메뉴 건너뛰기




Volumn 56, Issue 3, 2010, Pages 260-273

The use of transgenic mouse models in the study of male infertility

Author keywords

Animal model; Knockout; Male infertility; Transgenic

Indexed keywords

DNA; NEOMYCIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTAMINE; PROTAMINE P1; PROTAMINE P2; UNCLASSIFIED DRUG;

EID: 77953573527     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.3109/19396368.2010.485244     Document Type: Review
Times cited : (24)

References (119)
  • 1
    • 0034457577 scopus 로고    scopus 로고
    • The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
    • Abel, M. H., Wootton, A. N., Wilkins, V., Huhtaniemi, I., Knight, P. G. and Charlton, H. M. (2000) The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 141:1795-1803.
    • (2000) Endocrinology , vol.141 , pp. 1795-1803
    • Abel, M.H.1    Wootton, A.N.2    Wilkins, V.3    Huhtaniemi, I.4    Knight, P.G.5    Charlton, H.M.6
  • 2
    • 35348898408 scopus 로고    scopus 로고
    • Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure
    • Akinloye, O., Gromoll, J., Callies, C., Nieschlag, E. and Simoni, M. (2007) Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure. Andrologia 39:190-195.
    • (2007) Andrologia , vol.39 , pp. 190-195
    • Akinloye, O.1    Gromoll, J.2    Callies, C.3    Nieschlag, E.4    Simoni, M.5
  • 3
    • 0346025474 scopus 로고    scopus 로고
    • Human protamines and the developing spermatid: Their structure, function, expression and relationship with male infertility
    • Aoki, V. W. and Carrell, D. T. (2003) Human protamines and the developing spermatid: their structure, function, expression and relationship with male infertility. Asian J Androl 5:315-324.
    • (2003) Asian J Androl , vol.5 , pp. 315-324
    • Aoki, V.W.1    Carrell, D.T.2
  • 4
    • 33750168480 scopus 로고    scopus 로고
    • Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility
    • Aoki, V. W., Christensen, G. L., Atkins, J. F. and Carrell, D. T. (2006) Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. Fertil Steril 86:1416-1422.
    • (2006) Fertil Steril , vol.86 , pp. 1416-1422
    • Aoki, V.W.1    Christensen, G.L.2    Atkins, J.F.3    Carrell, D.T.4
  • 5
    • 0023839404 scopus 로고
    • Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males
    • Balhorn, R., Reed, S. and Tanphaichitr, N. (1988) Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males. Experientia 44:52-55.
    • (1988) Experientia , vol.44 , pp. 52-55
    • Balhorn, R.1    Reed, S.2    Tanphaichitr, N.3
  • 6
    • 0035849145 scopus 로고    scopus 로고
    • Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility
    • Bezold, G., Lange, M. and Peter, R. U. (2001). Homozygous methylenetetrahydrofolate reductase C677T mutation and male infertility. N Engl J Med 344:1172-1173.
    • (2001) N Engl J Med , vol.344 , pp. 1172-1173
    • Bezold, G.1    Lange, M.2    Peter, R.U.3
  • 7
    • 77649187253 scopus 로고    scopus 로고
    • Phenotyping male infertility in the mouse: How to get the most out of a 'non-performer'
    • Borg, C. L., Wolski, K. M., Gibbs, G. M. and O'Bryan, M. K. (2009) Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update Epub.
    • (2009) Hum Reprod Update Epub
    • Borg, C.L.1    Wolski, K.M.2    Gibbs, G.M.3    O'Bryan, M.K.4
  • 8
    • 0021358883 scopus 로고
    • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
    • Bradley, A., Evans, M., Kaufman, M. H. and Robertson, E. (1984). Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309:255-256.
    • (1984) Nature , vol.309 , pp. 255-256
    • Bradley, A.1    Evans, M.2    Kaufman, M.H.3    Robertson, E.4
  • 9
    • 0020083107 scopus 로고
    • Regulation of metallothioneinthymidine kinase fusion plasmids injected into mouse eggs
    • Brinster, R. L., Chen, H. Y., Warren, R., Sarthy, A. and Palmiter, R. D. (1982). Regulation of metallothioneinthymidine kinase fusion plasmids injected into mouse eggs. Nature 296:39-42.
    • (1982) Nature , vol.296 , pp. 39-42
    • Brinster, R.L.1    Chen, H.Y.2    Warren, R.3    Sarthy, A.4    Palmiter, R.D.5
  • 10
    • 34347241706 scopus 로고    scopus 로고
    • Altered protamine expression and diminished spermatogenesis: What is the link?
    • Carrell, D. T., Emery, B. R. and Hammoud, S. (2007). Altered protamine expression and diminished spermatogenesis: what is the link? Hum Reprod Update 13:313-327.
    • (2007) Hum Reprod Update , vol.13 , pp. 313-327
    • Carrell, D.T.1    Emery, B.R.2    Hammoud, S.3
  • 11
    • 0012711668 scopus 로고
    • The mutation theory of organic evolution, from the standpoint of animal breeding
    • Castle, W. E. (1905) The Mutation Theory of Organic Evolution, from the Standpoint of Animal Breeding. Science 21:521-525.
    • (1905) Science , vol.21 , pp. 521-525
    • Castle, W.E.1
  • 14
    • 30844437720 scopus 로고    scopus 로고
    • Identification of polymorphisms in the Hrb, GOPC, and Csnk2a2 genes in two men with globozoospermia
    • Christensen, G. L., Ivanov, I. P., Atkins, J. F., Campbell, B. and Carrell, D. T. (2006a) Identification of polymorphisms in the Hrb, GOPC, and Csnk2a2 genes in two men with globozoospermia. J Androl 27:11-15.
