BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity

Journal of Neuro-Oncology

Volumn 98, Issue 1, 2010, Pages 31-39

  Kramer, Frauke ^a   Stöver, Timo ^a   Warnecke, Athanasia ^a   Diensthuber, Marc ^a   Lenarz, Thomas ^a   Wissel, Kirsten ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Brain derived neurotrophic factor; Ki 67 labelling index; Neurotrophic factors; Peripheral nerve; Vestibular schwannoma

Indexed keywords

ARTEMIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN RET; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; LABELING INDEX; NERVOUS TISSUE; NEURILEMOMA; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VESTIBULAR SCHWANNOMA;

ADULT; AGED; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; KI-67 ANTIGEN; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROMA, ACOUSTIC; PERIPHERAL NERVES; RNA, MESSENGER; STATISTICS AS TOPIC; STATISTICS, NONPARAMETRIC; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UP-REGULATION; YOUNG ADULT;

EID: 77953612681     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-0063-6     Document Type: Article

References (53)

1. M Tos J Thomsen 1984 Epidemiology of acoustic neuromas J Laryngol Otol 98 685 692 10.1017/S0022215100147292 1:STN:280:DyaL2c3ms1Ghsg%3D%3D 6747450
2. DG Evans A Moran A King S Saeed N Gurusinghe R Ramsden 2005 Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought Otol Neurotol 26 93 97 10.1097/00129492-200501000-00016 15699726 (Pubitemid 40130216)
3. A Herwadker EA Vokurka DG Evans RT Ramsden A Jackson 2005 Size and growth of sporadic vestibular schwannoma: predictive value of information available at presentation Otol Neurotol 26 86 92 10.1097/00129492-200501000-00015 15699725 (Pubitemid 40130215)
4. A Gomez-Brouchet MB Delisle C Cognard JP Charlet O Deguine B Fraysse 2001 Vestibular schwannomas: correlations between magnetic resonance imaging and histopathologic appearance Otol Neurotol 22 79 86 10.1097/00129492-200101000- 00016 1:STN:280:DC%2BD3M3itVektQ%3D%3D 11314722
5. H Weerda TI Gamberger A Siegner M Gjuric ER Tamm 1998 Effects of transforming growth factor-β1 and basic fibroblast growth factor on proliferation of cell cultures derived from human vestibular nerve schwannoma Acta Otolaryngol 118 337 343 10.1080/00016489850183412 1:STN:280: DyaK1czhsl2isQ%3D%3D 9655207 (Pubitemid 28273173)
6. MR Cardillo R Filipo S Monini N Aliotta M Barbara 1999 Transforming growth factor-beta1 expression in human acoustic neuroma Am J Otol 20 65 68 1:STN:280:DyaK1M7hsVOjtQ%3D%3D 9918175
7. M Diensthuber A Brandis T Lenarz T Stover 2004 Co-expression of transforming growth factor-β1 and glial cell line-derived neurotrophic factor in vestibular schwannoma Otol Neurotol 25 359 365 10.1097/00129492- 200405000-00026 1:STN:280:DC%2BD2c3mtFGksg%3D%3D 15129118 (Pubitemid 39079821)
8. D Koutsimpelas T Stripf UR Heinrich WJ Mann J Brieger 2007 Expression of vascular endothelial growth factor and basic fibroblast growth factor in sporadic vestibular schwannomas correlates to growth characteristics Otol Neurotol 28 1094 1099 10.1097/MAO.0b013e31814b2787 17721409 (Pubitemid 350191085)
9. M Löttrich C Mawrin K Chamaon E Kirches K Dietzmann B Freigang 2007 Expression of transforming growth factor-beta receptor type 1 and type 2 in human sporadic vestibular Schwannoma Pathol Res Pract 203 245 249 10.1016/j.prp.2006.12.007 17317032 (Pubitemid 46605951)
