메뉴 건너뛰기




Volumn 35, Issue 1, 2010, Pages 27-33

Molecular therapy of pancreatic cancer

Author keywords

Carcinoma, pancreatic ductal; Clinical trials as topic; Surgical procedures, operative

Indexed keywords

ANTINEOPLASTIC AGENT; AXITINIB; BEGACESTAT; BEVACIZUMAB; BRYOSTATIN 1; CAPECITABINE; CETUXIMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; ETALOCIB; FOCAL ADHESION KINASE INHIBITOR; GEMCITABINE; GV 1001; MRK 003; NOTCH RECEPTOR; OXALIPLATIN; PACLITAXEL; PLACEBO; PROTEIN S 100; S 100 P; SOMATOMEDIN C RECEPTOR; SORAFENIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VATALANIB;

EID: 77953581007     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (41)
  • 3
    • 0036883940 scopus 로고    scopus 로고
    • Pancreastic cancer biology and genetics
    • Bardeesy N, DePinho RA. Pancreastic cancer biology and genetics. Nat Rev Cancer 2002;2:897-909.
    • (2002) Nat Rev Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 5
    • 0030870485 scopus 로고    scopus 로고
    • Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer
    • Noble S, Goa KL. Gemcitabine: a review of its pharmacology and clinical potential in non-small lung cancer and pancreatic cancer. Drugs 1997;54:447-72. (Pubitemid 27395596)
    • (1997) Drugs , vol.54 , Issue.3 , pp. 447-472
    • Noble, S.1    Goa, K.L.2
  • 6
    • 18844375044 scopus 로고    scopus 로고
    • Treatment for pancreatic cancer: Curent therapy and continued progress
    • Lockhart AC, Rothenberg ML, Berlin JD. Treatment for pancreatic cancer: curent therapy and continued progress. Gastroenterology. 2005;128:1642-54.
    • (2005) Gastroenterology , vol.128 , pp. 1642-1654
    • Lockhart, A.C.1    Rothenberg, M.L.2    Berlin, J.D.3
  • 8
    • 34250180939 scopus 로고    scopus 로고
    • Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: A randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Cebtral European Cooperative Oncology Group
    • Herrmann R, Bodoky G, Ruhstaller T, Glimelius B, Bajetta E, Schüller J et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Cebtral European Cooperative Oncology Group. J Clin Oncol 2007;24:2212-7.
    • (2007) J Clin Oncol , vol.24 , pp. 2212-2217
    • Herrmann, R.1    Bodoky, G.2    Ruhstaller, T.3    Glimelius, B.4    Bajetta, E.5    Schüller, J.6
  • 9
    • 73949135518 scopus 로고    scopus 로고
    • Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol 2009;27:5513-8.
    • (2009) J Clin Oncol , vol.27 , pp. 5513-5518
    • Cunningham, D.1    Chau, I.2    Stocken, D.D.3    Valle, J.W.4    Smith, D.5    Steward, W.6
  • 10
    • 77949647348 scopus 로고    scopus 로고
    • Targeted therapies for pancreatic cancer
    • Phillip PA. Targeted therapies for pancreatic cancer. Gastrintest Cancer Res 2008;2:15-9.
    • (2008) Gastrintest Cancer Res , vol.2 , pp. 15-19
    • Phillip, P.A.1
  • 11
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compraed with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trail of the National Cancer Institute of Canada Clinicial Trials Group
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S et al. Erlotinib plus gemcitabine compraed with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trail of the National Cancer Institute of Canada Clinicial Trials Group. J Clin Oncol 2007;25:1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6
  • 12
    • 77953599829 scopus 로고    scopus 로고
    • Erlotinib 150mg daily plus chemotherapy in advanced pancreatic cancer: An interim safety analysis of a multicenter, randomized, cross-over phase III trial of the Arbeitsgemeinschaft Internistische Onkologie
    • Epup ahead of print
    • Boeck S, Vehling-Kaiser U, Waldschmidt D, Kettner E, Märten A, Winkelmann C et al. Erlotinib 150mg daily plus chemotherapy in advanced pancreatic cancer: an interim safety analysis of a multicenter, randomized, cross-over phase III trial of the Arbeitsgemeinschaft Internistische Onkologie. Anticancer Drug 2009; Epup ahead of print.
    • (2009) Anticancer Drug
    • Boeck, S.1    Vehling-Kaiser, U.2    Waldschmidt, D.3    Kettner, E.4    Märten, A.5    Winkelmann, C.6
  • 13
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer. A multicenter phase II Trial
    • Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer. A multicenter phase II Trial. J Clin Oncol 2004;22:2610-6.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6
  • 14
    • 37549027274 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: A randomised, multicentre, phase II trial
    • Cascinu S, Berardi R, Labianca R, Siena S, Falcone A, Aitini E et al. Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial. Lancet Oncol 2008;9:39-44.
    • (2008) Lancet Oncol , vol.9 , pp. 39-44
    • Cascinu, S.1    Berardi, R.2    Labianca, R.3    Siena, S.4    Falcone, A.5    Aitini, E.6
  • 15