    • (2006) J Androl , vol.27 , pp. 11-15
    • Christensen, G.L.1    Ivanov, I.P.2    Atkins, J.F.3    Campbell, B.4    Carrell, D.T.5
  • 16
    • 33646878815 scopus 로고    scopus 로고
    • Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males
    • Christensen, G. L.,Wooding, S. P., Ivanov, I. P., Atkins, J. F. and Carrell, D. T. (2006b) Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. Mol Hum Reprod 12:257-262.
    • (2006) Mol Hum Reprod , vol.12 , pp. 257-262
    • Christensen, G.L.1    Wooding, S.P.2    Ivanov, I.P.3    Atkins, J.F.4    Carrell, D.T.5
  • 17
    • 33746130403 scopus 로고    scopus 로고
    • RNAi in mice: A promising approach to decipher gene functions in vivo
    • Coumoul, X. and Deng, C. X. (2006) RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie 88:637-643.
    • (2006) Biochimie , vol.88 , pp. 637-643
    • Coumoul, X.1    Deng, C.X.2
  • 18
    • 0038813659 scopus 로고    scopus 로고
    • Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis
    • Crackower, M. A., Kolas, N. K., Noguchi, J., Sarao, R., Kikuchi, K., Kaneko, H., et al. (2003). Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science 300: 1291-1295.
    • (2003) Science , vol.300 , pp. 1291-1295
    • Crackower, M.A.1    Kolas, N.K.2    Noguchi, J.3    Sarao, R.4    Kikuchi, K.5    Kaneko, H.6
  • 19
    • 33749530027 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis i and spermiogenesis
    • Dantzer, F., Mark, M., Quenet, D., Scherthan, H., Huber, A., Liebe, B., et al. (2006). Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci USA 103:14854-14859.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14854-14859
    • Dantzer, F.1    Mark, M.2    Quenet, D.3    Scherthan, H.4    Huber, A.5    Liebe, B.6
  • 20
    • 0033105760 scopus 로고    scopus 로고
    • Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
    • de Vries, S. S., Baart, E. B., Dekker, M., Siezen, A., de Rooij, D. G., de Boer, P., et al. (1999) Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev 13:523-531.
    • (1999) Genes Dev , vol.13 , pp. 523-531
    • De Vries, S.S.1    Baart, E.B.2    Dekker, M.3    Siezen, A.4    De Rooij, D.G.5    De Boer, P.6
  • 21
    • 34447577370 scopus 로고    scopus 로고
    • Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile
    • Dev, A., Nayernia, K., Meins, M., Adham, I., Lacone, F. and Engel, W. (2007) Mice deficient for RNA-binding protein brunol1 show reduction of spermatogenesis but are fertile. Mol Reprod Dev 74:1456-1464.
    • (2007) Mol Reprod Dev , vol.74 , pp. 1456-1464
    • Dev, A.1    Nayernia, K.2    Meins, M.3    Adham, I.4    Lacone, F.5    Engel, W.6
  • 22
    • 0033767836 scopus 로고    scopus 로고
    • Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    • Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P. and Mark, M. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127:4277-4291.
    • (2000) Development , vol.127 , pp. 4277-4291
    • Dupont, S.1    Krust, A.2    Gansmuller, A.3    Dierich, A.4    Chambon, P.5    Mark, M.6
  • 23
    • 0029954688 scopus 로고    scopus 로고
    • Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
    • Dymecki, S. M. (1996) Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci USA 93:6191-6196.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6191-6196
    • Dymecki, S.M.1
  • 24
    • 0029925360 scopus 로고    scopus 로고
    • Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility
    • Esther, C. R., Jr., Howard, T. E., Marino, E. M., Goddard, J. M., Capecchi, M. R. and Bernstein, K. E. (1996) Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 74:953-965.
    • (1996) Lab Invest , vol.74 , pp. 953-965
    • Esther Jr., C.R.1    Howard, T.E.2    Marino, E.M.3    Goddard, J.M.4    Capecchi, M.R.5    Bernstein, K.E.6
  • 25
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans, M. J. and Kaufman, M. H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 27
    • 36749054110 scopus 로고    scopus 로고
    • DNA mismatch repair gene hMLH3 variants in meiotic arrest
    • Ferras, C., Zhou, X. L., Sousa, M., Lindblom, A. and Barros, A. (2007) DNA mismatch repair gene hMLH3 variants in meiotic arrest. Fertil Steril 88:1681-1684.
    • (2007) Fertil Steril , vol.88 , pp. 1681-1684
    • Ferras, C.1    Zhou, X.L.2    Sousa, M.3    Lindblom, A.4    Barros, A.5
  • 28
    • 0036252276 scopus 로고    scopus 로고
    • Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1
    • Firestein, R., Nagy, P. L., Daly, M., Huie, P., Conti, M. and Cleary, M. L. (2002). Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. J Clin Invest 109:1165-1172.
    • (2002) J Clin Invest , vol.109 , pp. 1165-1172
    • Firestein, R.1    Nagy, P.L.2    Daly, M.3    Huie, P.4    Conti, M.5    Cleary, M.L.6
  • 29
    • 0020396492 scopus 로고
    • Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
    • Folger, K. R., Wong, E. A., Wahl, G. and Capecchi, M. R. (1982). Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2:1372-1387.
    • (1982) Mol Cell Biol , vol.2 , pp. 1372-1387
    • Folger, K.R.1    Wong, E.A.2    Wahl, G.3    Capecchi, M.R.4
  • 30
    • 26244431698 scopus 로고    scopus 로고
    • Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology
    • Galan, J. J., Buch, B., Cruz, N., Segura, A., Moron, F. J., Bassas, L., et al. (2005). Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology. Fertil Steril 84:910-918.