10. L Notterpek 2003 Neurotrophins in myelination: a new role for a puzzling receptor Trends Neurosci 26 232 234 10.1016/S0166-2236(03)00099-7 1:CAS:528:DC%2BD3sXjs1Wksrg%3D 12744836 (Pubitemid 36556150)
11. SS Rosenberg BK Ng JR Chan 2006 The quest of remyelination: a new role for neurotrophins and their receptors Brain Pathol 16 288 294 10.1111/j.1750-3639.2006.00035.x 1:CAS:528:DC%2BD2sXkslKltA%3D%3D 17107598
12. T Ogata S Yamamoto K Nakamura S Tanaka 2006 Signaling axis in schwann cell proliferation and differentiation Mol Neurobiol 33 51 62 10.1385/MN:33:1:051 1:CAS:528:DC%2BD28XivFSqsL8%3D 16388110
13. EO Johnson A Charchanti PN Soucacos 2008 Nerve repair: experimental and clinical evaluation of neurotrophic factors in peripheral nerve regeneration Injury 39 Suppl 3 S37 S42 10.1016/j.injury.2008.06.015 18723170
14. SD Skaper 2008 The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors CNS Neurol Disord Drug Targets 7 46 62 10.2174/187152708783885174 1:CAS:528: DC%2BD1cXkt1anuro%3D 18289031 (Pubitemid 351516216)
15. TW Gould H Enomoto 2009 Neurotrophic modulation of motor neuron development Neuroscientist 15 105 116 10.1177/1073858408324787 1:CAS:528:DC%2BD1MXisVGqs7k%3D 19218234
16. RH Baloh MG Tansey PA Lampe TJ Fahrner H Enomoto KS Simburger M Leitner T Araki EM Johnson Jr J Milbrandt 1998 Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFR-α-Ret receptor complex Neuron 21 1291 1302 10.1016/S0896-6273(00) 80649-2 1:CAS:528:DyaK1MXntV2nsA%3D%3D 9883723 (Pubitemid 29022532)
17. PT Kotzbauer PA Lampe RO Heuckeroth JP Golden DJ Creedon EM Johnson Jr J Milbrandt 1996 Neurturin, a relative of glial cell line-derived neurotrophic factor Nature 384 467 470 10.1038/384467a0 1:CAS:528:DyaK28XnsFWqurY%3D 8945474 (Pubitemid 26414664)
18. P Akerud J Alberch S Eketjäll J Wagner E Arenas 1999 Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons J Neurochem 73 70 78 10.1046/j.1471-4159.1999.0730070.x 1:CAS:528:DyaK1MXktVelsbw%3D 10386956 (Pubitemid 29289112)
19. R Andres A Forgie S Wyatt Q Chen FJ de Sauvage AM Davies 2001 Multiple effects of artemin on sympathetic neurone generation, survival and growth Development 128 3685 3695 1:CAS:528:DC%2BD3MXnvVejsro%3D 11585795
20. M Paveliev MS Airaksinen M Saarma 2004 GDNF family ligands activate multiple events during axonal growth in mature sensory neurons Mol Cell Neurosci 25 453 459 10.1016/j.mcn.2003.11.010 1:CAS:528:DC%2BD2cXitFKmsbY%3D 15033173 (Pubitemid 38366410)
21. Z Zhou X Peng DJ Fink M Mata 2009 HSV-mediated transfer of artemin overcomes myelin inhibition to improve outcome after spinal cord injury Mol Ther 17 1173 1179 10.1038/mt.2009.52 1:CAS:528:DC%2BD1MXjt1Ggt70%3D 19293775
22. CA Kiszewski E Becceril J Baquera LD Aguilar R Hernandez-Pando 2003 Expression of transforming growth factor-β isoforms and their receptors in lepromatous and tuberculoid leprosy Scand J Immunol 57 279 285 10.1046/j.1365-3083.2003.01210.x 1:CAS:528:DC%2BD3sXjtVelu7Y%3D 12641657 (Pubitemid 36356821)
23. A Wimmel B Wiedenmann S Rosewicz 2003 Autocrine growth inhibition by transforming growth factor β1 (TGF-β1) in human neuroendocrine tumor cells Gut 52 1308 1316 10.1136/gut.52.9.1308 1:CAS:528:DC%2BD3sXnsFCgtL8%3D 12912863 (Pubitemid 37026464)
