Analgesic and anti-inflammatory activities of the methanol extract of kalanchoe gracilis (L.) DC stem in mice

American Journal of Chinese Medicine

Volumn 38, Issue 3, 2010, Pages 529-546

  Lai, Zhen Rung ^a   Peng, Wen Huang ^a   Ho, Yu Ling ^c   Huang, Shun Chieh ^b   Huang, Tai Hung ^b   Lai, Shang Chih ^a   Ku, Yoe Ray ^e   Tsai, Jen Chieh ^b   Wang, Ching Ying ^a   Chang, Yuan Shiun ^a,d  

^a Graduate Institute of Chinese Pharmaceutical Sciences   (China)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e Executive Yuan   (Taiwan)

Author keywords

Analgesia; Anti inflammation; Eupafolin; Kalanchoe gracilis; Malondialdehyde; Nitric oxide; Tumor necrosis factor

Indexed keywords

ACETIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; FORMALDEHYDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INDOMETACIN; INTERLEUKIN 1BETA; KALANCHOE GRACILIS EXTRACT; MALONALDEHYDE; METHANOL; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; ENZYME ACTIVITY; KALANCHOE GRACILIS; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PAW EDEMA; STATISTICAL SIGNIFICANCE; WRITHING TEST;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INTERLEUKIN-1BETA; KALANCHOE; LIVER; MALE; MALONDIALDEHYDE; METHANOL; MICE; MICE, INBRED ICR; NITRIC ACID; PAIN; PAIN MEASUREMENT; PHYTOTHERAPY; PLANT EXTRACTS; PLANT STEMS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77953561434     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X10008032     Document Type: Article

References (43)