    • (2005) Fertil Steril , vol.84 , pp. 910-918
    • Galan, J.J.1    Buch, B.2    Cruz, N.3    Segura, A.4    Moron, F.J.5    Bassas, L.6
  • 31
    • 33751374120 scopus 로고    scopus 로고
    • Association of genetic markers within the KIT and KITLG genes with human male infertility
    • Galan, J. J., De Felici, M., Buch, B., Rivero, M. C., Segura, A., Royo, J. L., et al. (2006). Association of genetic markers within the KIT and KITLG genes with human male infertility. Hum Reprod 21:3185-3192.
    • (2006) Hum Reprod , vol.21 , pp. 3185-3192
    • Galan, J.J.1    De Felici, M.2    Buch, B.3    Rivero, M.C.4    Segura, A.5    Royo, J.L.6
  • 32
    • 52949105697 scopus 로고    scopus 로고
    • A common protamine 1 promoter polymorphism (-190 C-4A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients
    • Gazquez, C., Oriola, J., de Mateo, S., Vidal-Taboada, J. M., Ballesca, J. L. and Oliva, R. (2008). A common protamine 1 promoter polymorphism (-190 C-4A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. J Androl 29:540-548.
    • (2008) J Androl , vol.29 , pp. 540-548
    • Gazquez, C.1    Oriola, J.2    De Mateo, S.3    Vidal-Taboada, J.M.4    Ballesca, J.L.5    Oliva, R.6
  • 33
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 34
    • 51449097713 scopus 로고    scopus 로고
    • Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility
    • Griffin, J., Emery, B. R., Christensen, G. L. and Carrell, D. T. (2008) Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility. Syst Biol Reprod Med 54:163-165.
    • (2008) Syst Biol Reprod Med , vol.54 , pp. 163-165
    • Griffin, J.1    Emery, B.R.2    Christensen, G.L.3    Carrell, D.T.4
  • 35
    • 80051528499 scopus 로고    scopus 로고
    • Identification of genetic variation in the 5' and 30 non-coding regions of the protamine genes in patients with protamine deregulation
    • Hammoud, S., Emery, B. R., Aoki, V. W. and Carrell, D. T. (2007) Identification of genetic variation in the 5' and 30 non-coding regions of the protamine genes in patients with protamine deregulation. Arch Androl 53:267-274.
    • (2007) Arch Androl , vol.53 , pp. 267-274
    • Hammoud, S.1    Emery, B.R.2    Aoki, V.W.3    Carrell, D.T.4
  • 36
    • 63149113449 scopus 로고    scopus 로고
    • Sequence alterations in the YBX2 gene are associated with male factor infertility
    • Hammoud, S., Emery, B. R., Dunn, D., Weiss, R. B. and Carrell, D. T. (2009) Sequence alterations in the YBX2 gene are associated with male factor infertility. Fertil Steril 91:1090-1095.
    • (2009) Fertil Steril , vol.91 , pp. 1090-1095
    • Hammoud, S.1    Emery, B.R.2    Dunn, D.3    Weiss, R.B.4    Carrell, D.T.5
  • 37
    • 27844440989 scopus 로고    scopus 로고
    • A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
    • Hayashi, K., Yoshida, K. and Matsui, Y. (2005) A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature 438:374-378.
    • (2005) Nature , vol.438 , pp. 374-378
    • Hayashi, K.1    Yoshida, K.2    Matsui, Y.3
  • 38
    • 34547629188 scopus 로고    scopus 로고
    • Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference
    • Hitz, C., Wurst, W. and Kuhn, R. (2007) Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Res 35:e90.
    • (2007) Nucleic Acids Res , vol.35
    • Hitz, C.1    Wurst, W.2    Kuhn, R.3
  • 39
    • 0036702774 scopus 로고    scopus 로고
    • Conditional over-expression of estrogen receptor alpha in a transgenic mouse model
    • Hruska, K. S., Tilli, M. T., Ren, S., Cotarla, I., Kwong, T., Li, M., et al. (2002). Conditional over-expression of estrogen receptor alpha in a transgenic mouse model. Transgenic Res 11:361-372.
    • (2002) Transgenic Res , vol.11 , pp. 361-372
    • Hruska, K.S.1    Tilli, M.T.2    Ren, S.3    Cotarla, I.4    Kwong, T.5    Li, M.6
  • 40
    • 0037266378 scopus 로고    scopus 로고
    • DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse
    • Hsia, K. T., Millar, M. R., King, S., Selfridge, J., Redhead, N. J., Melton, D. W., et al. (2003). DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Development 130:369-378.
    • (2003) Development , vol.130 , pp. 369-378
    • Hsia, K.T.1    Millar, M.R.2    King, S.3    Selfridge, J.4    Redhead, N.J.5    Melton, D.W.6
  • 42
    • 33645793459 scopus 로고    scopus 로고
    • An SNP in protamine 1: A possible genetic cause of male infertility?
    • Iguchi, N., Yang, S., Lamb, D. J. and Hecht, N. B. (2006) An SNP in protamine 1: a possible genetic cause of male infertility? J Med Genet 43:382-384.
    • (2006) J Med Genet , vol.43 , pp. 382-384
    • Iguchi, N.1    Yang, S.2    Lamb, D.J.3    Hecht, N.B.4
  • 43
    • 70450257662 scopus 로고    scopus 로고
    • Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice
    • Imai, H., Hakkaku, N., Iwamoto, R., Suzuki, J., Suzuki, T., Tajima, Y., et al. (2009). Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem 284:32522-32532.
    • (2009) J Biol Chem , vol.284 , pp. 32522-32532
    • Imai, H.1    Hakkaku, N.2    Iwamoto, R.3    Suzuki, J.4    Suzuki, T.5    Tajima, Y.6
  • 45
    • 0035140361 scopus 로고    scopus 로고
    • Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males
    • Imai, H., Suzuki, K., Ishizaka, K., Ichinose, S., Oshima, H., Okayasu, I., et al. (2001). Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males. Biol Reprod 64:674-683.