24. W Henke K Herdel K Jung D Schnorr SA Loening 1997 Betaine improves the PCR amplification of GC-rich DNA sequences Nucleic Acids Res 25 3957 3958 10.1093/nar/25.19.3957 1:CAS:528:DyaK2sXmsF2ntrc%3D 9380524 (Pubitemid 27420509)
25. PH Aguiar M Tatagiba E Dankoweit-Timpe C Matthies M Samii H Ostertag 1995 Proliferative activity of acoustic neurilemomas without neurofibromatosis determined by monoclonal antibody MIB-1 Acta Neurochir 134 35 39 10.1007/BF01428499 1:STN:280:DyaK2MzpslKksA%3D%3D
26. PH Aguiar M Tatagiba M Samii E Dankoweit-Timpe H Ostertag 1995 The comparison between the growth fraction of bilateral vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibular schwannomas using the monoclonal antibody MIB-1 Acta Neurochir 134 40 45 10.1007/BF01428500 1:STN:280:DyaK2MzpslKksQ%3D%3D
27. S Charabi L Klinken M Tos J Thomsen 1994 Histopathology and growth pattern of cystic acoustic neuromas Laryngoscope 104 1348 1352 10.1288/00005537-199411000-00006 1:STN:280:DyaK2M%2FlslOlsA%3D%3D 7968163
28. J Mukherjee D Kamnasaran A Balasubramaniam I Radovanovic G Zadeh TR Kiehl A Guha 2009 Human schwannomas express activated platelet-derived growth factor receptors and c-kit and growth inhibited by Gleevec (Imatinib mesylate) Cancer Res 69 5099 5107 10.1158/0008-5472.CAN-08-4475 1:CAS:528:DC%2BD1MXnt1equrw%3D 19509233
29. H Cravioto 1969 The ultrastructure of acoustic nerve tumors Acta Neuropathol 12 116 140 10.1007/BF00692501 1:STN:280:DyaF1M3hvFSgtw%3D%3D 5789731
30. AJ Ridley JB Davis P Stroobant H Land 1989 Transforming growth factors beta 1 and beta 2 are mitogens for rat Schwann cells J Cell Biol 109 3419 3424 10.1083/jcb.109.6.3419 1:CAS:528:DyaL1MXmt1Gqsbs%3D 2557356 (Pubitemid 20017991)
31. S Einheber MJ Hannocks CN Metz DB Rifkin JL Salzer 1995 Transforming growth factor-beta 1 regulates axon/Schwann cell interactions J Cell Biol 129 443 458 10.1083/jcb.129.2.443 1:CAS:528:DyaK2MXkvFCis70%3D 7536747
32. V Guenard LA Gwynn PM Wood 1995 Transforming growth factor-beta blocks myelination but not ensheathment of axons by Schwann cells in vitro J Neurosci 15 419 428 1:CAS:528:DyaK2MXjtFeju7s%3D 7823146
33. M Bizzarri R Filipo MG Valente D Bernardeschi F Ronchetti S Monini I Chiappini M Barbara 2002 Release of transforming growth factor beta-1 in a vestibular schwannoma cell line Acta Otolaryngol 122 785 787 10.1080/003655402/000028049 12484657 (Pubitemid 35398892)
34. T Iwase CG Jung H Bae M Zhang B Soliven 2005 Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells J Neurochem 94 1488 1499 10.1111/j.1471-4159.2005.03290.x 1:CAS:528:DC%2BD2MXhtVaksbrM 16086701 (Pubitemid 41324633)
35. GO Ceyhan NA Giese M Erkan AG Kerscher MN Wente T Giese MW Büchler H Friess 2006 The neurotrophic factor artemin promotes pancreatic cancer invasion Ann Surg 244 274 281 10.1097/01.sla.0000217642.68697.55 16858191 (Pubitemid 44305543)
36. S Dooley H Weng PR Mertens 2009 Hypotheses on the role of transforming growth factor-beta in the onset and progression of hepatocellular carcinoma Dig Dis 27 93 101 10.1159/000218340 19546546
37. H Futami R Sakai 2009 RET protein promotes non-adherent growth of NB-39-nu neuroblastoma cell line Cancer Sci 100 1034 1039 10.1111/j.1349-7006. 2009.01143.x 1:CAS:528:DC%2BD1MXntlSjt7Y%3D 19320641
38. WH Ng GQ Wan ZN Peng HP Too 2009 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas J Clin Neurosci 16 427 436 10.1016/j.jocn.2008.06. 002 1:CAS:528:DC%2BD1MXhs1arsbk%3D 19138852