    • 63949086163 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: A multicentre phase II study
    • Kullmann F, Hollerbach S, Dollinger MM, Harder J, Fuchs M, Messmann H et al. Cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line metastatic pancreatic cancer: a multicentre phase II study. Br J Cancer 2009;7:1032-6.
    • (2009) Br J Cancer , vol.7 , pp. 1032-1036
    • Kullmann, F.1    Hollerbach, S.2    Dollinger, M.M.3    Harder, J.4    Fuchs, M.5    Messmann, H.6
  • 16
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 17
    • 0036531923 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer
    • Baker CH, Solorzano CC, Fidler IJ. Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res 2002;62:1996-2003.
    • (2002) Cancer Res , vol.62 , pp. 1996-2003
    • Baker, C.H.1    Solorzano, C.C.2    Fidler, I.J.3
  • 18
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler HL, Friberg G, Singh DA, Locker G, Nattam S, Kozloff M et al. Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005;23:8033-40.
    • (2005) J Clin Oncol , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3    Locker, G.4    Nattam, S.5    Kozloff, M.6
  • 19
    • 0035217589 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
    • Solorzano CC, Baker CH, Bruns CJ, Killion JJ, Ellis LM, Wood J et al. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother. Radiopharm 2001;16:359-370. (Pubitemid 33151113)
    • (2001) Cancer Biotherapy and Radiopharmaceuticals , vol.16 , Issue.5 , pp. 359-370
    • Solorzano, C.C.1    Baker, C.H.2    Bruns, C.J.3    Killion, J.J.4    Ellis, L.M.5    Wood, J.6    Fidler, I.J.7
  • 20
    • 31544460436 scopus 로고    scopus 로고
    • Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A., Takimoto CH, Piccart M, Schwartz B, Giannaris T et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 2006;12:144-51.
    • (2006) Clin Cancer Res , vol.12 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3    Piccart, M.4    Schwartz, B.5    Giannaris, T.6
  • 21
    • 65549142508 scopus 로고    scopus 로고
    • Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines
    • Ulivi P, Arienti C, Amadori D, Fabbri F, Carloni S, Tesei A et al. Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines. J Cell Physiol 2009;220:214-21.
    • (2009) J Cell Physiol , vol.220 , pp. 214-221
    • Ulivi, P.1    Arienti, C.2    Amadori, D.3    Fabbri, F.4    Carloni, S.5    Tesei, A.6
  • 22
    • 45449090215 scopus 로고    scopus 로고
    • Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: An open-label randomised phase II study
    • Spano JP, Chodkiewicz C, Maurel J, Wong R, Wasan H, Barone C et al. Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet 2008;371:2101-8.
    • (2008) Lancet , vol.371 , pp. 2101-2108
    • Spano, J.P.1    Chodkiewicz, C.2    Maurel, J.3    Wong, R.4    Wasan, H.5    Barone, C.6
  • 23
    • 19944427548 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines
    • Fukasawa M, Korc M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin. Cancer Res 2005;11:407-9.
    • (2005) Clin. Cancer Res , vol.11 , pp. 407-409
    • Fukasawa, M.1    Korc, M.2
  • 24
    • 73949102694 scopus 로고    scopus 로고
    • Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer
    • Epub ahead of print
    • Starling N, Watkins D, Cunningham D, Thomas J, Webb J, Brown G et al. Dose finding and early efficacy study of gemcitabine plus capecitabine in combination with bevacizumab plus erlotinib in advanced pancreatic cancer. J Clin Oncol 2009; [Epub ahead of print].
    • (2009) J Clin Oncol
    • Starling, N.1    Watkins, D.2    Cunningham, D.3    Thomas, J.4    Webb, J.5    Brown, G.6
  • 25
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, Humblet Y,Gill S, Van Laethem JL et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;13:2231-7.
    • (2009) J Clin Oncol , vol.13 , pp. 2231-2237
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3    Humblet, Y.4    Gill, S.5    Van Laethem, J.L.6
  • 26
    • 0037376416 scopus 로고    scopus 로고
    • An overwiew of the Notch signaling pathway
    • Baron M. An overwiew of the Notch signaling pathway. Semin Cell Dec Biol 2003;14:113-9.
    • (2003) Semin Cell Dec Biol , vol.14 , pp. 113-119
    • Baron, M.1
  • 27
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999;284:770-6.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 28
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003;6:565-76.
    • (2003) Cancer Cell , vol.6 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3    Zechner, U.4    Argani, P.5    Iacobuzio-Donahue, C.A.6
  • 29
    • 65249125270 scopus 로고    scopus 로고
    • Inhibition of?-Secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    • Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV et al. Inhibition of ?-Secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology 2009;136:1741-9.