    • (2001) Biol Reprod , vol.64 , pp. 674-683
    • Imai, H.1    Suzuki, K.2    Ishizaka, K.3    Ichinose, S.4    Oshima, H.5    Okayasu, I.6
  • 46
    • 74049138337 scopus 로고    scopus 로고
    • Mutations in the protamine locus: Association with spermatogenic failure?
    • Imken, L., Rouba, H., El Houate, B., Louanjli, N., Barakat, A., Chafik, A., et al. (2009). Mutations in the protamine locus: association with spermatogenic failure? Mol Hum Reprod 15:733-738.
    • (2009) Mol Hum Reprod , vol.15 , pp. 733-738
    • Imken, L.1    Rouba, H.2    El Houate, B.3    Louanjli, N.4    Barakat, A.5    Chafik, A.6
  • 47
    • 68549099756 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia
    • Irie, S., Tsujimura, A., Miyagawa, Y., Ueda, T., Matsuoka, Y., Matsui, Y., et al. (2009). Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia. J Androl 30:426-431.
    • (2009) J Androl , vol.30 , pp. 426-431
    • Irie, S.1    Tsujimura, A.2    Miyagawa, Y.3    Ueda, T.4    Matsuoka, Y.5    Matsui, Y.6
  • 48
    • 48249091281 scopus 로고    scopus 로고
    • ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population
    • Ji, G., Gu, A., Xia, Y., Lu, C., Liang, J., Wang, S., et al. (2008). ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population. Reprod Biomed Online 17(1): 36-41.
    • (2008) Reprod Biomed Online , vol.17 , Issue.1 , pp. 36-41
    • Ji, G.1    Gu, A.2    Xia, Y.3    Lu, C.4    Liang, J.5    Wang, S.6
  • 50
    • 33845864217 scopus 로고    scopus 로고
    • Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene
    • Kawa, S., Ito, C., Toyama, Y., Maekawa, M., Tezuka, T., Nakamura, T., et al. (2006). Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene. Proc Natl Acad Sci USA 103:19344-19349.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19344-19349
    • Kawa, S.1    Ito, C.2    Toyama, Y.3    Maekawa, M.4    Tezuka, T.5    Nakamura, T.6
  • 51
    • 14044257216 scopus 로고    scopus 로고
    • Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation
    • Kelly, T. L., Neaga, O. R., Schwahn, B. C., Rozen, R. and Trasler, J. M. (2005). Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. Biol Reprod 72:667-677.
    • (2005) Biol Reprod , vol.72 , pp. 667-677
    • Kelly, T.L.1    Neaga, O.R.2    Schwahn, B.C.3    Rozen, R.4    Trasler, J.M.5
  • 52
    • 0034654307 scopus 로고    scopus 로고
    • Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses
    • Kissel, H., Timokhina, I., Hardy, M. P., Rothschild, G., Tajima, Y., Soares, V., et al. (2000). Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J 19:1312-1326.
    • (2000) EMBO J , vol.19 , pp. 1312-1326
    • Kissel, H.1    Timokhina, I.2    Hardy, M.P.3    Rothschild, G.4    Tajima, Y.5    Soares, V.6
  • 53
    • 0032956610 scopus 로고    scopus 로고
    • CAG repeat length in the androgen receptor gene of infertile Japanese males with oligozoospermia
    • Komori, S., Kasumi, H., Kanazawa, R., Sakata, K., Nakata, Y., Kato, H., et al. (1999). CAG repeat length in the androgen receptor gene of infertile Japanese males with oligozoospermia. Mol Hum Reprod 5:14-16.
    • (1999) Mol Hum Reprod , vol.5 , pp. 14-16
    • Komori, S.1    Kasumi, H.2    Kanazawa, R.3    Sakata, K.4    Nakata, Y.5    Kato, H.6
  • 54
    • 3242671308 scopus 로고    scopus 로고
    • Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene
    • Kotaja, N., De Cesare, D., Macho, B., Monaco, L., Brancorsini, S., Goossens, E., et al. (2004). Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene. Proc Natl Acad Sci USA 101:10620-10625.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10620-10625
    • Kotaja, N.1    De Cesare, D.2    MacHo, B.3    Monaco, L.4    Brancorsini, S.5    Goossens, E.6
  • 55
    • 0034142209 scopus 로고    scopus 로고
    • Male sterility and enhanced radiation sensitivity in TLS(-/-) mice
    • Kuroda, M., Sok, J., Webb, L., Baechtold, H., Urano, F., Yin, Y., et al. (2000). Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. EMBO J 19:453-462.
    • (2000) EMBO J , vol.19 , pp. 453-462
    • Kuroda, M.1    Sok, J.2    Webb, L.3    Baechtold, H.4    Urano, F.5    Yin, Y.6
  • 57
    • 68049133284 scopus 로고    scopus 로고
    • Identification of potentially damaging amino acid substitutions leading to human male infertility
    • Kuzmin, A., Jarvi, K., Lo, K., Spencer, L., Chow, G. Y., Macleod, G., et al. (2009). Identification of potentially damaging amino acid substitutions leading to human male infertility. Biol Reprod 81:319-326.
    • (2009) Biol Reprod , vol.81 , pp. 319-326
    • Kuzmin, A.1    Jarvi, K.2    Lo, K.3    Spencer, L.4    Chow, G.Y.5    MacLeod, G.6
  • 58
    • 33751380396 scopus 로고    scopus 로고
    • Association study of four polymorphisms in three folaterelated enzyme genes with non-obstructive male infertility
    • Lee, H. C., Jeong, Y. M., Lee, S. H., Cha, K. Y., Song, S. H., Kim, N. K., et al. (2006). Association study of four polymorphisms in three folaterelated enzyme genes with non-obstructive male infertility. Hum Reprod 21:3162-3170.
