Stability and biodistribution of a biodegradable macromolecular MRI contrast agent Gd-DTPA cystamine copolymers (GDCC) in rats

Pharmaceutical Research

Volumn 27, Issue 7, 2010, Pages 1390-1397

  Wu, Xueming ^a   Zong, Yuda ^b   Ye, Zhen ^b   Lu, Zheng Rong ^a  

^a Case Western Reserve University   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Biodistribution; Gadolinium; GDCC; MRI contrast agent; Stability

Indexed keywords

CUPROUS ION; GADOBENATE DIMEGLUMINE; GADODIAMIDE; GADOLINIUM PENTETATE CYSTAMINE COPOLYMER; GADOLINIUM PENTETATE DERIVATIVE; GADOTERIDOL; UNCLASSIFIED DRUG; ZINC ION; CONTRAST MEDIUM; CYSTAMINE; GADOLINIUM PENTETATE; ORGANOMETALLIC COMPOUND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CONTRAST RADIOGRAPHY; CONTROLLED STUDY; COPPER BLOOD LEVEL; DRUG CONFORMATION; DRUG DISTRIBUTION; DRUG STABILITY; KIDNEY PARENCHYMA; LIVER; MACROMOLECULE; MALE; METALLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; ULTRAFILTRATION; URINE LEVEL; ZINC BLOOD LEVEL; ANIMAL; BIOAVAILABILITY; CHEMISTRY;

ANIMALS; BIOLOGICAL AVAILABILITY; CONTRAST MEDIA; CYSTAMINE; DRUG STABILITY; GADOLINIUM DTPA; MAGNETIC RESONANCE IMAGING; MALE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 77953621975     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0131-9     Document Type: Article

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