The molecular chaperone α-Crystallin as an excipient in an insulin formulation

Pharmaceutical Research

Volumn 27, Issue 7, 2010, Pages 1337-1347

  Rasmussen, Tue ^a,b   Tantipolphan, Ruedeeporn ^b   Van De Weert, Marco ^a   Jiskoot, Wim ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

crystallin; Fibrillation; Formulation design; Insulin; Protein excipients

Indexed keywords

ALPHA CRYSTALLIN; EXCIPIENT; HUMAN SERUM ALBUMIN; POLYSORBATE 80; RECOMBINANT HUMAN INSULIN; SUCROSE; CHAPERONE; INSULIN; SERUM ALBUMIN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG STABILITY; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OPTICAL DENSITY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY; ANIMAL; BOVINAE; CHEMISTRY; COMPARATIVE STUDY; HUMAN; MEDICINAL CHEMISTRY; SPECTROFLUOROMETRY;

ALPHA-CRYSTALLINS; ANIMALS; CATTLE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DRUG STABILITY; EXCIPIENTS; HUMANS; INSULIN; MOLECULAR CHAPERONES; SERUM ALBUMIN; SPECTROMETRY, FLUORESCENCE;

EID: 77953614892     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0116-8     Document Type: Article

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