Ameliorating effects of Kangen-karyu on neuronal damage in rats subjected to repeated cerebral ischemia

Journal of Natural Medicines

Volumn 64, Issue 2, 2010, Pages 167-174

  Pu, Fengling ^a   Kaneko, Tomohiro ^a,b   Enoki, Makiko ^a   Irie, Keiichi ^a   Okamoto, Takuya ^c   Sei, Yasuo ^c   Egashira, Nobuaki ^d   Oishi, Ryozo ^d   Mishima, Kenichi ^a   Kamimura, Hidetoshi ^b   Iwasaki, Katsunori ^a   Fujiwara, Michihiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b Fukuoka University Chikushi Hospital   (Japan)

^c Iskra Industry Co Ltd   (Japan)

^d KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cerebral ischemia; Danshen; Glutamate release; Kangen karyu

Indexed keywords

CHINESE DRUG; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CHINESE MEDICINE; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; IN VITRO STUDY; KANGEN KARYU; MALE; MEMORY DISORDER; NERVE INJURY; NEUROPROTECTION; NONHUMAN; RAT;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 77953564329     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0392-y     Document Type: Article

References (31)

1. Satoh A, Yokozawa T, Cho EJ, Okamoto T, Sei Y (2004) Antioxidative effects related to the potential anti-aging properties of the Chinese prescription Kangen-karyu and Carthami Flos in senescence-accelerated mice. Arch Gerontol Geriatr 39:69-82
2. Yokozawa T, Cho EJ, Okamoto T, Sei Y (2006) Effects of the Chinese prescription Kangen-karyu and its crude drug Tanjin on ageing process in rats. J Pharm Pharmacol 58:1591-1599
3. Lam FF, Yeung JH, Chan KM, Or PM (2007) Relaxant effects of danshen aqueous extract and its constituent danshensu on rat coronary artery are mediated by inhibition of calcium channels. Vascul Pharmacol 46:271-277
4. Zhu HB, Zhang L, Wang ZH, Tian JW, Fu FH, Liu K, Li CL (2005) Therapeutic effects of hydroxysafflor yellow A on focal cerebral ischemic injury in rats and its primary mechanisms. J Asian Nat Prod Res 7:607-613
5. Yoo MY, Lee BH, Choi YH, Lee JW, Seo JH, Oh KS, Koo HN, Seo HW, Yon GH, Kwon DY, Kim YS, Ryu SY (2006) Vasorelaxant effect of the rootbark extract of Paeonia moutan on isolated rat thoracic aorta. Planta Med 72:1338-1341
6. Nakazawa K, Fujimori K, Inoue K, Sekita S, Takanaka A (1989) Effects of extract from a herbal drug, cnidium rhizome (senkyu), on contraction, heart rates and membrane potentials of isolated guinea pig atria. Yakugaku Zasshi 109:662-671
7. Nakai M, Qin Z, Wang Y, Chase TN (2000) NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117. Brain Res 859:207-216
8. Anderson MF, Blomstrand F, Blomstrand C, Eriksson PS, Nilsson M (2003) Astrocytes and stroke: networking for survival? Neurochem Res 28:293-305
9. Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149-171
10. Pulsinelli WA, Brierley JB (1979) A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267-272
11. Pu F, Motohashi K, Kaneko T, Tanaka Y, Manome N, Irie K, Takata J, Egashira N, Oishi R, Okamoto T, Sei Y, Yokozawa T, Mishima K, Iwasaki K, Fujiwara M (2009) Neuroprotective effects of Kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats. J Pharmacol Sci 109:424-430
12. Pu F, Mishima K, Irie K, Motohashi K, Tanaka Y, Orito K, Egawa T, Kitamura Y, Egashira N, Iwasaki K, Fujiwara M (2007) Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J Pharmacol Sci 104:329-334
13. Pu F, Mishima K, Egashira N, Iwasaki K, Kaneko T, Uchida T, Irie K, Ishibashi D, Fujii H, Kosuna K, Fujiwara M (2004) Protective effect of buckwheat polyphenols against long-lasting impairment of spatial memory associated with hippocampal neuronal damage in rats subjected to repeated cerebral ischemia. J Pharmacol Sci 94:393-402
14. Wityk RJ, Lewin JJ 3rd (2006) Blood pressure management during acute ischaemic stroke. Expert Opin Pharmacother 7:247-258
15. Pu F, Mishima K, Irie K, Egashira N, Ishibashi D, Matsumoto Y, Ikeda T, Iwasaki K, Fujii H, Kosuna K, Fujiwara M (2005) Differential effects of buckwheat and kudingcha extract on neuronal damage in cultured hippocampal neurons and spatial memory impairment induced by scopolamine in an eight-arm radial maze. J Health Science 51:636-644
16. Hatip-Al-Khatib I, Iwasaki K, Egashira N, Ishibashi D, Mishima K, Fujiwara M (2007) Comparison of single- and repeatedischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion. J Pharmacol Sci 103:83-91
17. Irie K, Mishima K, Ishibashi D, Egashira N, Iwasaki K, Fujiwara M (2002) Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia. Life Sci 72:621-629
18. Rossi DJ, Brady JD, Mohr C (2007) Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10:1377-1386
19. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Ståhlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M (2008) Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 28:468-481
20. Taoufik E, Probert L (2008) Ischemic neuronal damage. Curr Pharm Des 14:3565-3573
21. Ouyang C, Guo L, Lu Q, Xu X, Wang H (2007) Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum. Neurosci Lett 420:174-178
22. Green AR, Hainsworth AH, Jackson DM (2000) GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neuropharmacology 39:1483-1494
23. Górecki DC, Lukasiuk K, Szklarczyk A, Kaczmarek L (1998) Kainate-evoked changes in dystrophin messenger RNA levels in the rat hippocampus. Neuroscience 84:467-477
24. Kimura M, Katayama K, Nishizawa Y (1999) Role of glutamate receptors and voltage-dependent calcium channels in glutamate toxicity in energy-compromised cortical neurons. Jpn J Pharmacol 80:351-358
25. Bae JH, Mun KC, Park WK, Lee SR, Suh SI, Baek WK, Yim MB, Kwon TK, Song DK (2002) EGCG attenuates AMPA-induced intracellular calcium increase in hippocampal neurons. Biochem Biophys Res Commun 290:1506-1512
26. Lee CM, Wong HN, Chui KY, Choang TF, Hon PM, Chang HM (1991) Miltirone a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett 127:237-241
27. Kuang P, Xiang J ( 1994) Effect of Radix Salviae Miltiorrhizae on EAA and IAA during cerebral ischemia in gerbils: a microdialysis study. J Tradit Chin Med 14:45-50
28. Zhang F, White JG, Iadecola C (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 14:217-226
29. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T (1994) L-Arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 25:429-435
30. Hosomi N, Mizushige K, Kitadai M, Ohyama H, Ichihara SI, Takahashi T, Matsuo H (1999) Induced hypertension treatment to improve cerebral ischemic injury after transient forebrain ischemia. Brain Res 835:188-196
31. Diringer MN, Axelrod Y (2007) Hemodynamic manipulation in the neuro-intensive care unit: cerebral perfusion pressure therapy in head injury and hemodynamic augmentation for cerebral vasospasm. Curr Opin Crit Care 13:156-162