    • (2006) Hum Reprod , vol.21 , pp. 3162-3170
    • Lee, H.C.1    Jeong, Y.M.2    Lee, S.H.3    Cha, K.Y.4    Song, S.H.5    Kim, N.K.6
  • 59
    • 0036191345 scopus 로고    scopus 로고
    • Lack of association between polymorphisms in the testis-specific angiotensin converting enzyme gene and male infertility in an Asian population
    • Liao, W. X. and Roy, A. C. (2002) Lack of association between polymorphisms in the testis-specific angiotensin converting enzyme gene and male infertility in an Asian population. Mol Hum Reprod 8:299-303.
    • (2002) Mol Hum Reprod , vol.8 , pp. 299-303
    • Liao, W.X.1    Roy, A.C.2
  • 60
    • 18244374210 scopus 로고    scopus 로고
    • The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression
    • Libby, B. J., De La Fuente, R., O'Brien, M. J., Wigglesworth, K., Cobb, J., Inselman, A., et al. (2002). The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Dev Biol 242:174-187.
    • (2002) Dev Biol , vol.242 , pp. 174-187
    • Libby, B.J.1    De La Fuente, R.2    O'Brien, M.J.3    Wigglesworth, K.4    Cobb, J.5    Inselman, A.6
  • 62
    • 14544280215 scopus 로고    scopus 로고
    • Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis
    • Martianov, I., Brancorsini, S., Catena, R., Gansmuller, A., Kotaja, N., Parvinen, M., et al. (2005). Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. Proc Natl Acad Sci USA 102:2808-2813.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2808-2813
    • Martianov, I.1    Brancorsini, S.2    Catena, R.3    Gansmuller, A.4    Kotaja, N.5    Parvinen, M.6
  • 63
    • 55549115368 scopus 로고    scopus 로고
    • The biology of infertility: Research advances and clinical challenges
    • Matzuk, M. M. and Lamb, D. J. (2008) The biology of infertility: research advances and clinical challenges. Nat Med 14:1197-1213.
    • (2008) Nat Med , vol.14 , pp. 1197-1213
    • Matzuk, M.M.1    Lamb, D.J.2
  • 64
    • 0000815989 scopus 로고
    • Successful development and birth of mice cultivated in vitro as early embryos
    • McLaren, A. and Biggers, J. D. (1958) Successful development and birth of mice cultivated in vitro as early embryos. Nature 182:877-878.
    • (1958) Nature , vol.182 , pp. 877-878
    • McLaren, A.1    Biggers, J.D.2
  • 65
    • 26944433026 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations
    • Miyagawa, Y., Nishimura, H., Tsujimura, A., Matsuoka, Y., Matsumiya, K., Okuyama, A., et al. (2005). Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. J Androl 26:779-786.
    • (2005) J Androl , vol.26 , pp. 779-786
    • Miyagawa, Y.1    Nishimura, H.2    Tsujimura, A.3    Matsuoka, Y.4    Matsumiya, K.5    Okuyama, A.6
  • 67
    • 0025245614 scopus 로고
    • Embryonic stem cells alone are able to support fetal development in the mouse
    • Nagy, A., Gocza, E., Diaz, E. M., Prideaux, V. R., Ivanyi, E., Markkula, M., et al. (1990). Embryonic stem cells alone are able to support fetal development in the mouse. Development 110:815-821.
    • (1990) Development , vol.110 , pp. 815-821
    • Nagy, A.1    Gocza, E.2    Diaz, E.M.3    Prideaux, V.R.4    Ivanyi, E.5    Markkula, M.6
  • 68
    • 33745255403 scopus 로고    scopus 로고
    • Protamines and male infertility
    • Oliva, R. (2006) Protamines and male infertility. Hum Reprod Update 12:417-435.
    • (2006) Hum Reprod Update , vol.12 , pp. 417-435
    • Oliva, R.1
  • 69
    • 12944335303 scopus 로고    scopus 로고
    • Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
    • Osuga, J., Ishibashi, S., Oka, T., Yagyu, H., Tozawa, R., Fujimoto, A., et al. (2000). Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity. Proc Natl Acad Sci USA 97:787-792.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 787-792
    • Osuga, J.1    Ishibashi, S.2    Oka, T.3    Yagyu, H.4    Tozawa, R.5    Fujimoto, A.6
  • 70
    • 13144267780 scopus 로고    scopus 로고
    • Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant
    • Print, C. G., Loveland, K. L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N., et al. (1998). Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Proc Natl Acad Sci USA 95:12424-12431.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12424-12431
    • Print, C.G.1    Loveland, K.L.2    Gibson, L.3    Meehan, T.4    Stylianou, A.5    Wreford, N.6
  • 71
    • 16044372544 scopus 로고    scopus 로고
    • Inactivation of the HR6B ubiquitinconjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification
    • Roest, H. P., van Klaveren, J., de Wit, J., van Gurp, C. G., Koken, M. H., Vermey, M., et al. (1996). Inactivation of the HR6B ubiquitinconjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification. Cell 86:799-810.
    • (1996) Cell , vol.86 , pp. 799-810
    • Roest, H.P.1    Van Klaveren, J.2    De Wit, J.3    Van Gurp, C.G.4    Koken, M.H.5    Vermey, M.6
  • 72
    • 0033634652 scopus 로고    scopus 로고
    • The mouse Spo11 gene is required for meiotic chromosome synapsis
    • Romanienko, P. J. and Camerini-Otero, R. D. (2000) The mouse Spo11 gene is required for meiotic chromosome synapsis. Mol Cell 6:975-987.
