Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent

Pharmaceutical Research

Volumn 22, Issue 4, 2005, Pages 596-602

  Wang, Xinghe ^a   Feng, Yi ^b   Ke, Tianyi ^a   Schabel, Matthias ^c   Lu, Zheng Rong ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

(Gd DTPA) cystamine copolymers; Biodegradable macromolecular contrast agent; Gd tissue accumulation; MRI; Pharmacokinetics

Indexed keywords

CONTRAST MEDIUM; COPOLYMER; CYSTAMINE DERIVATIVE; GADODIAMIDE; GADOLINIUM; PENTETIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; BLOOD POOL SCINTISCANNING; COMPARTMENT MODEL; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG HALF LIFE; DRUG RETENTION; EVALUATION; MACROMOLECULE; MALE; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; CONTRAST MEDIA; CYSTAMINE; GADOLINIUM; GADOLINIUM DTPA; KIDNEY; MAGNETIC RESONANCE IMAGING; MALE; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 18044383907     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-2489-7     Document Type: Article

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