, Galve-de Rochemonteiz B, et al.: NF-kappaB is an essential intermediate in the activation of endothelial cells by anti-beta2glycoprotein I antibodies. Thromb Haemost 2002; 88:851-857.
    • (2002) Thromb Haemost , vol.88 , pp. 851-857
    • Dunoyer-Geindre, S.1    de Moerloose, P.2    Galve-de Rochemonteiz, B.3
  • 26
    • 8344267910 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2glycoprotein I antibodies
    • Bohgaki M, Atsumi T, Yamashita Y, et al.: The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2glycoprotein I antibodies. Int Immunol 2004, 16:1632-1641.
    • (2004) Int Immunol , vol.16 , pp. 1632-1641
    • Bohgaki, M.1    Atsumi, T.2    Yamashita, Y.3
  • 27
    • 18644361988 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    • Vega-Ostertag M, Casper K, Swerlick R, et al.: Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005, 52:1545-1554.
    • (2005) Arthritis Rheum , vol.52 , pp. 1545-1554
    • Vega-Ostertag, M.1    Casper, K.2    Swerlick, R.3
  • 28
    • 17644365392 scopus 로고    scopus 로고
    • Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
    • Simoncini S, Sapet C, Camoin-Jau L, et al.: Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 2004, 17:489-500.
    • (2004) Int Immunol , vol.17 , pp. 489-500
    • Simoncini, S.1    Sapet, C.2    Camoin-Jau, L.3
  • 29
    • 31044449865 scopus 로고    scopus 로고
    • Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway
    • López-Pedrera C, Buendía P, Cuadrado MJ, et al.: Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006, 54:301-311.
    • (2006) Arthritis Rheum , vol.54 , pp. 301-311
    • López-Pedrera, C.1    Buendía, P.2    Cuadrado, M.J.3
  • 30
    • 34250750888 scopus 로고    scopus 로고
    • An inhibitor of p38 mitogen-activated protein kinase abrogates procoagulant and proinflammatory effects of antiphospholipid antibodies in vivo [abstract]
    • Pierangeli SS, Vega-Ostertag ME, Liu X: An inhibitor of p38 mitogen-activated protein kinase abrogates procoagulant and proinflammatory effects of antiphospholipid antibodies in vivo [abstract]. Blood 2005, 106:43a.
    • (2005) Blood , vol.106
    • Pierangeli, S.S.1    Vega-Ostertag, M.E.2    Liu, X.3
  • 31
    • 0006722561 scopus 로고    scopus 로고
    • Human beta2glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipids binding and offers epitopes for anti-beta2glycoprotein I antibodies
    • Del Papa N, Sheng YH, Raschi E, et al.: Human beta2glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipids binding and offers epitopes for anti-beta2glycoprotein I antibodies. J Immunol 1998, 160:5572-5578.
    • (1998) J Immunol , vol.160 , pp. 5572-5578
    • Del Papa, N.1    Sheng, Y.H.2    Raschi, E.3
  • 32
    • 33745861703 scopus 로고    scopus 로고
    • A peptide that mimics the Vth region of beta2glycoprotein I reverses antiphospholipid-mediated thrombosis in mice
    • Vega Ostertag M, Liu X, Henderson V, Pierangeli SS: A peptide that mimics the Vth region of beta2glycoprotein I reverses antiphospholipid-mediated thrombosis in mice. Lupus 2006, 15:358-365.
    • (2006) Lupus , vol.15 , pp. 358-365
    • Vega Ostertag, M.1    Liu, X.2    Henderson, V.3    Pierangeli, S.S.4
  • 33
    • 14944367961 scopus 로고    scopus 로고
    • Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies
    • Zhang J, McCrae KR: Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies. Blood 2005, 105:1964-1969.
    • (2005) Blood , vol.105 , pp. 1964-1969
    • Zhang, J.1    McCrae, K.R.2
  • 34
    • 33744481250 scopus 로고    scopus 로고
    • Auto-antibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome
    • Cesarman-Maus G, Rios-Luna NP, Deora AB, et al.: Auto-antibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome. Blood 2006, 107:4375-4382.
    • (2006) Blood , vol.107 , pp. 4375-4382
    • Cesarman-Maus, G.1    Rios-Luna, N.P.2    Deora, A.B.3
  • 35
    • 14144253793 scopus 로고    scopus 로고
    • Pathogenic role of anti-b2glycoprotein I antibodies in antiphospholipid associated fetal loss: Characterization of b2glycoprotein I binding to trophoblasts cells and functional effects of anti-b2glycoprotein I antibodies in vitro
    • Di Simone N, Raschi E, Testoni C, et al.: Pathogenic role of anti-b2glycoprotein I antibodies in antiphospholipid associated fetal loss: characterization of b2glycoprotein I binding to trophoblasts cells and functional effects of anti-b2glycoprotein I antibodies in vitro. Ann Rheum Dis 2005, 64:462-467.
    • (2005) Ann Rheum Dis , vol.64 , pp. 462-467
    • Di Simone, N.1    Raschi, E.2    Testoni, C.3
  • 36
    • 0034121236 scopus 로고    scopus 로고
    • Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2glycoprotein I
    • Di Simone N, Meroni PL, Del Papa N, et al.: Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2glycoprotein I. Arthritis Rheum 2000, 43:140-151.
    • (2000) Arthritis Rheum , vol.43 , pp. 140-151
    • Di Simone, N.1    Meroni, P.L.2    Del Papa, N.3
  • 37
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi E, Testoni C, Bosisio D, et al.: Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003, 101:3495-3500.