39. S Qiao T Iwashita M Ichihara Y Murakumo A Yamaguchi M Isogai K Sakata M Takahashi 2009 Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis Clin Neuropathol 28 105 112 1:STN:280:DC%2BD1M3msF2hsQ%3D%3D 19353842
40. JR Chan JM Cosgaya YK Wu EM Shooter 2001 Neurotrophins are key mediators of myelination program in the peripheral nervous system Proc Natl Acad Sci USA 98 14661 14668 10.1073/pnas.251543398 1:CAS:528:DC%2BD3MXptFCksb0%3D 11717413 (Pubitemid 33121448)
41. NTR as a positive modulator of myelination Science 298 1245 1248 10.1126/science.1076595 1:CAS:528:DC%2BD38XosVeru74%3D 12424382 (Pubitemid 35285494)
42. RJ Tolwani JM Cosgaya S Varma R Jacob LE Kuo EM Shooter 2004 BDNF overexpression produces a long-term increase in myelin formation in the peripheral nervous system J Neurosci Res 77 662 669 10.1002/jnr.20181 1:CAS:528:DC%2BD2cXnsVKmt74%3D 15352212 (Pubitemid 39194607)
43. DM de Groot AJ Coenen A Verhofstad F van Herp GJ Martens 2006 In vivo induction of glial cell proliferation and axonal outgrowth and myelination by brain-derived neurotrophic factor Mol Endocrinol 20 2987 2998 10.1210/me.2006-0168 16887884 (Pubitemid 44833550)
44. J Xiao AW Wong MM Willingham SK Kaasinen IA Hendry J Howitt U Putz GL Barrett TJ Kilpatrick SS Murray 2009 BDNF exerts contrasting effects on peripheral myelination of NGF-dependent and BDNF-dependent DRG neurons J Neurosci 29 4016 4022 10.1523/JNEUROSCI.3811-08.2009 1:CAS:528: DC%2BD1MXktlakt7o%3D 19339597
45. BL Hempstead JL Salzer 2002 A glial spin on neurotrophins Science 298 1184 1186 10.1126/science.1078709 1:CAS:528:DC%2BD38Xptlyrsr8%3D 12424359 (Pubitemid 35285470)
46. XF Zhou HY Li 2007 Roles of glial p75NTR in axonal regeneration J Neurosci Res 85 1601 1605 10.1002/jnr.21220 1:CAS:528:DC%2BD2sXmsFeqsb8%3D 17335080 (Pubitemid 46849607)
47. B Bonetti L Panzeri M Carner G Zamboni N Rizzuto G Moretto 1997 Human neoplastic Schwann cells: changes in the expression of neurotrophins and their low-affinity receptor p75 Neuropathol Appl Neurobiol 23 380 386 10.1111/j.1365-2990.1997.tb01312.x 1:CAS:528:DyaK2sXntlygurw%3D 9364463
48. J Gerdes H Lemke H Baisch HH Wacker U Schwab H Stein 1984 Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67 J Immunol 133 1710 1715 1:STN:280: DyaL2c3ptVKgtA%3D%3D 6206131
49. K Niemczyk FM Vaneecloo MH Lecomte JP Lejeune L Lemaitre H Skarzynski C Vincent F Dubrulle 2000 Correlation between Ki-67 index and some clinical aspects of acoustic neuromas (vestibular schwannomas) Otolaryngol Head Neck Surg 123 779 783 10.1067/mhn.2000.111356 1:STN:280:DC%2BD3M%2Fnt1Sjug%3D%3D 11112979
50. H Steinhart F Triebswetter S Wolf H Gress J Bohlender H Iro 2003 Das Wachstum von Schwannomen des Nervus vestibularis korreliert mit der Zellproliferation Laryngo Rhino Otol 82 318 321 10.1055/s-2003-39722 1:STN:280:DC%2BD3s3nt1Kqtg%3D%3D (Pubitemid 36753070)
51. BF O'Reilly A Kishore JA Crowther C Smith 2004 Correlation of the growth factor receptor expression with clinical growth in vestibular schwannoma Otol Neurotol 25 791 796 10.1097/00129492-200409000-00024 15354013 (Pubitemid 39223258)
52. Russel DS, Rubinstein LJ (1989) Pathology of tumors of the nervous system, 5th edn. Edward Arnold, London, pp 533-560
53. Jänisch W, Güthert H, Schreiber D (1976) Pathologie der Tumoren des Zentralnervensystems. Gustav Fischer, Jena, pp 260-269