    • (2009) Gastroenterology , vol.136 , pp. 1741-1749
    • Plentz, R.1    Park, J.S.2    Rhim, A.D.3    Abravanel, D.4    Hezel, A.F.5    Sharma, S.V.6
  • 30
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells
    • Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res 2006;66:2778-84.
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 31
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;3:483-93.
    • (2006) Mol Cancer Ther , vol.3 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 32
    • 20344407571 scopus 로고    scopus 로고
    • Immunotherapy for pancreatic cancer - Science driving clinical progress
    • Laheru D, Jaffee EM. Immunotherapy for pancreatic cancer - science driving clinical progress. Nat Rev Cancer 2005;5:459-67.
    • (2005) Nat Rev Cancer , vol.5 , pp. 459-467
    • Laheru, D.1    Jaffee, E.M.2
  • 33
    • 40949157885 scopus 로고    scopus 로고
    • Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastastic pancreatic cancer: A pilot study of safety, feasibility, and immune activation
    • Laheru D, Lutz E, Burke J, Biedrzycki B, Solt S, Onners B, Tartakovsky I, et al. Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastastic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Can Res 2008;14:1455-63.
    • (2008) Clin Can Res , vol.14 , pp. 1455-1463
    • Laheru, D.1    Lutz, E.2    Burke, J.3    Biedrzycki, B.4    Solt, S.5    Onners, B.6    Tartakovsky, I.7
  • 34
    • 69549120297 scopus 로고    scopus 로고
    • Randomized double-blind phase II trial comparing gemcitabine plus LY293111 versus gemcitabine plus placebo in advanced adenocarcinoma of the pancreas
    • Saif MW, Oettle H, Vervenne WL, Thomas JP, Spitzer G, Visseren-Grul C et al. Randomized double-blind phase II trial comparing gemcitabine plus LY293111 versus gemcitabine plus placebo in advanced adenocarcinoma of the pancreas. Cancer J 2009;4:339-43.
    • (2009) Cancer J , vol.4 , pp. 339-343
    • Saif, M.W.1    Oettle, H.2    Vervenne, W.L.3    Thomas, J.P.4    Spitzer, G.5    Visseren-Grul, C.6
  • 35
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study
    • Bernhardt SL, Gjertsen MK, Trachsel S, Möller M, Eriksen JA, Meo M et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer 2006;95:1474-82.
    • (2006) Br J Cancer , vol.95 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3    Möller, M.4    Eriksen, J.A.5    Meo, M.6
  • 36
    • 33845906040 scopus 로고    scopus 로고
    • Effect of chromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models
    • Arumugan T, Ramachandran V, Logsdon CD. Effect of chromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models. J natl Cancer Inst 2006;95:1806-18.
    • (2006) J Natl Cancer Inst , vol.95 , pp. 1806-1818
    • Arumugan, T.1    Ramachandran, V.2    Logsdon, C.D.3
  • 38
    • 77953572150 scopus 로고    scopus 로고
    • Vascular targeting by EndoTAG-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer
    • Epub ahead of print
    • Eichhorn ME, Ischenko I, Luedemann S, Strieth S, Papyan A, Werner A et al. Vascular targeting by EndoTAG-1 enhances therapeutic efficacy of conventional chemotherapy in lung and pancreatic cancer. Int J Cancer 2009 [Epub ahead of print.
    • (2009) Int J Cancer
    • Eichhorn, M.E.1    Ischenko, I.2    Luedemann, S.3    Strieth, S.4    Papyan, A.5    Werner, A.6
  • 39
    • 77951078231 scopus 로고    scopus 로고
    • Phase II study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma
    • Epub ahead of print
    • Lam AP, Sparano JA, Vinciguerra V, Ocean AJ, Christos P, Hochster H et al. Phase II study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma. Am J Clin Oncol 2009 [Epub ahead of print].
    • (2009) Am J Clin Oncol
    • Lam, A.P.1    Sparano, J.A.2    Vinciguerra, V.3    Ocean, A.J.4    Christos, P.5    Hochster, H.6
  • 40
    • 73949107880 scopus 로고    scopus 로고
    • Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment
    • Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N et al. Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment. JCO 2009;27:5660-9.
    • (2009) JCO , vol.27 , pp. 5660-5669
    • Philip, P.A.1    Mooney, M.2    Jaffe, D.3    Eckhardt, G.4    Moore, M.5    Meropol, N.6
  • 41
    • 73949155519 scopus 로고    scopus 로고
    • Changing the paradgim in conducting randomized clinical studies in advanced pancreatic cancer: An opportunity for better clinical development
    • Tabernero J, Macarulla T. Changing the paradgim in conducting randomized clinical studies in advanced pancreatic cancer: an opportunity for better clinical development. JCO 2009;27:5487-491.
    • (2009) JCO , vol.27 , pp. 5487-5491
    • Tabernero, J.1    Macarulla, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.