    • (2003) Blood , vol.101 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3
  • 38
    • 34250721890 scopus 로고    scopus 로고
    • • Pierangeli SS, Vega-Ostertag ME, Raschi E, et al.: Toll-like receptor 4 is involved in antiphospholipid-mediated thrombosis: In vivo studies. Ann Rheum Dis 2007, Epub ahead of print. This study demonstrates the involvement of TLR4 in aPL-mediated effects in vivo.
    • • Pierangeli SS, Vega-Ostertag ME, Raschi E, et al.: Toll-like receptor 4 is involved in antiphospholipid-mediated thrombosis: In vivo studies. Ann Rheum Dis 2007, Epub ahead of print. This study demonstrates the involvement of TLR4 in aPL-mediated effects in vivo.
  • 39
    • 0037100538 scopus 로고    scopus 로고
    • C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils
    • Wojta J, Kaun C, Zorn G, et al.: C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils. Blood 2002, 100:517-523.
    • (2002) Blood , vol.100 , pp. 517-523
    • Wojta, J.1    Kaun, C.2    Zorn, G.3
  • 40
    • 0033009331 scopus 로고    scopus 로고
    • Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss
    • Carbone J, Orera M, Rodriguez-Mahou M, et al.: Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss. Lupus 1999, 8:274-278.
    • (1999) Lupus , vol.8 , pp. 274-278
    • Carbone, J.1    Orera, M.2    Rodriguez-Mahou, M.3
  • 41
    • 0034100612 scopus 로고    scopus 로고
    • Detection of complement-fixing antiphospholipid antibodies in association with thrombosis
    • Munakata Y, Saito T, Matsuda K, et al.: Detection of complement-fixing antiphospholipid antibodies in association with thrombosis. Thromb Haemost 2000, 83:728-731.
    • (2000) Thromb Haemost , vol.83 , pp. 728-731
    • Munakata, Y.1    Saito, T.2    Matsuda, K.3
  • 42
    • 0026706529 scopus 로고
    • Antiphospholipid antibodies and complement activation in patients with cerebral ischemia
    • Davis WD, Brey RL: Antiphospholipid antibodies and complement activation in patients with cerebral ischemia. Clin Exp Immunol 1992, 10:455-460.
    • (1992) Clin Exp Immunol , vol.10 , pp. 455-460
    • Davis, W.D.1    Brey, R.L.2
  • 43
    • 0023678887 scopus 로고
    • Immune mediated mechanism for thrombosis: Antiphospholipid antibody binding to platelet membranes
    • Khamashta MA, Harris EN, Gharavi AE, et al.: Immune mediated mechanism for thrombosis: antiphospholipid antibody binding to platelet membranes. Ann Rheum Dis 1988, 47:849-854.
    • (1988) Ann Rheum Dis , vol.47 , pp. 849-854
    • Khamashta, M.A.1    Harris, E.N.2    Gharavi, A.E.3
  • 44
    • 0028959014 scopus 로고
    • Comparison of the effect of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation
    • Campbell AL, Pierangeli SS, Wellhausen S, Harris EN: Comparison of the effect of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. Thromb Haemost 1995, 73:529-534.
    • (1995) Thromb Haemost , vol.73 , pp. 529-534
    • Campbell, A.L.1    Pierangeli, S.S.2    Wellhausen, S.3    Harris, E.N.4
  • 45
    • 0141445991 scopus 로고    scopus 로고
    • Dimers of beta2 glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′
    • Lutters BC, Derksen RH, Tekelenburg WL, et al.: Dimers of beta2 glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem 2003, 278:33831-33838.
    • (2003) J Biol Chem , vol.278 , pp. 33831-33838
    • Lutters, B.C.1    Derksen, R.H.2    Tekelenburg, W.L.3
  • 46
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    • Espinola RG, Pierangeli SS, Gharavi AE, Harris EN: Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies. Thromb Haemost 2002, 87:518-522.
    • (2002) Thromb Haemost , vol.87 , pp. 518-522
    • Espinola, R.G.1    Pierangeli, S.S.2    Gharavi, A.E.3    Harris, E.N.4
  • 47
    • 0031594156 scopus 로고    scopus 로고
    • Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: Association with increased excretion of platelet-derived thromboxane urinary metabolites
    • Forastiero R, Martinuzzo M, Carreras LO, Maclouf J: Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. Thromb Haemost 1998, 79:42-45.
    • (1998) Thromb Haemost , vol.79 , pp. 42-45
    • Forastiero, R.1    Martinuzzo, M.2    Carreras, L.O.3    Maclouf, J.4
  • 48
    • 0031594519 scopus 로고    scopus 로고
    • Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome
    • Robbins DL, Leung S, Miller-Blair DJ, ZIboh V: Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome. J Rheumatol 1998, 25:51-56.
    • (1998) J Rheumatol , vol.25 , pp. 51-56
    • Robbins, D.L.1    Leung, S.2    Miller-Blair, D.J.3    ZIboh, V.4
  • 49
    • 4444273214 scopus 로고    scopus 로고
    • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    • Vega-Ostertag M, Harris EN, Pierangeli SS: Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. Arthritis Rheum 2004, 50:2911-2919.
    • (2004) Arthritis Rheum , vol.50 , pp. 2911-2919
    • Vega-Ostertag, M.1    Harris, E.N.2    Pierangeli, S.S.3
  • 50
    • 33747023522 scopus 로고    scopus 로고
    • 2-GPI complex can directly bind GPIb on platelets and induce their activation.
    • 2-GPI complex can directly bind GPIb on platelets and induce their activation.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.