    • (2000) Mol Cell , vol.6 , pp. 975-987
    • Romanienko, P.J.1    Camerini-Otero, R.D.2
  • 73
    • 0035036205 scopus 로고    scopus 로고
    • Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2
    • Ronfani, L., Ferraguti, M., Croci, L., Ovitt, C. E., Scholer, H. R., Consalez, G. G., et al. (2001). Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2. Development 128:1265-1273.
    • (2001) Development , vol.128 , pp. 1265-1273
    • Ronfani, L.1    Ferraguti, M.2    Croci, L.3    Ovitt, C.E.4    Scholer, H.R.5    Consalez, G.G.6
  • 74
    • 0030885623 scopus 로고    scopus 로고
    • The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
    • Ruggiu, M., Speed, R., Taggart, M., McKay, S. J., Kilanowski, F., Saunders, P., et al. (1997). The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. Nature 389:73-77.
    • (1997) Nature , vol.389 , pp. 73-77
    • Ruggiu, M.1    Speed, R.2    Taggart, M.3    McKay, S.J.4    Kilanowski, F.5    Saunders, P.6
  • 75
    • 77249164982 scopus 로고    scopus 로고
    • LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest
    • Sakugawa, N., Miyamoto, T., Tsujimura, A., Koh, E., Miyagawa, Y., Sato, H., et al. (2009). LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest. J Assist Reprod Genet 26(9-10):545-552.
    • (2009) J Assist Reprod Genet , vol.26 , Issue.9-10 , pp. 545-552
    • Sakugawa, N.1    Miyamoto, T.2    Tsujimura, A.3    Koh, E.4    Miyagawa, Y.5    Sato, H.6
  • 76
    • 33745446478 scopus 로고    scopus 로고
    • Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest
    • Sato, H., Miyamoto, T., Yogev, L., Namiki, M., Koh, E., Hayashi, H., et al. (2006). Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest. J Hum Genet 51:533-540.
    • (2006) J Hum Genet , vol.51 , pp. 533-540
    • Sato, H.1    Miyamoto, T.2    Yogev, L.3    Namiki, M.4    Koh, E.5    Hayashi, H.6
  • 77
    • 0023352241 scopus 로고
    • Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae
    • Sauer, B. (1987) Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae. Mol Cell Biol 7:2087-2096.
    • (1987) Mol Cell Biol , vol.7 , pp. 2087-2096
    • Sauer, B.1
  • 78
    • 0142091380 scopus 로고    scopus 로고
    • A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
    • Schultz, N., Hamra, F. K. and Garbers, D. L. (2003) A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. Proc Natl Acad Sci USA 100:12201-12206.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12201-12206
    • Schultz, N.1    Hamra, F.K.2    Garbers, D.L.3
  • 80
    • 70350680930 scopus 로고    scopus 로고
    • Single nucleotide polymorphism analysis of the folliclestimulating hormone (FSH) receptor in Japanese with male infertility: Identification of codon combination with heterozygous variations of the two discrete FSH receptor gene
    • Shimoda, C., Koh, E., Yamamoto, K., Matsui, F., Sugimoto, K., Sin, H. S., et al. (2009). Single nucleotide polymorphism analysis of the folliclestimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene. Endocr J 56:859-865.
    • (2009) Endocr J , vol.56 , pp. 859-865
    • Shimoda, C.1    Koh, E.2    Yamamoto, K.3    Matsui, F.4    Sugimoto, K.5    Sin, H.S.6
  • 81
    • 16244371735 scopus 로고    scopus 로고
    • Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population
    • Singh, K., Singh, S. K., Sah, R., Singh, I. and Raman, R. (2005) Mutation C677T in the methylenetetrahydrofolate reductase gene is associated with male infertility in an Indian population. Int J Androl 28:115-119.
    • (2005) Int J Androl , vol.28 , pp. 115-119
    • Singh, K.1    Singh, S.K.2    Sah, R.3    Singh, I.4    Raman, R.5
  • 82
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano, P. (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 83
    • 0027501676 scopus 로고
    • Production of chimeras between embryonic stem cells and embryos
    • Stewart, C. L. (1993) Production of chimeras between embryonic stem cells and embryos. Methods Enzymol 225:823-855.
    • (1993) Methods Enzymol , vol.225 , pp. 823-855
    • Stewart, C.L.1
  • 87
    • 0037081289 scopus 로고    scopus 로고
    • Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene
    • Takahashi, H., Koshimizu, U., Miyazaki, J. and Nakamura, T. (2002) Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene. Dev Biol 241:259-272.
    • (2002) Dev Biol , vol.241 , pp. 259-272
    • Takahashi, H.1    Koshimizu, U.2    Miyazaki, J.3    Nakamura, T.4
  • 88
    • 33644922689 scopus 로고    scopus 로고
    • Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein
    • Tanaka, H., Matsuoka, Y., Onishi, M., Kitamura, K., Miyagawa, Y., Nishimura, H., et al. (2006). Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein. Int J Androl 29:353-359.
    • (2006) Int J Androl , vol.29 , pp. 353-359
    • Tanaka, H.1    Matsuoka, Y.2    Onishi, M.3    Kitamura, K.4    Miyagawa, Y.5    Nishimura, H.6
  • 89
    • 0037291314 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the protamine-1 and 2 genes of fertile and infertile human male populations
    • Tanaka, H., Miyagawa, Y., Tsujimura, A., Matsumiya, K., Okuyama, A. and Nishimune, Y. (2003) Single nucleotide polymorphisms in the protamine-1 and 2 genes of fertile and infertile human male populations. Mol Hum Reprod 9:69-73.