1. Artese, L., A. Piattelli, M. Quaranta, A. Colasante and P. Musani. Immunoreactivity for interleukin-1 α and tumor necrosis factor-β and ultrastructural features of monocytes/macrophages in periapical granulomas. J. Endod. 17: 483-487, 1991.
2. Ataoglu, T., M. Üngör, B. Serpek, S. Halilonlu, H. Ataoglu and H. Ari. Interleukin-1α and tumour necrosis factor-β levels in periapical exudates. Int. Endod. J. 35: 181-185, 2002.
3. Bonnie, S.P., Y.K. Ying, Y.C. Tsui and C.L. Yeuk. Anti-oxidative and anti-inflammatory activities of two different species of a Chinese herb I-Tiao-Gung. Life Sci. 77: 2830-2839, 2005.
4. Carlberg, I. and B. Mannervik. Glutathione reductase. Methods Enzymol. 113: 484-499, 1985.
5. Cuzzocrea, S., B. Zingarelli, G. Calapai, F. Nava and A.P. Caputi. Zymosanactivated plasma induces paw oedema by nitric oxide and prostaglandin production. Life Sci. 60: 215-220, 1997.
6. Cuzzocrea, S., G. Costantino, B. Zingarelli, E. Mazzon, A. Micali and A.P. Caputi. The protective role of endogenous glutathione in carrageenan induced pleurisy in the rat. Eur. J. Pharmacol. 372: 187-197, 1999. (Pubitemid 29251291)
7. Dawson, J., A.D. Sedgwick, J.C. Edwards and P. Lees. A comparative study of the cellular exudative and histological responses to carrageenan, dextran and zymosan in the mouse. Int. J. Tissue React. 13: 171-185, 1991.
8. Deraedt, R., S. Jouquey, F. Delevallee and M. Flahaut. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 61: 17-24, 1980.
9. Di, R.M., J.P. Papadimitrion and D.A. Willoughby. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 104: 15-29, 1971.
10. Duarte, I.D., M. Nakamura and S.H. Ferreira. Participation of the sympathetic system in acetic acidinduced writhing in mice. Braz. J. Med. Biol. Res. 21: 341-343, 1988.
11. Dudhgaonkar, S.P., S.K. Tandan, A.S. Bhat, S.H. Jadhav and D. Kumar. Synergistic antiinflammatory interaction between meloxicam and aminoguanidine hydrocholide in carrageenan-induced acute inflammation in rats. Life Sci. 78: 1044-1058, 2006.
12. Flohe, L. and W.A. Gunzler. Glutathione peroxidase. Methods Enzymol. 105: 115-121, 1984.
13. Franzotti, E.M., C.V. Santos, H.M. Rodrigues, R.H. Mourao, M.R. Andrade and A.R. Antoniolli. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca). J. Ethnopharmacol. 72: 273-277, 2000.
14. Gabor, M. Progress in clinical and biological research. In: V. Cody, E. Middleton and J.B. Harborne (eds.) Plant Flavonoids in Biology and Medicine. Alan R. Liss, New York, 1986, p. 47.
15. Ge, J.F., T.Y. Wang, B. Zhao, X.W. Lv, Y. Jin, L. Peng, S.C. Yu and J. Li. Anti-inflammatory effect of triterpenoic acids of Eriobotrya japonica (Thunb.) Lindl. leaf on rat model of chronic bronchitis. Am. J. Chin. Med. 37: 309-321, 2009.
16. Green, L.C., D.A. Vagner, J. Glogowski, P.L. Skipper, J.S. Wishhnok and S.R. Tannenbaum. Analysis of nitrate, nitrite, and (15N) nitrate in biological fluids. Anal. Biochem. 26: 131-138, 1982.
17. Huang, T.S. Flora of Taiwan, 2nd ed., Vol.3. Tah Jinn Printing Company, Ltd., Taiwan, 1998, pp. 268-269.
18. Janero, D.R. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med. 9: 515-540, 1990.
19. Kan, W.S. Illustrated Flora of Taiwan Medicinal Plants. Chinese Medicine Publishing, Taiwan, 1958, pp. 202.
20. Kao, M.C. Handbook of Taiwan Medicinal Plants. Southern Materials Center, Taiwan, 1981, pp. 193.
21. Karin, C.S.L., S.L. Yan, M.F. Roberts and J.D. Phillipson. Eupafolin rhamnosides from Kalanchoe gracilis. J. Nat. Prod. 52: 970-974, 1989.
22. Kim S.J., J.S. Kim, I.Y. Choi, D.H. Kim, M.C. Kim, H.J. An, H.J. Na, N.H. Kim, P.D. Moon, N.Y. Myung, J.Y. Lee, H.J. Jeong, J.Y. Um, T.Y. Shin, H.M. Kim and S.H. Hong. Anti-inflammatory activity of Schizonepeta tenuifolia through the inhibition of MAPK phosphorylation in mouse peritoneal macrophages. Am. J. Chin. Med. 36: 1145-1158, 2008.
23. Kirkova, M., T. Kassabova and E. Russanov. In vivo effects of indomethacin I. Activity of antioxidant enzymes and lipid peroxidation. Gen. Pharmacol. 23: 503-507, 1992.
24. Koster, R., M. Anderson and E.J. Beer. Acetic acid for analgesic screening. Fed. Proc. 18: 412-416, 1959.
25. Lai, S.C., W.H. Peng, S.C. Huang, Y.L. Ho, T.H. Huang, Z.R. Lai and Y.S. Chang. Analgesic and anti-inflammatory activities of methanol extract from Desmodium triflorum DC in mice. Am. J. Chin. Med. 37: 573-588, 2009.
26. Lin, Y.C., H.Y. Cheng, T.H. Huang, H.W. Huang, Y.H. Lee and W.H. Peng. Analgesic and antiinflammatory activities of Torenia concolor Lindley var. formosana Yamazaki and betulin in mice. Am. J. Chin. Med. 37: 97-111, 2009.
27. Lu, T.C., Y.Z. Ko, H.W. Huang, Y.C. Hung, Y.C. Lin and W.H. Peng. Analgesic and anti-inflamatory activities of aqueous extract from Glycine tomentella root in mice. J. Ethnopharmacol. 113: 142-148, 2007.
28. Mascolo, N., R. Jain, S.C. Jain and F. Capasso. Ethnopharmacologic investigation of ginger (Zingiber officinale). J. Ethnopharmacol. 27: 129-140, 1989.
29. Misra, H.P. and I. Fridovich. The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247: 3170-3175, 1972.
30. Moshage, H., B. Kok and J.R. Huizenga. Nitrite and nitrate determination in plasma: a critical evaluation. Clin. Chem. 41: 892-896, 1995.
31. Nantel, F., D. Denis, R. Gordon, A. Northey, M. Cirino, K.M. Metters and C.C. Chan. Distribution and regulation of cyclooxygenase-2 in carrageenan induced inflammation. Br. J. Pharmacol. 128: 853-859, 1999.
32. Planas, E., S. Sanchez, L. Rodriguez, O. Pol and M.M. Puig. Antinociceptive/anti-edema effects of liposomal morphine during acute inflammation of the rat paw. Pharmacology 60: 121-127, 2000.
33. Ronaldo, A.R., L.V. Mariana, M.T. Sara, B.P.P. Adrriana, P. Steve, S.H. Ferreira and Q.C. Fernando. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol. 387: 111-118, 2000.
34. Salvemini, D., Z. Wang, D.M. Bourdon, M.K. Stern, M.G. Curne and P.T. Manning. Evidence of peroxynitrite involvement in the carrageenan induced rat paw edema. Eur. J. Pharmacol. 303: 217-220, 1996.
35. Shibata, M., T. Ohkubo, H. Takahashi and R. Inoki. Modified formalin test: characteristic biphasic pain response. Pain 38: 347-352, 1989.
36. Spector, W.G. and D.A. Willoughby. The inflammatory response. Bacteriol. Rev. 27: 117-154, 1963.
37. Tatum, V.L., C. Changchit and C.K. Chow. Measurement of malondialdehyde by high performance liquid chromatography with fluorescence detection. Lipids 25: 226-229, 1990.
38. Tjølsen, A., O.G. Berge, S. Hunskaar, J.H. Rosland and K. Hole. The formalin test: an evaluation of the method. Pain 51: 5-17, 1992.
39. Ueno, A., H. Naraba, Y. Ikeda, F. Ushikubi, T. Murata, S. Naramiya and S. Ohishi. Intrinsic prostacyclin contributes to exudation induced by bradikinin or carrageenan: a study on the paw edema induced in IP-receptor deficient mice. Life Sci. 66: 155-160, 2000.
40. Voilley, N. Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAids). Curr. Drug Targets Inflamm. Allergy 3: 71-79, 2004.
41. Winter, C.A., E.A. Risley and G.W. Nuss. Carrageenan-induced oedema in hind paw on the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111: 544-547, 1962.
42. Wu, P.L., Y.L. Hsu, T.S. Wu, K.F. Bastow and K.H. Lee. Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis. Org. Lett. 23: 5207-5210, 2006.
43. Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110, 1983.