Activation of Protease Activated Receptor 2 by Exogenous Agonist Exacerbates Early Radiation Injury in Rat Intestine

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 4, 2010, Pages 1206-1212

  Wang, Junru ^a   Boerma, Marjan ^a   Kulkarni, Ashwini ^a   Hollenberg, Morley D ^b,c   Hauer Jensen, Martin ^a,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Intestines; PAR2 activating peptide; PAR2 agonist; protease activated receptor 2; radiation injury

Indexed keywords

IMMUNOHISTOCHEMICAL ANALYSIS; INTRAPERITONEALLY; MITOGENIC; MORPHOMETRY; PAR2 AGONIST; PROTEASE ACTIVATED RECEPTORS; PROTEASE-ACTIVATED RECEPTOR 2; RADIATION INJURY; RADIATION-INDUCED; SIDE EFFECT; SINGLE-DOSE; SMALL BOWEL; TREATMENT GROUP; WALL THICKNESS;

CHEMICAL ACTIVATION; IRRADIATION; PEPTIDES;

RADIATION;

AMIDE; PEPTIDE; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ENTEROPATHY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE WALL; MALE; MORPHOMETRICS; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RAT;

ANIMALS; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; OLIGOPEPTIDES; RADIATION INJURIES, EXPERIMENTAL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-2; UP-REGULATION;

EID: 77953599257     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.12.075     Document Type: Article

References (36)

1. Wang J., Zheng H., Hollenberg M.D., et al. Upregulation and activation of proteinase-activated receptor-2 (PAR-2) in early and delayed radiation injury in the rat intestine: Influence of biological PAR-2 activators. Radiat Res 160 (2003) 524-535
2. Hollenberg M.D., and Compton S.J. for the International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54 (2002) 203-217
3. Vergnolle N., Wallace J.L., Bunnett N.W., et al. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 22 (2001) 146-152
4. Hauer-Jensen M., Poulakos L., and Osborne J.W. Effects of accelerated fractionation on radiation injury of the small intestine: A new rat model. Int J Radiat Oncol Biol Phys 14 (1988) 1205-1212
5. Al-Ani B., Saifeddine M., Kawabata A., et al. Proteinase-activated receptor 2 (PAR2): Development of a ligand-binding assay correlating with activation of PAR2 by PAR1 and PAR2-derived peptide ligands. J Pharmacol Exp Ther 290 (1999) 753-760
6. Kennedy R.H., Melchert R.B., and Joseph J. Cardiovascular effects of hyperhomocysteinemia in conscious unrestrained rats. Am J Hypertens 19 (2006) 94-97
7. Langberg C.W., Sauer T., Reitan J.B., et al. Relationship between intestinal fibrosis and histopathologic and morphometric changes in consequential and late radiation enteropathy. Acta Oncol 35 (1996) 81-87
8. Baddeley A.J., Gundersen H.J., and Cruz-Orive L.M. Estimation of surface area from vertical sections. J Microsc 142 (1986) 259-276
9. Wang J., Zheng H., Ou X., et al. Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: Possible link between endothelial dysfunction and chronic radiation fibrosis. Am J Pathol 160 (2002) 2063-2072
10. Zheng H., Wang J.R., Koteliansky V.E., et al. Recombinant soluble transforming growth factor beta type II receptor ameliorates radiation enteropathy in mice. Gastroenterology 119 (2000) 1286-1296
11. Boughton-Smith N.K., Wallace J.L., Whittle B.J., et al. Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease. Agents Actions 25 (1988) 115-123
12. Zheng H., Wang J., and Hauer-Jensen M. Role of mast cells in early and delayed radiation injury in rat intestine. Radiat Res 153 (2000) 533-539
13. Raviv G., Kiss R., Vanegas J.P., et al. Objective measurement of the different collagen types in the corpus cavernosum of potent and impotent men: An immunohistochemical staining with computerized-image analysis. World J Urol 15 (1997) 50-55
14. Wang J., Zheng H., and Hauer-Jensen M. Influence of short-term octreotide administration on chronic tissue injury, transforming growth factor β (TGF-β) overexpression, and collagen accumulation in irradiated rat intestine. J Pharmacol Exp Ther 297 (2001) 35-42
15. Richter K.K., Langberg C.W., Sung C.C., et al. Association of transforming growth factor beta: immunoreactivity with specific histopathologic lesions in subacute and chronic experimental radiation enteropathy. Radiother Oncol 39 (1996) 243-251
16. MacFarlane S.R., Seatter M.J., Kanke T., et al. Proteinase-activated receptors. Pharmacol Rev 53 (2001) 245-282
17. McGuire J.J., Saifeddine M., Triggle C.R., et al. 2-Furoyl-LIGRLO-amide: A potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 309 (2004) 1124-1131
18. 2 that regulates intestinal transport. Proc Natl Acad Sci USA 95 (1998) 7766-7771
19. Corvera C.U., Déry O., McConalogue K., et al. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 100 (1997) 1383-1393
20. Mirza H., Yatsula V., and Bahou W.F. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. J Clin Invest 97 (1996) 1705-1714
21. Akers I.A., Parsons M., Hill M.R., et al. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol 278 (2000) L193-L201
22. Emilsson K., Wahlestedt C., Sun M.K., et al. Vascular effects of proteinase-activated receptor 2 agonist peptide. J Vasc Res 34 (1997) 267-272
23. Kawabata A., Kuroda R., Minami T., et al. Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw. Br J Pharmacol 125 (1998) 419-422
24. Bueno L., and Fioramonti J. Protease-activated receptor 2 and gut permeability. Neurogastroenterol Motil 20 (2008) 580-587
25. 2 in pain and inflammation. Trends Pharmacol Sci 23 (2002) 153-155
26. Storck J., Kusters B., Vahland M., et al. Trypsin induced von Willebrand factor release from human endothelial cells is mediated by PAR-2 activation. Thromb Res 84 (1996) 463-473
27. Vergnolle N. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. J Immunol 163 (1999) 5064-5069
28. Jacob C., Yang P.C., Darmoul D., et al. Mast cell tryptase controls paracellular permeability of the intestine: Role of protease-activated receptor 2 and beta-arrestins. J Biol Chem 280 (2005) 31936-31948
29. Cenac N., Coelho A.M., Nguyen C., et al. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol 161 (2002) 1903-1915
30. Cottrell G.S., Amadesi S., Pikios S., et al. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology 132 (2007) 2422-2437
31. Hyun E., Andrade-Gordon P., Steinhoff M., et al. Protease-activated receptor-2 activation: A major actor in intestinal inflammation. Gut 57 (2008) 1222-1229
32. Cataruzza F., Cenac N., Barocelli E., et al. Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Am J Pathol 169 (2006) 177-188
33. Fiorucci S., Mencarelli A., Palazzetti B., et al. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci USA 98 (2001) 13936-13941
34. Dulon S., Cande C., Bunnett N.W., et al. Proteinase-activated receptor-2 and human lung epithelial cells: Disarming by neutrophil serine proteinases. Am J Respir Cell Mol Biol 28 (2003) 339-346
35. Fukuzumi T., Waki N., Kanakura Y., et al. Differences in irradiation susceptibility and turnover between mucosal and connective tissue-type mast cells of mice. Exp Hematol 18 (1990) 843-847
36. Albrecht M., Muller K., Kohn F.M., et al. Ionizing radiation induces degranulation of human mast cells and release of tryptase. Int J Radiat Biol 83 (2007) 535-541