    • (2003) Mol Hum Reprod , vol.9 , pp. 69-73
    • Tanaka, H.1    Miyagawa, Y.2    Tsujimura, A.3    Matsumiya, K.4    Okuyama, A.5    Nishimune, Y.6
  • 90
    • 0036847112 scopus 로고    scopus 로고
    • Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure
    • Teng, Y. N., Lin, Y. M., Lin, Y. H., Tsao, S. Y., Hsu, C. C., Lin, S. J., et al. (2002). Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure. J Clin Endocrinol Metab 87:5258-5264.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5258-5264
    • Teng, Y.N.1    Lin, Y.M.2    Lin, Y.H.3    Tsao, S.Y.4    Hsu, C.C.5    Lin, S.J.6
  • 91
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas, K. R. and Capecchi, M. R. (1990) Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346:847-850.
    • (1990) Nature , vol.346 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 92
    • 0022542596 scopus 로고
    • High frequency targeting of genes to specific sites in the mammalian genome
    • Thomas, K. R., Folger, K. R. and Capecchi, M. R. (1986) High frequency targeting of genes to specific sites in the mammalian genome. Cell 44:419-428.
    • (1986) Cell , vol.44 , pp. 419-428
    • Thomas, K.R.1    Folger, K.R.2    Capecchi, M.R.3
  • 93
    • 37549020694 scopus 로고    scopus 로고
    • Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: A missense mutation associated with loss of GRTH phosphorylation
    • Tsai-Morris, C. H., Koh, E., Sheng, Y., Maeda, Y., Gutti, R., Namiki, M., et al. (2007). Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation. Mol Hum Reprod 13:887-892.
    • (2007) Mol Hum Reprod , vol.13 , pp. 887-892
    • Tsai-Morris, C.H.1    Koh, E.2    Sheng, Y.3    Maeda, Y.4    Gutti, R.5    Namiki, M.6
  • 94
    • 2342469921 scopus 로고    scopus 로고
    • Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis
    • Tsai-Morris, C. H., Sheng, Y., Lee, E., Lei, K. J. and Dufau, M. L. (2004) Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis. Proc Natl Acad Sci USA 101:6373-6378.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6373-6378
    • Tsai-Morris, C.H.1    Sheng, Y.2    Lee, E.3    Lei, K.J.4    Dufau, M.L.5
  • 95
    • 11144260211 scopus 로고    scopus 로고
    • No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population
    • Tschanter, P., Kostova, E., Luetjens, C. M., Cooper, T. G., Nieschlag, E. and Gromoll, J. (2004) No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. Hum Reprod 19:2771-2776.
    • (2004) Hum Reprod , vol.19 , pp. 2771-2776
    • Tschanter, P.1    Kostova, E.2    Luetjens, C.M.3    Cooper, T.G.4    Nieschlag, E.5    Gromoll, J.6
  • 96
    • 0041821717 scopus 로고    scopus 로고
    • Conserved role of nanos proteins in germ cell development
    • Tsuda, M., Sasaoka, Y., Kiso, M., Abe, K., Haraguchi, S., Kobayashi, S., et al. (2003). Conserved role of nanos proteins in germ cell development. Science 301:1239-1241.
    • (2003) Science , vol.301 , pp. 1239-1241
    • Tsuda, M.1    Sasaoka, Y.2    Kiso, M.3    Abe, K.4    Haraguchi, S.5    Kobayashi, S.6
  • 97
    • 0032944179 scopus 로고    scopus 로고
    • Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene
    • Varmuza, S., Jurisicova, A., Okano, K., Hudson, J., Boekelheide, K. and Shipp, E. B. (1999). Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene. Dev Biol 205:98-110.
    • (1999) Dev Biol , vol.205 , pp. 98-110
    • Varmuza, S.1    Jurisicova, A.2    Okano, K.3    Hudson, J.4    Boekelheide, K.5    Shipp, E.B.6
  • 99
    • 33244475321 scopus 로고    scopus 로고
    • Transgenic RNAi: A tool to study testis-specific genes
    • Williams, C. J. and Schultz, R. M. (2006) Transgenic RNAi: a tool to study testis-specific genes. Mol Cell Endocrinol 247(1-2):1-3.
    • (2006) Mol Cell Endocrinol , vol.247 , Issue.1-2 , pp. 1-3
    • Williams, C.J.1    Schultz, R.M.2
  • 100
    • 0037133166 scopus 로고    scopus 로고
    • The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production
    • Wishart, M. and Dixon, J. (2002) The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Proc Natl Acad Sci USA 99:2112-2117.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2112-2117
    • Wishart, M.1    Dixon, J.2
  • 101
    • 0027906457 scopus 로고
    • Non-injection methods for the production of embryonic stem cellembryo chimaeras
    • Wood, S. A., Allen, N. D., Rossant, J., Auerbach, A. and Nagy, A. (1993) Non-injection methods for the production of embryonic stem cellembryo chimaeras. Nature 365:87-89.
    • (1993) Nature , vol.365 , pp. 87-89
    • Wood, S.A.1    Allen, N.D.2    Rossant, J.3    Auerbach, A.4    Nagy, A.5
  • 103
    • 19944419800 scopus 로고    scopus 로고
    • Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis
    • Xu, H., Beasley,M. D., Warren,W. D., van der Horst, G. T. andMcKay,M. J. (2005) Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell 8:949-961.
    • (2005) Dev Cell , vol.8 , pp. 949-961
    • Xu, H.1    Beasley, M.D.2    Warren, W.D.3    Van Der Horst, G.T.4    McKay, M.J.5
  • 104
    • 70449531394 scopus 로고    scopus 로고
    • The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia
    • Xu, K., Lu, T., Zhou, H., Bai, L. and Xiang, Y. (2010) The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia. Clin Chim Acta 411(1-2):49-52.
    • (2010) Clin Chim Acta , vol.411 , Issue.1-2 , pp. 49-52
    • Xu, K.1    Lu, T.2    Zhou, H.3    Bai, L.4    Xiang, Y.5
  • 105
    • 0032879917 scopus 로고    scopus 로고
    • Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit
    • Xu, X., Toselli, P. A., Russell, L. D. and Seldin, D. C. (1999) Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Nat Genet 23:118-121.
    • (1999) Nat Genet , vol.23 , pp. 118-121
    • Xu, X.1    Toselli, P.A.2    Russell, L.D.3    Seldin, D.C.4
  • 106
    • 84875408392 scopus 로고    scopus 로고
    • Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3
    • Yamaji, M., Tanaka, T., Shigeta, M., Chuma, S., Saga, Y. and Saitou, M. (2009) Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3. Reproduction Epub.
    • (2009) Reproduction Epub
    • Yamaji, M.1    Tanaka, T.2    Shigeta, M.3    Chuma, S.4    Saga, Y.5    Saitou, M.6
  • 107
    • 67349230842 scopus 로고    scopus 로고
    • Male infertility caused by spermiogenic defects: Lessons from gene knockouts
    • Yan, W. (2009) Male infertility caused by spermiogenic defects: lessons from gene knockouts. Mol Cell Endocrinol 306(1-2):24-32.
    • (2009) Mol Cell Endocrinol , vol.306 , Issue.1-2 , pp. 24-32
    • Yan, W.1
  • 108
    • 17644414487 scopus 로고    scopus 로고
    • Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility
    • Yang, J., Medvedev, S., Yu, J., Tang, L. C., Agno, J. E., Matzuk, M. M., et al. (2005). Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc Natl Acad Sci USA 102:5755-5760.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5755-5760
    • Yang, J.1    Medvedev, S.2    Yu, J.3    Tang, L.C.4    Agno, J.E.5    Matzuk, M.M.6
  • 110
    • 0037108766 scopus 로고    scopus 로고
    • Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
    • Yeh, S., Tsai, M. Y., Xu, Q.,Mu, X. M., Lardy, H., Huang, K. E., et al. (2002). Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci USA 99:13498-13503.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13498-13503
    • Yeh, S.1    Tsai, M.Y.2    Xu, Q.3    Mu, X.M.4    Lardy, H.5    Huang, K.E.6
  • 111
    • 0034712735 scopus 로고    scopus 로고
    • Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice
    • Yu, Y. E., Zhang, Y., Unni, E., Shirley, C. R., Deng, J. M., Russell, L. D., et al. (2000). Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci USA 97:4683-4688.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4683-4688
    • Yu, Y.E.1    Zhang, Y.2    Unni, E.3    Shirley, C.R.4    Deng, J.M.5    Russell, L.D.6
  • 112
    • 0033975302 scopus 로고    scopus 로고
    • The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
    • Yuan, L., Liu, J. G., Zhao, J., Brundell, E., Daneholt, B. and Hoog, C. (2000) The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell 5:73-83.
    • (2000) Mol Cell , vol.5 , pp. 73-83
    • Yuan, L.1    Liu, J.G.2    Zhao, J.3    Brundell, E.4    Daneholt, B.5    Hoog, C.6
  • 113
    • 36749019705 scopus 로고    scopus 로고
    • Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility
    • Yun, Y. J., Lee, H. C., Kim, J. E., Song, S. H. and Lee, S. (2007). Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility. Fertil Steril 88:1706-1708.
    • (2007) Fertil Steril , vol.88 , pp. 1706-1708
    • Yun, Y.J.1    Lee, H.C.2    Kim, J.E.3    Song, S.H.4    Lee, S.5
  • 114
    • 0030990991 scopus 로고    scopus 로고
    • Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
    • Zambrowicz, B. P., Imamoto, A., Fiering, S., Herzenberg, L. A., Kerr, W. G. and Soriano, P. (1997). Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3789-3794
    • Zambrowicz, B.P.1    Imamoto, A.2    Fiering, S.3    Herzenberg, L.A.4    Kerr, W.G.5    Soriano, P.6
  • 115
  • 116
    • 33847615320 scopus 로고    scopus 로고
    • Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men
    • Zhang, W., Zhang, S., Xiao, C., Yang, Y. and Zhoucun, A. (2007) Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. Reproduction 133:511-516.
    • (2007) Reproduction , vol.133 , pp. 511-516
    • Zhang, W.1    Zhang, S.2    Xiao, C.3    Yang, Y.4    Zhoucun, A.5
  • 117
    • 0034797470 scopus 로고    scopus 로고
    • Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice
    • Zhao, M., Shirley, C. R., Yu, Y. E., Mohapatra, B., Zhang, Y., Unni, E., et al. (2001). Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol 21:7243-7255.
    • (2001) Mol Cell Biol , vol.21 , pp. 7243-7255
    • Zhao, M.1    Shirley, C.R.2    Yu, Y.E.3    Mohapatra, B.4    Zhang, Y.5    Unni, E.6
  • 118
    • 29644437235 scopus 로고    scopus 로고
    • The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia
    • Zhoucun, A., Zhang, S., Yang, Y., Ma, Y., Zhang, W. and Lin, L. (2006) The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. Eur J Obstet Gynecol Reprod Biol 124:61-64.
    • (2006) Eur J Obstet Gynecol Reprod Biol , vol.124 , pp. 61-64
    • Zhoucun, A.1    Zhang, S.2    Yang, Y.3    Ma, Y.4    Zhang, W.5    Lin, L.6
  • 119
    • 0033368701 scopus 로고    scopus 로고
    • Meiotic chromosomes: Integrating structure and function
    • Zickler, D. and Kleckner, N. (1999) Meiotic chromosomes: integrating structure and function. Annu Rev Genet 33:603-754.
    • (1999) Annu Rev Genet , vol.33 , pp. 603-754
    • Zickler, D.1    Kleckner, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.